Q7M764 (U17L2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ubiquitin carboxyl-terminal hydrolase 17
Short name=USP17
EC=3.4.19.12

Alternative name(s):
Deubiquitinating enzyme 17-like protein 2
Deubiquitinating protein 3
Short name=DUB-3
Deubiquitinating protein 6
Ubiquitin carboxyl-terminal hydrolase 17-like protein 2
Ubiquitin thioesterase 17-like protein 2
Ubiquitin-specific-processing protease 17-like protein 2

Gene names

Name:	Usp17l2
Synonyms:	Dub3, Dub6, Usp17

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	540 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection. Ref.3
Catalytic activity	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Subunit structure	Interacts with SUDS3; the interaction is direct By similarity.
Subcellular location	Nucleus By similarity. Endoplasmic reticulum By similarity.
Sequence similarities	Belongs to the peptidase C19 family. USP17 subfamily.
Sequence caution	The sequence CAD66057.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Apoptosis Cell cycle Ubl conjugation pathway
Cellular component	Endoplasmic reticulum Nucleus
Molecular function	Hydrolase Protease Thiol protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	CAAX-box protein processing Inferred from sequence or structural similarity. Source: UniProtKB apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW mitotic cell cycle checkpoint Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of Ras GTPase activity Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of histone deacetylation Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of protein processing Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of protein targeting to membrane Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of MDA-5 signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of RIG-I signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of Rho GTPase activity Inferred from sequence or structural similarity. Source: UniProtKB protein K48-linked deubiquitination Inferred from sequence or structural similarity. Source: UniProtKB protein K63-linked deubiquitination Inferred from sequence or structural similarity. Source: UniProtKB regulation of apoptotic process Inferred from sequence or structural similarity. Source: UniProtKB regulation of cell migration Inferred from sequence or structural similarity. Source: UniProtKB regulation of cell proliferation Inferred from sequence or structural similarity. Source: UniProtKB regulation of defense response to virus by host Inferred from sequence or structural similarity. Source: UniProtKB regulation of ruffle assembly Inferred from sequence or structural similarity. Source: UniProtKB ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	endoplasmic reticulum membrane Inferred from sequence or structural similarity. Source: UniProtKB nucleus Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	ubiquitin thiolesterase activity Inferred from sequence or structural similarity. Source: UniProtKB ubiquitin-specific protease activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 540	540	Ubiquitin carboxyl-terminal hydrolase 17		PRO_5000095963
Sites
	Active site	94	1	Nucleophile By similarity
	Active site	341	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7M764 [UniParc]. Last modified July 13, 2010. Version 2. Checksum: C71382D289659704	FASTA	540	60,219
	10 20 30 40 50 60 MVVSLSFPEE TGGENLPSAP LEDSSKFFEE VFGDMVFARS FPEADPALSS PDAPELHQDE 70 80 90 100 110 120 AQVVEELTTN GKHSLSWESP QGPGCGLQNT GNSCYLNAAL QCLTHTPPLA DYMLSQEHSQ 130 140 150 160 170 180 TCCSPEGCKM CAMEAHVTQS LLHSHSGDVM KPSQILTSAF HKHQQEDAHE FLMFTLETMH 190 200 210 220 230 240 ESCLQVHRQS DPTPQDTSPI HDIFGGWWRS QIKCLHCQGT SHTFDPFLDV PLDISSAQSV 250 260 270 280 290 300 NQALWDTGKS EELLGENAYY CGRCRQKMPA SKTLHVHIAP KVLLLVLKRF SAFTGNKLDR 310 320 330 340 350 360 KVSYPEFLDL KPYLSEPTGG PLPYALYAVL VHDGATSNSG HYFCCVKAGH GKWYKMDDTK 370 380 390 400 410 420 VTRCDVTSVL NENAYVLFYV QQTDLKQVSI DMPEGRVHEV LDPKYQLKKS RRKKRKKQCH 430 440 450 460 470 480 CTDDAGEACE NREKRAKKET SLGEGKVPQE VNHEKAGQKH GNTKLVPQEQ NHQRAGQNLR 490 500 510 520 530 540 NTEVELDLPV DAIVIHQPRS TANWGTDAPD KENQPWHNGD RLLTSQGLMS PGQLCSQGGR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[2]	"Human and mouse proteases: a comparative genomic approach." Puente X.S., Sanchez L.M., Overall C.M., Lopez-Otin C. Nat. Rev. Genet. 4:544-558(2003) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[3]	"Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A." Pereg Y., Liu B.Y., O'Rourke K.M., Sagolla M., Dey A., Komuves L., French D.M., Dixit V.M. Nat. Cell Biol. 12:400-406(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC110621 Genomic DNA. No translation available. BN000117 Genomic DNA. Translation: CAD66057.1. Sequence problems.
IPI	IPI00662782.
UniGene	Mm.14130.
3D structure databases
ProteinModelPortal	Q7M764.
SMR	Q7M764. Positions 48-404.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000051716.
Protein family/group databases
MEROPS	C19.082.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:3643640. Dub3.
Phylogenomic databases
eggNOG	COG5533.
HOGENOM	HOG000144638.
HOVERGEN	HBG007129.
Gene expression databases
Genevestigator	Q7M764.
Family and domain databases
InterPro	IPR018200. Pept_C19ubi-hydrolase_C_CS. IPR001394. Peptidase_C19. [Graphical view]
Pfam	PF00443. UCH. 1 hit. [Graphical view]
PROSITE	PS00972. UCH_2_1. 1 hit. PS00973. UCH_2_2. 1 hit. PS50235. UCH_2_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

U17L2_MOUSE

Accession

Primary (citable) accession number: Q7M764
Secondary accession number(s): D3YU85

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 13, 2010
Last sequence update:	July 13, 2010
Last modified:	May 1, 2013
This is version 55 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program