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Protein

Ubiquitin carboxyl-terminal hydrolase 17-like protein E

Gene

Usp17le

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.1 Publication

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei94NucleophilePROSITE-ProRule annotation1
Active sitei341Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processApoptosis, Cell cycle, Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.082.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 17-like protein E (EC:3.4.19.12)
Short name:
USP17-E
Alternative name(s):
Deubiquitinating enzyme 17-like protein 2
Deubiquitinating protein 3
Short name:
DUB-3
Deubiquitinating protein 6
Ubiquitin carboxyl-terminal hydrolase 17-like protein 2
Ubiquitin thioesterase 17-like protein 2
Ubiquitin-specific-processing protease 17-like protein 2
Gene namesi
Name:Usp17le
Synonyms:Dub3, Dub6, Usp17, Usp17l2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:107697. Usp17le.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_50000959631 – 540Ubiquitin carboxyl-terminal hydrolase 17-like protein EAdd BLAST540

Proteomic databases

PaxDbiQ7M764.
PRIDEiQ7M764.

Interactioni

Subunit structurei

Interacts with SUDS3; the interaction is direct.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051716.

Structurei

3D structure databases

ProteinModelPortaliQ7M764.
SMRiQ7M764.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 382USPAdd BLAST298

Sequence similaritiesi

Belongs to the peptidase C19 family. USP17 subfamily.Curated

Phylogenomic databases

eggNOGiKOG1865. Eukaryota.
ENOG410XQ92. LUCA.
HOGENOMiHOG000144638.
HOVERGENiHBG007129.
InParanoidiQ7M764.
PhylomeDBiQ7M764.

Family and domain databases

InterProiView protein in InterPro
IPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
PfamiView protein in Pfam
PF00443. UCH. 1 hit.
PROSITEiView protein in PROSITE
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7M764-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVSLSFPEE TGGENLPSAP LEDSSKFFEE VFGDMVFARS FPEADPALSS
60 70 80 90 100
PDAPELHQDE AQVVEELTTN GKHSLSWESP QGPGCGLQNT GNSCYLNAAL
110 120 130 140 150
QCLTHTPPLA DYMLSQEHSQ TCCSPEGCKM CAMEAHVTQS LLHSHSGDVM
160 170 180 190 200
KPSQILTSAF HKHQQEDAHE FLMFTLETMH ESCLQVHRQS DPTPQDTSPI
210 220 230 240 250
HDIFGGWWRS QIKCLHCQGT SHTFDPFLDV PLDISSAQSV NQALWDTGKS
260 270 280 290 300
EELLGENAYY CGRCRQKMPA SKTLHVHIAP KVLLLVLKRF SAFTGNKLDR
310 320 330 340 350
KVSYPEFLDL KPYLSEPTGG PLPYALYAVL VHDGATSNSG HYFCCVKAGH
360 370 380 390 400
GKWYKMDDTK VTRCDVTSVL NENAYVLFYV QQTDLKQVSI DMPEGRVHEV
410 420 430 440 450
LDPKYQLKKS RRKKRKKQCH CTDDAGEACE NREKRAKKET SLGEGKVPQE
460 470 480 490 500
VNHEKAGQKH GNTKLVPQEQ NHQRAGQNLR NTEVELDLPV DAIVIHQPRS
510 520 530 540
TANWGTDAPD KENQPWHNGD RLLTSQGLMS PGQLCSQGGR
Length:540
Mass (Da):60,219
Last modified:July 13, 2010 - v2
Checksum:iC71382D289659704
GO

Sequence cautioni

The sequence CAD66057 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC110621 Genomic DNA. No translation available.
BN000117 Genomic DNA. Translation: CAD66057.1. Sequence problems.
CCDSiCCDS85368.1.
UniGeneiMm.14130.

Genome annotation databases

UCSCiuc029wnn.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiU17PE_MOUSE
AccessioniPrimary (citable) accession number: Q7M764
Secondary accession number(s): D3YU85
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 13, 2010
Last modified: August 30, 2017
This is version 80 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families