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Q7MF46 (PHNX_VIBVY) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphonoacetaldehyde hydrolase

Short name=Phosphonatase
EC=3.11.1.1
Alternative name(s):
Phosphonoacetaldehyde phosphonohydrolase
Gene names
Name:phnX
Ordered Locus Names:VVA0474
OrganismVibrio vulnificus (strain YJ016) [Complete proteome] [HAMAP]
Taxonomic identifier196600 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length271 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in phosphonate degradation By similarity. HAMAP-Rule MF_01375

Catalytic activity

Phosphonoacetaldehyde + H2O = acetaldehyde + phosphate. HAMAP-Rule MF_01375

Cofactor

Binds 1 Mg2+ ion per subunit By similarity. HAMAP-Rule MF_01375

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01375

Sequence similarities

Belongs to the HAD-like hydrolase superfamily. PhnX family.

Sequence caution

The sequence BAC96500.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   LigandMagnesium
Metal-binding
Schiff base
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processorganic phosphonate catabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionmagnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

phosphonoacetaldehyde hydrolase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 271271Phosphonoacetaldehyde hydrolase HAMAP-Rule MF_01375
PRO_0000284606

Sites

Active site121Nucleophile By similarity
Active site541Schiff-base intermediate with substrate By similarity
Metal binding121Magnesium By similarity
Metal binding141Magnesium; via carbonyl oxygen By similarity
Metal binding1881Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7MF46 [UniParc].

Last modified April 17, 2007. Version 2.
Checksum: 820603F976FD7878

FASTA27129,617
        10         20         30         40         50         60 
MNKSPIQAVI FDWAGTIVDF GSFAPTSIFV EAFKQGFDFE IDLEEAREPM GLGKWDHIQA 

        70         80         90        100        110        120 
VGRIPAVDKR WNEKFGRSMI SEDIDAIYAA FMPLQKAKVA DHAEPILNAI EVVNGLKDKG 

       130        140        150        160        170        180 
IKIGSCSGYP REVMDVLIPV AADYGYQPDY VVATDDLPQG GRPAPFMALK NVIELGVSDV 

       190        200        210        220        230        240 
KACVKVDDSA PGIFEGHNAG MWTVGLLLSG NEAGLTFEEY QAADEATLEK AREKARAKLL 

       250        260        270 
KSSPHYLIDT IADFPEVVAD IERRLAAGER P 

« Hide

References

[1]"Comparative genome analysis of Vibrio vulnificus, a marine pathogen."
Chen C.-Y., Wu K.-M., Chang Y.-C., Chang C.-H., Tsai H.-C., Liao T.-L., Liu Y.-M., Chen H.-J., Shen A.B.-T., Li J.-C., Su T.-L., Shao C.-P., Lee C.-T., Hor L.-I., Tsai S.-F.
Genome Res. 13:2577-2587(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: YJ016.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000038 Genomic DNA. Translation: BAC96500.1. Different initiation.
RefSeqNP_936530.1. NC_005140.1.

3D structure databases

ProteinModelPortalQ7MF46.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING196600.VVA0474.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC96500; BAC96500; BAC96500.
GeneID2621241.
KEGGvvy:VVA0474.
PATRIC20174340. VBIVibVul40472_3677.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0637.
HOGENOMHOG000217971.
KOK05306.
OMAGATWEEY.
OrthoDBEOG6ZH2FH.

Enzyme and pathway databases

BioCycVVUL196600:GJ9W-3868-MONOMER.

Family and domain databases

Gene3D1.10.150.240. 1 hit.
3.40.50.1000. 2 hits.
HAMAPMF_01375. PhnX.
InterProIPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA.
IPR023198. PGP_dom2.
IPR006323. Phosphonoacetald_hydro.
[Graphical view]
PfamPF13419. HAD_2. 1 hit.
[Graphical view]
SUPFAMSSF56784. SSF56784. 1 hit.
TIGRFAMsTIGR01509. HAD-SF-IA-v3. 1 hit.
TIGR01422. phosphonatase. 1 hit.
ProtoNetSearch...

Entry information

Entry namePHNX_VIBVY
AccessionPrimary (citable) accession number: Q7MF46
Entry history
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: May 14, 2014
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families