Reviewed, UniProtKB/Swiss-Prot Q7MF12 (BETA_VIBVY)

Names and origin

Protein names

Recommended name:
    Choline dehydrogenase
      Short name=CHD
      Short name=CDH
    EC=1.1.99.1

Gene names

Name:	betA
Ordered Locus Names:	VVA0508

Organism

Vibrio vulnificus (strain YJ016) [Complete proteome] [HAMAP]

Taxonomic identifier

196600 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	560 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine By similarity.
Catalytic activity	Choline + acceptor = betaine aldehyde + reduced acceptor.
Cofactor	FAD By similarity.
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1.
Sequence similarities	Belongs to the GMC oxidoreductase family.

Ontologies

Keywords
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular alcohol metabolic process Inferred from electronic annotation. Source: InterPro glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro choline dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 560	560	Choline dehydrogenase		PRO_0000205607
Regions
	Nucleotide binding	6 – 35	30	FAD Probable
Sites
	Active site	470	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7MF12-1 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: 9CCA2CBA8EEA613B	FASTA	560	62,359
	10 20 30 40 50 60 MQQHYDYIIV GAGSAGCVLA DRLSESGDHS VLLLEAGGSD KSIFIQMPTA LSYPMNSEKY 70 80 90 100 110 120 AWQFETDAEA DLDGRRLHCP RGKVLGGSSS INGMVYVRGH ACDFDEWEEQ GAKGWNYQAC 130 140 150 160 170 180 LPYFRRAENW IDGEDEYRGG DGPLSTCAGN KMTLNPLYRA FIDAGKEAGY PETSDYNGYQ 190 200 210 220 230 240 QEGFGPMHMT VKNGVRASTS NAYLSRAKKR SNFKLIKGVV VQRILLEEKR AVGVEFELAG 250 260 270 280 290 300 ELRTCFAKNE VISSAGSIGS VQLLQLSGIG PKTVLEKAGV TPVYHLPGVG QNLQDHLEVY 310 320 330 340 350 360 FQYHCQKPIT LNGKLDWFSK GLIGTEWILT RKGLGATNHF ESCAFIRSRA GLKWPNIQYH 370 380 390 400 410 420 FLPAAMRYDG QAAFDGHGFQ VHVGPNKPES RGRVEIVSAN PLDKPKIQFN YLSTERDRQD 430 440 450 460 470 480 WRDCIRLTRE ILAQPAMDEF RGEEIQPGIN VATDAEIDQW VKENVESAYH PSCSCKMGAD 490 500 510 520 530 540 DDPMAVLDEE CRVRGITNLR VVDSSVFPTI PNGNLNAPTI MVAERAADLI LHKQPLPPQR 550 560 SKVWLAPSWE TQQRTGEPMR

References

[1]

"Comparative genome analysis of Vibrio vulnificus, a marine pathogen." Chen C.-Y., Wu K.-M., Chang Y.-C., Chang C.-H., Tsai H.-C., Liao T.-L., Liu Y.-M., Chen H.-J., Shen A.B.-T., Li J.-C., Su T.-L., Shao C.-P., Lee C.-T., Hor L.-I., Tsai S.-F. Genome Res. 13:2577-2587(2003) [PubMed: 14656965] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000038 Genomic DNA. Translation: BAC96534.1.
RefSeq	NP_936564.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2621166.
GenomeReviews	Gene locus VVA0508 in contig BA000038_GR.
KEGG	vvy:VVA0508.
NMPDR	fig|196600.1.peg.3835.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q7MF12.
Enzyme and pathway databases
BioCyc	VVUL196600:VVA0508-MON.
Family and domain databases
HAMAP	MF_00750. [Tree]
InterPro	IPR011533. Choline_dehydrogenase. IPR012132. GMC_OxRdtase. IPR000172. GMC_OxRdtase_N. IPR007867. GMC_OxRtase_C. [Graphical view]
Pfam	PF05199. GMC_oxred_C. 1 hit. PF00732. GMC_oxred_N. 1 hit. [Graphical view]
PIRSF	PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMs	TIGR01810. betA. 1 hit.
PROSITE	PS00623. GMC_OXRED_1. 1 hit. PS00624. GMC_OXRED_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETA_VIBVY

Accession

Primary (citable) accession number: Q7MF12

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 16, 2004
Last sequence update:	December 15, 2003
Last modified:	November 25, 2008
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)