Q7MGL2 (PURE_VIBVY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N5-carboxyaminoimidazole ribonucleotide mutase
Short name=N5-CAIR mutase
EC=5.4.99.18

Alternative name(s):
5-(carboxyamino)imidazole ribonucleotide mutase

Gene names

Name:	purE
Ordered Locus Names:	VV3218

Organism

Vibrio vulnificus (strain YJ016) [Complete proteome] [HAMAP]

Taxonomic identifier

196600 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio › Vibrio vulnificus

Protein attributes

Sequence length	161 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) By similarity.
Catalytic activity	5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.
Subunit structure	Homooctamer By similarity.
Sequence similarities	Belongs to the AIR carboxylase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	5-(carboxyamino)imidazole ribonucleotide mutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 161	161	N5-carboxyaminoimidazole ribonucleotide mutase		PRO_0000074985
Sites
	Binding site	9	1	Substrate By similarity
	Binding site	12	1	Substrate By similarity
	Binding site	39	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7MGL2 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: 17C09D4D44350A01	FASTA	161	16,696
	10 20 30 40 50 60 MKVGIIMGSK SDWPTMKLAA EMLDRFGVEY ETKVVSAHRT PHLLAEYAST AKERGLKVII 70 80 90 100 110 120 AGAGGAAHLP GMAAAFTSLP VLGVPVQSRA LSGLDSLYSI VQMPKGIAVG TLAIGEAGAA 130 140 150 160 NAGLLAAQIL GTHDENIMAK VEAFRSEQTE SVLANPNPAE D

References

[1]

"Comparative genome analysis of Vibrio vulnificus, a marine pathogen." Chen C.-Y., Wu K.-M., Chang Y.-C., Chang C.-H., Tsai H.-C., Liao T.-L., Liu Y.-M., Chen H.-J., Shen A.B.-T., Li J.-C., Su T.-L., Shao C.-P., Lee C.-T., Hor L.-I., Tsai S.-F. Genome Res. 13:2577-2587(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: YJ016.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000037 Genomic DNA. Translation: BAC95982.1.
RefSeq	NP_936011.1. NC_005139.1.
3D structure databases
ProteinModelPortal	Q7MGL2.
SMR	Q7MGL2. Positions 3-145.
ModBase	Search...
Protein-protein interaction databases
STRING	196600.VV3218.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAC95982; BAC95982; BAC95982.
GeneID	2626094.
KEGG	vvy:VV3218.
PATRIC	20173337. VBIVibVul40472_3184.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0041.
HOGENOM	HOG000034140.
KO	K01588.
OMA	QSDWATM.
ProtClustDB	CLSK2391357.
Enzyme and pathway databases
UniPathway	UPA00074; UER00943.
Family and domain databases
Gene3D	3.40.50.7700. 1 hit.
InterPro	IPR024694. N5-CAIR_mutase_PurE. IPR000031. N5-CAIR_Mutase_PurE_dom. [Graphical view]
Pfam	PF00731. AIRC. 1 hit. [Graphical view]
PIRSF	PIRSF001338. AIR_carboxylase. 1 hit.
SMART	SM01001. AIRC. 1 hit. [Graphical view]
SUPFAM	SSF52255. AIR_carboxyl. 1 hit.
TIGRFAMs	TIGR01162. purE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PURE_VIBVY

Accession

Primary (citable) accession number: Q7MGL2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
Last sequence update:	December 15, 2003
Last modified:	May 1, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program