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Q7MF46

- PHNX_VIBVY

UniProt

Q7MF46 - PHNX_VIBVY

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Protein

Phosphonoacetaldehyde hydrolase

Gene

phnX

Organism
Vibrio vulnificus (strain YJ016)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in phosphonate degradation.UniRule annotation

Catalytic activityi

Phosphonoacetaldehyde + H2O = acetaldehyde + phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg(2+) ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei12 – 121NucleophileUniRule annotation
Metal bindingi12 – 121MagnesiumUniRule annotation
Metal bindingi14 – 141Magnesium; via carbonyl oxygenUniRule annotation
Active sitei54 – 541Schiff-base intermediate with substrateUniRule annotation
Metal bindingi188 – 1881MagnesiumUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphonoacetaldehyde hydrolase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. organic phosphonate catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding, Schiff base

Enzyme and pathway databases

BioCyciVVUL196600:GJ9W-3868-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphonoacetaldehyde hydrolaseUniRule annotation (EC:3.11.1.1UniRule annotation)
Short name:
PhosphonataseUniRule annotation
Alternative name(s):
Phosphonoacetaldehyde phosphonohydrolaseUniRule annotation
Gene namesi
Name:phnXUniRule annotation
Ordered Locus Names:VVA0474
OrganismiVibrio vulnificus (strain YJ016)
Taxonomic identifieri196600 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000002675: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271Phosphonoacetaldehyde hydrolasePRO_0000284606Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi196600.VVA0474.

Structurei

3D structure databases

ProteinModelPortaliQ7MF46.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HAD-like hydrolase superfamily. PhnX family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0637.
HOGENOMiHOG000217971.
KOiK05306.
OMAiGATWEEY.
OrthoDBiEOG6ZH2FH.

Family and domain databases

Gene3Di1.10.150.240. 1 hit.
3.40.50.1000. 2 hits.
HAMAPiMF_01375. PhnX.
InterProiIPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA.
IPR023198. PGP_dom2.
IPR006323. Phosphonoacetald_hydro.
[Graphical view]
PfamiPF13419. HAD_2. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01509. HAD-SF-IA-v3. 1 hit.
TIGR01422. phosphonatase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7MF46-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNKSPIQAVI FDWAGTIVDF GSFAPTSIFV EAFKQGFDFE IDLEEAREPM
60 70 80 90 100
GLGKWDHIQA VGRIPAVDKR WNEKFGRSMI SEDIDAIYAA FMPLQKAKVA
110 120 130 140 150
DHAEPILNAI EVVNGLKDKG IKIGSCSGYP REVMDVLIPV AADYGYQPDY
160 170 180 190 200
VVATDDLPQG GRPAPFMALK NVIELGVSDV KACVKVDDSA PGIFEGHNAG
210 220 230 240 250
MWTVGLLLSG NEAGLTFEEY QAADEATLEK AREKARAKLL KSSPHYLIDT
260 270
IADFPEVVAD IERRLAAGER P
Length:271
Mass (Da):29,617
Last modified:April 17, 2007 - v2
Checksum:i820603F976FD7878
GO

Sequence cautioni

The sequence BAC96500.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000038 Genomic DNA. Translation: BAC96500.1. Different initiation.
RefSeqiNP_936530.1. NC_005140.1.

Genome annotation databases

EnsemblBacteriaiBAC96500; BAC96500; BAC96500.
GeneIDi2621241.
KEGGivvy:VVA0474.
PATRICi20174340. VBIVibVul40472_3677.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000038 Genomic DNA. Translation: BAC96500.1 . Different initiation.
RefSeqi NP_936530.1. NC_005140.1.

3D structure databases

ProteinModelPortali Q7MF46.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196600.VVA0474.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC96500 ; BAC96500 ; BAC96500 .
GeneIDi 2621241.
KEGGi vvy:VVA0474.
PATRICi 20174340. VBIVibVul40472_3677.

Phylogenomic databases

eggNOGi COG0637.
HOGENOMi HOG000217971.
KOi K05306.
OMAi GATWEEY.
OrthoDBi EOG6ZH2FH.

Enzyme and pathway databases

BioCyci VVUL196600:GJ9W-3868-MONOMER.

Family and domain databases

Gene3Di 1.10.150.240. 1 hit.
3.40.50.1000. 2 hits.
HAMAPi MF_01375. PhnX.
InterProi IPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA.
IPR023198. PGP_dom2.
IPR006323. Phosphonoacetald_hydro.
[Graphical view ]
Pfami PF13419. HAD_2. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 1 hit.
TIGRFAMsi TIGR01509. HAD-SF-IA-v3. 1 hit.
TIGR01422. phosphonatase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YJ016.

Entry informationi

Entry nameiPHNX_VIBVY
AccessioniPrimary (citable) accession number: Q7MF46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: November 26, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3