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Q7M926

- SYL_WOLSU

UniProt

Q7M926 - SYL_WOLSU

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei588 – 5881ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:WS1245
    OrganismiWolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes)
    Taxonomic identifieri273121 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeWolinella
    ProteomesiUP000000422: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 819819Leucine--tRNA ligasePRO_0000152119Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi273121.WS1245.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7M926.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5011"HIGH" regionAdd
    BLAST
    Motifi585 – 5895"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiPVIHCPK.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7M926-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEYNPKAIEK KWQEHWKNKR THEPLSDTSL PKKYILSMFP YPSGRIHMGH    50
    VRNYCIGDAI ARHFRKQNFN VLHPIGWDAF GMPAENAAIK HKSHPKKWTY 100
    DNISNMREEL DSLGLSFSNE REFATCDPIY SKWEQKFFID MWNRGLIYRK 150
    KGFLNWCPND QTVLANEQVI EGRCWRCDTE VVQKEMFQYY VKITDYAEEL 200
    LGSLDTLEGR WPSQVLTMQR NWIGRSEGLS FAFKLTSSSK ERIGGSFDSF 250
    EVFTTRPDTL YGVTYCALAP EHPLVRELMR QGKLPQESLE ALAKMQNIPA 300
    KERAMIPKEG VALGLEAIHP LTGEAIPLWA ANFVLTDYGS GAVMAVPAHD 350
    ERDFEFAKKY QLPQKQVILS GAAPSLDEAA YTESGTLINS GIFDGLESES 400
    AKEKIIRYFE EHSLGRGVIN YRLRDWGISR QRYWGTPIPL IHCPSCGIVP 450
    EDFSNLPITL PEDVIIDGEG NPLEKHPAWK ECRCPKCGGK ATRETDTMDT 500
    FVESSWYFLR YTTPKEEWET HALNEAMQRY WMGVDEYIGG IEHAILHLLY 550
    ARFFTKVLRD LGYTETNEPF THLLTQGMVL KDGAKMSKSK GNVVDPDELI 600
    ERFGADTARL FVLFAAPPTR ELEWNDSAVE GAYRFIKRLC DKTQFVQKVS 650
    SLPQIETATL SKTEKLARKK VHETLLKAQE VYSRKNAYAF NTLIASCMEA 700
    LNALSDQENP AIFTEGYFIL LSVLEPIIPH VAWELSQEYF GLANFKPLTP 750
    DTQALKSDSL TIAITVNGKK RGEIEMAPGS SNEAMLEAAK NEVSKWLEGM 800
    SIIKEIVVPD KLVNLVVKP 819
    Length:819
    Mass (Da):93,291
    Last modified:December 15, 2003 - v1
    Checksum:i8B1FF4634CB6F840
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571660 Genomic DNA. Translation: CAE10325.1.
    RefSeqiNP_907425.1. NC_005090.1.
    WP_011139112.1. NC_005090.1.

    Genome annotation databases

    EnsemblBacteriaiCAE10325; CAE10325; WS1245.
    GeneIDi2554496.
    KEGGiwsu:WS1245.
    PATRICi24039508. VBIWolSuc63014_1172.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571660 Genomic DNA. Translation: CAE10325.1 .
    RefSeqi NP_907425.1. NC_005090.1.
    WP_011139112.1. NC_005090.1.

    3D structure databases

    ProteinModelPortali Q7M926.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273121.WS1245.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE10325 ; CAE10325 ; WS1245 .
    GeneIDi 2554496.
    KEGGi wsu:WS1245.
    PATRICi 24039508. VBIWolSuc63014_1172.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi PVIHCPK.
    OrthoDBi EOG63Z74X.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W.

    Entry informationi

    Entry nameiSYL_WOLSU
    AccessioniPrimary (citable) accession number: Q7M926
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3