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Reviewed, UniProtKB/Swiss-Prot Q7MF12 (BETA_VIBVY)

Last modified November 25, 2008. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Choline dehydrogenase
      Short name=CHD
      Short name=CDH
    EC=1.1.99.1
Gene names
Name: betA
Ordered Locus Names: VVA0508
OrganismVibrio vulnificus (strain YJ016) [Complete proteome] [HAMAP]
Taxonomic identifier196600 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length560 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine By similarity.

Catalytic activity

Choline + acceptor = betaine aldehyde + reduced acceptor.

Cofactor

FAD By similarity.

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1.

Sequence similarities

Belongs to the GMC oxidoreductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 560560Choline dehydrogenase
PRO_0000205607

Regions

Nucleotide binding6 – 3530FAD Probable

Sites

Active site4701 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7MF12-1 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 9CCA2CBA8EEA613B

FASTA56062,359
        10         20         30         40         50         60 
MQQHYDYIIV GAGSAGCVLA DRLSESGDHS VLLLEAGGSD KSIFIQMPTA LSYPMNSEKY 

        70         80         90        100        110        120 
AWQFETDAEA DLDGRRLHCP RGKVLGGSSS INGMVYVRGH ACDFDEWEEQ GAKGWNYQAC 

       130        140        150        160        170        180 
LPYFRRAENW IDGEDEYRGG DGPLSTCAGN KMTLNPLYRA FIDAGKEAGY PETSDYNGYQ 

       190        200        210        220        230        240 
QEGFGPMHMT VKNGVRASTS NAYLSRAKKR SNFKLIKGVV VQRILLEEKR AVGVEFELAG 

       250        260        270        280        290        300 
ELRTCFAKNE VISSAGSIGS VQLLQLSGIG PKTVLEKAGV TPVYHLPGVG QNLQDHLEVY 

       310        320        330        340        350        360 
FQYHCQKPIT LNGKLDWFSK GLIGTEWILT RKGLGATNHF ESCAFIRSRA GLKWPNIQYH 

       370        380        390        400        410        420 
FLPAAMRYDG QAAFDGHGFQ VHVGPNKPES RGRVEIVSAN PLDKPKIQFN YLSTERDRQD 

       430        440        450        460        470        480 
WRDCIRLTRE ILAQPAMDEF RGEEIQPGIN VATDAEIDQW VKENVESAYH PSCSCKMGAD 

       490        500        510        520        530        540 
DDPMAVLDEE CRVRGITNLR VVDSSVFPTI PNGNLNAPTI MVAERAADLI LHKQPLPPQR 

       550        560 
SKVWLAPSWE TQQRTGEPMR 

« Hide

References

[1]"Comparative genome analysis of Vibrio vulnificus, a marine pathogen."
Chen C.-Y., Wu K.-M., Chang Y.-C., Chang C.-H., Tsai H.-C., Liao T.-L., Liu Y.-M., Chen H.-J., Shen A.B.-T., Li J.-C., Su T.-L., Shao C.-P., Lee C.-T., Hor L.-I., Tsai S.-F.
Genome Res. 13:2577-2587(2003) [PubMed: 14656965] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

BA000038 Genomic DNA. Translation: BAC96534.1.
RefSeqNP_936564.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID2621166.
GenomeReviewsGene locus VVA0508 in contig BA000038_GR.
KEGGvvy:VVA0508.
NMPDRfig|196600.1.peg.3835.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ7MF12.

Enzyme and pathway databases

BioCycVVUL196600:VVA0508-MON.

Family and domain databases

HAMAPMF_00750.
[Tree]
InterProIPR011533. Choline_dehydrogenase.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsTIGR01810. betA. 1 hit.
PROSITEPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETA_VIBVY
AccessionPrimary (citable) accession number: Q7MF12
Entry history
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: December 15, 2003
Last modified: November 25, 2008
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents