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Q7MG04

- BGAL_VIBVY

UniProt

Q7MG04 - BGAL_VIBVY

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Protein
Beta-galactosidase
Gene
lacZ, VVA0165
Organism
Vibrio vulnificus (strain YJ016)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.UniRule annotation

Cofactori

Binds 2 magnesium ions per monomer By similarity.UniRule annotation
Binds 1 sodium ion per monomer By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei100 – 1001Substrate By similarity
Metal bindingi198 – 1981Sodium By similarity
Binding sitei198 – 1981Substrate By similarity
Sitei353 – 3531Transition state stabilizer By similarity
Sitei387 – 3871Transition state stabilizer By similarity
Metal bindingi412 – 4121Magnesium 1 By similarity
Metal bindingi414 – 4141Magnesium 1 By similarity
Active sitei457 – 4571Proton donor By similarity
Metal bindingi457 – 4571Magnesium 1 By similarity
Binding sitei457 – 4571Substrate By similarity
Active sitei533 – 5331Nucleophile By similarity
Metal bindingi593 – 5931Magnesium 2 By similarity
Metal bindingi597 – 5971Sodium; via carbonyl oxygen By similarity
Metal bindingi600 – 6001Sodium By similarity
Binding sitei600 – 6001Substrate By similarity
Binding sitei1005 – 10051Substrate By similarity

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC
  2. carbohydrate binding Source: InterPro
  3. magnesium ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding, Sodium

Enzyme and pathway databases

BioCyciVVUL196600:GJ9W-3552-MONOMER.

Protein family/group databases

CAZyiGH2. Glycoside Hydrolase Family 2.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidase (EC:3.2.1.23)
Short name:
Beta-gal
Alternative name(s):
Lactase
Gene namesi
Name:lacZ
Ordered Locus Names:VVA0165
OrganismiVibrio vulnificus (strain YJ016)
Taxonomic identifieri196600 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000002675: Chromosome II

Subcellular locationi

GO - Cellular componenti

  1. beta-galactosidase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10311031Beta-galactosidaseUniRule annotation
PRO_0000367013Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi196600.VVA0165.

Structurei

3D structure databases

ProteinModelPortaliQ7MG04.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni533 – 5364Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3250.
HOGENOMiHOG000252443.
KOiK01190.
OMAiNPPFVPK.
OrthoDBiEOG6XWV0T.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
2.60.40.320. 2 hits.
2.70.98.10. 1 hit.
3.20.20.80. 1 hit.
HAMAPiMF_01687. Beta_gal.
InterProiIPR004199. B-gal_small/dom_5.
IPR011013. Gal_mutarotase_SF_dom.
IPR008979. Galactose-bd-like.
IPR014718. Glyco_hydro-type_carb-bd_sub.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR023933. Glyco_hydro_2_beta_Galsidase.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR006103. Glyco_hydro_2_TIM.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF02929. Bgal_small_N. 1 hit.
PF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view]
PRINTSiPR00132. GLHYDRLASE2.
SMARTiSM01038. Bgal_small_N. 1 hit.
[Graphical view]
SUPFAMiSSF49303. SSF49303. 2 hits.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
SSF74650. SSF74650. 1 hit.
PROSITEiPS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7MG04-1 [UniParc]FASTAAdd to Basket

« Hide

MTAFSEILQR RDWENPQSVN IHCLKAHSPL ASFRDMAHAR DGIHAQRQSL     50
NGQWKFKLFD APEQVDGQFT QADFNDAEWD EIPVPSNWQL HGYDKPIYAN 100
IKYPFDVNPP FVPRENPTGC YRTRVSLSPE DLLNTQRIIF DGVNSAFHLW 150
CNGTWVGYSQ DSRLPAEFDL TSHLVAGENT LAVMVMRWCD GSYLEDQDMW 200
WLSGIFRDVT LLSKPQHCIE DVFITPDLDA CYRDGSLSIV TTIAAPETYQ 250
VQVQLFEGTQ AVTEPNIDRP HNRRIDERGT WNDVVFQTLH LREPKKWTAE 300
TPNLYRLVVS LLDENGTHLE SEAYPVGFRK VEISEGQLKL NGKPLLIRGV 350
NRHEHHPELG HVMTEEDMIR DICLMKQYNF NAVRTAHYPN HPRWYELCDQ 400
YGLYVCDEAN IETHGMQPMS RLSSDPQWAH AYMSRYTQMV LRDKNHPSII 450
IWSLGNESGH GSNHNAMYAW SKNFDPSRPV QYEGGGSNTT ATDIIAPMYA 500
RVNTLIADEA VPKWPIKKWI SLPNETRPLI LCEYAHAMGN SLGSFDEYWA 550
AFREFPRLQG GFIWDWVDQG LSQWDENGQH FWAYGGDFGD EINDRQFCIN 600
GLIFPDRTVH PTLQEAKYCQ RMITVSLQEQ TQKACTLLVT NENLFRATDN 650
EQLNWSLLEN GQVIQTGSLA LSVEADSQTR LEIALNFTPK AQAQYHLNTD 700
ICLIEATSWA PAGHVVATEQ MALRNHAGLA IPTLRTQPAP KLTQDGHAIV 750
VSSLDEKHQW RWDSQSGLLM EWNVDGKAQM LAAPQDNFFR APLDNDIGIS 800
EVDNVDPNAW VCRWEMAGIG QWERHCVHCD SETLAHTVVV TTTFAYHFGG 850
DVQAITQWTH TLSNDGEMLL DVDVTLADTL PPMPRIGLEL QLPLYQADTP 900
ITWQGLGPFE NYPDRLAAAR FGLHTQTLAQ MHTPYIFPTD SGLRCGTQWL 950
QVNELAISGD FQFSVSQYAQ QQLAEAKHTH DLLAQERIYL RLDHQHMGVG 1000
GDDSWSPSVH KEFQLTEKHY RYQLRFKPAS R 1031
Length:1,031
Mass (Da):117,763
Last modified:December 15, 2003 - v1
Checksum:i3A3E6A9AD4BC5560
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000038 Genomic DNA. Translation: BAC96191.1.
RefSeqiNP_936221.1. NC_005140.1.

Genome annotation databases

EnsemblBacteriaiBAC96191; BAC96191; BAC96191.
GeneIDi2621483.
KEGGivvy:VVA0165.
PATRICi20173734. VBIVibVul40472_3382.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000038 Genomic DNA. Translation: BAC96191.1 .
RefSeqi NP_936221.1. NC_005140.1.

3D structure databases

ProteinModelPortali Q7MG04.
ModBasei Search...

Protein-protein interaction databases

STRINGi 196600.VVA0165.

Protein family/group databases

CAZyi GH2. Glycoside Hydrolase Family 2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC96191 ; BAC96191 ; BAC96191 .
GeneIDi 2621483.
KEGGi vvy:VVA0165.
PATRICi 20173734. VBIVibVul40472_3382.

Phylogenomic databases

eggNOGi COG3250.
HOGENOMi HOG000252443.
KOi K01190.
OMAi NPPFVPK.
OrthoDBi EOG6XWV0T.

Enzyme and pathway databases

BioCyci VVUL196600:GJ9W-3552-MONOMER.

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
2.60.40.320. 2 hits.
2.70.98.10. 1 hit.
3.20.20.80. 1 hit.
HAMAPi MF_01687. Beta_gal.
InterProi IPR004199. B-gal_small/dom_5.
IPR011013. Gal_mutarotase_SF_dom.
IPR008979. Galactose-bd-like.
IPR014718. Glyco_hydro-type_carb-bd_sub.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR023933. Glyco_hydro_2_beta_Galsidase.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR006103. Glyco_hydro_2_TIM.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF02929. Bgal_small_N. 1 hit.
PF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view ]
PRINTSi PR00132. GLHYDRLASE2.
SMARTi SM01038. Bgal_small_N. 1 hit.
[Graphical view ]
SUPFAMi SSF49303. SSF49303. 2 hits.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
SSF74650. SSF74650. 1 hit.
PROSITEi PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YJ016.

Entry informationi

Entry nameiBGAL_VIBVY
AccessioniPrimary (citable) accession number: Q7MG04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: December 15, 2003
Last modified: May 14, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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