Reviewed, UniProtKB/Swiss-Prot Q7MBG9 (STHA_PHOLL)

Names and origin

Protein names

Recommended name:
    Soluble pyridine nucleotide transhydrogenase
      Short name=STH
    EC=1.6.1.1
Alternative name(s):
    NAD(P)(+) transhydrogenase [B-specific]

Gene names

Name:	sthA
Synonyms:	udhA
Ordered Locus Names:	plu4739

Organism

Photorhabdus luminescens subsp. laumondii [Complete proteome] [HAMAP]

Taxonomic identifier

141679 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Photorhabdus

Protein attributes

Sequence length	465 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation By similarity.
Catalytic activity	NADPH + NAD(+) = NADP(+) + NADH.
Cofactor	Binds 1 FAD per subunit By similarity.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	FAD Flavoprotein NAD NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	NADP metabolic process Inferred from electronic annotation. Source: HAMAP cell redox homeostasis Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro NAD(P)+ transhydrogenase (B-specific) activity Inferred from electronic annotation. Source: HAMAP electron carrier activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 465	465	Soluble pyridine nucleotide transhydrogenase		PRO_0000068067
Regions
	Nucleotide binding	35 – 44	10	FAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7MBG9-1 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: 782044DE12946CCE	FASTA	465	51,482
	10 20 30 40 50 60 MQHIHFDAIV IGSGPGGEGA AMGLVKQGKS VAVIERYNNV GGGCTHWGTI PSKALRHAVS 70 80 90 100 110 120 RIIEFNQNPL YSDNSRVLRS SFAEILRRAE MVINQQTRMR QGFYERNGCR MFSGEATFID 130 140 150 160 170 180 DHRVSVRYAD DNHDILSADK IIIATGSRPY CPPDVDFTHS RIYNSDSILK LDHEPRHVII 190 200 210 220 230 240 YGAGVIGCEY ASIFRGLGVK VDLINTRNHL LAFLDQEMSD ALSYHFWNSG IVIRHNEEYS 250 260 270 280 290 300 KIEGVDDGVI VHLKSGKKVK ADCLLYANGR TGNTDTLGLK NVGLEADSRG LLKVNKIYQT 310 320 330 340 350 360 SNENIYAVGD VIGYPSLASA AYDQGRIAAQ AMTKGNAEVH LIEDIPTGIY TIPEISSVGK 370 380 390 400 410 420 TEQQLTAMKV PYEVGRAQFK HLARAQIAGM NVGSLKILFH RETKEILGIH CFGERAAEII 430 440 450 460 HIGQAIMEQK GESNTIEYFV NTTFNYPTMA EAYRVAALNG LNRLF

References

[1]

"The genome sequence of the entomopathogenic bacterium Photorhabdus luminescens." Duchaud E., Rusniok C., Frangeul L., Buchrieser C., Givaudan A., Taourit S., Bocs S., Boursaux-Eude C., Chandler M., Charles J.-F., Dassa E., Derose R., Derzelle S., Freyssinet G., Gaudriault S., Medigue C., Lanois A., Powell K. , Siguier P., Vincent R., Wingate V., Zouine M., Glaser P., Boemare N., Danchin A., Kunst F. Nat. Biotechnol. 21:1307-1313(2003) [PubMed: 14528314] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TT01.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX571874 Genomic DNA. Translation: CAE17111.1.
RefSeq	NP_931901.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2804786.
GenomeReviews	Gene locus plu4739 in contig BX470251_GR.
KEGG	plu:plu4739.
NMPDR	fig|243265.1.peg.4524.
Organism-specific databases
PhotoList	plu4739.
CMR	Search...
Phylogenomic databases
HOGENOM	Q7MBG9.
Enzyme and pathway databases
BioCyc	PLUM243265:PLU4739-MON.
Family and domain databases
HAMAP	MF_00247. [Tree]
InterPro	IPR000759. Adrndx_reductase. IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR000815. Hg_reductase. IPR001100. Pyr_nuc-diS_OxRdtase. IPR004099. Pyr_nucl-diS_OxRdtase_dimer. IPR001327. Pyr_OxRdtase_NAD_bd. [Graphical view]
Gene3D	G3DSA:3.30.390.30. Pyr_redox_dim. 1 hit.
Pfam	PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. PF02852. Pyr_redox_dim. 1 hit. [Graphical view]
PRINTS	PR00419. ADXRDTASE. PR00368. FADPNR. PR00945. HGRDTASE. PR00411. PNDRDTASEI.
ProDom	PD000139. FAD_pyr_redox. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

STHA_PHOLL

Accession

Primary (citable) accession number: Q7MBG9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 24, 2004
Last sequence update:	December 15, 2003
Last modified:	November 25, 2008
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)