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Q7MF12

- BETA_VIBVY

UniProt

Q7MF12 - BETA_VIBVY

Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Vibrio vulnificus (strain YJ016)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

    Catalytic activityi

    Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
    Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

    Cofactori

    FAD.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei470 – 4701UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi6 – 3530FADUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
    2. choline dehydrogenase activity Source: UniProtKB-HAMAP
    3. flavin adenine dinucleotide binding Source: InterPro

    GO - Biological processi

    1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein, NAD

    Enzyme and pathway databases

    BioCyciRETL1328306-WGS:GSTH-6142-MONOMER.
    VVUL196600:GJ9W-3902-MONOMER.
    UniPathwayiUPA00529; UER00385.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
    Short name:
    CDHUniRule annotation
    Short name:
    CHDUniRule annotation
    Alternative name(s):
    Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
    Short name:
    BADHUniRule annotation
    Gene namesi
    Name:betAUniRule annotation
    Ordered Locus Names:VVA0508
    OrganismiVibrio vulnificus (strain YJ016)
    Taxonomic identifieri196600 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000002675: Chromosome II

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 560560Oxygen-dependent choline dehydrogenasePRO_0000205607Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi196600.VVA0508.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7MF12.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GMC oxidoreductase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2303.
    HOGENOMiHOG000139600.
    KOiK00108.
    OMAiREMHCPR.
    OrthoDBiEOG67HJQP.

    Family and domain databases

    HAMAPiMF_00750. Choline_dehydrogen.
    InterProiIPR011533. BetA.
    IPR012132. GMC_OxRdtase.
    IPR000172. GMC_OxRdtase_N.
    IPR007867. GMC_OxRtase_C.
    [Graphical view]
    PfamiPF05199. GMC_oxred_C. 1 hit.
    PF00732. GMC_oxred_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
    TIGRFAMsiTIGR01810. betA. 1 hit.
    PROSITEiPS00623. GMC_OXRED_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7MF12-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQQHYDYIIV GAGSAGCVLA DRLSESGDHS VLLLEAGGSD KSIFIQMPTA    50
    LSYPMNSEKY AWQFETDAEA DLDGRRLHCP RGKVLGGSSS INGMVYVRGH 100
    ACDFDEWEEQ GAKGWNYQAC LPYFRRAENW IDGEDEYRGG DGPLSTCAGN 150
    KMTLNPLYRA FIDAGKEAGY PETSDYNGYQ QEGFGPMHMT VKNGVRASTS 200
    NAYLSRAKKR SNFKLIKGVV VQRILLEEKR AVGVEFELAG ELRTCFAKNE 250
    VISSAGSIGS VQLLQLSGIG PKTVLEKAGV TPVYHLPGVG QNLQDHLEVY 300
    FQYHCQKPIT LNGKLDWFSK GLIGTEWILT RKGLGATNHF ESCAFIRSRA 350
    GLKWPNIQYH FLPAAMRYDG QAAFDGHGFQ VHVGPNKPES RGRVEIVSAN 400
    PLDKPKIQFN YLSTERDRQD WRDCIRLTRE ILAQPAMDEF RGEEIQPGIN 450
    VATDAEIDQW VKENVESAYH PSCSCKMGAD DDPMAVLDEE CRVRGITNLR 500
    VVDSSVFPTI PNGNLNAPTI MVAERAADLI LHKQPLPPQR SKVWLAPSWE 550
    TQQRTGEPMR 560
    Length:560
    Mass (Da):62,359
    Last modified:December 15, 2003 - v1
    Checksum:i9CCA2CBA8EEA613B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000038 Genomic DNA. Translation: BAC96534.1.
    RefSeqiNP_936564.1. NC_005140.1.
    WP_011151879.1. NC_005140.1.

    Genome annotation databases

    EnsemblBacteriaiBAC96534; BAC96534; BAC96534.
    GeneIDi2621166.
    KEGGivvy:VVA0508.
    PATRICi20174402. VBIVibVul40472_3708.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000038 Genomic DNA. Translation: BAC96534.1 .
    RefSeqi NP_936564.1. NC_005140.1.
    WP_011151879.1. NC_005140.1.

    3D structure databases

    ProteinModelPortali Q7MF12.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 196600.VVA0508.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC96534 ; BAC96534 ; BAC96534 .
    GeneIDi 2621166.
    KEGGi vvy:VVA0508.
    PATRICi 20174402. VBIVibVul40472_3708.

    Phylogenomic databases

    eggNOGi COG2303.
    HOGENOMi HOG000139600.
    KOi K00108.
    OMAi REMHCPR.
    OrthoDBi EOG67HJQP.

    Enzyme and pathway databases

    UniPathwayi UPA00529 ; UER00385 .
    BioCyci RETL1328306-WGS:GSTH-6142-MONOMER.
    VVUL196600:GJ9W-3902-MONOMER.

    Family and domain databases

    HAMAPi MF_00750. Choline_dehydrogen.
    InterProi IPR011533. BetA.
    IPR012132. GMC_OxRdtase.
    IPR000172. GMC_OxRdtase_N.
    IPR007867. GMC_OxRtase_C.
    [Graphical view ]
    Pfami PF05199. GMC_oxred_C. 1 hit.
    PF00732. GMC_oxred_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
    TIGRFAMsi TIGR01810. betA. 1 hit.
    PROSITEi PS00623. GMC_OXRED_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: YJ016.

    Entry informationi

    Entry nameiBETA_VIBVY
    AccessioniPrimary (citable) accession number: Q7MF12
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 16, 2004
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3