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Q7MF46

- PHNX_VIBVY

UniProt

Q7MF46 - PHNX_VIBVY

Protein

Phosphonoacetaldehyde hydrolase

Gene

phnX

Organism
Vibrio vulnificus (strain YJ016)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 2 (17 Apr 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Involved in phosphonate degradation.UniRule annotation

    Catalytic activityi

    Phosphonoacetaldehyde + H2O = acetaldehyde + phosphate.UniRule annotation

    Cofactori

    Binds 1 Mg2+ ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei12 – 121NucleophileUniRule annotation
    Metal bindingi12 – 121MagnesiumUniRule annotation
    Metal bindingi14 – 141Magnesium; via carbonyl oxygenUniRule annotation
    Active sitei54 – 541Schiff-base intermediate with substrateUniRule annotation
    Metal bindingi188 – 1881MagnesiumUniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. phosphonoacetaldehyde hydrolase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. organic phosphonate catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Magnesium, Metal-binding, Schiff base

    Enzyme and pathway databases

    BioCyciVVUL196600:GJ9W-3868-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphonoacetaldehyde hydrolaseUniRule annotation (EC:3.11.1.1UniRule annotation)
    Short name:
    PhosphonataseUniRule annotation
    Alternative name(s):
    Phosphonoacetaldehyde phosphonohydrolaseUniRule annotation
    Gene namesi
    Name:phnXUniRule annotation
    Ordered Locus Names:VVA0474
    OrganismiVibrio vulnificus (strain YJ016)
    Taxonomic identifieri196600 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000002675: Chromosome II

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 271271Phosphonoacetaldehyde hydrolasePRO_0000284606Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi196600.VVA0474.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7MF46.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HAD-like hydrolase superfamily. PhnX family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0637.
    HOGENOMiHOG000217971.
    KOiK05306.
    OMAiGATWEEY.
    OrthoDBiEOG6ZH2FH.

    Family and domain databases

    Gene3Di1.10.150.240. 1 hit.
    3.40.50.1000. 2 hits.
    HAMAPiMF_01375. PhnX.
    InterProiIPR023214. HAD-like_dom.
    IPR006439. HAD-SF_hydro_IA.
    IPR023198. PGP_dom2.
    IPR006323. Phosphonoacetald_hydro.
    [Graphical view]
    PfamiPF13419. HAD_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 1 hit.
    TIGRFAMsiTIGR01509. HAD-SF-IA-v3. 1 hit.
    TIGR01422. phosphonatase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7MF46-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNKSPIQAVI FDWAGTIVDF GSFAPTSIFV EAFKQGFDFE IDLEEAREPM    50
    GLGKWDHIQA VGRIPAVDKR WNEKFGRSMI SEDIDAIYAA FMPLQKAKVA 100
    DHAEPILNAI EVVNGLKDKG IKIGSCSGYP REVMDVLIPV AADYGYQPDY 150
    VVATDDLPQG GRPAPFMALK NVIELGVSDV KACVKVDDSA PGIFEGHNAG 200
    MWTVGLLLSG NEAGLTFEEY QAADEATLEK AREKARAKLL KSSPHYLIDT 250
    IADFPEVVAD IERRLAAGER P 271
    Length:271
    Mass (Da):29,617
    Last modified:April 17, 2007 - v2
    Checksum:i820603F976FD7878
    GO

    Sequence cautioni

    The sequence BAC96500.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000038 Genomic DNA. Translation: BAC96500.1. Different initiation.
    RefSeqiNP_936530.1. NC_005140.1.

    Genome annotation databases

    EnsemblBacteriaiBAC96500; BAC96500; BAC96500.
    GeneIDi2621241.
    KEGGivvy:VVA0474.
    PATRICi20174340. VBIVibVul40472_3677.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000038 Genomic DNA. Translation: BAC96500.1 . Different initiation.
    RefSeqi NP_936530.1. NC_005140.1.

    3D structure databases

    ProteinModelPortali Q7MF46.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 196600.VVA0474.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC96500 ; BAC96500 ; BAC96500 .
    GeneIDi 2621241.
    KEGGi vvy:VVA0474.
    PATRICi 20174340. VBIVibVul40472_3677.

    Phylogenomic databases

    eggNOGi COG0637.
    HOGENOMi HOG000217971.
    KOi K05306.
    OMAi GATWEEY.
    OrthoDBi EOG6ZH2FH.

    Enzyme and pathway databases

    BioCyci VVUL196600:GJ9W-3868-MONOMER.

    Family and domain databases

    Gene3Di 1.10.150.240. 1 hit.
    3.40.50.1000. 2 hits.
    HAMAPi MF_01375. PhnX.
    InterProi IPR023214. HAD-like_dom.
    IPR006439. HAD-SF_hydro_IA.
    IPR023198. PGP_dom2.
    IPR006323. Phosphonoacetald_hydro.
    [Graphical view ]
    Pfami PF13419. HAD_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 1 hit.
    TIGRFAMsi TIGR01509. HAD-SF-IA-v3. 1 hit.
    TIGR01422. phosphonatase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: YJ016.

    Entry informationi

    Entry nameiPHNX_VIBVY
    AccessioniPrimary (citable) accession number: Q7MF46
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 17, 2007
    Last sequence update: April 17, 2007
    Last modified: October 1, 2014
    This is version 75 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3