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Q7M8K9

- HISX_WOLSU

UniProt

Q7M8K9 - HISX_WOLSU

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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei240 – 2401SubstrateUniRule annotation
Metal bindingi262 – 2621ZincUniRule annotation
Binding sitei262 – 2621SubstrateUniRule annotation
Metal bindingi265 – 2651ZincUniRule annotation
Binding sitei265 – 2651SubstrateUniRule annotation
Active sitei330 – 3301Proton acceptorUniRule annotation
Active sitei331 – 3311Proton acceptorUniRule annotation
Binding sitei331 – 3311SubstrateUniRule annotation
Metal bindingi364 – 3641ZincUniRule annotation
Binding sitei364 – 3641SubstrateUniRule annotation
Binding sitei418 – 4181SubstrateUniRule annotation
Metal bindingi423 – 4231ZincUniRule annotation
Binding sitei423 – 4231SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:WS1587
OrganismiWolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes)
Taxonomic identifieri273121 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeWolinella
ProteomesiUP000000422: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 432432Histidinol dehydrogenasePRO_0000135879Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273121.WS1587.

Structurei

3D structure databases

ProteinModelPortaliQ7M8K9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiCAIANRI.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7M8K9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRKIKRLNSS LAEFRREFDE LLLRGNVDMD TVIPVVSGLI KEIRTQGDAA
60 70 80 90 100
LLAHVAKFDR WNPKSAMELK IDPSLMKRAY EGLEASLREA LHSAYNRIHS
110 120 130 140 150
FHSKQKPQSW LDFEENGTIL GQKVTPMDRA GLYIPGGKAA YPSSLLMNAI
160 170 180 190 200
PAIVAGVKEI VVCTPTPENE PNELLLAACH LCGIKEVYKV GGASAIAAMA
210 220 230 240 250
YGTESLGRVD VITGPGNIYV ATAKKLVFGQ VNIDMVAGPS EIGILADESA
260 270 280 290 300
KAPWVALDLL SQAEHDEMAS SILVTPSVEL ADAVDVEVER ALERLDRKEI
310 320 330 340 350
SSKSIYTRGA IIIAKDMNEA VSLMNEIAPE HLEVLVENPF GWLPEIRHAG
360 370 380 390 400
AIFLGENTPE PIGDYIAGPN HTLPTGGTAR FYSPLSTEHF MKKSSILSFS
410 420 430
ERGIRELGHH CAKLAQTEGL DAHKESVLAR LV
Length:432
Mass (Da):47,077
Last modified:December 15, 2003 - v1
Checksum:iB16897BD6F174B82
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571661 Genomic DNA. Translation: CAE10626.1.
RefSeqiNP_907726.1. NC_005090.1.
WP_011139410.1. NC_005090.1.

Genome annotation databases

EnsemblBacteriaiCAE10626; CAE10626; WS1587.
GeneIDi2553857.
KEGGiwsu:WS1587.
PATRICi24040150. VBIWolSuc63014_1488.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571661 Genomic DNA. Translation: CAE10626.1 .
RefSeqi NP_907726.1. NC_005090.1.
WP_011139410.1. NC_005090.1.

3D structure databases

ProteinModelPortali Q7M8K9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273121.WS1587.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE10626 ; CAE10626 ; WS1587 .
GeneIDi 2553857.
KEGGi wsu:WS1587.
PATRICi 24040150. VBIWolSuc63014_1488.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi CAIANRI.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W.

Entry informationi

Entry nameiHISX_WOLSU
AccessioniPrimary (citable) accession number: Q7M8K9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: December 15, 2003
Last modified: November 26, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3