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Q7MEH9

- GCSP_VIBVY

UniProt

Q7MEH9 - GCSP_VIBVY

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Protein

Glycine dehydrogenase (decarboxylating)

Gene
gcvP, VVA0691
Organism
Vibrio vulnificus (strain YJ016)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciVVUL196600:GJ9W-4087-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:VVA0691
OrganismiVibrio vulnificus (strain YJ016)
Taxonomic identifieri196600 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000002675: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 954954Glycine dehydrogenase (decarboxylating)UniRule annotationPRO_0000166947Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei704 – 7041N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PRIDEiQ7MEH9.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi196600.VVA0691.

Structurei

3D structure databases

ProteinModelPortaliQ7MEH9.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiTAYLTHP.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7MEH9-1 [UniParc]FASTAAdd to Basket

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MTELLQSLNT QHEFVGRHNG PNHADQQKML STINAESLDA LIAQTVPAQI    50
RLEKPMQLAE AQSEADMLAS IKKFADLNQV KRTFIGQGYY NTFTPNVILR 100
NVLENPGWYT AYTPYQPEIS QGRLESLLNY QQMVMDLTGM DIANASLLDE 150
ATAAAEAMTL CQRAGKSKSK VFFVADDVHP QTIEVIKTRA KYFGFDVVIG 200
NVDALPQTEA FGALLQYPST TGEVRDLTDV IAQAQANKTL VSVATDLLAS 250
ALVKPAGEMG ADVVIGSAQR FGVPMGYGGP HAAFMATREQ HKRTMPGRVI 300
GVSIDAKGNQ ALRMAMQTRE QHIRREKATS NICTAQALLA NMASFFAVYH 350
GEEGIRTIAR RTHHMTAILA AGLTKSGYEL AHNAFFDTIT INTGDKTQAL 400
YAKAQAADIN LRLLDGQIGI SFDETTTVAD IDALFAIFDV KESVNALSTD 450
IAGNEFAAIP EACRRTSRFL SHPVFNTHHS ETQMMRYLKQ LENKDFSLTH 500
GMIPLGSCTM KLNAAAEMIP VTWPEFGALH PFAPIEQAAG YTALAEDLKA 550
KLCEITGYDA FSLQPNSGAS GEYAGLIAIQ RYHESRGEGH RNVCLIPSSA 600
HGTNPATAAM VSMKVVVVKC DENGNIDLVD LAAKIEKHQE NLSSIMITYP 650
STHGVYEEQV KEVCEMVHAA GGQVYLDGAN MNAQVGLTSP GFIGSDVSHL 700
NLHKTFCIPH GGGGPGMGPI GVKSHLAPFL PGHIENGVEG KEFAVSAADL 750
GSASILPISW AYIAMMGADG LTEATKVAIL NANYVMERLR PHYPVLYRGT 800
NGRVAHECII DIRPLKEETG ISEEDIAKRL MDYGFHAPTM SFPVAGTLMV 850
EPTESEDLEE LDRFCDAMIA IREEMTKVKN GEWPLENNPL VNAPHTQVDL 900
MEEQWDRPYP REIACFPSAA TKRSKYWPTV NRVDNVYGDR NLVCSCPGIE 950
NYEE 954
Length:954
Mass (Da):104,208
Last modified:December 15, 2003 - v1
Checksum:iFC6C3127F6357598
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000038 Genomic DNA. Translation: BAC96717.1.
RefSeqiNP_936747.1. NC_005140.1.

Genome annotation databases

EnsemblBacteriaiBAC96717; BAC96717; BAC96717.
GeneIDi2622655.
KEGGivvy:VVA0691.
PATRICi20174762. VBIVibVul40472_3886.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000038 Genomic DNA. Translation: BAC96717.1 .
RefSeqi NP_936747.1. NC_005140.1.

3D structure databases

ProteinModelPortali Q7MEH9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196600.VVA0691.

Proteomic databases

PRIDEi Q7MEH9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC96717 ; BAC96717 ; BAC96717 .
GeneIDi 2622655.
KEGGi vvy:VVA0691.
PATRICi 20174762. VBIVibVul40472_3886.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi TAYLTHP.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci VVUL196600:GJ9W-4087-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YJ016.

Entry informationi

Entry nameiGCSP_VIBVY
AccessioniPrimary (citable) accession number: Q7MEH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: December 15, 2003
Last modified: May 14, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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