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Q7M9A7

- MDH_WOLSU

UniProt

Q7M9A7 - MDH_WOLSU

Protein

Malate dehydrogenase

Gene

mdh

Organism
Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei30 – 301NADUniRule annotation
    Binding sitei79 – 791SubstrateUniRule annotation
    Binding sitei85 – 851SubstrateUniRule annotation
    Binding sitei92 – 921NADUniRule annotation
    Binding sitei117 – 1171SubstrateUniRule annotation
    Binding sitei148 – 1481SubstrateUniRule annotation
    Active sitei172 – 1721Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi5 – 106NADUniRule annotation
    Nucleotide bindingi115 – 1173NADUniRule annotation

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
    Gene namesi
    Name:mdhUniRule annotation
    Synonyms:citH
    Ordered Locus Names:WS1064
    OrganismiWolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes)
    Taxonomic identifieri273121 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeWolinella
    ProteomesiUP000000422: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 314314Malate dehydrogenasePRO_0000113477Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi273121.WS1064.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7M9A7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0039.
    HOGENOMiHOG000213794.
    KOiK00024.
    OMAiYGQNDIC.
    OrthoDBiEOG6091FG.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_00487. Malate_dehydrog_3.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSiPR00086. LLDHDRGNASE.
    SUPFAMiSSF56327. SSF56327. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7M9A7-1 [UniParc]FASTAAdd to Basket

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    MGIIGAGHVG STVAFILATQ GICQEIIIKD LNLDTARGIA LDMGHAASAT    50
    KTHTIVRVAN EPSDLRGCDV VVFCAGSPRQ PGMSRDDLLL ANAKVIRTVL 100
    SEVKPYIQES VLVMVSNPLD AMVYTAIKES GLSPLQVLGM AGILDSARMA 150
    SFIFEKLGYG SDQIVASVMG GHGDDMVPLP RYSNVAGVPI TELLEPQEIE 200
    EIIHRTRNAG AEIVGYLKKG SAYFAPAKST AIMVEAILKN SHQVFPCSVL 250
    LQGEYGYSDV VGGVPVKLGS RGVCEIIELE LLHEERERFD QSIQSVKSLI 300
    DALYHHAFFV SSRP 314
    Length:314
    Mass (Da):33,735
    Last modified:December 15, 2003 - v1
    Checksum:i4D60B182A3AFC3A0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571659 Genomic DNA. Translation: CAE10162.1.
    RefSeqiNP_907262.1. NC_005090.1.
    WP_011138955.1. NC_005090.1.

    Genome annotation databases

    EnsemblBacteriaiCAE10162; CAE10162; WS1064.
    GeneIDi2555454.
    KEGGiwsu:WS1064.
    PATRICi24039166. VBIWolSuc63014_1004.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571659 Genomic DNA. Translation: CAE10162.1 .
    RefSeqi NP_907262.1. NC_005090.1.
    WP_011138955.1. NC_005090.1.

    3D structure databases

    ProteinModelPortali Q7M9A7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273121.WS1064.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE10162 ; CAE10162 ; WS1064 .
    GeneIDi 2555454.
    KEGGi wsu:WS1064.
    PATRICi 24039166. VBIWolSuc63014_1004.

    Phylogenomic databases

    eggNOGi COG0039.
    HOGENOMi HOG000213794.
    KOi K00024.
    OMAi YGQNDIC.
    OrthoDBi EOG6091FG.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_00487. Malate_dehydrog_3.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSi PR00086. LLDHDRGNASE.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W.

    Entry informationi

    Entry nameiMDH_WOLSU
    AccessioniPrimary (citable) accession number: Q7M9A7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3