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Protein
Submitted name:

Dehydrogenase

Gene

VVA1599

Organism
Vibrio vulnificus (strain YJ016)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei91 – 911NADPCombined sources

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 184NADPCombined sources
Nucleotide bindingi37 – 393NADPCombined sources
Nucleotide bindingi43 – 442NADPCombined sources
Nucleotide bindingi68 – 692NADPCombined sources
Nucleotide bindingi158 – 1669NADPCombined sources

GO - Molecular functioni

  1. identical protein binding Source: IntAct
  2. nucleotide binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

NADPCombined sources, Nucleotide-bindingCombined sources

Enzyme and pathway databases

BioCyciVVUL196600:GJ9W-4999-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
DehydrogenaseImported
Gene namesi
Ordered Locus Names:VVA1599Imported
OrganismiVibrio vulnificus (strain YJ016)Imported
Taxonomic identifieri196600 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000002675 Componenti: Chromosome II

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-8298803,EBI-8298803

Protein-protein interaction databases

MINTiMINT-8408766.
STRINGi196600.VVA1599.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3UCEX-ray1.80A/B/C/D1-223[»]
3UCFX-ray2.35A/B/C/D1-223[»]
ProteinModelPortaliQ7MBY8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG1028.
OMAiRKVVANT.
OrthoDBiEOG679TBX.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PRINTSiPR00081. GDHRDH.

Sequencei

Sequence statusi: Complete.

Q7MBY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMGSDKTVYV VLGGTSGIGA ELAKQLESEH TIVHVASRQT GLDISDEKSV
60 70 80 90 100
YHYFETIGAF DHLIVTAGSY APAGKVVDVE VTQAKYAFDT KFWGAVLAAK
110 120 130 140 150
HGARYLKQGG SITLTSGMLS RKVVANTYVK AAINAAIEAT TKVLAKELAP
160 170 180 190 200
IRVNAISPGL TKTEAYKGMN ADDRDAMYQR TQSHLPVGKV GEASDIAMAY
210 220
LFAIQNSYMT GTVIDVDGGA LLG
Length:223
Mass (Da):23,654
Last modified:December 15, 2003 - v1
Checksum:iCBD4EEFF037FAD09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000038 Genomic DNA. Translation: BAC97625.1.
RefSeqiNP_937655.1. NC_005140.1.

Genome annotation databases

EnsemblBacteriaiBAC97625; BAC97625; BAC97625.
KEGGivvy:VVA1599.
PATRICi20176456. VBIVibVul40472_4729.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000038 Genomic DNA. Translation: BAC97625.1.
RefSeqiNP_937655.1. NC_005140.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3UCEX-ray1.80A/B/C/D1-223[»]
3UCFX-ray2.35A/B/C/D1-223[»]
ProteinModelPortaliQ7MBY8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-8408766.
STRINGi196600.VVA1599.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC97625; BAC97625; BAC97625.
KEGGivvy:VVA1599.
PATRICi20176456. VBIVibVul40472_4729.

Phylogenomic databases

eggNOGiCOG1028.
OMAiRKVVANT.
OrthoDBiEOG679TBX.

Enzyme and pathway databases

BioCyciVVUL196600:GJ9W-4999-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PRINTSiPR00081. GDHRDH.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YJ016Imported.
  2. "Structural and biochemical characterization of an atypical short-chain dehydrogenase/reductase reveals an unusual cofactor preference."
    Buysschaert G., Verstraete K., Savvides S.N., Vergauwen B.
    FEBS J. 280:1358-1370(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) IN COMPLEX WITH NADP.

Entry informationi

Entry nameiQ7MBY8_VIBVY
AccessioniPrimary (citable) accession number: Q7MBY8
Entry historyi
Integrated into UniProtKB/TrEMBL: December 15, 2003
Last sequence update: December 15, 2003
Last modified: April 29, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.