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Q7MF12

- BETA_VIBVY

UniProt

Q7MF12 - BETA_VIBVY

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Protein

Oxygen-dependent choline dehydrogenase

Gene
betA, VVA0508
Organism
Vibrio vulnificus (strain YJ016)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate By similarity.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FAD By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei470 – 4701 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi6 – 3530FAD By similarityAdd
BLAST

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  2. choline dehydrogenase activity Source: UniProtKB-HAMAP
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-6142-MONOMER.
VVUL196600:GJ9W-3902-MONOMER.
UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenase (EC:1.1.99.1)
Short name:
CDH
Short name:
CHD
Alternative name(s):
Betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Gene namesi
Name:betA
Ordered Locus Names:VVA0508
OrganismiVibrio vulnificus (strain YJ016)
Taxonomic identifieri196600 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000002675: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 560560Oxygen-dependent choline dehydrogenaseUniRule annotationPRO_0000205607Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi196600.VVA0508.

Structurei

3D structure databases

ProteinModelPortaliQ7MF12.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2303.
HOGENOMiHOG000139600.
KOiK00108.
OMAiREMHCPR.
OrthoDBiEOG67HJQP.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7MF12-1 [UniParc]FASTAAdd to Basket

« Hide

MQQHYDYIIV GAGSAGCVLA DRLSESGDHS VLLLEAGGSD KSIFIQMPTA    50
LSYPMNSEKY AWQFETDAEA DLDGRRLHCP RGKVLGGSSS INGMVYVRGH 100
ACDFDEWEEQ GAKGWNYQAC LPYFRRAENW IDGEDEYRGG DGPLSTCAGN 150
KMTLNPLYRA FIDAGKEAGY PETSDYNGYQ QEGFGPMHMT VKNGVRASTS 200
NAYLSRAKKR SNFKLIKGVV VQRILLEEKR AVGVEFELAG ELRTCFAKNE 250
VISSAGSIGS VQLLQLSGIG PKTVLEKAGV TPVYHLPGVG QNLQDHLEVY 300
FQYHCQKPIT LNGKLDWFSK GLIGTEWILT RKGLGATNHF ESCAFIRSRA 350
GLKWPNIQYH FLPAAMRYDG QAAFDGHGFQ VHVGPNKPES RGRVEIVSAN 400
PLDKPKIQFN YLSTERDRQD WRDCIRLTRE ILAQPAMDEF RGEEIQPGIN 450
VATDAEIDQW VKENVESAYH PSCSCKMGAD DDPMAVLDEE CRVRGITNLR 500
VVDSSVFPTI PNGNLNAPTI MVAERAADLI LHKQPLPPQR SKVWLAPSWE 550
TQQRTGEPMR 560
Length:560
Mass (Da):62,359
Last modified:December 15, 2003 - v1
Checksum:i9CCA2CBA8EEA613B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000038 Genomic DNA. Translation: BAC96534.1.
RefSeqiNP_936564.1. NC_005140.1.
WP_011151879.1. NC_005140.1.

Genome annotation databases

EnsemblBacteriaiBAC96534; BAC96534; BAC96534.
GeneIDi2621166.
KEGGivvy:VVA0508.
PATRICi20174402. VBIVibVul40472_3708.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000038 Genomic DNA. Translation: BAC96534.1 .
RefSeqi NP_936564.1. NC_005140.1.
WP_011151879.1. NC_005140.1.

3D structure databases

ProteinModelPortali Q7MF12.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196600.VVA0508.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC96534 ; BAC96534 ; BAC96534 .
GeneIDi 2621166.
KEGGi vvy:VVA0508.
PATRICi 20174402. VBIVibVul40472_3708.

Phylogenomic databases

eggNOGi COG2303.
HOGENOMi HOG000139600.
KOi K00108.
OMAi REMHCPR.
OrthoDBi EOG67HJQP.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00385 .
BioCyci RETL1328306-WGS:GSTH-6142-MONOMER.
VVUL196600:GJ9W-3902-MONOMER.

Family and domain databases

HAMAPi MF_00750. Choline_dehydrogen.
InterProi IPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view ]
Pfami PF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsi TIGR01810. betA. 1 hit.
PROSITEi PS00623. GMC_OXRED_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YJ016.

Entry informationi

Entry nameiBETA_VIBVY
AccessioniPrimary (citable) accession number: Q7MF12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: December 15, 2003
Last modified: September 3, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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