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Q7MGL2 (PURE_VIBVY) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
N5-carboxyaminoimidazole ribonucleotide mutase

Short name=N5-CAIR mutase
EC=5.4.99.18
Alternative name(s):
5-(carboxyamino)imidazole ribonucleotide mutase
Gene names
Name:purE
Ordered Locus Names:VV3218
OrganismVibrio vulnificus (strain YJ016) [Complete proteome] [HAMAP]
Taxonomic identifier196600 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length161 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) By similarity.

Catalytic activity

5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.

Subunit structure

Homooctamer By similarity.

Sequence similarities

Belongs to the AIR carboxylase family.

Ontologies

Keywords
   Biological processPurine biosynthesis
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process'de novo' IMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_function5-(carboxyamino)imidazole ribonucleotide mutase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 161161N5-carboxyaminoimidazole ribonucleotide mutase
PRO_0000074985

Sites

Binding site91Substrate By similarity
Binding site121Substrate By similarity
Binding site391Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7MGL2 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 17C09D4D44350A01

FASTA16116,696
        10         20         30         40         50         60 
MKVGIIMGSK SDWPTMKLAA EMLDRFGVEY ETKVVSAHRT PHLLAEYAST AKERGLKVII 

        70         80         90        100        110        120 
AGAGGAAHLP GMAAAFTSLP VLGVPVQSRA LSGLDSLYSI VQMPKGIAVG TLAIGEAGAA 

       130        140        150        160 
NAGLLAAQIL GTHDENIMAK VEAFRSEQTE SVLANPNPAE D 

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References

[1]"Comparative genome analysis of Vibrio vulnificus, a marine pathogen."
Chen C.-Y., Wu K.-M., Chang Y.-C., Chang C.-H., Tsai H.-C., Liao T.-L., Liu Y.-M., Chen H.-J., Shen A.B.-T., Li J.-C., Su T.-L., Shao C.-P., Lee C.-T., Hor L.-I., Tsai S.-F.
Genome Res. 13:2577-2587(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: YJ016.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000037 Genomic DNA. Translation: BAC95982.1.
RefSeqNP_936011.1. NC_005139.1.

3D structure databases

ProteinModelPortalQ7MGL2.
SMRQ7MGL2. Positions 3-145.
ModBaseSearch...

Protein-protein interaction databases

STRING196600.VV3218.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC95982; BAC95982; BAC95982.
GeneID2626094.
KEGGvvy:VV3218.
PATRIC20173337. VBIVibVul40472_3184.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0041.
HOGENOMHOG000034140.
KOK01588.
OMAQSDWATM.
ProtClustDBCLSK2391357.

Enzyme and pathway databases

UniPathwayUPA00074; UER00943.

Family and domain databases

Gene3D3.40.50.7700. 1 hit.
InterProIPR024694. N5-CAIR_mutase_PurE.
IPR000031. N5-CAIR_Mutase_PurE_dom.
[Graphical view]
PfamPF00731. AIRC. 1 hit.
[Graphical view]
PIRSFPIRSF001338. AIR_carboxylase. 1 hit.
SMARTSM01001. AIRC. 1 hit.
[Graphical view]
SUPFAMSSF52255. AIR_carboxyl. 1 hit.
TIGRFAMsTIGR01162. purE. 1 hit.
ProtoNetSearch...

Entry information

Entry namePURE_VIBVY
AccessionPrimary (citable) accession number: Q7MGL2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: December 15, 2003
Last modified: May 1, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families