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Q7M764

- U17PE_MOUSE

UniProt

Q7M764 - U17PE_MOUSE

Protein

Ubiquitin carboxyl-terminal hydrolase 17-like protein E

Gene

Usp17le

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 2 (13 Jul 2010)
      Previous versions | rss
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    Functioni

    Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.1 Publication

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei94 – 941NucleophilePROSITE-ProRule annotation
    Active sitei341 – 3411Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ubiquitin-specific protease activity Source: UniProtKB
    2. ubiquitin thiolesterase activity Source: UniProtKB

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. CAAX-box protein processing Source: UniProtKB
    3. cell cycle checkpoint Source: UniProtKB
    4. mitotic cell cycle checkpoint Source: UniProtKB
    5. negative regulation of histone deacetylation Source: UniProtKB
    6. negative regulation of protein processing Source: UniProtKB
    7. negative regulation of protein targeting to membrane Source: UniProtKB
    8. negative regulation of Ras GTPase activity Source: UniProtKB
    9. positive regulation of MDA-5 signaling pathway Source: UniProtKB
    10. positive regulation of Rho GTPase activity Source: UniProtKB
    11. positive regulation of RIG-I signaling pathway Source: UniProtKB
    12. protein deubiquitination Source: UniProtKB
    13. protein K48-linked deubiquitination Source: UniProtKB
    14. protein K63-linked deubiquitination Source: UniProtKB
    15. regulation of apoptotic process Source: UniProtKB
    16. regulation of cell migration Source: UniProtKB
    17. regulation of cell proliferation Source: UniProtKB
    18. regulation of defense response to virus by host Source: UniProtKB
    19. regulation of ruffle assembly Source: UniProtKB
    20. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Apoptosis, Cell cycle, Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC19.082.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 17-like protein E (EC:3.4.19.12)
    Short name:
    USP17-E
    Alternative name(s):
    Deubiquitinating enzyme 17-like protein 2
    Deubiquitinating protein 3
    Short name:
    DUB-3
    Deubiquitinating protein 6
    Ubiquitin carboxyl-terminal hydrolase 17-like protein 2
    Ubiquitin thioesterase 17-like protein 2
    Ubiquitin-specific-processing protease 17-like protein 2
    Gene namesi
    Name:Usp17le
    Synonyms:Dub3, Dub6, Usp17, Usp17l2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:3643640. Usp17le.

    Subcellular locationi

    Nucleus By similarity. Endoplasmic reticulum By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Endoplasmic reticulum, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 540540Ubiquitin carboxyl-terminal hydrolase 17-like protein EPRO_5000095963Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriQ7M764.

    Interactioni

    Subunit structurei

    Interacts with SUDS3; the interaction is direct.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000051716.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7M764.
    SMRiQ7M764. Positions 48-404.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini85 – 382298USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family. USP17 subfamily.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5533.
    HOGENOMiHOG000144638.
    HOVERGENiHBG007129.
    PhylomeDBiQ7M764.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7M764-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVVSLSFPEE TGGENLPSAP LEDSSKFFEE VFGDMVFARS FPEADPALSS    50
    PDAPELHQDE AQVVEELTTN GKHSLSWESP QGPGCGLQNT GNSCYLNAAL 100
    QCLTHTPPLA DYMLSQEHSQ TCCSPEGCKM CAMEAHVTQS LLHSHSGDVM 150
    KPSQILTSAF HKHQQEDAHE FLMFTLETMH ESCLQVHRQS DPTPQDTSPI 200
    HDIFGGWWRS QIKCLHCQGT SHTFDPFLDV PLDISSAQSV NQALWDTGKS 250
    EELLGENAYY CGRCRQKMPA SKTLHVHIAP KVLLLVLKRF SAFTGNKLDR 300
    KVSYPEFLDL KPYLSEPTGG PLPYALYAVL VHDGATSNSG HYFCCVKAGH 350
    GKWYKMDDTK VTRCDVTSVL NENAYVLFYV QQTDLKQVSI DMPEGRVHEV 400
    LDPKYQLKKS RRKKRKKQCH CTDDAGEACE NREKRAKKET SLGEGKVPQE 450
    VNHEKAGQKH GNTKLVPQEQ NHQRAGQNLR NTEVELDLPV DAIVIHQPRS 500
    TANWGTDAPD KENQPWHNGD RLLTSQGLMS PGQLCSQGGR 540
    Length:540
    Mass (Da):60,219
    Last modified:July 13, 2010 - v2
    Checksum:iC71382D289659704
    GO

    Sequence cautioni

    The sequence CAD66057.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC110621 Genomic DNA. No translation available.
    BN000117 Genomic DNA. Translation: CAD66057.1. Sequence problems.
    UniGeneiMm.14130.

    Genome annotation databases

    UCSCiuc029wnn.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC110621 Genomic DNA. No translation available.
    BN000117 Genomic DNA. Translation: CAD66057.1 . Sequence problems.
    UniGenei Mm.14130.

    3D structure databases

    ProteinModelPortali Q7M764.
    SMRi Q7M764. Positions 48-404.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000051716.

    Protein family/group databases

    MEROPSi C19.082.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi uc029wnn.1. mouse.

    Organism-specific databases

    MGIi MGI:3643640. Usp17le.

    Phylogenomic databases

    eggNOGi COG5533.
    HOGENOMi HOG000144638.
    HOVERGENi HBG007129.
    PhylomeDBi Q7M764.

    Miscellaneous databases

    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q7M764.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "Human and mouse proteases: a comparative genomic approach."
      Puente X.S., Sanchez L.M., Overall C.M., Lopez-Otin C.
      Nat. Rev. Genet. 4:544-558(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    3. "Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A."
      Pereg Y., Liu B.Y., O'Rourke K.M., Sagolla M., Dey A., Komuves L., French D.M., Dixit V.M.
      Nat. Cell Biol. 12:400-406(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiU17PE_MOUSE
    AccessioniPrimary (citable) accession number: Q7M764
    Secondary accession number(s): D3YU85
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 13, 2010
    Last sequence update: July 13, 2010
    Last modified: October 1, 2014
    This is version 64 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3