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Q7MEH9

- GCSP_VIBVY

UniProt

Q7MEH9 - GCSP_VIBVY

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Vibrio vulnificus (strain YJ016)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciVVUL196600:GJ9W-4087-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:VVA0691
OrganismiVibrio vulnificus (strain YJ016)
Taxonomic identifieri196600 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000002675: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 954954Glycine dehydrogenase (decarboxylating)PRO_0000166947Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei704 – 7041N6-(pyridoxal phosphate)lysineUniRule annotation

Proteomic databases

PRIDEiQ7MEH9.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi196600.VVA0691.

Structurei

3D structure databases

ProteinModelPortaliQ7MEH9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiTAYLTHP.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7MEH9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTELLQSLNT QHEFVGRHNG PNHADQQKML STINAESLDA LIAQTVPAQI
60 70 80 90 100
RLEKPMQLAE AQSEADMLAS IKKFADLNQV KRTFIGQGYY NTFTPNVILR
110 120 130 140 150
NVLENPGWYT AYTPYQPEIS QGRLESLLNY QQMVMDLTGM DIANASLLDE
160 170 180 190 200
ATAAAEAMTL CQRAGKSKSK VFFVADDVHP QTIEVIKTRA KYFGFDVVIG
210 220 230 240 250
NVDALPQTEA FGALLQYPST TGEVRDLTDV IAQAQANKTL VSVATDLLAS
260 270 280 290 300
ALVKPAGEMG ADVVIGSAQR FGVPMGYGGP HAAFMATREQ HKRTMPGRVI
310 320 330 340 350
GVSIDAKGNQ ALRMAMQTRE QHIRREKATS NICTAQALLA NMASFFAVYH
360 370 380 390 400
GEEGIRTIAR RTHHMTAILA AGLTKSGYEL AHNAFFDTIT INTGDKTQAL
410 420 430 440 450
YAKAQAADIN LRLLDGQIGI SFDETTTVAD IDALFAIFDV KESVNALSTD
460 470 480 490 500
IAGNEFAAIP EACRRTSRFL SHPVFNTHHS ETQMMRYLKQ LENKDFSLTH
510 520 530 540 550
GMIPLGSCTM KLNAAAEMIP VTWPEFGALH PFAPIEQAAG YTALAEDLKA
560 570 580 590 600
KLCEITGYDA FSLQPNSGAS GEYAGLIAIQ RYHESRGEGH RNVCLIPSSA
610 620 630 640 650
HGTNPATAAM VSMKVVVVKC DENGNIDLVD LAAKIEKHQE NLSSIMITYP
660 670 680 690 700
STHGVYEEQV KEVCEMVHAA GGQVYLDGAN MNAQVGLTSP GFIGSDVSHL
710 720 730 740 750
NLHKTFCIPH GGGGPGMGPI GVKSHLAPFL PGHIENGVEG KEFAVSAADL
760 770 780 790 800
GSASILPISW AYIAMMGADG LTEATKVAIL NANYVMERLR PHYPVLYRGT
810 820 830 840 850
NGRVAHECII DIRPLKEETG ISEEDIAKRL MDYGFHAPTM SFPVAGTLMV
860 870 880 890 900
EPTESEDLEE LDRFCDAMIA IREEMTKVKN GEWPLENNPL VNAPHTQVDL
910 920 930 940 950
MEEQWDRPYP REIACFPSAA TKRSKYWPTV NRVDNVYGDR NLVCSCPGIE

NYEE
Length:954
Mass (Da):104,208
Last modified:December 15, 2003 - v1
Checksum:iFC6C3127F6357598
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000038 Genomic DNA. Translation: BAC96717.1.
RefSeqiNP_936747.1. NC_005140.1.

Genome annotation databases

EnsemblBacteriaiBAC96717; BAC96717; BAC96717.
GeneIDi2622655.
KEGGivvy:VVA0691.
PATRICi20174762. VBIVibVul40472_3886.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000038 Genomic DNA. Translation: BAC96717.1 .
RefSeqi NP_936747.1. NC_005140.1.

3D structure databases

ProteinModelPortali Q7MEH9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196600.VVA0691.

Proteomic databases

PRIDEi Q7MEH9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC96717 ; BAC96717 ; BAC96717 .
GeneIDi 2622655.
KEGGi vvy:VVA0691.
PATRICi 20174762. VBIVibVul40472_3886.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi TAYLTHP.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci VVUL196600:GJ9W-4087-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YJ016.

Entry informationi

Entry nameiGCSP_VIBVY
AccessioniPrimary (citable) accession number: Q7MEH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: December 15, 2003
Last modified: November 26, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3