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Q7MGK6

- DEF2_VIBVY

UniProt

Q7MGK6 - DEF2_VIBVY

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Protein
Peptide deformylase 2
Gene
def2, VV3225
Organism
Vibrio vulnificus (strain YJ016)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions By similarity.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Binds 1 Fe2+ ion By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi123 – 1231Iron By similarity
Metal bindingi165 – 1651Iron By similarity
Active sitei166 – 1661 By similarity
Metal bindingi169 – 1691Iron By similarity

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. peptide deformylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciVVUL196600:GJ9W-3350-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylase 2 (EC:3.5.1.88)
Short name:
PDF 2
Alternative name(s):
Polypeptide deformylase 2
Gene namesi
Name:def2
Ordered Locus Names:VV3225
OrganismiVibrio vulnificus (strain YJ016)
Taxonomic identifieri196600 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000002675: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 202202Peptide deformylase 2UniRule annotation
PRO_0000082880Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi196600.VV3225.

Structurei

3D structure databases

ProteinModelPortaliQ7MGK6.
SMRiQ7MGK6. Positions 34-200.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0242.
HOGENOMiHOG000243509.
KOiK01462.
OMAiELLAICI.
OrthoDBiEOG664CMF.

Family and domain databases

Gene3Di3.90.45.10. 1 hit.
HAMAPiMF_00163. Pep_deformylase.
InterProiIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERiPTHR10458. PTHR10458. 1 hit.
PfamiPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFiPIRSF004749. Pep_def. 1 hit.
PRINTSiPR01576. PDEFORMYLASE.
SUPFAMiSSF56420. SSF56420. 1 hit.
TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7MGK6-1 [UniParc]FASTAAdd to Basket

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MLLGCCHLGY KMSRIEPTRF VLFRHSSTFR VHMSVLQVLT FPDDRLRTVA    50
KPVEKVTPEI QKIVDDMIET MYDEEGIGLA ATQVDIHQRI VVIDISESRN 100
EPMVLINPEI LEKRGEDGIE EGCLSVPGAR ALVPRAAEVT VKALDRDGHE 150
FTLEADDLLA ICIQHELDHL QGKLFVDYLS PLKRKRIQDK LAKIKRFNEK 200
QR 202
Length:202
Mass (Da):23,099
Last modified:December 15, 2003 - v1
Checksum:i95DF963B38BF060A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000037 Genomic DNA. Translation: BAC95989.1.
RefSeqiNP_936018.1. NC_005139.1.
WP_011151422.1. NC_005139.1.

Genome annotation databases

EnsemblBacteriaiBAC95989; BAC95989; BAC95989.
GeneIDi2626101.
KEGGivvy:VV3225.
PATRICi20173351. VBIVibVul40472_3191.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000037 Genomic DNA. Translation: BAC95989.1 .
RefSeqi NP_936018.1. NC_005139.1.
WP_011151422.1. NC_005139.1.

3D structure databases

ProteinModelPortali Q7MGK6.
SMRi Q7MGK6. Positions 34-200.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196600.VV3225.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC95989 ; BAC95989 ; BAC95989 .
GeneIDi 2626101.
KEGGi vvy:VV3225.
PATRICi 20173351. VBIVibVul40472_3191.

Phylogenomic databases

eggNOGi COG0242.
HOGENOMi HOG000243509.
KOi K01462.
OMAi ELLAICI.
OrthoDBi EOG664CMF.

Enzyme and pathway databases

BioCyci VVUL196600:GJ9W-3350-MONOMER.

Family and domain databases

Gene3Di 3.90.45.10. 1 hit.
HAMAPi MF_00163. Pep_deformylase.
InterProi IPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view ]
PANTHERi PTHR10458. PTHR10458. 1 hit.
Pfami PF01327. Pep_deformylase. 1 hit.
[Graphical view ]
PIRSFi PIRSF004749. Pep_def. 1 hit.
PRINTSi PR01576. PDEFORMYLASE.
SUPFAMi SSF56420. SSF56420. 1 hit.
TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YJ016.

Entry informationi

Entry nameiDEF2_VIBVY
AccessioniPrimary (citable) accession number: Q7MGK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: December 15, 2003
Last modified: September 3, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi