Q7MDL6 (ADD_VIBVY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenosine deaminase
EC=3.5.4.4

Alternative name(s):
Adenosine aminohydrolase

Gene names

Name:	add
Ordered Locus Names:	VVA1020

Organism

Vibrio vulnificus (strain YJ016) [Complete proteome] [HAMAP]

Taxonomic identifier

196600 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	331 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Adenosine + H2O = inosine + NH3. HAMAP MF_00540
Cofactor	Binds 1 zinc ion per subunit By similarity. HAMAP MF_00540
Sequence similarities	Belongs to the adenosine and AMP deaminases family. Adenosine deaminase subfamily.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	adenosine deaminase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 331	331	Adenosine deaminase HAMAP MF_00540		PRO_0000194401
Sites
	Active site	200	1	Proton donor By similarity
	Metal binding	12	1	Zinc; catalytic By similarity
	Metal binding	14	1	Zinc; catalytic By similarity
	Metal binding	197	1	Zinc; catalytic By similarity
	Metal binding	278	1	Zinc; catalytic By similarity
	Binding site	14	1	Substrate By similarity
	Binding site	16	1	Substrate By similarity
	Binding site	170	1	Substrate; via amide nitrogen and carbonyl oxygen By similarity
	Site	221	1	Important for catalytic activity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7MDL6 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: 43AD5119240D712A	FASTA	331	36,997
	10 20 30 40 50 60 MNYFDLPKID LHCHLDGSVR PQTIIDLADE QNLTLPSRDI NVIKEMMVAP ETCPNLDEYL 70 80 90 100 110 120 KRFELPGMVM QTAEALERIS FELFEDAANE NVKYLEVRFG PLLHQVKGLS LDDIMDSVVR 130 140 150 160 170 180 GMKRAEAQYD IHGNYILSIL RTMPKDQIKA VLEAGAKHLN DGIVAFDLAG SEIPGFCHEF 190 200 210 220 230 240 VPYAQYAKEL GYRITIHAGE QGAGQNVYDA ISLLGAERVG HGIFIHNHPE AYQLVKGEEV 250 260 270 280 290 300 ALETCPSSNV QTKAVNSLSE HPIKAFYKDG IAVTINTDNR TVSNTTMTDE VRKVVEAFEL 310 320 330 TEAEYFDIYT ISVNNAFTSD AVKQHLLSFA Q

References

[1]

"Comparative genome analysis of Vibrio vulnificus, a marine pathogen." Chen C.-Y., Wu K.-M., Chang Y.-C., Chang C.-H., Tsai H.-C., Liao T.-L., Liu Y.-M., Chen H.-J., Shen A.B.-T., Li J.-C., Su T.-L., Shao C.-P., Lee C.-T., Hor L.-I., Tsai S.-F. Genome Res. 13:2577-2587(2003) [PubMed: 14656965] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: YJ016.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000038 Genomic DNA. Translation: BAC97046.1.
RefSeq	NP_937076.1. NC_005140.1.
3D structure databases
ProteinModelPortal	Q7MDL6.
ModBase	Search...
Protein-protein interaction databases
STRING	Q7MDL6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2621878.
GenomeReviews	Gene locus VVA1020 in contig BA000038_GR.
KEGG	vvy:VVA1020.
NMPDR	fig|196600.1.peg.4347.
PATRIC	20175370. VBIVibVul40472_4189.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1816.
HOGENOM	HBG630382.
OMA	PYYMAMN.
PhylomeDB	Q7MDL6.
ProtClustDB	PRK09358.
Enzyme and pathway databases
BioCyc	VVUL196600:VVA1020-MONOMER.
Family and domain databases
HAMAP	MF_00540. A_deaminase. [Tree]
InterPro	IPR001365. A/AMP_deaminase_dom. IPR006330. A_deaminase. [Graphical view]
KO	K01488.
PANTHER	PTHR11409:SF21. PTHR11409:SF21. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. Aden_deam. 1 hit.
PROSITE	PS00485. A_DEAMINASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADD_VIBVY

Accession

Primary (citable) accession number: Q7MDL6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 2, 2004
Last sequence update:	December 15, 2003
Last modified:	January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program