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Q7M9A7

- MDH_WOLSU

UniProt

Q7M9A7 - MDH_WOLSU

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Protein

Malate dehydrogenase

Gene

mdh

Organism
Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei30 – 301NADUniRule annotation
Binding sitei79 – 791SubstrateUniRule annotation
Binding sitei85 – 851SubstrateUniRule annotation
Binding sitei92 – 921NADUniRule annotation
Binding sitei117 – 1171SubstrateUniRule annotation
Binding sitei148 – 1481SubstrateUniRule annotation
Active sitei172 – 1721Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi5 – 106NADUniRule annotation
Nucleotide bindingi115 – 1173NADUniRule annotation

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Synonyms:citH
Ordered Locus Names:WS1064
OrganismiWolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes)
Taxonomic identifieri273121 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeWolinella
ProteomesiUP000000422: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Malate dehydrogenasePRO_0000113477Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273121.WS1064.

Structurei

3D structure databases

ProteinModelPortaliQ7M9A7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213794.
KOiK00024.
OMAiYGQNDIC.
OrthoDBiEOG6091FG.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7M9A7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGIIGAGHVG STVAFILATQ GICQEIIIKD LNLDTARGIA LDMGHAASAT
60 70 80 90 100
KTHTIVRVAN EPSDLRGCDV VVFCAGSPRQ PGMSRDDLLL ANAKVIRTVL
110 120 130 140 150
SEVKPYIQES VLVMVSNPLD AMVYTAIKES GLSPLQVLGM AGILDSARMA
160 170 180 190 200
SFIFEKLGYG SDQIVASVMG GHGDDMVPLP RYSNVAGVPI TELLEPQEIE
210 220 230 240 250
EIIHRTRNAG AEIVGYLKKG SAYFAPAKST AIMVEAILKN SHQVFPCSVL
260 270 280 290 300
LQGEYGYSDV VGGVPVKLGS RGVCEIIELE LLHEERERFD QSIQSVKSLI
310
DALYHHAFFV SSRP
Length:314
Mass (Da):33,735
Last modified:December 15, 2003 - v1
Checksum:i4D60B182A3AFC3A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571659 Genomic DNA. Translation: CAE10162.1.
RefSeqiNP_907262.1. NC_005090.1.
WP_011138955.1. NC_005090.1.

Genome annotation databases

EnsemblBacteriaiCAE10162; CAE10162; WS1064.
GeneIDi2555454.
KEGGiwsu:WS1064.
PATRICi24039166. VBIWolSuc63014_1004.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571659 Genomic DNA. Translation: CAE10162.1 .
RefSeqi NP_907262.1. NC_005090.1.
WP_011138955.1. NC_005090.1.

3D structure databases

ProteinModelPortali Q7M9A7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273121.WS1064.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE10162 ; CAE10162 ; WS1064 .
GeneIDi 2555454.
KEGGi wsu:WS1064.
PATRICi 24039166. VBIWolSuc63014_1004.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000213794.
KOi K00024.
OMAi YGQNDIC.
OrthoDBi EOG6091FG.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W.

Entry informationi

Entry nameiMDH_WOLSU
AccessioniPrimary (citable) accession number: Q7M9A7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: December 15, 2003
Last modified: October 1, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3