Q7MEL2 (ACKA2_VIBVY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetate kinase 2
EC=2.7.2.1

Alternative name(s):
Acetokinase 2

Gene names

Name:	ackA2
Ordered Locus Names:	VVA0658

Organism

Vibrio vulnificus (strain YJ016) [Complete proteome] [HAMAP]

Taxonomic identifier

196600 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	397 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate = ADP + acetyl phosphate. HAMAP MF_00020 ATP + propanoate = ADP + propanoyl phosphate. HAMAP MF_00020
Pathway	Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. HAMAP MF_00020
Subcellular location	Cytoplasm By similarity HAMAP MF_00020.
Sequence similarities	Belongs to the acetokinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	organic acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 397	397	Acetate kinase 2 HAMAP MF_00020		PRO_0000107644

Sequences

	Sequence		Length	Mass (Da)
	Q7MEL2 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: 338D8558CC8AF001	FASTA	397	42,595
	10 20 30 40 50 60 MSNSFVLVIN SGSSSLKFAV INSVTGEAVL SGLGECFGLE DARMGWKYSG EKTEIAIEGE 70 80 90 100 110 120 DNHHKIAIGK LVGLTEELGL TKDIVAVGHR IVHGGEKFTS TVRINEEVTA EIEKLADLAP 130 140 150 160 170 180 LHNPAGAIGI RAAMEAFPAL PQFAVFDTAF HQTMPKRAFT GAIANELYTD FGIRRYGFHG 190 200 210 220 230 240 TSHYFVSREA AKMLNKPIEE SSFISVHLGN GASVCAINNG ESVDTSMGFT PLSGLMMGTR 250 260 270 280 290 300 CGDLDPGIIE YLLKKGWSQE KVFNSLNKAS GFLGVSGLTS DARGILEAME QGHEGATLAF 310 320 330 340 350 360 QVFTYRVAKY IASYLAALDS FDGIIFTGGI GENSLPIRRE ILKNLKLLGF VEDEKGNEDA 370 380 390 RFGNAGVIAT SALLNAVAMV IPTNEEFVIA QQSVELL

References

[1]

"Comparative genome analysis of Vibrio vulnificus, a marine pathogen." Chen C.-Y., Wu K.-M., Chang Y.-C., Chang C.-H., Tsai H.-C., Liao T.-L., Liu Y.-M., Chen H.-J., Shen A.B.-T., Li J.-C., Su T.-L., Shao C.-P., Lee C.-T., Hor L.-I., Tsai S.-F. Genome Res. 13:2577-2587(2003) [PubMed: 14656965] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: YJ016.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000038 Genomic DNA. Translation: BAC96684.1.
RefSeq	NP_936714.1. NC_005140.1.
3D structure databases
ProteinModelPortal	Q7MEL2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q7MEL2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2622622.
GenomeReviews	Gene locus VVA0658 in contig BA000038_GR.
KEGG	vvy:VVA0658.
PATRIC	20174694. VBIVibVul40472_3852.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0282.
HOGENOM	HBG285863.
OMA	AMEEGHE.
ProtClustDB	PRK12440.
Enzyme and pathway databases
BioCyc	VVUL196600:VVA0658-MONOMER.
Family and domain databases
HAMAP	MF_00020. Acetate_kinase. [Tree]
InterPro	IPR004372. Ac/Proprionate_kinase. IPR000890. Aliphatic_acid_kin_short-chain. IPR023865. Aliphatic_acid_kinase_CS. [Graphical view]
KO	K00925.
PANTHER	PTHR21060. Acetate_kin. 1 hit.
Pfam	PF00871. Acetate_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTS	PR00471. ACETATEKNASE.
TIGRFAMs	TIGR00016. AckA. 1 hit.
PROSITE	PS01075. ACETATE_KINASE_1. 1 hit. PS01076. ACETATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACKA2_VIBVY

Accession

Primary (citable) accession number: Q7MEL2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 21, 2004
Last sequence update:	December 15, 2003
Last modified:	January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program