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Q7M926 (SYL_WOLSU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:WS1245
OrganismWolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes) [Complete proteome] [HAMAP]
Taxonomic identifier273121 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeWolinella

Protein attributes

Sequence length819 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 819819Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000152119

Regions

Motif40 – 5011"HIGH" region HAMAP-Rule MF_00049
Motif585 – 5895"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site5881ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7M926 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 8B1FF4634CB6F840

FASTA81993,291
        10         20         30         40         50         60 
MEYNPKAIEK KWQEHWKNKR THEPLSDTSL PKKYILSMFP YPSGRIHMGH VRNYCIGDAI 

        70         80         90        100        110        120 
ARHFRKQNFN VLHPIGWDAF GMPAENAAIK HKSHPKKWTY DNISNMREEL DSLGLSFSNE 

       130        140        150        160        170        180 
REFATCDPIY SKWEQKFFID MWNRGLIYRK KGFLNWCPND QTVLANEQVI EGRCWRCDTE 

       190        200        210        220        230        240 
VVQKEMFQYY VKITDYAEEL LGSLDTLEGR WPSQVLTMQR NWIGRSEGLS FAFKLTSSSK 

       250        260        270        280        290        300 
ERIGGSFDSF EVFTTRPDTL YGVTYCALAP EHPLVRELMR QGKLPQESLE ALAKMQNIPA 

       310        320        330        340        350        360 
KERAMIPKEG VALGLEAIHP LTGEAIPLWA ANFVLTDYGS GAVMAVPAHD ERDFEFAKKY 

       370        380        390        400        410        420 
QLPQKQVILS GAAPSLDEAA YTESGTLINS GIFDGLESES AKEKIIRYFE EHSLGRGVIN 

       430        440        450        460        470        480 
YRLRDWGISR QRYWGTPIPL IHCPSCGIVP EDFSNLPITL PEDVIIDGEG NPLEKHPAWK 

       490        500        510        520        530        540 
ECRCPKCGGK ATRETDTMDT FVESSWYFLR YTTPKEEWET HALNEAMQRY WMGVDEYIGG 

       550        560        570        580        590        600 
IEHAILHLLY ARFFTKVLRD LGYTETNEPF THLLTQGMVL KDGAKMSKSK GNVVDPDELI 

       610        620        630        640        650        660 
ERFGADTARL FVLFAAPPTR ELEWNDSAVE GAYRFIKRLC DKTQFVQKVS SLPQIETATL 

       670        680        690        700        710        720 
SKTEKLARKK VHETLLKAQE VYSRKNAYAF NTLIASCMEA LNALSDQENP AIFTEGYFIL 

       730        740        750        760        770        780 
LSVLEPIIPH VAWELSQEYF GLANFKPLTP DTQALKSDSL TIAITVNGKK RGEIEMAPGS 

       790        800        810 
SNEAMLEAAK NEVSKWLEGM SIIKEIVVPD KLVNLVVKP 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX571660 Genomic DNA. Translation: CAE10325.1.
RefSeqNP_907425.1. NC_005090.1.

3D structure databases

ProteinModelPortalQ7M926.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273121.WS1245.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE10325; CAE10325; WS1245.
GeneID2554496.
KEGGwsu:WS1245.
PATRIC24039508. VBIWolSuc63014_1172.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200747.
KOK01869.
OMAPVIHCPK.
OrthoDBEOG63Z74X.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_WOLSU
AccessionPrimary (citable) accession number: Q7M926
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: December 15, 2003
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries