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Q7MGP6 (GPPA_VIBVY) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

EC=3.6.1.40
Alternative name(s):
Guanosine pentaphosphate phosphohydrolase
pppGpp-5'-phosphohydrolase
Gene names
Name:gppA
Ordered Locus Names:VV3184
OrganismVibrio vulnificus (strain YJ016) [Complete proteome] [HAMAP]
Taxonomic identifier196600 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length497 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities By similarity. HAMAP-Rule MF_01550

Catalytic activity

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate. HAMAP-Rule MF_01550

Pathway

Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2. HAMAP-Rule MF_01550

Sequence similarities

Belongs to the GppA/Ppx family. GppA subfamily.

Sequence caution

The sequence BAC95948.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 497497Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase HAMAP-Rule MF_01550
PRO_0000194296

Sequences

Sequence LengthMass (Da)Tools
Q7MGP6 [UniParc].

Last modified December 20, 2005. Version 2.
Checksum: A4EB735219F4792C

FASTA49754,755
        10         20         30         40         50         60 
MSQAGNSPLY AAIDLGSNSF HMLVVRHIDG SVQTMAKIKR KVRLAAGLDE HNALSKEAMQ 

        70         80         90        100        110        120 
RGWDCLSLFA ERLQDIPAEH IRIVGTATLR TATNVDLFLQ KANQILGHPI EVISGEEEAA 

       130        140        150        160        170        180 
TIYKGVAHTS GGSGRRLVVD IGGASTELII GEGFEAKALT SLKMGCVTWL ENFFKDRQLS 

       190        200        210        220        230        240 
ARNFEAAIEG AKQTLLPILE QYKSLGWDVC VGASGTVQAL QEIMLAQGMD EVITHAKLKR 

       250        260        270        280        290        300 
LQKQAMLADH LEELEIEGLT LERALVFPSG LSILIAIFEL LEIDAMTLAG GALREGLAYE 

       310        320        330        340        350        360 
MMSELRQDDI RARTIGSIQS RYQLDSQYGQ QVANLALKLL QQVGDVMWIP EPQGAMLLET 

       370        380        390        400        410        420 
TAKLHEIGLT IDFKKGGEHS AYLMQHLDLP GFTRAQKFLM GEIARRYREG LTSLPEQHAL 

       430        440        450        460        470        480 
SGNSGKRLLR LLRLAVILSH RRQPSLEPEV TLSAEGDKLT LAIDAQWLEN NPLTAAELEL 

       490 
EANRQTDIGW PLVIESR 

« Hide

References

[1]"Comparative genome analysis of Vibrio vulnificus, a marine pathogen."
Chen C.-Y., Wu K.-M., Chang Y.-C., Chang C.-H., Tsai H.-C., Liao T.-L., Liu Y.-M., Chen H.-J., Shen A.B.-T., Li J.-C., Su T.-L., Shao C.-P., Lee C.-T., Hor L.-I., Tsai S.-F.
Genome Res. 13:2577-2587(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: YJ016.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000037 Genomic DNA. Translation: BAC95948.1. Different initiation.
RefSeqNP_935977.2. NC_005139.1.

3D structure databases

ProteinModelPortalQ7MGP6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING196600.VV3184.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC95948; BAC95948; BAC95948.
GeneID2626055.
KEGGvvy:VV3184.
PATRIC20173262. VBIVibVul40472_3152.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0248.
HOGENOMHOG000258672.
KOK01524.
OMAGLHIEYK.
OrthoDBEOG6M6JN6.

Enzyme and pathway databases

BioCycVVUL196600:GJ9W-3304-MONOMER.
UniPathwayUPA00908; UER00884.

Family and domain databases

HAMAPMF_01550. GppA.
InterProIPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamPF02541. Ppx-GppA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGPPA_VIBVY
AccessionPrimary (citable) accession number: Q7MGP6
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: May 14, 2014
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways