ID   Q7MBY8_VIBVY            Unreviewed;       223 AA.
AC   Q7MBY8;
DT   15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT   15-DEC-2003, sequence version 1.
DT   27-MAR-2024, entry version 131.
DE   SubName: Full=Dehydrogenase {ECO:0000313|EMBL:BAC97625.1};
GN   OrderedLocusNames=VVA1599 {ECO:0000313|EMBL:BAC97625.1};
OS   Vibrio vulnificus (strain YJ016).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=196600 {ECO:0000313|EMBL:BAC97625.1, ECO:0000313|Proteomes:UP000002675};
RN   [1] {ECO:0000313|EMBL:BAC97625.1, ECO:0000313|Proteomes:UP000002675}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJ016 {ECO:0000313|EMBL:BAC97625.1,
RC   ECO:0000313|Proteomes:UP000002675};
RX   PubMed=14656965; DOI=10.1101/gr.1295503;
RA   Chen C.Y., Wu K.M., Chang Y.C., Chang C.H., Tsai H.C., Liao T.L., Liu Y.M.,
RA   Chen H.J., Shen A.B., Li J.C., Su T.L., Shao C.P., Lee C.T., Hor L.I.,
RA   Tsai S.F.;
RT   "Comparative genome analysis of Vibrio vulnificus, a marine pathogen.";
RL   Genome Res. 13:2577-2587(2003).
RN   [2] {ECO:0007829|PDB:3UCE, ECO:0007829|PDB:3UCF}
RP   X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) IN COMPLEX WITH NADPH.
RX   PubMed=23311896; DOI=10.1111/febs.12128;
RA   Buysschaert G., Verstraete K., Savvides S.N., Vergauwen B.;
RT   "Structural and biochemical characterization of an atypical short-chain
RT   dehydrogenase/reductase reveals an unusual cofactor preference.";
RL   FEBS J. 280:1358-1370(2013).
CC   -!- INTERACTION:
CC       Q7MBY8; Q7MBY8: VVA1599; NbExp=2; IntAct=EBI-8298803, EBI-8298803;
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000256|ARBA:ARBA00006484}.
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DR   EMBL; BA000038; BAC97625.1; -; Genomic_DNA.
DR   PDB; 3UCE; X-ray; 1.80 A; A/B/C/D=1-223.
DR   PDB; 3UCF; X-ray; 2.35 A; A/B/C/D=1-223.
DR   PDBsum; 3UCE; -.
DR   PDBsum; 3UCF; -.
DR   AlphaFoldDB; Q7MBY8; -.
DR   SMR; Q7MBY8; -.
DR   MINT; Q7MBY8; -.
DR   STRING; 672.VV93_v1c44690; -.
DR   KEGG; vvy:VVA1599; -.
DR   eggNOG; COG1028; Bacteria.
DR   HOGENOM; CLU_010194_1_2_6; -.
DR   Proteomes; UP000002675; Chromosome II.
DR   GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR002347; SDR_fam.
DR   PANTHER; PTHR43477; DIHYDROANTICAPSIN 7-DEHYDROGENASE; 1.
DR   PANTHER; PTHR43477:SF1; DIHYDROANTICAPSIN 7-DEHYDROGENASE; 1.
DR   Pfam; PF13561; adh_short_C2; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:3UCE, ECO:0007829|PDB:3UCF};
KW   Nucleotide-binding {ECO:0007829|PDB:3UCE};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT   BINDING         13
FT                   /ligand="NADPH"
FT                   /ligand_id="ChEBI:CHEBI:57783"
FT                   /evidence="ECO:0007829|PDB:3UCE"
FT   BINDING         18
FT                   /ligand="NADPH"
FT                   /ligand_id="ChEBI:CHEBI:57783"
FT                   /evidence="ECO:0007829|PDB:3UCE"
FT   BINDING         37
FT                   /ligand="NADPH"
FT                   /ligand_id="ChEBI:CHEBI:57783"
FT                   /evidence="ECO:0007829|PDB:3UCE"
FT   BINDING         38
FT                   /ligand="NADPH"
FT                   /ligand_id="ChEBI:CHEBI:57783"
FT                   /evidence="ECO:0007829|PDB:3UCE"
FT   BINDING         39
FT                   /ligand="NADPH"
FT                   /ligand_id="ChEBI:CHEBI:57783"
FT                   /evidence="ECO:0007829|PDB:3UCE"
FT   BINDING         43
FT                   /ligand="NADPH"
FT                   /ligand_id="ChEBI:CHEBI:57783"
FT                   /evidence="ECO:0007829|PDB:3UCE"
FT   BINDING         44
FT                   /ligand="NADPH"
FT                   /ligand_id="ChEBI:CHEBI:57783"
FT                   /evidence="ECO:0007829|PDB:3UCE"
FT   BINDING         68
FT                   /ligand="NADPH"
FT                   /ligand_id="ChEBI:CHEBI:57783"
FT                   /evidence="ECO:0007829|PDB:3UCE"
FT   BINDING         69
FT                   /ligand="NADPH"
FT                   /ligand_id="ChEBI:CHEBI:57783"
FT                   /evidence="ECO:0007829|PDB:3UCE"
FT   BINDING         91
FT                   /ligand="NADPH"
FT                   /ligand_id="ChEBI:CHEBI:57783"
FT                   /evidence="ECO:0007829|PDB:3UCE"
FT   BINDING         161
FT                   /ligand="NADPH"
FT                   /ligand_id="ChEBI:CHEBI:57783"
FT                   /evidence="ECO:0007829|PDB:3UCE"
FT   BINDING         163
FT                   /ligand="NADPH"
FT                   /ligand_id="ChEBI:CHEBI:57783"
FT                   /evidence="ECO:0007829|PDB:3UCE"
FT   BINDING         166
FT                   /ligand="NADPH"
FT                   /ligand_id="ChEBI:CHEBI:57783"
FT                   /evidence="ECO:0007829|PDB:3UCE"
SQ   SEQUENCE   223 AA;  23654 MW;  CBD4EEFF037FAD09 CRC64;
     MMGSDKTVYV VLGGTSGIGA ELAKQLESEH TIVHVASRQT GLDISDEKSV YHYFETIGAF
     DHLIVTAGSY APAGKVVDVE VTQAKYAFDT KFWGAVLAAK HGARYLKQGG SITLTSGMLS
     RKVVANTYVK AAINAAIEAT TKVLAKELAP IRVNAISPGL TKTEAYKGMN ADDRDAMYQR
     TQSHLPVGKV GEASDIAMAY LFAIQNSYMT GTVIDVDGGA LLG
//