Q7MBG9 (STHA_PHOLL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Soluble pyridine nucleotide transhydrogenase
Short name=STH
EC=1.6.1.1

Alternative name(s):
NAD(P)(+) transhydrogenase [B-specific]

Gene names

Name:	sthA
Synonyms:	udhA
Ordered Locus Names:	plu4739

Organism

Photorhabdus luminescens subsp. laumondii (strain TT01) [Complete proteome] [HAMAP]

Taxonomic identifier

243265 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Photorhabdus

Protein attributes

Sequence length	465 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation By similarity. HAMAP MF_00247
Catalytic activity	NADPH + NAD+ = NADP+ + NADH. HAMAP MF_00247
Cofactor	Binds 1 FAD per subunit By similarity. HAMAP MF_00247
Subcellular location	Cytoplasm By similarity HAMAP MF_00247.
Sequence similarities	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	FAD Flavoprotein NAD NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NAD(P)+ transhydrogenase (B-specific) activity Inferred from electronic annotation. Source: EC flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 465	465	Soluble pyridine nucleotide transhydrogenase HAMAP MF_00247		PRO_0000068067
Regions
	Nucleotide binding	35 – 44	10	FAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7MBG9 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: 782044DE12946CCE	FASTA	465	51,482
	10 20 30 40 50 60 MQHIHFDAIV IGSGPGGEGA AMGLVKQGKS VAVIERYNNV GGGCTHWGTI PSKALRHAVS 70 80 90 100 110 120 RIIEFNQNPL YSDNSRVLRS SFAEILRRAE MVINQQTRMR QGFYERNGCR MFSGEATFID 130 140 150 160 170 180 DHRVSVRYAD DNHDILSADK IIIATGSRPY CPPDVDFTHS RIYNSDSILK LDHEPRHVII 190 200 210 220 230 240 YGAGVIGCEY ASIFRGLGVK VDLINTRNHL LAFLDQEMSD ALSYHFWNSG IVIRHNEEYS 250 260 270 280 290 300 KIEGVDDGVI VHLKSGKKVK ADCLLYANGR TGNTDTLGLK NVGLEADSRG LLKVNKIYQT 310 320 330 340 350 360 SNENIYAVGD VIGYPSLASA AYDQGRIAAQ AMTKGNAEVH LIEDIPTGIY TIPEISSVGK 370 380 390 400 410 420 TEQQLTAMKV PYEVGRAQFK HLARAQIAGM NVGSLKILFH RETKEILGIH CFGERAAEII 430 440 450 460 HIGQAIMEQK GESNTIEYFV NTTFNYPTMA EAYRVAALNG LNRLF

References

[1]

"The genome sequence of the entomopathogenic bacterium Photorhabdus luminescens." Duchaud E., Rusniok C., Frangeul L., Buchrieser C., Givaudan A., Taourit S., Bocs S., Boursaux-Eude C., Chandler M., Charles J.-F., Dassa E., Derose R., Derzelle S., Freyssinet G., Gaudriault S., Medigue C., Lanois A., Powell K. , Siguier P., Vincent R., Wingate V., Zouine M., Glaser P., Boemare N., Danchin A., Kunst F. Nat. Biotechnol. 21:1307-1313(2003) [PubMed: 14528314] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TT01.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX571874 Genomic DNA. Translation: CAE17111.1.
RefSeq	NP_931901.1. NC_005126.1.
3D structure databases
ProteinModelPortal	Q7MBG9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2804786.
GenomeReviews	Gene locus plu4739 in contig BX470251_GR.
KEGG	plu:plu4739.
NMPDR	fig|243265.1.peg.4524.
PATRIC	20514292. VBIPhoLum48522_5358.
Organism-specific databases
GenoList	plu4739.
CMR	Search...
Phylogenomic databases
HOGENOM	HBG515043.
OMA	GEGNTIE.
PhylomeDB	Q7MBG9.
ProtClustDB	PRK05249.
Enzyme and pathway databases
BioCyc	PLUM243265:PLU4739-MONOMER.
Family and domain databases
HAMAP	MF_00247. SthA. [Tree]
InterPro	IPR016156. FAD/NAD-linked_Rdtase_dimer. IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR004099. Pyr_nucl-diS_OxRdtase_dimer. IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD. IPR001327. Pyr_OxRdtase_NAD-bd_dom. IPR022962. STH. [Graphical view]
Gene3D	G3DSA:3.30.390.30. Pyr_redox_dim. 1 hit.
KO	K00322.
Pfam	PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. PF02852. Pyr_redox_dim. 1 hit. [Graphical view]
PRINTS	PR00368. FADPNR.
SUPFAM	SSF55424. FAD/NAD-linked_reductase_dimer. 1 hit.
ProtoNet	Search...

Entry information

Entry name

STHA_PHOLL

Accession

Primary (citable) accession number: Q7MBG9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 24, 2004
Last sequence update:	December 15, 2003
Last modified:	January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program