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Q7MGT5 (PUR9_VIBVY) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH

Including the following 2 domains:

  1. Phosphoribosylaminoimidazolecarboxamide formyltransferase
    EC=2.1.2.3
    Alternative name(s):
    AICAR transformylase
  2. IMP cyclohydrolase
    EC=3.5.4.10
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
Gene names
Name:purH
Ordered Locus Names:VV3142
OrganismVibrio vulnificus (strain YJ016) [Complete proteome] [HAMAP]
Taxonomic identifier196600 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length530 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP-Rule MF_00139

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 530530Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
PRO_0000192148

Sequences

Sequence LengthMass (Da)Tools
Q7MGT5 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 11AF0EB19B359153

FASTA53057,464
        10         20         30         40         50         60 
MNNARPIRRA LISVSDKTGI VEFAQALAER GVDILSTGGT ARLLAEQGIA VTEVSDYTGF 

        70         80         90        100        110        120 
PEMMDGRVKT LHPKVHGGVL GRRGQDDEVM AKHGINPIDM VVVNLYPFAE TVAKEGCTLA 

       130        140        150        160        170        180 
DAVENIDIGG PTMVRSAAKN HKDVTIVVNA SDYHRVITEM DANDTSLTLE TRFDLAIAAF 

       190        200        210        220        230        240 
EHTAAYDGMI ANYFGTMVPS YGENKEGDEE SKFPRTFNQQ FIKKQDMRYG ENSHQAAAFY 

       250        260        270        280        290        300 
VEANPQEASV ATARQIQGKA LSYNNIADTD AALECVKEFN EPACVIVKHA NPCGVALGKD 

       310        320        330        340        350        360 
ILEAYNRAYQ TDPTSAFGGI IAFNQELDAE TATAIVERQF VEVIIAPSVS AEAMEVVAAK 

       370        380        390        400        410        420 
KNVRLLECGE WTTKTTGFDV KRVNGGLLVQ DRDQGMVSLD DLKVVSKRQP TEEELKDALF 

       430        440        450        460        470        480 
CWKVAKYVKS NAIVYSKGDM TIGVGAGQMS RVYSAKIAGI KAADEGLQVE GCVMASDAFF 

       490        500        510        520        530 
PFRDGIDAAA EAGIKCVIQP GGSMRDDEVI AAADEHGMAM IFTGMRHFRH 

« Hide

References

[1]"Comparative genome analysis of Vibrio vulnificus, a marine pathogen."
Chen C.-Y., Wu K.-M., Chang Y.-C., Chang C.-H., Tsai H.-C., Liao T.-L., Liu Y.-M., Chen H.-J., Shen A.B.-T., Li J.-C., Su T.-L., Shao C.-P., Lee C.-T., Hor L.-I., Tsai S.-F.
Genome Res. 13:2577-2587(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: YJ016.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000037 Genomic DNA. Translation: BAC95906.1.
RefSeqNP_935935.1. NC_005139.1.

3D structure databases

ProteinModelPortalQ7MGT5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING196600.VV3142.

Proteomic databases

PRIDEQ7MGT5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC95906; BAC95906; BAC95906.
GeneID2626002.
KEGGvvy:VV3142.
PATRIC20173164. VBIVibVul40472_3114.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0138.
HOGENOMHOG000230373.
KOK00602.
OMARAFKTDP.
OrthoDBEOG6QCDFF.

Enzyme and pathway databases

BioCycVVUL196600:GJ9W-3251-MONOMER.
UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR9_VIBVY
AccessionPrimary (citable) accession number: Q7MGT5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: December 15, 2003
Last modified: May 14, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways