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Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotation

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi284Magnesium or manganese 1UniRule annotation1
Metal bindingi296Magnesium or manganese 1UniRule annotation1
Metal bindingi296Magnesium or manganese 2UniRule annotation1
Metal bindingi298Magnesium or manganese 2UniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi162 – 211ATPUniRule annotationAdd BLAST50

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciWSUC273121:G1GTD-430-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlUniRule annotation
Synonyms:ddlA
Ordered Locus Names:WS0438
OrganismiWolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes)
Taxonomic identifieri273121 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeWolinella
Proteomesi
  • UP000000422 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001779061 – 345D-alanine--D-alanine ligaseAdd BLAST345

Interactioni

Protein-protein interaction databases

STRINGi273121.WS0438

Structurei

3D structure databases

ProteinModelPortaliQ7MA71
SMRiQ7MA71
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini133 – 340ATP-graspUniRule annotationAdd BLAST208

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CPF Bacteria
COG1181 LUCA
HOGENOMiHOG000102494
KOiK01921
OMAiRCDFFVI
OrthoDBiPOG091H06GK

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
HAMAPiMF_00047 Dala_Dala_lig, 1 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR000291 D-Ala_lig_Van_CS
IPR005905 D_ala_D_ala
IPR011095 Dala_Dala_lig_C
IPR011127 Dala_Dala_lig_N
IPR016185 PreATP-grasp_dom_sf
PfamiView protein in Pfam
PF07478 Dala_Dala_lig_C, 1 hit
PF01820 Dala_Dala_lig_N, 1 hit
SUPFAMiSSF52440 SSF52440, 1 hit
TIGRFAMsiTIGR01205 D_ala_D_alaTIGR, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS00843 DALA_DALA_LIGASE_1, 1 hit
PS00844 DALA_DALA_LIGASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q7MA71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLAVIFGGA SYEHEISIVS AISLKKILPA LEHFIFVDGN RDFYWIPASE
60 70 80 90 100
MRSKHFADGI YKKNPKLFLR PGGFYAKGLW GEKRVPFDTA LNLIHGGDGE
110 120 130 140 150
DGKLASLLEF FRIPFIGPRI EASVMSFNKH LTKLYAKERG VKTLPYLLAR
160 170 180 190 200
KNEKREFGNE FPLIVKPLRL GSSIGVSIAK NRQELDYALD VAFEFDEAAL
210 220 230 240 250
LEPFMQGIKE YNLAGCKING EYHFSIIEEP QKKEFLDFDK KYLDFSRTQK
260 270 280 290 300
LLKADLSEAS ERLLKEAFIK LYDDSFEGSL IRCDFFVQNQ EVFLNEINPI
310 320 330 340
PGSLANYLFE DFPKILQSLA HNLPKERGIK IDYRYIHQIQ KAKGK
Length:345
Mass (Da):39,594
Last modified:December 15, 2003 - v1
Checksum:i88EA8FE3978E9DA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571658 Genomic DNA Translation: CAE09580.1
RefSeqiWP_011138380.1, NC_005090.1

Genome annotation databases

EnsemblBacteriaiCAE09580; CAE09580; WS0438
KEGGiwsu:WS0438

Similar proteinsi

Entry informationi

Entry nameiDDL_WOLSU
AccessioniPrimary (citable) accession number: Q7MA71
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: December 15, 2003
Last modified: March 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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