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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei588ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciWSUC273121:G1GTD-1194-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:WS1245
OrganismiWolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes)
Taxonomic identifieri273121 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeWolinella
Proteomesi
  • UP000000422 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001521191 – 819Leucine--tRNA ligaseAdd BLAST819

Proteomic databases

PRIDEiQ7M926

Interactioni

Protein-protein interaction databases

STRINGi273121.WS1245

Structurei

3D structure databases

ProteinModelPortaliQ7M926
SMRiQ7M926
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 50"HIGH" regionAdd BLAST11
Motifi585 – 589"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q7M926-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYNPKAIEK KWQEHWKNKR THEPLSDTSL PKKYILSMFP YPSGRIHMGH
60 70 80 90 100
VRNYCIGDAI ARHFRKQNFN VLHPIGWDAF GMPAENAAIK HKSHPKKWTY
110 120 130 140 150
DNISNMREEL DSLGLSFSNE REFATCDPIY SKWEQKFFID MWNRGLIYRK
160 170 180 190 200
KGFLNWCPND QTVLANEQVI EGRCWRCDTE VVQKEMFQYY VKITDYAEEL
210 220 230 240 250
LGSLDTLEGR WPSQVLTMQR NWIGRSEGLS FAFKLTSSSK ERIGGSFDSF
260 270 280 290 300
EVFTTRPDTL YGVTYCALAP EHPLVRELMR QGKLPQESLE ALAKMQNIPA
310 320 330 340 350
KERAMIPKEG VALGLEAIHP LTGEAIPLWA ANFVLTDYGS GAVMAVPAHD
360 370 380 390 400
ERDFEFAKKY QLPQKQVILS GAAPSLDEAA YTESGTLINS GIFDGLESES
410 420 430 440 450
AKEKIIRYFE EHSLGRGVIN YRLRDWGISR QRYWGTPIPL IHCPSCGIVP
460 470 480 490 500
EDFSNLPITL PEDVIIDGEG NPLEKHPAWK ECRCPKCGGK ATRETDTMDT
510 520 530 540 550
FVESSWYFLR YTTPKEEWET HALNEAMQRY WMGVDEYIGG IEHAILHLLY
560 570 580 590 600
ARFFTKVLRD LGYTETNEPF THLLTQGMVL KDGAKMSKSK GNVVDPDELI
610 620 630 640 650
ERFGADTARL FVLFAAPPTR ELEWNDSAVE GAYRFIKRLC DKTQFVQKVS
660 670 680 690 700
SLPQIETATL SKTEKLARKK VHETLLKAQE VYSRKNAYAF NTLIASCMEA
710 720 730 740 750
LNALSDQENP AIFTEGYFIL LSVLEPIIPH VAWELSQEYF GLANFKPLTP
760 770 780 790 800
DTQALKSDSL TIAITVNGKK RGEIEMAPGS SNEAMLEAAK NEVSKWLEGM
810
SIIKEIVVPD KLVNLVVKP
Length:819
Mass (Da):93,291
Last modified:December 15, 2003 - v1
Checksum:i8B1FF4634CB6F840
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571660 Genomic DNA Translation: CAE10325.1
RefSeqiWP_011139112.1, NC_005090.1

Genome annotation databases

EnsemblBacteriaiCAE10325; CAE10325; WS1245
KEGGiwsu:WS1245

Similar proteinsi

Entry informationi

Entry nameiSYL_WOLSU
AccessioniPrimary (citable) accession number: Q7M926
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: December 15, 2003
Last modified: May 23, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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