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Q7MAE0 (SYW_WOLSU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan--tRNA ligase

EC=6.1.1.2
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name=TrpRS
Gene names
Name:trpS
Ordered Locus Names:WS0311
OrganismWolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes) [Complete proteome] [HAMAP]
Taxonomic identifier273121 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeWolinella

Protein attributes

Sequence length328 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp). HAMAP-Rule MF_00140

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00140

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00140.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtryptophanyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tryptophan-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 328328Tryptophan--tRNA ligase HAMAP-Rule MF_00140
PRO_0000136711

Regions

Motif12 – 209"HIGH" region HAMAP-Rule MF_00140
Motif195 – 1995"KMSKS" region HAMAP-Rule MF_00140

Sites

Binding site1981ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7MAE0 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 9E27F479E4983586

FASTA32837,038
        10         20         30         40         50         60 
MIKKRVFSGI QPTGNIHLGN YLGAVKNWVD SQDEFDNIFC IVNSHAITIK QDPALLRAKT 

        70         80         90        100        110        120 
YELAAVLLAC GIDMKKSKLF IQSEVDEHAA LAWILDCNIP MGDMSRMTQF KDKSQKNPKN 

       130        140        150        160        170        180 
INIGLFNYPA LMAADILLYQ TDFVPVGEDQ KQHLELTRDV AERFNRDYGE TFKIPEPMIP 

       190        200        210        220        230        240 
KMGARIMGLD DPTKKMSKSE GKPNHGIALL DTPDEILKKF KKATTDSENL VRFNPEQIGI 

       250        260        270        280        290        300 
FNLLTIYQIF TGYSQEVIEA EFEGKGYGIF KVAVAEAVIE GLKPIQERYA KLTKEQGYLE 

       310        320 
EVLSHGASEV RKIAQKTYKE VKERVGLI 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX571657 Genomic DNA. Translation: CAE09462.1.
RefSeqNP_906562.1. NC_005090.1.

3D structure databases

ProteinModelPortalQ7MAE0.
SMRQ7MAE0. Positions 4-328.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273121.WS0311.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE09462; CAE09462; WS0311.
GeneID2554724.
KEGGwsu:WS0311.
PATRIC24037714. VBIWolSuc63014_0298.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0180.
HOGENOMHOG000059940.
KOK01867.
OMAIDPKKHI.
OrthoDBEOG686NJQ.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00140_B. Trp_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERPTHR10055. PTHR10055. 1 hit.
PfamPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSPR01039. TRNASYNTHTRP.
TIGRFAMsTIGR00233. trpS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYW_WOLSU
AccessionPrimary (citable) accession number: Q7MAE0
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: December 15, 2003
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries