SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q7MF13

- BETB_VIBVY

UniProt

Q7MF13 - BETB_VIBVY

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

NAD/NADP-dependent betaine aldehyde dehydrogenase

Gene
betB, VVA0507
Organism
Vibrio vulnificus (strain YJ016)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid By similarity.UniRule annotation

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

Binds 2 potassium ions per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi23 – 231Potassium 1 By similarity
Metal bindingi90 – 901Potassium 1 By similarity
Active sitei159 – 1591Charge relay system By similarity
Metal bindingi241 – 2411Potassium 2; via carbonyl oxygen By similarity
Active sitei247 – 2471Proton acceptor By similarity
Binding sitei281 – 2811NAD/NADP By similarity
Binding sitei382 – 3821NAD/NADP By similarity
Metal bindingi452 – 4521Potassium 2; via carbonyl oxygen By similarity
Metal bindingi455 – 4551Potassium 2; via carbonyl oxygen By similarity
Active sitei459 – 4591Charge relay system By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi147 – 1504NAD/NADP By similarity
Nucleotide bindingi173 – 1764NAD/NADP By similarity
Nucleotide bindingi225 – 2306NAD/NADP By similarity

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, NADP, Potassium

Enzyme and pathway databases

BioCyciVVUL196600:GJ9W-3901-MONOMER.
UniPathwayiUPA00529; UER00386.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD/NADP-dependent betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Gene namesi
Name:betB
Ordered Locus Names:VVA0507
OrganismiVibrio vulnificus (strain YJ016)
Taxonomic identifieri196600 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000002675: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486NAD/NADP-dependent betaine aldehyde dehydrogenaseUniRule annotationPRO_0000056557Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei281 – 2811Cysteine sulfenic acid (-SOH) By similarity

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Dimer of dimers By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi196600.VVA0507.

Structurei

3D structure databases

ProteinModelPortaliQ7MF13.
SMRiQ7MF13. Positions 4-485.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
KOiK00130.
OMAiSIFEARW.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPiMF_00804. BADH.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7MF13-1 [UniParc]FASTAAdd to Basket

« Hide

MEVTAHYIGG KPFVGDTGES FATLNPATGE VLAHIEQADE RVLAHAIESA    50
KLGFSVWSSM SAAERSRCLL KAAQLIRDHN DELAELEVRD TGKPIQEASV 100
VDIATGADVI EYFAGLVNGL GGEQQSLGSN QFFYTRREPL GICAGIGAWN 150
YPIQIAMWKA APALAAGNAM IFKPSEETPL SALKLAELFT QAGVPDGVFN 200
VVQGDYRVGQ MLTAHPEIAK VSFTGESGTG KKVMADSAAT LKPVTMELGG 250
KSPLIIFDDA DLDDAVSAAM VANFYTQGEV CTHGTRVYVQ RAMYDAFVEQ 300
LKERTEKLIV GDPMNMETQI GSLISKSHLE KVLGAISSAK ESGATLLTGG 350
FQVTERGLEK GCFVAPTVFV DCRDEMPHVQ NEIFGPVMSV LVFDDEDEVI 400
ARANNTQYGL AAGVFTQNLS KAHRVIHQLQ AGICWINTWG NSPAEMPVGG 450
YKLSGIGREN GQETLLHYTQ TKSVFVELGA FDSPYA 486
Length:486
Mass (Da):52,251
Last modified:December 15, 2003 - v1
Checksum:iB2082D528188B338
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000038 Genomic DNA. Translation: BAC96533.1.
RefSeqiNP_936563.1. NC_005140.1.
WP_011151878.1. NC_005140.1.

Genome annotation databases

EnsemblBacteriaiBAC96533; BAC96533; BAC96533.
GeneIDi2621165.
KEGGivvy:VVA0507.
PATRICi20174400. VBIVibVul40472_3707.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000038 Genomic DNA. Translation: BAC96533.1 .
RefSeqi NP_936563.1. NC_005140.1.
WP_011151878.1. NC_005140.1.

3D structure databases

ProteinModelPortali Q7MF13.
SMRi Q7MF13. Positions 4-485.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196600.VVA0507.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC96533 ; BAC96533 ; BAC96533 .
GeneIDi 2621165.
KEGGi vvy:VVA0507.
PATRICi 20174400. VBIVibVul40472_3707.

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000271505.
KOi K00130.
OMAi SIFEARW.
OrthoDBi EOG6BS8QW.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00386 .
BioCyci VVUL196600:GJ9W-3901-MONOMER.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPi MF_00804. BADH.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YJ016.

Entry informationi

Entry nameiBETB_VIBVY
AccessioniPrimary (citable) accession number: Q7MF13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: December 15, 2003
Last modified: September 3, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi