Q7MFC4 (MALK_VIBVY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Maltose/maltodextrin import ATP-binding protein MalK
EC=3.6.3.19

Gene names

Name:	malK
Ordered Locus Names:	VVA0396

Organism

Vibrio vulnificus (strain YJ016) [Complete proteome] [HAMAP]

Taxonomic identifier

196600 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	371 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Responsible for energy coupling to the transport system By similarity. HAMAP MF_01709
Catalytic activity	ATP + H2O + maltose(Out) = ADP + phosphate + maltose(In). HAMAP MF_01709
Subunit structure	The complex is composed of two ATP-binding proteins (MalK), two transmembrane proteins (MalG and MalK) and a solute-binding protein (MalE) By similarity.
Subcellular location	Cell inner membrane; Peripheral membrane protein By similarity HAMAP MF_01709.
Sequence similarities	Belongs to the ABC transporter superfamily. Maltooligosaccharide importer (TC 3.A.1.1.1) family. [View classification] Contains 1 ABC transporter domain.

Ontologies

Keywords
Biological process	Sugar transport Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	ATP-binding cassette (ABC) transporter complex Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW maltose-transporting ATPase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 371	371	Maltose/maltodextrin import ATP-binding protein MalK HAMAP MF_01709		PRO_0000092487
Regions
	Domain	4 – 234	231	ABC transporter
	Nucleotide binding	36 – 43	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7MFC4 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: C01927AD1C1D6D0A	FASTA	371	41,042
	10 20 30 40 50 60 MASVTLKNVC KAYGDVLISK NVDLEINEGE FVVFVGPSGC GKSTLLRCIA GLEDITSGDL 70 80 90 100 110 120 YIGEERMNDV EPSKRGVGMV FQSYALYPHL NLYDNMSFGL KLAKADKKEI DKRVEQAAEI 130 140 150 160 170 180 LQLGHLLERL PKALSGGQRQ RVAIGRTLVS QPKVFLLDEP LSNLDAALRV QMRAQITKLQ 190 200 210 220 230 240 RQLGCTMIYV THDQVEAMTM ADKIVVLDGG FVSQVGKPLE LYHYPENRFV AGFIGSPKMN 250 260 270 280 290 300 FMSVQIVDVE SERVQVKLSN GVTFWVPVDG TTVNKGDRMS LGVRPEHLVS SAQGDAVIDG 310 320 330 340 350 360 EVMIVEKLGN ETQVYLNLES ADADVIYRQP DTLDVDSGDR LEIGIPAHRC HLFHSDGRAC 370 KRLFNEKGVE R

References

[1]

"Comparative genome analysis of Vibrio vulnificus, a marine pathogen." Chen C.-Y., Wu K.-M., Chang Y.-C., Chang C.-H., Tsai H.-C., Liao T.-L., Liu Y.-M., Chen H.-J., Shen A.B.-T., Li J.-C., Su T.-L., Shao C.-P., Lee C.-T., Hor L.-I., Tsai S.-F. Genome Res. 13:2577-2587(2003) [PubMed: 14656965] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: YJ016.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000038 Genomic DNA. Translation: BAC96422.1.
RefSeq	NP_936452.1. NC_005140.1.
3D structure databases
ProteinModelPortal	Q7MFC4.
SMR	Q7MFC4. Positions 2-369.
ModBase	Search...
Protein-protein interaction databases
STRING	Q7MFC4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2621283.
GenomeReviews	Gene locus VVA0396 in contig BA000038_GR.
KEGG	vvy:VVA0396.
PATRIC	20174188. VBIVibVul40472_3602.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3839.
HOGENOM	HBG758042.
OMA	ETSIHVC.
ProtClustDB	PRK11000.
Enzyme and pathway databases
BioCyc	VVUL196600:VVA0396-MONOMER.
Family and domain databases
HAMAP	MF_01709. ABC_ATPase_MalK. [Tree]
InterPro	IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR015855. ABC_transpr_MalK. IPR003593. ATPase_AAA+_core. IPR008995. Mo/tungstate-bd. IPR013611. Transp-assoc_OB_typ2. [Graphical view]
KO	K10111.
Pfam	PF00005. ABC_tran. 1 hit. PF08402. TOBE_2. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
SUPFAM	SSF50331. MOP_like. 1 hit.
PROSITE	PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. PS51245. MALK. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MALK_VIBVY

Accession

Primary (citable) accession number: Q7MFC4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 25, 2004
Last sequence update:	December 15, 2003
Last modified:	January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program