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Q7MF13 (BETB_VIBVY) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Betaine aldehyde dehydrogenase
Short name=BADH
EC=1.2.1.8
Gene names
Name:betB
Ordered Locus Names:VVA0507
OrganismVibrio vulnificus (strain YJ016) [Complete proteome] [HAMAP]
Taxonomic identifier196600 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio ›

Protein attributes

Sequence length486 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP-Rule MF_00804

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. HAMAP-Rule MF_00804

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycine betaine biosynthetic process from choline

Inferred from electronic annotation. Source: HAMAP

   Molecular_functionbetaine-aldehyde dehydrogenase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 486486Betaine aldehyde dehydrogenase HAMAP-Rule MF_00804
PRO_0000056557

Regions

Nucleotide binding225 – 2306NAD By similarity

Sites

Active site2471 By similarity
Active site2811 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7MF13 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: B2082D528188B338

FASTA48652,251
        10         20         30         40         50         60 
MEVTAHYIGG KPFVGDTGES FATLNPATGE VLAHIEQADE RVLAHAIESA KLGFSVWSSM 

        70         80         90        100        110        120 
SAAERSRCLL KAAQLIRDHN DELAELEVRD TGKPIQEASV VDIATGADVI EYFAGLVNGL 

       130        140        150        160        170        180 
GGEQQSLGSN QFFYTRREPL GICAGIGAWN YPIQIAMWKA APALAAGNAM IFKPSEETPL 

       190        200        210        220        230        240 
SALKLAELFT QAGVPDGVFN VVQGDYRVGQ MLTAHPEIAK VSFTGESGTG KKVMADSAAT 

       250        260        270        280        290        300 
LKPVTMELGG KSPLIIFDDA DLDDAVSAAM VANFYTQGEV CTHGTRVYVQ RAMYDAFVEQ 

       310        320        330        340        350        360 
LKERTEKLIV GDPMNMETQI GSLISKSHLE KVLGAISSAK ESGATLLTGG FQVTERGLEK 

       370        380        390        400        410        420 
GCFVAPTVFV DCRDEMPHVQ NEIFGPVMSV LVFDDEDEVI ARANNTQYGL AAGVFTQNLS 

       430        440        450        460        470        480 
KAHRVIHQLQ AGICWINTWG NSPAEMPVGG YKLSGIGREN GQETLLHYTQ TKSVFVELGA 


FDSPYA

« Hide

References

[1]"Comparative genome analysis of Vibrio vulnificus, a marine pathogen."
Chen C.-Y., Wu K.-M., Chang Y.-C., Chang C.-H., Tsai H.-C., Liao T.-L., Liu Y.-M., Chen H.-J., Shen A.B.-T., Li J.-C., Su T.-L., Shao C.-P., Lee C.-T., Hor L.-I., Tsai S.-F.
Genome Res. 13:2577-2587(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: YJ016.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000038 Genomic DNA. Translation: BAC96533.1.
RefSeqNP_936563.1. NC_005140.1.

3D structure databases

ProteinModelPortalQ7MF13.
SMRQ7MF13. Positions 4-485.
ModBaseSearch...

Protein-protein interaction databases

STRING196600.VVA0507.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC96533; BAC96533; BAC96533.
GeneID2621165.
KEGGvvy:VVA0507.
PATRIC20174400. VBIVibVul40472_3707.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHOG000271505.
KOK00130.
OMANQQQVGD.
ProtClustDBPRK13252.

Enzyme and pathway databases

UniPathwayUPA00529; UER00386.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPMF_00804. BADH.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. Betaine_Ald_DH.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. False negative.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETB_VIBVY
AccessionPrimary (citable) accession number: Q7MF13
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: December 15, 2003
Last modified: May 1, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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