Q7M8A5 (KAD_WOLSU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenylate kinase
Short name=AK
EC=2.7.4.3

Alternative name(s):
ATP-AMP transphosphorylase

Gene names

Name:	adk
Ordered Locus Names:	WS1782

Organism

Wolinella succinogenes [Complete proteome] [HAMAP]

Taxonomic identifier

844 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Wolinella

Protein attributes

Sequence length	190 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth By similarity. HAMAP MF_00235
Catalytic activity	ATP + AMP = 2 ADP. HAMAP MF_00235
Pathway	Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1. HAMAP MF_00235
Subunit structure	Monomer By similarity. HAMAP MF_00235
Subcellular location	Cytoplasm By similarity HAMAP MF_00235.
Domain	Consists of three domains, a large central CORE domain and two small peripheral domains, AMP binding and LID. The LID domain closes over the site of phosphoryl transfer upon ATP binding By similarity. HAMAP MF_00235
Sequence similarities	Belongs to the adenylate kinase family.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 190	190	Adenylate kinase HAMAP MF_00235		PRO_0000158888
Regions
	Nucleotide binding	9 – 17	9	ATP By similarity
	Nucleotide binding	35 – 63	29	AMP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7M8A5 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: 178F4F9A10B5EB19	FASTA	190	20,843
	10 20 30 40 50 60 MKKLFLIIGA PGSGKTTDAE IIAKNNPDSI NHYSTGELLR AEVASGSERG KIIEGFTSKG 70 80 90 100 110 120 NLVPLEIVVE TIVSAIKNAP KNVVLIDGYP RSTEQMEALD KILKEESDVE LTNVIEVEVS 130 140 150 160 170 180 EQVACDRVLG RARGADDNAE VFRNRMSVYL APLKPIQAFY TAKGILHKIN GERTIEEIVS 190 EMEGFIKSRL

References

[1]

"Complete genome sequence and analysis of Wolinella succinogenes." Baar C., Eppinger M., Raddatz G., Simon J., Lanz C., Klimmek O., Nandakumar R., Gross R., Rosinus A., Keller H., Jagtap P., Linke B., Meyer F., Lederer H., Schuster S.C. Proc. Natl. Acad. Sci. U.S.A. 100:11690-11695(2003) [PubMed: 14500908] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSMZ 1740.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX571661 Genomic DNA. Translation: CAE10804.1.
RefSeq	NP_907904.1. NC_005090.1.
3D structure databases
ProteinModelPortal	Q7M8A5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2555315.
GenomeReviews	Gene locus WS1782 in contig BX571656_GR.
KEGG	wsu:WS1782.
NMPDR	fig|273121.1.peg.1631.
PATRIC	24040522. VBIWolSuc63014_1673.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG630208.
OMA	EMQKYIL.
ProtClustDB	PRK00279.
Enzyme and pathway databases
BioCyc	WSUC273121:WS1782-MONOMER.
Family and domain databases
HAMAP	MF_00235. Adenylate_kinase_Adk. [Tree]
InterPro	IPR000850. Adenylate_kin. [Graphical view]
KO	K00939.
PANTHER	PTHR23359. Adenylate_kin. 1 hit.
Pfam	PF00406. ADK. 1 hit. [Graphical view]
PRINTS	PR00094. ADENYLTKNASE.
PROSITE	PS00113. ADENYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAD_WOLSU

Accession

Primary (citable) accession number: Q7M8A5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	December 15, 2003
Last modified:	January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program