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Q7MEE8

- FTHS_VIBVY

UniProt

Q7MEE8 - FTHS_VIBVY

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Vibrio vulnificus (strain YJ016)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciVVUL196600:GJ9W-4118-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:VVA0722
OrganismiVibrio vulnificus (strain YJ016)
Taxonomic identifieri196600 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000002675: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 582582Formate--tetrahydrofolate ligasePRO_0000199411Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi196600.VVA0722.

Structurei

3D structure databases

ProteinModelPortaliQ7MEE8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7MEE8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSDIDICRT TPLKPIEQIA AKAGLLADEF ETHGLYKAKV SARCVKRLAE
60 70 80 90 100
QQDGKLVLVT AITPTPLGEG KTVTTIGLAQ GLQSLNQSVM ACIRQPSMGP
110 120 130 140 150
VFGVKGGAAG GGYSQVAPMD ELNLHLTGDI HAVTAAHNLA AAAIDARIYH
160 170 180 190 200
EQRAGYQAFE ARTGLPALRI DPDRVVWKRV MDHNDRALRK VRVGLNDEGK
210 220 230 240 250
TINGFEREEG FDISAASELM AILALSKNLQ DMRERIGKVV LAYNLDGEPV
260 270 280 290 300
SAEQLQVAGA MTVTLKEAIK PTLMQTLEGV PTLIHAGPFA NIAHGNSSII
310 320 330 340 350
ADEIALKLSS YVVTEAGFGS DMGLEKACNI KSSTSHKAPD CVVIVATLRG
360 370 380 390 400
LKANSGLYDL KPGMPLPDAL FQPDRAALES GFSNLKWHID NAQKYGLPAV
410 420 430 440 450
VAINQFPQDS AEELGQLKLW IQQLPLNVRV AISEGFAKGG KGMEAVAREV
460 470 480 490 500
IEACDAPANF RPLYRAEQTL EEKIITVCTK GYGCGEVQFS DTAKQQLALY
510 520 530 540 550
QTLGFGELAV CMAKTPLSIS SDSSLKGAPS GFTIMVREVR LCAGAGFVYA
560 570 580
LTGNVMTMPG LPDIPAFMAL DIDENGDIVG LS
Length:582
Mass (Da):62,143
Last modified:December 15, 2003 - v1
Checksum:iBB203316FAE0BF06
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000038 Genomic DNA. Translation: BAC96748.1.
RefSeqiNP_936778.1. NC_005140.1.

Genome annotation databases

EnsemblBacteriaiBAC96748; BAC96748; BAC96748.
GeneIDi2622571.
KEGGivvy:VVA0722.
PATRICi20174824. VBIVibVul40472_3917.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000038 Genomic DNA. Translation: BAC96748.1 .
RefSeqi NP_936778.1. NC_005140.1.

3D structure databases

ProteinModelPortali Q7MEE8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196600.VVA0722.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC96748 ; BAC96748 ; BAC96748 .
GeneIDi 2622571.
KEGGi vvy:VVA0722.
PATRICi 20174824. VBIVibVul40472_3917.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci VVUL196600:GJ9W-4118-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YJ016.

Entry informationi

Entry nameiFTHS_VIBVY
AccessioniPrimary (citable) accession number: Q7MEE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 15, 2003
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3