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Q7MGP6

- GPPA_VIBVY

UniProt

Q7MGP6 - GPPA_VIBVY

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Protein
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase
Gene
gppA, VV3184
Organism
Vibrio vulnificus (strain YJ016)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities By similarity.UniRule annotation

Catalytic activityi

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. guanosine pentaphosphate catabolic process Source: InterPro
  2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciVVUL196600:GJ9W-3304-MONOMER.
UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (EC:3.6.1.40)
Alternative name(s):
Guanosine pentaphosphate phosphohydrolase
pppGpp-5'-phosphohydrolase
Gene namesi
Name:gppA
Ordered Locus Names:VV3184
OrganismiVibrio vulnificus (strain YJ016)
Taxonomic identifieri196600 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000002675: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation
PRO_0000194296Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi196600.VV3184.

Structurei

3D structure databases

ProteinModelPortaliQ7MGP6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0248.
HOGENOMiHOG000258672.
KOiK01524.
OMAiGLHIEYK.
OrthoDBiEOG6M6JN6.

Family and domain databases

HAMAPiMF_01550. GppA.
InterProiIPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7MGP6-1 [UniParc]FASTAAdd to Basket

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MSQAGNSPLY AAIDLGSNSF HMLVVRHIDG SVQTMAKIKR KVRLAAGLDE    50
HNALSKEAMQ RGWDCLSLFA ERLQDIPAEH IRIVGTATLR TATNVDLFLQ 100
KANQILGHPI EVISGEEEAA TIYKGVAHTS GGSGRRLVVD IGGASTELII 150
GEGFEAKALT SLKMGCVTWL ENFFKDRQLS ARNFEAAIEG AKQTLLPILE 200
QYKSLGWDVC VGASGTVQAL QEIMLAQGMD EVITHAKLKR LQKQAMLADH 250
LEELEIEGLT LERALVFPSG LSILIAIFEL LEIDAMTLAG GALREGLAYE 300
MMSELRQDDI RARTIGSIQS RYQLDSQYGQ QVANLALKLL QQVGDVMWIP 350
EPQGAMLLET TAKLHEIGLT IDFKKGGEHS AYLMQHLDLP GFTRAQKFLM 400
GEIARRYREG LTSLPEQHAL SGNSGKRLLR LLRLAVILSH RRQPSLEPEV 450
TLSAEGDKLT LAIDAQWLEN NPLTAAELEL EANRQTDIGW PLVIESR 497
Length:497
Mass (Da):54,755
Last modified:December 20, 2005 - v2
Checksum:iA4EB735219F4792C
GO

Sequence cautioni

The sequence BAC95948.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000037 Genomic DNA. Translation: BAC95948.1. Different initiation.
RefSeqiNP_935977.2. NC_005139.1.

Genome annotation databases

EnsemblBacteriaiBAC95948; BAC95948; BAC95948.
GeneIDi2626055.
KEGGivvy:VV3184.
PATRICi20173262. VBIVibVul40472_3152.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000037 Genomic DNA. Translation: BAC95948.1 . Different initiation.
RefSeqi NP_935977.2. NC_005139.1.

3D structure databases

ProteinModelPortali Q7MGP6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196600.VV3184.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC95948 ; BAC95948 ; BAC95948 .
GeneIDi 2626055.
KEGGi vvy:VV3184.
PATRICi 20173262. VBIVibVul40472_3152.

Phylogenomic databases

eggNOGi COG0248.
HOGENOMi HOG000258672.
KOi K01524.
OMAi GLHIEYK.
OrthoDBi EOG6M6JN6.

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00884 .
BioCyci VVUL196600:GJ9W-3304-MONOMER.

Family and domain databases

HAMAPi MF_01550. GppA.
InterProi IPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view ]
Pfami PF02541. Ppx-GppA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YJ016.

Entry informationi

Entry nameiGPPA_VIBVY
AccessioniPrimary (citable) accession number: Q7MGP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: May 14, 2014
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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