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Q7M926

- SYL_WOLSU

UniProt

Q7M926 - SYL_WOLSU

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei588 – 5881ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:WS1245
OrganismiWolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes)
Taxonomic identifieri273121 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeWolinella
ProteomesiUP000000422: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 819819Leucine--tRNA ligasePRO_0000152119Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273121.WS1245.

Structurei

3D structure databases

ProteinModelPortaliQ7M926.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5011"HIGH" regionAdd
BLAST
Motifi585 – 5895"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiPVIHCPK.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7M926-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEYNPKAIEK KWQEHWKNKR THEPLSDTSL PKKYILSMFP YPSGRIHMGH
60 70 80 90 100
VRNYCIGDAI ARHFRKQNFN VLHPIGWDAF GMPAENAAIK HKSHPKKWTY
110 120 130 140 150
DNISNMREEL DSLGLSFSNE REFATCDPIY SKWEQKFFID MWNRGLIYRK
160 170 180 190 200
KGFLNWCPND QTVLANEQVI EGRCWRCDTE VVQKEMFQYY VKITDYAEEL
210 220 230 240 250
LGSLDTLEGR WPSQVLTMQR NWIGRSEGLS FAFKLTSSSK ERIGGSFDSF
260 270 280 290 300
EVFTTRPDTL YGVTYCALAP EHPLVRELMR QGKLPQESLE ALAKMQNIPA
310 320 330 340 350
KERAMIPKEG VALGLEAIHP LTGEAIPLWA ANFVLTDYGS GAVMAVPAHD
360 370 380 390 400
ERDFEFAKKY QLPQKQVILS GAAPSLDEAA YTESGTLINS GIFDGLESES
410 420 430 440 450
AKEKIIRYFE EHSLGRGVIN YRLRDWGISR QRYWGTPIPL IHCPSCGIVP
460 470 480 490 500
EDFSNLPITL PEDVIIDGEG NPLEKHPAWK ECRCPKCGGK ATRETDTMDT
510 520 530 540 550
FVESSWYFLR YTTPKEEWET HALNEAMQRY WMGVDEYIGG IEHAILHLLY
560 570 580 590 600
ARFFTKVLRD LGYTETNEPF THLLTQGMVL KDGAKMSKSK GNVVDPDELI
610 620 630 640 650
ERFGADTARL FVLFAAPPTR ELEWNDSAVE GAYRFIKRLC DKTQFVQKVS
660 670 680 690 700
SLPQIETATL SKTEKLARKK VHETLLKAQE VYSRKNAYAF NTLIASCMEA
710 720 730 740 750
LNALSDQENP AIFTEGYFIL LSVLEPIIPH VAWELSQEYF GLANFKPLTP
760 770 780 790 800
DTQALKSDSL TIAITVNGKK RGEIEMAPGS SNEAMLEAAK NEVSKWLEGM
810
SIIKEIVVPD KLVNLVVKP
Length:819
Mass (Da):93,291
Last modified:December 15, 2003 - v1
Checksum:i8B1FF4634CB6F840
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571660 Genomic DNA. Translation: CAE10325.1.
RefSeqiNP_907425.1. NC_005090.1.
WP_011139112.1. NC_005090.1.

Genome annotation databases

EnsemblBacteriaiCAE10325; CAE10325; WS1245.
GeneIDi2554496.
KEGGiwsu:WS1245.
PATRICi24039508. VBIWolSuc63014_1172.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571660 Genomic DNA. Translation: CAE10325.1 .
RefSeqi NP_907425.1. NC_005090.1.
WP_011139112.1. NC_005090.1.

3D structure databases

ProteinModelPortali Q7M926.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273121.WS1245.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE10325 ; CAE10325 ; WS1245 .
GeneIDi 2554496.
KEGGi wsu:WS1245.
PATRICi 24039508. VBIWolSuc63014_1172.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi PVIHCPK.
OrthoDBi EOG63Z74X.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W.

Entry informationi

Entry nameiSYL_WOLSU
AccessioniPrimary (citable) accession number: Q7M926
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: December 15, 2003
Last modified: October 29, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3