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Q7MA71 (DDL_WOLSU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Synonyms:ddlA
Ordered Locus Names:WS0438
OrganismWolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes) [Complete proteome] [HAMAP]
Taxonomic identifier273121 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeWolinella

Protein attributes

Sequence length345 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 345345D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_0000177906

Regions

Domain133 – 340208ATP-grasp
Nucleotide binding162 – 21150ATP By similarity

Sites

Metal binding2841Magnesium or manganese 1 By similarity
Metal binding2961Magnesium or manganese 1 By similarity
Metal binding2961Magnesium or manganese 2 By similarity
Metal binding2981Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7MA71 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 88EA8FE3978E9DA7

FASTA34539,594
        10         20         30         40         50         60 
MNLAVIFGGA SYEHEISIVS AISLKKILPA LEHFIFVDGN RDFYWIPASE MRSKHFADGI 

        70         80         90        100        110        120 
YKKNPKLFLR PGGFYAKGLW GEKRVPFDTA LNLIHGGDGE DGKLASLLEF FRIPFIGPRI 

       130        140        150        160        170        180 
EASVMSFNKH LTKLYAKERG VKTLPYLLAR KNEKREFGNE FPLIVKPLRL GSSIGVSIAK 

       190        200        210        220        230        240 
NRQELDYALD VAFEFDEAAL LEPFMQGIKE YNLAGCKING EYHFSIIEEP QKKEFLDFDK 

       250        260        270        280        290        300 
KYLDFSRTQK LLKADLSEAS ERLLKEAFIK LYDDSFEGSL IRCDFFVQNQ EVFLNEINPI 

       310        320        330        340 
PGSLANYLFE DFPKILQSLA HNLPKERGIK IDYRYIHQIQ KAKGK 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX571658 Genomic DNA. Translation: CAE09580.1.
RefSeqNP_906680.1. NC_005090.1.

3D structure databases

ProteinModelPortalQ7MA71.
SMRQ7MA71. Positions 1-324.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273121.WS0438.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE09580; CAE09580; WS0438.
GeneID2554297.
KEGGwsu:WS0438.
PATRIC24037964. VBIWolSuc63014_0418.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000102494.
KOK01921.
OMAHNGLLKN.
OrthoDBEOG6ND0KB.

Enzyme and pathway databases

UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_WOLSU
AccessionPrimary (citable) accession number: Q7MA71
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: December 15, 2003
Last modified: May 14, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways