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Q7M8K9 (HISX_WOLSU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histidinol dehydrogenase

Short name=HDH
EC=1.1.1.23
Gene names
Name:hisD
Ordered Locus Names:WS1587
OrganismWolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes) [Complete proteome] [HAMAP]
Taxonomic identifier273121 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeWolinella

Protein attributes

Sequence length432 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity. HAMAP-Rule MF_01024

Catalytic activity

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH. HAMAP-Rule MF_01024

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_01024

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. HAMAP-Rule MF_01024

Sequence similarities

Belongs to the histidinol dehydrogenase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Histidine biosynthesis
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processhistidine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: InterPro

histidinol dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 432432Histidinol dehydrogenase HAMAP-Rule MF_01024
PRO_0000135879

Sites

Active site3301Proton acceptor By similarity
Active site3311Proton acceptor By similarity
Metal binding2621Zinc By similarity
Metal binding2651Zinc By similarity
Metal binding3641Zinc By similarity
Metal binding4231Zinc By similarity
Binding site2401Substrate By similarity
Binding site2621Substrate By similarity
Binding site2651Substrate By similarity
Binding site3311Substrate By similarity
Binding site3641Substrate By similarity
Binding site4181Substrate By similarity
Binding site4231Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7M8K9 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: B16897BD6F174B82

FASTA43247,077
        10         20         30         40         50         60 
MRKIKRLNSS LAEFRREFDE LLLRGNVDMD TVIPVVSGLI KEIRTQGDAA LLAHVAKFDR 

        70         80         90        100        110        120 
WNPKSAMELK IDPSLMKRAY EGLEASLREA LHSAYNRIHS FHSKQKPQSW LDFEENGTIL 

       130        140        150        160        170        180 
GQKVTPMDRA GLYIPGGKAA YPSSLLMNAI PAIVAGVKEI VVCTPTPENE PNELLLAACH 

       190        200        210        220        230        240 
LCGIKEVYKV GGASAIAAMA YGTESLGRVD VITGPGNIYV ATAKKLVFGQ VNIDMVAGPS 

       250        260        270        280        290        300 
EIGILADESA KAPWVALDLL SQAEHDEMAS SILVTPSVEL ADAVDVEVER ALERLDRKEI 

       310        320        330        340        350        360 
SSKSIYTRGA IIIAKDMNEA VSLMNEIAPE HLEVLVENPF GWLPEIRHAG AIFLGENTPE 

       370        380        390        400        410        420 
PIGDYIAGPN HTLPTGGTAR FYSPLSTEHF MKKSSILSFS ERGIRELGHH CAKLAQTEGL 

       430 
DAHKESVLAR LV 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX571661 Genomic DNA. Translation: CAE10626.1.
RefSeqNP_907726.1. NC_005090.1.

3D structure databases

ProteinModelPortalQ7M8K9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273121.WS1587.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE10626; CAE10626; WS1587.
GeneID2553857.
KEGGwsu:WS1587.
PATRIC24040150. VBIWolSuc63014_1488.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0141.
HOGENOMHOG000243914.
KOK00013.
OMACAIANRI.
OrthoDBEOG6CVVCR.

Enzyme and pathway databases

UniPathwayUPA00031; UER00014.

Family and domain databases

HAMAPMF_01024. HisD.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000099. Histidinol_dh. 1 hit.
PRINTSPR00083. HOLDHDRGNASE.
SUPFAMSSF53720. SSF53720. 1 hit.
TIGRFAMsTIGR00069. hisD. 1 hit.
PROSITEPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHISX_WOLSU
AccessionPrimary (citable) accession number: Q7M8K9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: December 15, 2003
Last modified: May 14, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways