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Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Vibrio vulnificus (strain YJ016)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: betaine biosynthesis via choline pathway

This protein is involved in step 1 of the subpathway that synthesizes betaine aldehyde from choline (cytochrome c reductase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Oxygen-dependent choline dehydrogenase (betA)
This subpathway is part of the pathway betaine biosynthesis via choline pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes betaine aldehyde from choline (cytochrome c reductase route), the pathway betaine biosynthesis via choline pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei470Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi6 – 35FADUniRule annotationAdd BLAST30

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
Short name:
CDHUniRule annotation
Short name:
CHDUniRule annotation
Alternative name(s):
Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betAUniRule annotation
Ordered Locus Names:VVA0508
OrganismiVibrio vulnificus (strain YJ016)
Taxonomic identifieri196600 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000002675 Componenti: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002056071 – 560Oxygen-dependent choline dehydrogenaseAdd BLAST560

Structurei

3D structure databases

ProteinModelPortaliQ7MF12.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GMC oxidoreductase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000139600.
KOiK00108.
OMAiWPEYDFI.
OrthoDBiPOG091H04UT.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
HAMAPiMF_00750. Choline_dehydrogen. 1 hit.
InterProiIPR011533. BetA.
IPR023753. FAD/NAD-binding_dom.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
SUPFAMiSSF51905. SSF51905. 2 hits.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7MF12-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQQHYDYIIV GAGSAGCVLA DRLSESGDHS VLLLEAGGSD KSIFIQMPTA
60 70 80 90 100
LSYPMNSEKY AWQFETDAEA DLDGRRLHCP RGKVLGGSSS INGMVYVRGH
110 120 130 140 150
ACDFDEWEEQ GAKGWNYQAC LPYFRRAENW IDGEDEYRGG DGPLSTCAGN
160 170 180 190 200
KMTLNPLYRA FIDAGKEAGY PETSDYNGYQ QEGFGPMHMT VKNGVRASTS
210 220 230 240 250
NAYLSRAKKR SNFKLIKGVV VQRILLEEKR AVGVEFELAG ELRTCFAKNE
260 270 280 290 300
VISSAGSIGS VQLLQLSGIG PKTVLEKAGV TPVYHLPGVG QNLQDHLEVY
310 320 330 340 350
FQYHCQKPIT LNGKLDWFSK GLIGTEWILT RKGLGATNHF ESCAFIRSRA
360 370 380 390 400
GLKWPNIQYH FLPAAMRYDG QAAFDGHGFQ VHVGPNKPES RGRVEIVSAN
410 420 430 440 450
PLDKPKIQFN YLSTERDRQD WRDCIRLTRE ILAQPAMDEF RGEEIQPGIN
460 470 480 490 500
VATDAEIDQW VKENVESAYH PSCSCKMGAD DDPMAVLDEE CRVRGITNLR
510 520 530 540 550
VVDSSVFPTI PNGNLNAPTI MVAERAADLI LHKQPLPPQR SKVWLAPSWE
560
TQQRTGEPMR
Length:560
Mass (Da):62,359
Last modified:December 15, 2003 - v1
Checksum:i9CCA2CBA8EEA613B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000038 Genomic DNA. Translation: BAC96534.1.
RefSeqiWP_011151879.1. NC_005140.1.

Genome annotation databases

EnsemblBacteriaiBAC96534; BAC96534; BAC96534.
GeneIDi2621166.
KEGGivvy:VVA0508.
PATRICi20174402. VBIVibVul40472_3708.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000038 Genomic DNA. Translation: BAC96534.1.
RefSeqiWP_011151879.1. NC_005140.1.

3D structure databases

ProteinModelPortaliQ7MF12.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC96534; BAC96534; BAC96534.
GeneIDi2621166.
KEGGivvy:VVA0508.
PATRICi20174402. VBIVibVul40472_3708.

Phylogenomic databases

HOGENOMiHOG000139600.
KOiK00108.
OMAiWPEYDFI.
OrthoDBiPOG091H04UT.

Enzyme and pathway databases

UniPathwayiUPA00529; UER00385.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
HAMAPiMF_00750. Choline_dehydrogen. 1 hit.
InterProiIPR011533. BetA.
IPR023753. FAD/NAD-binding_dom.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
SUPFAMiSSF51905. SSF51905. 2 hits.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBETA_VIBVY
AccessioniPrimary (citable) accession number: Q7MF12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: December 15, 2003
Last modified: November 2, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.