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Q7M9A7

- MDH_WOLSU

UniProt

Q7M9A7 - MDH_WOLSU

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Protein

Malate dehydrogenase

Gene
mdh, citH, WS1064
Organism
Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei30 – 301NAD By similarity
Binding sitei79 – 791Substrate By similarity
Binding sitei85 – 851Substrate By similarity
Binding sitei92 – 921NAD By similarity
Binding sitei117 – 1171Substrate By similarity
Binding sitei148 – 1481Substrate By similarity
Active sitei172 – 1721Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi5 – 106NAD By similarity
Nucleotide bindingi115 – 1173NAD By similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
Synonyms:citH
Ordered Locus Names:WS1064
OrganismiWolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes)
Taxonomic identifieri273121 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeWolinella
ProteomesiUP000000422: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Malate dehydrogenaseUniRule annotationPRO_0000113477Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273121.WS1064.

Structurei

3D structure databases

ProteinModelPortaliQ7M9A7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213794.
KOiK00024.
OMAiYGQNDIC.
OrthoDBiEOG6091FG.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7M9A7-1 [UniParc]FASTAAdd to Basket

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MGIIGAGHVG STVAFILATQ GICQEIIIKD LNLDTARGIA LDMGHAASAT    50
KTHTIVRVAN EPSDLRGCDV VVFCAGSPRQ PGMSRDDLLL ANAKVIRTVL 100
SEVKPYIQES VLVMVSNPLD AMVYTAIKES GLSPLQVLGM AGILDSARMA 150
SFIFEKLGYG SDQIVASVMG GHGDDMVPLP RYSNVAGVPI TELLEPQEIE 200
EIIHRTRNAG AEIVGYLKKG SAYFAPAKST AIMVEAILKN SHQVFPCSVL 250
LQGEYGYSDV VGGVPVKLGS RGVCEIIELE LLHEERERFD QSIQSVKSLI 300
DALYHHAFFV SSRP 314
Length:314
Mass (Da):33,735
Last modified:December 15, 2003 - v1
Checksum:i4D60B182A3AFC3A0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571659 Genomic DNA. Translation: CAE10162.1.
RefSeqiNP_907262.1. NC_005090.1.
WP_011138955.1. NC_005090.1.

Genome annotation databases

EnsemblBacteriaiCAE10162; CAE10162; WS1064.
GeneIDi2555454.
KEGGiwsu:WS1064.
PATRICi24039166. VBIWolSuc63014_1004.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571659 Genomic DNA. Translation: CAE10162.1 .
RefSeqi NP_907262.1. NC_005090.1.
WP_011138955.1. NC_005090.1.

3D structure databases

ProteinModelPortali Q7M9A7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273121.WS1064.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE10162 ; CAE10162 ; WS1064 .
GeneIDi 2555454.
KEGGi wsu:WS1064.
PATRICi 24039166. VBIWolSuc63014_1004.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000213794.
KOi K00024.
OMAi YGQNDIC.
OrthoDBi EOG6091FG.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W.

Entry informationi

Entry nameiMDH_WOLSU
AccessioniPrimary (citable) accession number: Q7M9A7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: December 15, 2003
Last modified: September 3, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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