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Q7M9A7 (MDH_WOLSU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Malate dehydrogenase

EC=1.1.1.37
Gene names
Name:mdh
Synonyms:citH
Ordered Locus Names:WS1064
OrganismWolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes) [Complete proteome] [HAMAP]
Taxonomic identifier273121 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeWolinella

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity. HAMAP-Rule MF_00487

Catalytic activity

(S)-malate + NAD+ = oxaloacetate + NADH. HAMAP-Rule MF_00487

Sequence similarities

Belongs to the LDH/MDH superfamily. MDH type 3 family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcellular carbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

malate metabolic process

Inferred from electronic annotation. Source: InterPro

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionL-malate dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 314314Malate dehydrogenase HAMAP-Rule MF_00487
PRO_0000113477

Regions

Nucleotide binding5 – 106NAD By similarity
Nucleotide binding115 – 1173NAD By similarity

Sites

Active site1721Proton acceptor By similarity
Binding site301NAD By similarity
Binding site791Substrate By similarity
Binding site851Substrate By similarity
Binding site921NAD By similarity
Binding site1171Substrate By similarity
Binding site1481Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7M9A7 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 4D60B182A3AFC3A0

FASTA31433,735
        10         20         30         40         50         60 
MGIIGAGHVG STVAFILATQ GICQEIIIKD LNLDTARGIA LDMGHAASAT KTHTIVRVAN 

        70         80         90        100        110        120 
EPSDLRGCDV VVFCAGSPRQ PGMSRDDLLL ANAKVIRTVL SEVKPYIQES VLVMVSNPLD 

       130        140        150        160        170        180 
AMVYTAIKES GLSPLQVLGM AGILDSARMA SFIFEKLGYG SDQIVASVMG GHGDDMVPLP 

       190        200        210        220        230        240 
RYSNVAGVPI TELLEPQEIE EIIHRTRNAG AEIVGYLKKG SAYFAPAKST AIMVEAILKN 

       250        260        270        280        290        300 
SHQVFPCSVL LQGEYGYSDV VGGVPVKLGS RGVCEIIELE LLHEERERFD QSIQSVKSLI 

       310 
DALYHHAFFV SSRP 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX571659 Genomic DNA. Translation: CAE10162.1.
RefSeqNP_907262.1. NC_005090.1.

3D structure databases

ProteinModelPortalQ7M9A7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273121.WS1064.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE10162; CAE10162; WS1064.
GeneID2555454.
KEGGwsu:WS1064.
PATRIC24039166. VBIWolSuc63014_1004.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0039.
HOGENOMHOG000213794.
KOK00024.
OMAYGQNDIC.
OrthoDBEOG6091FG.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPMF_00487. Malate_dehydrog_3.
InterProIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11540. PTHR11540. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSPR00086. LLDHDRGNASE.
SUPFAMSSF56327. SSF56327. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMDH_WOLSU
AccessionPrimary (citable) accession number: Q7M9A7
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: December 15, 2003
Last modified: May 14, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families