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Q7M764 (U17PE_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 17-like protein E

Short name=USP17-E
EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 17-like protein 2
Deubiquitinating protein 3
Short name=DUB-3
Deubiquitinating protein 6
Ubiquitin carboxyl-terminal hydrolase 17-like protein 2
Ubiquitin thioesterase 17-like protein 2
Ubiquitin-specific-processing protease 17-like protein 2
Gene names
Name:Usp17le
Synonyms:Dub3, Dub6, Usp17, Usp17l2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length540 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection. Ref.3

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subunit structure

Interacts with SUDS3; the interaction is direct By similarity.

Subcellular location

Nucleus By similarity. Endoplasmic reticulum By similarity.

Sequence similarities

Belongs to the peptidase C19 family. USP17 subfamily.

Contains 1 USP domain.

Sequence caution

The sequence CAD66057.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Biological processApoptosis
Cell cycle
Ubl conjugation pathway
   Cellular componentEndoplasmic reticulum
Nucleus
   Molecular functionHydrolase
Protease
Thiol protease
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processCAAX-box protein processing

Inferred from sequence or structural similarity. Source: UniProtKB

apoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

cell cycle checkpoint

Inferred from sequence or structural similarity. Source: UniProtKB

mitotic cell cycle checkpoint

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of Ras GTPase activity

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of histone deacetylation

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of protein processing

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of protein targeting to membrane

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of MDA-5 signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of RIG-I signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of Rho GTPase activity

Inferred from sequence or structural similarity. Source: UniProtKB

protein K48-linked deubiquitination

Inferred from sequence or structural similarity. Source: UniProtKB

protein K63-linked deubiquitination

Inferred from sequence or structural similarity. Source: UniProtKB

protein deubiquitination

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of apoptotic process

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of cell migration

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of cell proliferation

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of defense response to virus by host

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of ruffle assembly

Inferred from sequence or structural similarity. Source: UniProtKB

ubiquitin-dependent protein catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentendoplasmic reticulum membrane

Inferred from sequence or structural similarity. Source: UniProtKB

nucleus

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionubiquitin thiolesterase activity

Inferred from sequence or structural similarity. Source: UniProtKB

ubiquitin-specific protease activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 540540Ubiquitin carboxyl-terminal hydrolase 17-like protein E
PRO_5000095963

Regions

Domain85 – 382298USP

Sites

Active site941Nucleophile By similarity
Active site3411Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7M764 [UniParc].

Last modified July 13, 2010. Version 2.
Checksum: C71382D289659704

FASTA54060,219
        10         20         30         40         50         60 
MVVSLSFPEE TGGENLPSAP LEDSSKFFEE VFGDMVFARS FPEADPALSS PDAPELHQDE 

        70         80         90        100        110        120 
AQVVEELTTN GKHSLSWESP QGPGCGLQNT GNSCYLNAAL QCLTHTPPLA DYMLSQEHSQ 

       130        140        150        160        170        180 
TCCSPEGCKM CAMEAHVTQS LLHSHSGDVM KPSQILTSAF HKHQQEDAHE FLMFTLETMH 

       190        200        210        220        230        240 
ESCLQVHRQS DPTPQDTSPI HDIFGGWWRS QIKCLHCQGT SHTFDPFLDV PLDISSAQSV 

       250        260        270        280        290        300 
NQALWDTGKS EELLGENAYY CGRCRQKMPA SKTLHVHIAP KVLLLVLKRF SAFTGNKLDR 

       310        320        330        340        350        360 
KVSYPEFLDL KPYLSEPTGG PLPYALYAVL VHDGATSNSG HYFCCVKAGH GKWYKMDDTK 

       370        380        390        400        410        420 
VTRCDVTSVL NENAYVLFYV QQTDLKQVSI DMPEGRVHEV LDPKYQLKKS RRKKRKKQCH 

       430        440        450        460        470        480 
CTDDAGEACE NREKRAKKET SLGEGKVPQE VNHEKAGQKH GNTKLVPQEQ NHQRAGQNLR 

       490        500        510        520        530        540 
NTEVELDLPV DAIVIHQPRS TANWGTDAPD KENQPWHNGD RLLTSQGLMS PGQLCSQGGR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC110621 Genomic DNA. No translation available.
BN000117 Genomic DNA. Translation: CAD66057.1. Sequence problems.
UniGeneMm.14130.

3D structure databases

ProteinModelPortalQ7M764.
SMRQ7M764. Positions 48-404.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000051716.

Protein family/group databases

MEROPSC19.082.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCuc029wnn.1. mouse.

Organism-specific databases

MGIMGI:3643640. Usp17le.

Phylogenomic databases

eggNOGCOG5533.
HOGENOMHOG000144638.
HOVERGENHBG007129.
PhylomeDBQ7M764.

Gene expression databases

GenevestigatorQ7M764.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF00443. UCH. 1 hit.
[Graphical view]
PROSITEPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameU17PE_MOUSE
AccessionPrimary (citable) accession number: Q7M764
Secondary accession number(s): D3YU85
Entry history
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 13, 2010
Last modified: April 16, 2014
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot