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Q7M7Z5 (Q7M7Z5_WOLSU) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 HAMAP MF_01815
EC=2.3.1.180 HAMAP MF_01815
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III HAMAP MF_01815
Beta-ketoacyl-ACP synthase III HAMAP MF_01815
Gene names
Name:fabH HAMAP MF_01815
Ordered Locus Names:WS1988
OrganismWolinella succinogenes [Complete proteome] [HAMAP]
Taxonomic identifier844 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Wolinella

Protein attributes

Sequence length330 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815 SAAS SAAS013747

Subunit structure

Homodimer By similarity. HAMAP MF_01815 SAAS SAAS013747

Subcellular location

Cytoplasm By similarity HAMAP MF_01815 SAAS SAAS013747.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family. HAMAP MF_01815

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region255 – 2595ACP-binding By similarity HAMAP MF_01815

Sites

Active site1131 By similarity HAMAP MF_01815
Active site2541 By similarity HAMAP MF_01815
Active site2841 By similarity HAMAP MF_01815

Sequences

Sequence LengthMass (Da)Tools
Q7M7Z5 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 15829C8C38C18199

FASTA33035,887
        10         20         30         40         50         60 
MYASLRSIGA YIPQKAFTNA DMEKMVETSD EWIKKRTGIK TRHFAEANEA TSDLATKAAK 

        70         80         90        100        110        120 
VAMERAGVKP EEIDMLITAT ISPDYLCMPS TACVIAHNLG IEDKPAFDIS AACSGFIYLL 

       130        140        150        160        170        180 
SIAKAYIESG MAKTILVIGA EKLSAITDFT DRSTCVLFGD GAGAAIIGVT DSKEEAILDV 

       190        200        210        220        230        240 
NIAANGKYQD FLMTPGCGSR HPASQEVIDQ RLQFMKMKGN ETFKLAVKTL SNDVKEILER 

       250        260        270        280        290        300 
NHLTSKEIHH FIPHQANYRI IKAVGDLLDF TPEQIAITVD RFGNTSAASI PMAMNALYEE 

       310        320        330 
GRLKNGEKVL LDAFGGGLTW GSAILTFCGR

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References

[1]"Complete genome sequence and analysis of Wolinella succinogenes."
Baar C., Eppinger M., Raddatz G., Simon J., Lanz C., Klimmek O., Nandakumar R., Gross R., Rosinus A., Keller H., Jagtap P., Linke B., Meyer F., Lederer H., Schuster S.C.
Proc. Natl. Acad. Sci. U.S.A. 100:11690-11695(2003) [PubMed: 14500908] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSMZ 1740.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX571662 Genomic DNA. Translation: CAE10991.1.
RefSeqNP_908091.1. NC_005090.1.

3D structure databases

HSSPHSSP built from PDB template 1HNK based on UniProtKB P24249.
ProteinModelPortalQ7M7Z5.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2553956.
GenomeReviewsGene locus WS1988 in contig BX571656_GR.
KEGGwsu:WS1988.
NMPDRfig|273121.1.peg.1818.
PATRIC24040912. VBIWolSuc63014_1868.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG649927.
OMAMAKISPE.
ProtClustDBPRK09352.

Enzyme and pathway databases

BioCycWSUC273121:WS1988-MONOMER.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ7M7Z5_WOLSU
AccessionPrimary (citable) accession number: Q7M7Z5
Entry history
Integrated into UniProtKB/TrEMBL: December 15, 2003
Last sequence update: December 15, 2003
Last modified: December 14, 2011
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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