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Q7MBZ9 (UXUA_VIBVY) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mannonate dehydratase

EC=4.2.1.8
Alternative name(s):
D-mannonate hydro-lyase
Gene names
Name:uxuA
Ordered Locus Names:VVA1588
OrganismVibrio vulnificus (strain YJ016) [Complete proteome] [HAMAP]
Taxonomic identifier196600 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length395 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dehydration of D-mannonate By similarity. HAMAP-Rule MF_00106

Catalytic activity

D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O. HAMAP-Rule MF_00106

Cofactor

Fe2+ or Mn2+ ion By similarity. HAMAP-Rule MF_00106

Pathway

Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP-Rule MF_00106

Sequence similarities

Belongs to the mannonate dehydratase family.

Sequence caution

The sequence BAC97614.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   LigandIron
Manganese
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglucuronate catabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionmannonate dehydratase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 395395Mannonate dehydratase HAMAP-Rule MF_00106
PRO_0000170693

Sequences

Sequence LengthMass (Da)Tools
Q7MBZ9 [UniParc].

Last modified April 26, 2004. Version 2.
Checksum: E144A3DD6DE67727

FASTA39544,947
        10         20         30         40         50         60 
MEQTWRWYGP NDPVSLDDIC QAGATGIVNA LHHIPNGEVW SKEEILKRKA IIEEKGLTWS 

        70         80         90        100        110        120 
VVESVPVHEE IKTQTGNFQQ WIDNYKQTLR NLAECGIDTV CYNFMPVLDW TRTDLEFEMP 

       130        140        150        160        170        180 
DGSKALRFDQ IAFAAFELHI LKRPGAEADY SEAEQAQALE YFNNMSEAQI QQLTSNIIAG 

       190        200        210        220        230        240 
LPGAEEGYTL EEFQAQLDRY AGISKDKLRE HMAYFLSQLM PVCEAHGLKL AVHPDDPPRP 

       250        260        270        280        290        300 
ILGLPRIVST IEDIDWLTEK VPSKMNGLTM CTGSYGVRGD NDLVKMIKKH GERIYFTHLR 

       310        320        330        340        350        360 
STKREESNPM TFHEAAHLDG DVDMYNVVMA ILDEEQRRAE VGDHRLIPMR PDHGHQMLDD 

       370        380        390 
LKKKTNPGYS AIGRLKGLAE VRGLEMALKR AFYTK 

« Hide

References

[1]"Comparative genome analysis of Vibrio vulnificus, a marine pathogen."
Chen C.-Y., Wu K.-M., Chang Y.-C., Chang C.-H., Tsai H.-C., Liao T.-L., Liu Y.-M., Chen H.-J., Shen A.B.-T., Li J.-C., Su T.-L., Shao C.-P., Lee C.-T., Hor L.-I., Tsai S.-F.
Genome Res. 13:2577-2587(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: YJ016.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000038 Genomic DNA. Translation: BAC97614.1. Different initiation.
RefSeqNP_937644.1. NC_005140.1.

3D structure databases

ProteinModelPortalQ7MBZ9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING196600.VVA1588.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC97614; BAC97614; BAC97614.
GeneID2622450.
KEGGvvy:VVA1588.
PATRIC20176434. VBIVibVul40472_4718.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1312.
HOGENOMHOG000195381.
KOK01686.
OMAEGDVDMY.
OrthoDBEOG6ZSP6Z.
ProtClustDBPRK03906.

Enzyme and pathway databases

BioCycVVUL196600:GJ9W-4988-MONOMER.
UniPathwayUPA00246.

Family and domain databases

Gene3D3.20.20.150. 1 hit.
HAMAPMF_00106. UxuA.
InterProIPR004628. Man_deHydtase.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PfamPF03786. UxuA. 1 hit.
[Graphical view]
PIRSFPIRSF016049. Man_dehyd. 1 hit.
SUPFAMSSF51658. SSF51658. 1 hit.
TIGRFAMsTIGR00695. uxuA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUXUA_VIBVY
AccessionPrimary (citable) accession number: Q7MBZ9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: February 19, 2014
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways