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Protein

Glutamate--tRNA ligase 1

Gene

gltX1

Organism
Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei239ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciWSUC273121:G1GTD-2099-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase 1UniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetase 1UniRule annotation
Short name:
GluRS 1UniRule annotation
Gene namesi
Name:gltX1UniRule annotation
Ordered Locus Names:WS2217
OrganismiWolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes)
Taxonomic identifieri273121 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeWolinella
Proteomesi
  • UP000000422 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001196991 – 465Glutamate--tRNA ligase 1Add BLAST465

Proteomic databases

PRIDEiQ7M7L9

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi273121.WS2217

Structurei

3D structure databases

ProteinModelPortaliQ7M7L9
SMRiQ7M7L9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi8 – 18"HIGH" regionUniRule annotationAdd BLAST11
Motifi236 – 240"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252722
KOiK01885
OMAiAYYAFDT
OrthoDBiPOG091H021W

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q7M7L9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVTRFAPSP TGNLHIGGLR TALFSYLYAR KTGGKFLLRI EDTDLARNSH
60 70 80 90 100
DATKAIIEAF DWVGLSYDGE AIYQSERFPL YKEYIDRLIQ EGKAYYCYMS
110 120 130 140 150
KEELDALREE QRSRGETPRY DNRYRDFTGT PPSGVAPVVR IKAPLEGYIE
160 170 180 190 200
FEDGVKGEMK IGAKEMDDYI IARSDGTPTY NFVVSIDDAL MGVTDVIRGD
210 220 230 240 250
DHLTNTPKQI IVYQALGFPI PKFYHVPMIL NPEGRKLSKR DGAMGVMDYK
260 270 280 290 300
RAGYLPEAVL NFLVRLGWSH GDQEIFSMEE MLRFFDPKDL NSSASAYNQE
310 320 330 340 350
KFLWLNHHYI TQTPNERLEE LLLEFGCQPL SLGVREILYP ALKERAKTLA
360 370 380 390 400
ELAQMLQEIV QTPSELDTKM LEKVGNSENG EILENYALFL ESLESAGENP
410 420 430 440 450
KILEEETQAF LDIHGLKSGK LFQSVRLALL GKGGGPGIFE IMAAIGKEES
460
MARIQKASEI FKNRN
Length:465
Mass (Da):52,651
Last modified:December 15, 2003 - v1
Checksum:i3BD7947A4E04EA40
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571663 Genomic DNA Translation: CAE11205.1
RefSeqiWP_011139987.1, NC_005090.1

Genome annotation databases

EnsemblBacteriaiCAE11205; CAE11205; WS2217
KEGGiwsu:WS2217

Similar proteinsi

Entry informationi

Entry nameiSYE1_WOLSU
AccessioniPrimary (citable) accession number: Q7M7L9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: December 15, 2003
Last modified: May 23, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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