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Q7MGT5

- PUR9_VIBVY

UniProt

Q7MGT5 - PUR9_VIBVY

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Vibrio vulnificus (strain YJ016)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciVVUL196600:GJ9W-3251-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:VV3142
OrganismiVibrio vulnificus (strain YJ016)
Taxonomic identifieri196600 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000002675: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 530530Bifunctional purine biosynthesis protein PurHPRO_0000192148Add
BLAST

Proteomic databases

PRIDEiQ7MGT5.

Interactioni

Protein-protein interaction databases

STRINGi196600.VV3142.

Structurei

3D structure databases

ProteinModelPortaliQ7MGT5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7MGT5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNNARPIRRA LISVSDKTGI VEFAQALAER GVDILSTGGT ARLLAEQGIA
60 70 80 90 100
VTEVSDYTGF PEMMDGRVKT LHPKVHGGVL GRRGQDDEVM AKHGINPIDM
110 120 130 140 150
VVVNLYPFAE TVAKEGCTLA DAVENIDIGG PTMVRSAAKN HKDVTIVVNA
160 170 180 190 200
SDYHRVITEM DANDTSLTLE TRFDLAIAAF EHTAAYDGMI ANYFGTMVPS
210 220 230 240 250
YGENKEGDEE SKFPRTFNQQ FIKKQDMRYG ENSHQAAAFY VEANPQEASV
260 270 280 290 300
ATARQIQGKA LSYNNIADTD AALECVKEFN EPACVIVKHA NPCGVALGKD
310 320 330 340 350
ILEAYNRAYQ TDPTSAFGGI IAFNQELDAE TATAIVERQF VEVIIAPSVS
360 370 380 390 400
AEAMEVVAAK KNVRLLECGE WTTKTTGFDV KRVNGGLLVQ DRDQGMVSLD
410 420 430 440 450
DLKVVSKRQP TEEELKDALF CWKVAKYVKS NAIVYSKGDM TIGVGAGQMS
460 470 480 490 500
RVYSAKIAGI KAADEGLQVE GCVMASDAFF PFRDGIDAAA EAGIKCVIQP
510 520 530
GGSMRDDEVI AAADEHGMAM IFTGMRHFRH
Length:530
Mass (Da):57,464
Last modified:December 15, 2003 - v1
Checksum:i11AF0EB19B359153
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000037 Genomic DNA. Translation: BAC95906.1.
RefSeqiNP_935935.1. NC_005139.1.

Genome annotation databases

EnsemblBacteriaiBAC95906; BAC95906; BAC95906.
GeneIDi2626002.
KEGGivvy:VV3142.
PATRICi20173164. VBIVibVul40472_3114.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000037 Genomic DNA. Translation: BAC95906.1 .
RefSeqi NP_935935.1. NC_005139.1.

3D structure databases

ProteinModelPortali Q7MGT5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196600.VV3142.

Proteomic databases

PRIDEi Q7MGT5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC95906 ; BAC95906 ; BAC95906 .
GeneIDi 2626002.
KEGGi vvy:VV3142.
PATRICi 20173164. VBIVibVul40472_3114.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci VVUL196600:GJ9W-3251-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YJ016.

Entry informationi

Entry nameiPUR9_VIBVY
AccessioniPrimary (citable) accession number: Q7MGT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: December 15, 2003
Last modified: October 1, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3