Q7MH21 (ASTD_VIBVY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-succinylglutamate 5-semialdehyde dehydrogenase
EC=1.2.1.71

Alternative name(s):
Succinylglutamic semialdehyde dehydrogenase
Short name=SGSD

Gene names

Name:	astD
Ordered Locus Names:	VV3052

Organism

Vibrio vulnificus (strain YJ016) [Complete proteome] [HAMAP]

Taxonomic identifier

196600 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	485 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity. HAMAP MF_01174
Catalytic activity	N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O = N-succinyl-L-glutamate + NADH. HAMAP MF_01174
Pathway	Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5. HAMAP MF_01174
Sequence similarities	Belongs to the aldehyde dehydrogenase family. AstD subfamily.
Sequence caution	The sequence BAC95816.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Arginine metabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	succinylglutamate-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 485	485	N-succinylglutamate 5-semialdehyde dehydrogenase HAMAP MF_01174		PRO_0000262435
Regions
	Nucleotide binding	220 – 225	6	NAD By similarity
Sites
	Active site	243	1	By similarity
	Active site	278	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7MH21 [UniParc]. Last modified November 28, 2006. Version 2. Checksum: 58E5A7F6FBC190E8	FASTA	485	52,000
	10 20 30 40 50 60 MTQWIAGEWV EGLGEEFTSL SPYDNQVVWR GKGATAEQVE MAVKAARQAF VGWKKLSVAE 70 80 90 100 110 120 REAMVLAFAE QVKENSEEIA QVIAKETGKP LWETRTEAAA MAGKIAISIR AYHERTGESQ 130 140 150 160 170 180 KEAAGNQIVL RHRPLGVMAV FGPYNFPGHL PNGHIVPALL AGNTVVFKPS EQTPWTGELA 190 200 210 220 230 240 MKLWQAAGLP QGVINLVQGG KETGIALAES KGIDGLLFTG SANTGHLLHR QFAGQPGKML 250 260 270 280 290 300 ALEMGGNNPM VITDHYGDLD ATVYTIIQSA FISAGQRCTC ARRLYIPLGE KGDALITRLV 310 320 330 340 350 360 EATKKLRVDQ PFAEPAPFMG PQISEAAANF ILAAQANLQS LGGESLIEAK AGEAAFVTPG 370 380 390 400 410 420 IIDVTNIAEL PDEEYFGPLL QVVRYQTLEQ AVELANDTRF GLSAGLVSTD DGEWQYFVDH 430 440 450 460 470 480 IRAGIVNRNR QLTGASGDAP FGGPGASGNL RPSAYYAADY CAYPMASMEG EETLLPATLS PGVEL

References

[1]

"Comparative genome analysis of Vibrio vulnificus, a marine pathogen." Chen C.-Y., Wu K.-M., Chang Y.-C., Chang C.-H., Tsai H.-C., Liao T.-L., Liu Y.-M., Chen H.-J., Shen A.B.-T., Li J.-C., Su T.-L., Shao C.-P., Lee C.-T., Hor L.-I., Tsai S.-F. Genome Res. 13:2577-2587(2003) [PubMed: 14656965] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: YJ016.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000037 Genomic DNA. Translation: BAC95816.1. Different initiation.
RefSeq	NP_935845.1. NC_005139.1.
3D structure databases
ProteinModelPortal	Q7MH21.
ModBase	Search...
Protein-protein interaction databases
STRING	Q7MH21.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2625901.
GenomeReviews	Gene locus VV3052 in contig BA000037_GR.
KEGG	vvy:VV3052.
NMPDR	fig|196600.1.peg.3118.
PATRIC	20172972. VBIVibVul40472_3029.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1012.
HOGENOM	HBG752218.
OMA	DHIRAGI.
ProtClustDB	PRK09457.
Enzyme and pathway databases
BioCyc	VVUL196600:VV3052-MONOMER.
Family and domain databases
HAMAP	MF_01174. Aldedh_AstD. [Tree]
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. IPR017649. SuccinylGlu_semiald_DH_AstD. [Graphical view]
Gene3D	G3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit. G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KO	K06447.
PANTHER	PTHR11699:SF24. PTHR11699:SF24. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMs	TIGR03240. Arg_catab_astD. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ASTD_VIBVY

Accession

Primary (citable) accession number: Q7MH21

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	November 28, 2006
Last modified:	January 25, 2012
This is version 62 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program