Q7M8Y7 (AROA_WOLSU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	WS1309

Organism

Wolinella succinogenes [Complete proteome] [HAMAP]

Taxonomic identifier

844 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Wolinella

Protein attributes

Sequence length	437 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity. HAMAP MF_00210
Subcellular location	Cytoplasm By similarity HAMAP MF_00210.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 437	437	3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210		PRO_0000325400

Sequences

	Sequence		Length	Mass (Da)
	Q7M8Y7 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: 643D2BBECA443ECF	FASTA	437	47,716
	10 20 30 40 50 60 MRITQVTPLK EGFEIEIPNI ASDKSISHRS AIFSLLSSSP ARIHRYLQGE DTLHTLQIAQ 70 80 90 100 110 120 QLGLEVTKEG EGMVFTPPPS GIKEPFDVLD CGNAGTAIRL YVGLLAASKG YFVLNGDAYL 130 140 150 160 170 180 RRRPMNRVVK PLQSVGAQIF GRDEGNLAPL TILGRPLAAF DYQSPIASAQ VKSAMILAAL 190 200 210 220 230 240 QGEEASFFSE PERSRDHTER MLRGMGARID EDQEGRLTLF PLLGKRLDPL EMTIPADPSS 250 260 270 280 290 300 AFFFAVAAAI IPGARVKLQN VLLNPTRIEA FKVLESMGAR LHYSITSETY ETIGDIEVSH 310 320 330 340 350 360 HTLQGITVSE RISWLIDELP ALAIAMALAQ GKSRVQNAKE LRVKESDRIS VVVNNLRLLG 370 380 390 400 410 420 VEVEEFEDGY EITGGTLQGG VTIDSHGDHR IAMSFALAGL VVPLTINDSA CIDVSFPNFL 430 EILSSIAKVI HESQTSR

References

[1]

"Complete genome sequence and analysis of Wolinella succinogenes." Baar C., Eppinger M., Raddatz G., Simon J., Lanz C., Klimmek O., Nandakumar R., Gross R., Rosinus A., Keller H., Jagtap P., Linke B., Meyer F., Lederer H., Schuster S.C. Proc. Natl. Acad. Sci. U.S.A. 100:11690-11695(2003) [PubMed: 14500908] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSMZ 1740.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX571660 Genomic DNA. Translation: CAE10385.1.
RefSeq	NP_907485.1. NC_005090.1.
3D structure databases
HSSP	HSSP built from PDB template 1RF6 based on UniProtKB Q9S400.
ProteinModelPortal	Q7M8Y7.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2554128.
GenomeReviews	Gene locus WS1309 in contig BX571656_GR.
KEGG	wsu:WS1309.
NMPDR	fig|273121.1.peg.1212.
PATRIC	24039630. VBIWolSuc63014_1233.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG646626.
OMA	LECANIS.
ProtClustDB	PRK02427.
Enzyme and pathway databases
BioCyc	WSUC273121:WS1309-MONOMER.
Family and domain databases
HAMAP	MF_00210. EPSP_synth. [Tree]
InterPro	IPR001986. Enolpyruvate_Tfrase_dom. IPR006264. EPSP_synthase. IPR023193. EPSP_synthase_CS. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KO	K00800.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMs	TIGR01356. AroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_WOLSU

Accession

Primary (citable) accession number: Q7M8Y7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	December 15, 2003
Last modified:	January 25, 2012
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program