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Q7M8Z9

- UPPP_WOLSU

UniProt

Q7M8Z9 - UPPP_WOLSU

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Synonyms:bacA, upk
    Ordered Locus Names:WS1290
    OrganismiWolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes)
    Taxonomic identifieri273121 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeWolinella
    ProteomesiUP000000422: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 256256Undecaprenyl-diphosphatasePRO_0000151240Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi273121.WS1290.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1 – 2121HelicalUniRule annotationAdd
    BLAST
    Transmembranei41 – 6121HelicalUniRule annotationAdd
    BLAST
    Transmembranei69 – 8921HelicalUniRule annotationAdd
    BLAST
    Transmembranei96 – 11621HelicalUniRule annotationAdd
    BLAST
    Transmembranei172 – 19221HelicalUniRule annotationAdd
    BLAST
    Transmembranei207 – 22721HelicalUniRule annotationAdd
    BLAST
    Transmembranei233 – 25321HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218356.
    KOiK06153.
    OMAiVIYFRNE.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7M8Z9-1 [UniParc]FASTAAdd to Basket

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    MDIFHAIILG IVEGLTEFLP VSSTGHLILV SELLGIKQDD FHKTFEISIQ    50
    LGSILAVLAL FRERLFSGVD IWLKLAVAFI PTGALGFLLY KHVKALFAPS 100
    TVAYALILGG IVFLVLEWLH KDKEYKINSV ESIGYKEALA IGFFQALAMI 150
    PGTSRSGSTI VGGLILGLNR KVAAEFSFLL ALPTMFIATG YDLYKNSHTL 200
    SIENLSALGV GFVVAFIFAM IAVKGFLKFI SRFNFVPFGI YRIILGIIFL 250
    FYLDLI 256
    Length:256
    Mass (Da):28,163
    Last modified:December 15, 2003 - v1
    Checksum:i8AC5451D7B34CC59
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571660 Genomic DNA. Translation: CAE10368.1.
    RefSeqiNP_907468.1. NC_005090.1.
    WP_011139154.1. NC_005090.1.

    Genome annotation databases

    EnsemblBacteriaiCAE10368; CAE10368; WS1290.
    GeneIDi2554216.
    KEGGiwsu:WS1290.
    PATRICi24039596. VBIWolSuc63014_1216.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571660 Genomic DNA. Translation: CAE10368.1 .
    RefSeqi NP_907468.1. NC_005090.1.
    WP_011139154.1. NC_005090.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273121.WS1290.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE10368 ; CAE10368 ; WS1290 .
    GeneIDi 2554216.
    KEGGi wsu:WS1290.
    PATRICi 24039596. VBIWolSuc63014_1216.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218356.
    KOi K06153.
    OMAi VIYFRNE.
    OrthoDBi EOG6QP13M.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W.

    Entry informationi

    Entry nameiUPPP_WOLSU
    AccessioniPrimary (citable) accession number: Q7M8Z9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3