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Q7MGP6

- GPPA_VIBVY

UniProt

Q7MGP6 - GPPA_VIBVY

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Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Vibrio vulnificus (strain YJ016)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotation

Catalytic activityi

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. guanosine pentaphosphate catabolic process Source: InterPro
  2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciVVUL196600:GJ9W-3304-MONOMER.
UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation (EC:3.6.1.40UniRule annotation)
Alternative name(s):
Guanosine pentaphosphate phosphohydrolaseUniRule annotation
pppGpp-5'-phosphohydrolaseUniRule annotation
Gene namesi
Name:gppAUniRule annotation
Ordered Locus Names:VV3184
OrganismiVibrio vulnificus (strain YJ016)
Taxonomic identifieri196600 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000002675: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatasePRO_0000194296Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi196600.VV3184.

Structurei

3D structure databases

ProteinModelPortaliQ7MGP6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0248.
HOGENOMiHOG000258672.
KOiK01524.
OMAiGLHIEYK.
OrthoDBiEOG6M6JN6.

Family and domain databases

HAMAPiMF_01550. GppA.
InterProiIPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7MGP6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQAGNSPLY AAIDLGSNSF HMLVVRHIDG SVQTMAKIKR KVRLAAGLDE
60 70 80 90 100
HNALSKEAMQ RGWDCLSLFA ERLQDIPAEH IRIVGTATLR TATNVDLFLQ
110 120 130 140 150
KANQILGHPI EVISGEEEAA TIYKGVAHTS GGSGRRLVVD IGGASTELII
160 170 180 190 200
GEGFEAKALT SLKMGCVTWL ENFFKDRQLS ARNFEAAIEG AKQTLLPILE
210 220 230 240 250
QYKSLGWDVC VGASGTVQAL QEIMLAQGMD EVITHAKLKR LQKQAMLADH
260 270 280 290 300
LEELEIEGLT LERALVFPSG LSILIAIFEL LEIDAMTLAG GALREGLAYE
310 320 330 340 350
MMSELRQDDI RARTIGSIQS RYQLDSQYGQ QVANLALKLL QQVGDVMWIP
360 370 380 390 400
EPQGAMLLET TAKLHEIGLT IDFKKGGEHS AYLMQHLDLP GFTRAQKFLM
410 420 430 440 450
GEIARRYREG LTSLPEQHAL SGNSGKRLLR LLRLAVILSH RRQPSLEPEV
460 470 480 490
TLSAEGDKLT LAIDAQWLEN NPLTAAELEL EANRQTDIGW PLVIESR
Length:497
Mass (Da):54,755
Last modified:December 20, 2005 - v2
Checksum:iA4EB735219F4792C
GO

Sequence cautioni

The sequence BAC95948.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000037 Genomic DNA. Translation: BAC95948.1. Different initiation.
RefSeqiNP_935977.2. NC_005139.1.

Genome annotation databases

EnsemblBacteriaiBAC95948; BAC95948; BAC95948.
GeneIDi2626055.
KEGGivvy:VV3184.
PATRICi20173262. VBIVibVul40472_3152.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000037 Genomic DNA. Translation: BAC95948.1 . Different initiation.
RefSeqi NP_935977.2. NC_005139.1.

3D structure databases

ProteinModelPortali Q7MGP6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196600.VV3184.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC95948 ; BAC95948 ; BAC95948 .
GeneIDi 2626055.
KEGGi vvy:VV3184.
PATRICi 20173262. VBIVibVul40472_3152.

Phylogenomic databases

eggNOGi COG0248.
HOGENOMi HOG000258672.
KOi K01524.
OMAi GLHIEYK.
OrthoDBi EOG6M6JN6.

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00884 .
BioCyci VVUL196600:GJ9W-3304-MONOMER.

Family and domain databases

HAMAPi MF_01550. GppA.
InterProi IPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view ]
Pfami PF02541. Ppx-GppA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YJ016.

Entry informationi

Entry nameiGPPA_VIBVY
AccessioniPrimary (citable) accession number: Q7MGP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: October 1, 2014
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3