Q7MHF1 (PYRB_VIBVY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	VV2920

Organism

Vibrio vulnificus (strain YJ016) [Complete proteome] [HAMAP]

Taxonomic identifier

196600 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 309	309	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_0000113227

Sequences

	Sequence		Length	Mass (Da)
	Q7MHF1 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: B7AE74490C0BE969	FASTA	309	34,266
	10 20 30 40 50 60 MTNSLYKKHI ISIPELSRAE LELIVKTAGQ LKAEPNPELI KNKVVASCFF EPSTRTRLSF 70 80 90 100 110 120 ETAIQRIGGD VIGFDDGGNT SLAKKGETLS DSVQVISNYV DAFVMRHPQE GAARLASEFS 130 140 150 160 170 180 NGVPVINAGD GANQHPTQTL LDLFTISETQ DRLDNLNVAF VGDLKYGRTV HSLTQALAKF 190 200 210 220 230 240 NNIRFFFVAP DALAMPDYIL EDLDEAGISY SLHTDMETVI PELDILYMTR VQKERFDESE 250 260 270 280 290 300 YAHIKSAYIL TAALLEGARE NLKVLHPLPR VDEITTDVDK TPHAYYFQQA GNGVYAREAL LALVLNESL

References

[1]

"Comparative genome analysis of Vibrio vulnificus, a marine pathogen." Chen C.-Y., Wu K.-M., Chang Y.-C., Chang C.-H., Tsai H.-C., Liao T.-L., Liu Y.-M., Chen H.-J., Shen A.B.-T., Li J.-C., Su T.-L., Shao C.-P., Lee C.-T., Hor L.-I., Tsai S.-F. Genome Res. 13:2577-2587(2003) [PubMed: 14656965] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: YJ016.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000037 Genomic DNA. Translation: BAC95684.1.
RefSeq	NP_935713.1. NC_005139.1.
3D structure databases
ProteinModelPortal	Q7MHF1.
SMR	Q7MHF1. Positions 3-309.
ModBase	Search...
Protein-protein interaction databases
STRING	Q7MHF1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2625762.
GenomeReviews	Gene locus VV2920 in contig BA000037_GR.
KEGG	vvy:VV2920.
NMPDR	fig|196600.1.peg.2987.
PATRIC	20172702. VBIVibVul40472_2901.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0540.
HOGENOM	HBG579429.
OMA	FKQSFYG.
PhylomeDB	Q7MHF1.
ProtClustDB	PRK00856.
Enzyme and pathway databases
BioCyc	VVUL196600:VV2920-MONOMER.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
KO	K00609.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. Asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_VIBVY

Accession

Primary (citable) accession number: Q7MHF1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	December 15, 2003
Last modified:	January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program