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Q7M764

- U17PE_MOUSE

UniProt

Q7M764 - U17PE_MOUSE

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Protein

Ubiquitin carboxyl-terminal hydrolase 17-like protein E

Gene
Usp17le, Dub3, Dub6, Usp17, Usp17l2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.1 Publication

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei94 – 941Nucleophile By similarity
Active sitei341 – 3411Proton acceptor By similarity

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: UniProtKB
  2. ubiquitin thiolesterase activity Source: UniProtKB

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. CAAX-box protein processing Source: UniProtKB
  3. cell cycle checkpoint Source: UniProtKB
  4. mitotic cell cycle checkpoint Source: UniProtKB
  5. negative regulation of histone deacetylation Source: UniProtKB
  6. negative regulation of protein processing Source: UniProtKB
  7. negative regulation of protein targeting to membrane Source: UniProtKB
  8. negative regulation of Ras GTPase activity Source: UniProtKB
  9. positive regulation of MDA-5 signaling pathway Source: UniProtKB
  10. positive regulation of Rho GTPase activity Source: UniProtKB
  11. positive regulation of RIG-I signaling pathway Source: UniProtKB
  12. protein deubiquitination Source: UniProtKB
  13. protein K48-linked deubiquitination Source: UniProtKB
  14. protein K63-linked deubiquitination Source: UniProtKB
  15. regulation of apoptotic process Source: UniProtKB
  16. regulation of cell migration Source: UniProtKB
  17. regulation of cell proliferation Source: UniProtKB
  18. regulation of defense response to virus by host Source: UniProtKB
  19. regulation of ruffle assembly Source: UniProtKB
  20. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Apoptosis, Cell cycle, Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.082.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 17-like protein E (EC:3.4.19.12)
Short name:
USP17-E
Alternative name(s):
Deubiquitinating enzyme 17-like protein 2
Deubiquitinating protein 3
Short name:
DUB-3
Deubiquitinating protein 6
Ubiquitin carboxyl-terminal hydrolase 17-like protein 2
Ubiquitin thioesterase 17-like protein 2
Ubiquitin-specific-processing protease 17-like protein 2
Gene namesi
Name:Usp17le
Synonyms:Dub3, Dub6, Usp17, Usp17l2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:3643640. Usp17le.

Subcellular locationi

Nucleus By similarity. Endoplasmic reticulum By similarity

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 540540Ubiquitin carboxyl-terminal hydrolase 17-like protein EPRO_5000095963Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriQ7M764.

Interactioni

Subunit structurei

Interacts with SUDS3; the interaction is direct By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051716.

Structurei

3D structure databases

ProteinModelPortaliQ7M764.
SMRiQ7M764. Positions 48-404.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini85 – 382298USPAdd
BLAST

Sequence similaritiesi

Contains 1 USP domain.

Phylogenomic databases

eggNOGiCOG5533.
HOGENOMiHOG000144638.
HOVERGENiHBG007129.
PhylomeDBiQ7M764.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7M764-1 [UniParc]FASTAAdd to Basket

« Hide

MVVSLSFPEE TGGENLPSAP LEDSSKFFEE VFGDMVFARS FPEADPALSS    50
PDAPELHQDE AQVVEELTTN GKHSLSWESP QGPGCGLQNT GNSCYLNAAL 100
QCLTHTPPLA DYMLSQEHSQ TCCSPEGCKM CAMEAHVTQS LLHSHSGDVM 150
KPSQILTSAF HKHQQEDAHE FLMFTLETMH ESCLQVHRQS DPTPQDTSPI 200
HDIFGGWWRS QIKCLHCQGT SHTFDPFLDV PLDISSAQSV NQALWDTGKS 250
EELLGENAYY CGRCRQKMPA SKTLHVHIAP KVLLLVLKRF SAFTGNKLDR 300
KVSYPEFLDL KPYLSEPTGG PLPYALYAVL VHDGATSNSG HYFCCVKAGH 350
GKWYKMDDTK VTRCDVTSVL NENAYVLFYV QQTDLKQVSI DMPEGRVHEV 400
LDPKYQLKKS RRKKRKKQCH CTDDAGEACE NREKRAKKET SLGEGKVPQE 450
VNHEKAGQKH GNTKLVPQEQ NHQRAGQNLR NTEVELDLPV DAIVIHQPRS 500
TANWGTDAPD KENQPWHNGD RLLTSQGLMS PGQLCSQGGR 540
Length:540
Mass (Da):60,219
Last modified:July 13, 2010 - v2
Checksum:iC71382D289659704
GO

Sequence cautioni

The sequence CAD66057.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC110621 Genomic DNA. No translation available.
BN000117 Genomic DNA. Translation: CAD66057.1. Sequence problems.
UniGeneiMm.14130.

Genome annotation databases

UCSCiuc029wnn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC110621 Genomic DNA. No translation available.
BN000117 Genomic DNA. Translation: CAD66057.1 . Sequence problems.
UniGenei Mm.14130.

3D structure databases

ProteinModelPortali Q7M764.
SMRi Q7M764. Positions 48-404.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000051716.

Protein family/group databases

MEROPSi C19.082.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi uc029wnn.1. mouse.

Organism-specific databases

MGIi MGI:3643640. Usp17le.

Phylogenomic databases

eggNOGi COG5533.
HOGENOMi HOG000144638.
HOVERGENi HBG007129.
PhylomeDBi Q7M764.

Miscellaneous databases

SOURCEi Search...

Gene expression databases

Genevestigatori Q7M764.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "Human and mouse proteases: a comparative genomic approach."
    Puente X.S., Sanchez L.M., Overall C.M., Lopez-Otin C.
    Nat. Rev. Genet. 4:544-558(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  3. "Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A."
    Pereg Y., Liu B.Y., O'Rourke K.M., Sagolla M., Dey A., Komuves L., French D.M., Dixit V.M.
    Nat. Cell Biol. 12:400-406(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiU17PE_MOUSE
AccessioniPrimary (citable) accession number: Q7M764
Secondary accession number(s): D3YU85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 13, 2010
Last modified: April 16, 2014
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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