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Protein

Ubiquitin-conjugating enzyme E2 variant 2

Gene

Ube2v2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.1 Publication

GO - Molecular functioni

GO - Biological processi

  • DNA double-strand break processing Source: RGD
  • error-free postreplication DNA repair Source: RGD
  • negative regulation of neuron apoptotic process Source: RGD
  • positive regulation of DNA repair Source: RGD
  • positive regulation of neuron projection development Source: RGD
  • positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: RGD
  • positive regulation of synapse assembly Source: RGD
  • postreplication repair Source: GO_Central
  • protein K63-linked ubiquitination Source: GO_Central

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-RNO-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
R-RNO-5693571. Nonhomologous End-Joining (NHEJ).
R-RNO-69473. G2/M DNA damage checkpoint.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 variant 2
Alternative name(s):
Ubiquitin-conjugating enzyme variant MMS2
Gene namesi
Name:Ube2v2
Synonyms:Mms2, Uev2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi727838. Ube2v2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000826042 – 145Ubiquitin-conjugating enzyme E2 variant 2Add BLAST144

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ7M767.
PRIDEiQ7M767.

Expressioni

Developmental stagei

Highly expressed in embryonic cerebral cortex, hippocampus and cerebellum between day 18 and up to birth. Levels are distictly lower 10 days after birth, and not detectable in adults (at protein level).2 Publications

Inductioni

By angiotensin-II or its agonist CGP42112A, via MTUS1 and PTPN6 (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000001829.
ExpressionAtlasiQ7M767. baseline and differential.
GenevisibleiQ7M767. RN.

Interactioni

Subunit structurei

Heterodimer with UBE2N. Binds CHFR (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000062102.

Structurei

3D structure databases

ProteinModelPortaliQ7M767.
SMRiQ7M767.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0896. Eukaryota.
ENOG4111MDW. LUCA.
GeneTreeiENSGT00740000115534.
HOGENOMiHOG000036561.
HOVERGENiHBG054552.
InParanoidiQ7M767.
KOiK10704.
OMAiGPARTNY.
PhylomeDBiQ7M767.
TreeFamiTF316971.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiView protein in InterPro
IPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
PfamiView protein in Pfam
PF00179. UQ_con. 1 hit.
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiView protein in PROSITE
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7M767-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVSTGVKVP RNFRLLEELE EGQKGVGDGT VSWGLEDDED MTLTRWTGMI
60 70 80 90 100
IGPPRTNYEN RIYSLKVECG SKYPEAPPSV RFVTKINMNG INNSSGMVDA
110 120 130 140
RSIPVLAKWQ NSYSIKVVLQ ELRRLMMSKE NMKLPQPPEG QTYNN
Length:145
Mass (Da):16,353
Last modified:January 23, 2007 - v3
Checksum:i98D6316D61C36611
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ515244 mRNA. Translation: CAD56165.1.
BN000090 mRNA. Translation: CAD56854.1.
BC087593 mRNA. Translation: AAH87593.1.
RefSeqiNP_898875.1. NM_183052.2.
UniGeneiRn.3933.

Genome annotation databases

EnsembliENSRNOT00000031401; ENSRNOP00000062102; ENSRNOG00000001829.
GeneIDi287927.
KEGGirno:287927.
UCSCiRGD:727838. rat.

Similar proteinsi

Entry informationi

Entry nameiUB2V2_RAT
AccessioniPrimary (citable) accession number: Q7M767
Secondary accession number(s): Q8CHN0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: January 23, 2007
Last modified: November 22, 2017
This is version 110 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families