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Protein

Adenosine deaminase

Gene

add

Organism
Vibrio vulnificus (strain YJ016)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Adenosine + H2O = inosine + NH3.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi12Zinc; catalyticUniRule annotation1
Metal bindingi14Zinc; catalyticUniRule annotation1
Binding sitei14SubstrateUniRule annotation1
Binding sitei16SubstrateUniRule annotation1
Binding sitei170Substrate; via amide nitrogen and carbonyl oxygenUniRule annotation1
Metal bindingi197Zinc; catalyticUniRule annotation1
Active sitei200Proton donorUniRule annotation1
Sitei221Important for catalytic activityUniRule annotation1
Metal bindingi278Zinc; catalyticUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine deaminaseUniRule annotation (EC:3.5.4.4UniRule annotation)
Alternative name(s):
Adenosine aminohydrolaseUniRule annotation
Gene namesi
Name:addUniRule annotation
Ordered Locus Names:VVA1020
OrganismiVibrio vulnificus (strain YJ016)
Taxonomic identifieri196600 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000002675 Componenti: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001944011 – 331Adenosine deaminaseAdd BLAST331

Structurei

3D structure databases

ProteinModelPortaliQ7MDL6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosine and AMP deaminases family. Adenosine deaminase subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218816.
KOiK01488.
OMAiDWMVAVL.
OrthoDBiPOG091H02QG.

Family and domain databases

CDDicd01320. ADA. 1 hit.
HAMAPiMF_00540. A_deaminase. 1 hit.
InterProiIPR001365. A/AMP_deaminase_dom.
IPR028893. A_deaminase.
IPR006330. Ado/ade_deaminase.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF00962. A_deaminase. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR01430. aden_deam. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7MDL6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYFDLPKID LHCHLDGSVR PQTIIDLADE QNLTLPSRDI NVIKEMMVAP
60 70 80 90 100
ETCPNLDEYL KRFELPGMVM QTAEALERIS FELFEDAANE NVKYLEVRFG
110 120 130 140 150
PLLHQVKGLS LDDIMDSVVR GMKRAEAQYD IHGNYILSIL RTMPKDQIKA
160 170 180 190 200
VLEAGAKHLN DGIVAFDLAG SEIPGFCHEF VPYAQYAKEL GYRITIHAGE
210 220 230 240 250
QGAGQNVYDA ISLLGAERVG HGIFIHNHPE AYQLVKGEEV ALETCPSSNV
260 270 280 290 300
QTKAVNSLSE HPIKAFYKDG IAVTINTDNR TVSNTTMTDE VRKVVEAFEL
310 320 330
TEAEYFDIYT ISVNNAFTSD AVKQHLLSFA Q
Length:331
Mass (Da):36,997
Last modified:December 15, 2003 - v1
Checksum:i43AD5119240D712A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000038 Genomic DNA. Translation: BAC97046.1.
RefSeqiWP_011152304.1. NC_005140.1.

Genome annotation databases

EnsemblBacteriaiBAC97046; BAC97046; BAC97046.
GeneIDi2621878.
KEGGivvy:VVA1020.
PATRICi20175370. VBIVibVul40472_4189.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000038 Genomic DNA. Translation: BAC97046.1.
RefSeqiWP_011152304.1. NC_005140.1.

3D structure databases

ProteinModelPortaliQ7MDL6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC97046; BAC97046; BAC97046.
GeneIDi2621878.
KEGGivvy:VVA1020.
PATRICi20175370. VBIVibVul40472_4189.

Phylogenomic databases

HOGENOMiHOG000218816.
KOiK01488.
OMAiDWMVAVL.
OrthoDBiPOG091H02QG.

Family and domain databases

CDDicd01320. ADA. 1 hit.
HAMAPiMF_00540. A_deaminase. 1 hit.
InterProiIPR001365. A/AMP_deaminase_dom.
IPR028893. A_deaminase.
IPR006330. Ado/ade_deaminase.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF00962. A_deaminase. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR01430. aden_deam. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADD_VIBVY
AccessioniPrimary (citable) accession number: Q7MDL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: December 15, 2003
Last modified: November 30, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.