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Q7MEE8

- FTHS_VIBVY

UniProt

Q7MEE8 - FTHS_VIBVY

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Vibrio vulnificus (strain YJ016)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciVVUL196600:GJ9W-4118-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:VVA0722
    OrganismiVibrio vulnificus (strain YJ016)
    Taxonomic identifieri196600 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000002675: Chromosome II

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 582582Formate--tetrahydrofolate ligasePRO_0000199411Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi196600.VVA0722.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7MEE8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7MEE8-1 [UniParc]FASTAAdd to Basket

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    MLSDIDICRT TPLKPIEQIA AKAGLLADEF ETHGLYKAKV SARCVKRLAE    50
    QQDGKLVLVT AITPTPLGEG KTVTTIGLAQ GLQSLNQSVM ACIRQPSMGP 100
    VFGVKGGAAG GGYSQVAPMD ELNLHLTGDI HAVTAAHNLA AAAIDARIYH 150
    EQRAGYQAFE ARTGLPALRI DPDRVVWKRV MDHNDRALRK VRVGLNDEGK 200
    TINGFEREEG FDISAASELM AILALSKNLQ DMRERIGKVV LAYNLDGEPV 250
    SAEQLQVAGA MTVTLKEAIK PTLMQTLEGV PTLIHAGPFA NIAHGNSSII 300
    ADEIALKLSS YVVTEAGFGS DMGLEKACNI KSSTSHKAPD CVVIVATLRG 350
    LKANSGLYDL KPGMPLPDAL FQPDRAALES GFSNLKWHID NAQKYGLPAV 400
    VAINQFPQDS AEELGQLKLW IQQLPLNVRV AISEGFAKGG KGMEAVAREV 450
    IEACDAPANF RPLYRAEQTL EEKIITVCTK GYGCGEVQFS DTAKQQLALY 500
    QTLGFGELAV CMAKTPLSIS SDSSLKGAPS GFTIMVREVR LCAGAGFVYA 550
    LTGNVMTMPG LPDIPAFMAL DIDENGDIVG LS 582
    Length:582
    Mass (Da):62,143
    Last modified:December 15, 2003 - v1
    Checksum:iBB203316FAE0BF06
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000038 Genomic DNA. Translation: BAC96748.1.
    RefSeqiNP_936778.1. NC_005140.1.
    WP_011152059.1. NC_005140.1.

    Genome annotation databases

    EnsemblBacteriaiBAC96748; BAC96748; BAC96748.
    GeneIDi2622571.
    KEGGivvy:VVA0722.
    PATRICi20174824. VBIVibVul40472_3917.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000038 Genomic DNA. Translation: BAC96748.1 .
    RefSeqi NP_936778.1. NC_005140.1.
    WP_011152059.1. NC_005140.1.

    3D structure databases

    ProteinModelPortali Q7MEE8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 196600.VVA0722.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC96748 ; BAC96748 ; BAC96748 .
    GeneIDi 2622571.
    KEGGi vvy:VVA0722.
    PATRICi 20174824. VBIVibVul40472_3917.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci VVUL196600:GJ9W-4118-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: YJ016.

    Entry informationi

    Entry nameiFTHS_VIBVY
    AccessioniPrimary (citable) accession number: Q7MEE8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3