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Q7M9I4

- PNP_WOLSU

UniProt

Q7M9I4 - PNP_WOLSU

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, WS0899
Organism
Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi518 – 5181Magnesium By similarity
Metal bindingi524 – 5241Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:WS0899
OrganismiWolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes)
Taxonomic identifieri273121 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeWolinella
ProteomesiUP000000422: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 736736Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_0000329937Add
BLAST

Proteomic databases

PRIDEiQ7M9I4.

Interactioni

Protein-protein interaction databases

STRINGi273121.WS0899.

Structurei

3D structure databases

ProteinModelPortaliQ7M9I4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini584 – 64461KH
Add
BLAST
Domaini665 – 73268S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiHGNFKSN.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7M9I4-1 [UniParc]FASTAAdd to Basket

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MNATIKEIAL PNKTETFEFG AIAKQANGSV LYRCGKSVLL ASVCYESDER    50
VKEDFLPLTV QYIEKSYAAG KFPGGFIKRE SKPGDFETLT SRIIDRSLRP 100
LFPKGYAHPT QITVMVLSAQ NDADLQTMAL NAASAALFVS DIPLRKPVHG 150
LRIGKINGAL VVNPTTKEMS ESTLDLFVSG VEEDLLMIEM RTLASDEINN 200
TCFVGDCGMV AASASDILKI HQANEMKEEE LLEALELAKT SIKKASACYV 250
EAFTPLAKPD AILELKPDIT SSEIYQYIKE NHAIAIKEAI TRMAKSERHS 300
DLKRIAKEIA SSERAQESEW SFEAVYETVG KYKREAVRAL ILEERRRADG 350
RGLKEVRPID IQTNILPNAH ASALFTRGET QALVVATLGG DMDAQSYELL 400
TEKGSSKERF MVHYNFPSFS VGEAGMVGAP GRRELGHGNL AKRALEPTIE 450
EWGAQTIRLV SEILESNGSS SMATVCGGSL ALKAAGINTT ALVAGVAMGL 500
IVEAEKHAIL TDIMGLEDHD GDMDFKIAGT STGITAMQMD IKLGGLSMEI 550
LKEALYQAKE GREHILGIME KAQSEIIIND EILPSLQIFS INPGRIVDII 600
GQAGKTIKEI IERFEVAIDL NRDNGEVKVT GSNKQKVEAA KEHILSISNQ 650
EAPQRVRVAD VYSAGEVFKG KVKKIVDFGA FIELPKGGDG LLHVSKIVQH 700
RDQRIDEVIK EGEEIEVQIL SINKNKVELG RATRPN 736
Length:736
Mass (Da):80,526
Last modified:December 15, 2003 - v1
Checksum:i96BC12E4FA63C1A6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571659 Genomic DNA. Translation: CAE10004.1.
RefSeqiNP_907104.1. NC_005090.1.
WP_011138801.1. NC_005090.1.

Genome annotation databases

EnsemblBacteriaiCAE10004; CAE10004; WS0899.
GeneIDi2555106.
KEGGiwsu:WS0899.
PATRICi24038838. VBIWolSuc63014_0847.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571659 Genomic DNA. Translation: CAE10004.1 .
RefSeqi NP_907104.1. NC_005090.1.
WP_011138801.1. NC_005090.1.

3D structure databases

ProteinModelPortali Q7M9I4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273121.WS0899.

Proteomic databases

PRIDEi Q7M9I4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE10004 ; CAE10004 ; WS0899 .
GeneIDi 2555106.
KEGGi wsu:WS0899.
PATRICi 24038838. VBIWolSuc63014_0847.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi HGNFKSN.
OrthoDBi EOG6WT8CC.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W.

Entry informationi

Entry nameiPNP_WOLSU
AccessioniPrimary (citable) accession number: Q7M9I4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: December 15, 2003
Last modified: September 3, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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