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Q7M8K9

- HISX_WOLSU

UniProt

Q7M8K9 - HISX_WOLSU

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei240 – 2401SubstrateUniRule annotation
    Metal bindingi262 – 2621ZincUniRule annotation
    Binding sitei262 – 2621SubstrateUniRule annotation
    Metal bindingi265 – 2651ZincUniRule annotation
    Binding sitei265 – 2651SubstrateUniRule annotation
    Active sitei330 – 3301Proton acceptorUniRule annotation
    Active sitei331 – 3311Proton acceptorUniRule annotation
    Binding sitei331 – 3311SubstrateUniRule annotation
    Metal bindingi364 – 3641ZincUniRule annotation
    Binding sitei364 – 3641SubstrateUniRule annotation
    Binding sitei418 – 4181SubstrateUniRule annotation
    Metal bindingi423 – 4231ZincUniRule annotation
    Binding sitei423 – 4231SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDHUniRule annotation
    Gene namesi
    Name:hisDUniRule annotation
    Ordered Locus Names:WS1587
    OrganismiWolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes)
    Taxonomic identifieri273121 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeWolinella
    ProteomesiUP000000422: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 432432Histidinol dehydrogenasePRO_0000135879Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi273121.WS1587.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7M8K9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiCAIANRI.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7M8K9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRKIKRLNSS LAEFRREFDE LLLRGNVDMD TVIPVVSGLI KEIRTQGDAA    50
    LLAHVAKFDR WNPKSAMELK IDPSLMKRAY EGLEASLREA LHSAYNRIHS 100
    FHSKQKPQSW LDFEENGTIL GQKVTPMDRA GLYIPGGKAA YPSSLLMNAI 150
    PAIVAGVKEI VVCTPTPENE PNELLLAACH LCGIKEVYKV GGASAIAAMA 200
    YGTESLGRVD VITGPGNIYV ATAKKLVFGQ VNIDMVAGPS EIGILADESA 250
    KAPWVALDLL SQAEHDEMAS SILVTPSVEL ADAVDVEVER ALERLDRKEI 300
    SSKSIYTRGA IIIAKDMNEA VSLMNEIAPE HLEVLVENPF GWLPEIRHAG 350
    AIFLGENTPE PIGDYIAGPN HTLPTGGTAR FYSPLSTEHF MKKSSILSFS 400
    ERGIRELGHH CAKLAQTEGL DAHKESVLAR LV 432
    Length:432
    Mass (Da):47,077
    Last modified:December 15, 2003 - v1
    Checksum:iB16897BD6F174B82
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571661 Genomic DNA. Translation: CAE10626.1.
    RefSeqiNP_907726.1. NC_005090.1.
    WP_011139410.1. NC_005090.1.

    Genome annotation databases

    EnsemblBacteriaiCAE10626; CAE10626; WS1587.
    GeneIDi2553857.
    KEGGiwsu:WS1587.
    PATRICi24040150. VBIWolSuc63014_1488.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571661 Genomic DNA. Translation: CAE10626.1 .
    RefSeqi NP_907726.1. NC_005090.1.
    WP_011139410.1. NC_005090.1.

    3D structure databases

    ProteinModelPortali Q7M8K9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273121.WS1587.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE10626 ; CAE10626 ; WS1587 .
    GeneIDi 2553857.
    KEGGi wsu:WS1587.
    PATRICi 24040150. VBIWolSuc63014_1488.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi CAIANRI.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W.

    Entry informationi

    Entry nameiHISX_WOLSU
    AccessioniPrimary (citable) accession number: Q7M8K9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3