Reviewed, UniProtKB/Swiss-Prot Q7MEH7 (GLYA2_VIBVY)

Names and origin

Protein names

Recommended name:
    Serine hydroxymethyltransferase 2
      Short name=Serine methylase 2
      Short name=SHMT 2
    EC=2.1.2.1

Gene names

Name:	glyA2
Ordered Locus Names:	VVA0693

Organism

Vibrio vulnificus (strain YJ016) [Complete proteome] [HAMAP]

Taxonomic identifier

196600 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	431 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Interconversion of serine and glycine. HAMAP MF_00051
Catalytic activity	5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. HAMAP MF_00051
Cofactor	Pyridoxal phosphate By similarity.
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_00051
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the SHMT family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-serine metabolic process Inferred from electronic annotation. Source: InterPro glycine metabolic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glycine hydroxymethyltransferase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 431	431	Serine hydroxymethyltransferase 2 HAMAP MF_00051		PRO_0000113697
Amino acid modifications
	Modified residue	240	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7MEH7-1 [UniParc]. Last modified April 26, 2004. Version 2. Checksum: 757B8E8A4D4216AC	FASTA	431	46,459
	10 20 30 40 50 60 MNSHYQNHSL ENFFSTNLSA TDDAVFAGIQ AEFTRQNEQI ELIASENIVS KAVMQAQGTC 70 80 90 100 110 120 LTNKYAEGYP GRRYYGGCEH VDTVEAIAIE RAKKLFNCEY ANVQPHSGAQ ANGAVKLALL 130 140 150 160 170 180 QPGDTIMGMS LDAGGHLTHG ARPALSGKWF NAVQYGVDKE TLEINYDDVR ALAVEHKPKM 190 200 210 220 230 240 IIAGGSAIPR VIDFAKFREI ADEVGAILMV DMAHIAGLIA TGAHPSPLPH AHVVTTTTHK 250 260 270 280 290 300 TLRGPRGGMI LTNHEEIIKK INSAVFPGLQ GGPLMHVIAA KAVAFGEALG PEFKTYIDSV 310 320 330 340 350 360 INNAKVLAEV LQTRGCDIVT GGTDTHLMLV DLRPKGLKGN KAEEALERAG ITCNKNGIPF 370 380 390 400 410 420 DTEKPMITSG VRLGTPAGTS RGFGAEEFKL IGHWIGDVLD GLVENPEGNA EVEQRVRKEV 430 KALCSRFPLY Q

References

[1]

"Comparative genome analysis of Vibrio vulnificus, a marine pathogen." Chen C.-Y., Wu K.-M., Chang Y.-C., Chang C.-H., Tsai H.-C., Liao T.-L., Liu Y.-M., Chen H.-J., Shen A.B.-T., Li J.-C., Su T.-L., Shao C.-P., Lee C.-T., Hor L.-I., Tsai S.-F. Genome Res. 13:2577-2587(2003) [PubMed: 14656965] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000038 Genomic DNA. Translation: BAC96719.1. Different initiation.
RefSeq	NP_936749.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q7MEH7.
Genome annotation databases
GeneID	2622657.
GenomeReviews	Gene locus VVA0693 in contig BA000038_GR.
KEGG	vvy:VVA0693.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q7MEH7.
OMA	DGFFTES.
Enzyme and pathway databases
BioCyc	VVUL196600:VVA0693-MON.
Family and domain databases
HAMAP	MF_00051. [Tree]
InterPro	IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR001085. Ser_HO-MeTrfase. IPR019798. Ser_HO-MeTrfase_PLP_BS. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PANTHER	PTHR11680. Gly_HO-Metrfase. 1 hit.
Pfam	PF00464. SHMT. 1 hit. [Graphical view]
PIRSF	PIRSF000412. SHMT. 1 hit.
PROSITE	PS00096. SHMT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLYA2_VIBVY

Accession

Primary (citable) accession number: Q7MEH7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	April 26, 2004
Last modified:	November 3, 2009
This is version 42 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)