Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

N-acetylated-alpha-linked acidic dipeptidase-like protein

Gene

Naaladl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Has no NAAG hydrolyzing activity (By similarity). Exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC (By similarity).By similarity

Catalytic activityi

Release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly-gamma-glutamates.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi373Zinc 1Sequence analysis1
Metal bindingi383Zinc 1By similarity1
Metal bindingi383Zinc 2By similarity1
Active sitei421Nucleophile; for NAALADase activityBy similarity1
Metal bindingi422Zinc 2By similarity1
Metal bindingi450Zinc 1By similarity1
Metal bindingi550Zinc 2By similarity1
Active sitei622Charge relay systemSequence analysis1
Active sitei662Charge relay systemSequence analysis1
Active sitei685Charge relay systemSequence analysis1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Dipeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM28.011.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylated-alpha-linked acidic dipeptidase-like protein (EC:3.4.17.21)
Short name:
NAALADase L
Gene namesi
Name:Naaladl1
Synonyms:Gm964, Naaladasel
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2685810. Naaladl1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6CytoplasmicSequence analysis6
Transmembranei7 – 28Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST22
Topological domaini29 – 745ExtracellularSequence analysisAdd BLAST717

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001741241 – 745N-acetylated-alpha-linked acidic dipeptidase-like proteinAdd BLAST745

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi128N-linked (GlcNAc...)Sequence analysis1
Glycosylationi141N-linked (GlcNAc...)Sequence analysis1
Glycosylationi235N-linked (GlcNAc...)Sequence analysis1
Glycosylationi279N-linked (GlcNAc...)Sequence analysis1
Glycosylationi302N-linked (GlcNAc...)Sequence analysis1
Glycosylationi329N-linked (GlcNAc...)Sequence analysis1
Glycosylationi456N-linked (GlcNAc...)Sequence analysis1
Glycosylationi497N-linked (GlcNAc...)Sequence analysis1
Glycosylationi593N-linked (GlcNAc...)Sequence analysis1
Glycosylationi620N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ7M758.
PaxDbiQ7M758.
PeptideAtlasiQ7M758.
PRIDEiQ7M758.

PTM databases

iPTMnetiQ7M758.
PhosphoSitePlusiQ7M758.

Expressioni

Gene expression databases

BgeeiENSMUSG00000054999.
GenevisibleiQ7M758. MM.

Interactioni

Protein-protein interaction databases

IntActiQ7M758. 1 interactor.
STRINGi10090.ENSMUSP00000044231.

Structurei

3D structure databases

ProteinModelPortaliQ7M758.
SMRiQ7M758.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni268 – 584NAALADaseAdd BLAST317

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi635 – 639Poly-Ala5

Sequence similaritiesi

Belongs to the peptidase M28 family. M28B subfamily.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2195. Eukaryota.
COG2234. LUCA.
GeneTreeiENSGT00550000074421.
HOGENOMiHOG000211921.
HOVERGENiHBG051639.
InParanoidiQ7M758.
KOiK01301.
OMAiTSMDLAY.
OrthoDBiEOG091G02ZM.
PhylomeDBiQ7M758.
TreeFamiTF312981.

Family and domain databases

Gene3Di1.20.930.40. 1 hit.
InterProiIPR003137. PA_domain.
IPR007484. Peptidase_M28.
IPR007365. TFR-like_dimer_dom.
[Graphical view]
PfamiPF02225. PA. 1 hit.
PF04389. Peptidase_M28. 1 hit.
PF04253. TFR_dimer. 1 hit.
[Graphical view]
SUPFAMiSSF47672. SSF47672. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7M758-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHWVKILGVA LGAAALLGLG IILGHFAIPK ATSPLTSSTS DSQDLDLAIL
60 70 80 90 100
DSVMGQLDAS RIRENLRELS KEPHVATSPR DEALVQLLLG RWKDTATGLD
110 120 130 140 150
SAKTYEYRVL LSFPNAEQPN SVEVVGPNGT TFHSFQPFEK NLTGEQAGPN
160 170 180 190 200
VLQPYAAYAP PGTPKGLLVY ANQGSEEDFK ELETQGINLE GTIALTRYGG
210 220 230 240 250
VGRGAKAINA AKHGVVGVLV YTDPGDINDG KSLPNETFPN SWRLPPSGVE
260 270 280 290 300
RGSYYEYFGD PLTPYLPAHP SSFRLDPHNT SGFPPIPTQP IGFEDARDLL
310 320 330 340 350
CNLTGTSAPA FWQGALGCEY KLGPGFEPNG SFPAGSEVKV SVHNRLELRT
360 370 380 390 400
SSNVLGIIQG AVEPDRYVIY GNHRDSWVHG AVDPSSGTAV LLEISRVLGT
410 420 430 440 450
LLKKGTWRPR RSIIFASWGA EEFGLIGSTE FTEEFLSKLQ ERTVAYINVD
460 470 480 490 500
ISVFSNATLR AQGTPPVQSV IFSATKEISA PGSSGLSIYD NWIRYTNRTS
510 520 530 540 550
PVYGLVPSLG TLGAGSDYAA FVHFLGITSM DLAYTYDRSK TSARIYPTYH
560 570 580 590 600
TAFDTFDYVE KFLDPGFSSH QAVARTAGSV LLRLSDSLFL PLNVSDYSET
610 620 630 640 650
LQSFLQAAQE ALGTQLEKQN ISLGPLVTAV ANFKAAAASL GEHILTLQKS
660 670 680 690 700
SPDPLQVRMV NDQLMLLERA FLNPRAFPEE RHYSHVLWAP NTASVDTFPG
710 720 730 740
LANAYAKAQE INSGSEAWAE VQRQLSIVVT ALEGAAATLV PVADL
Length:745
Mass (Da):80,513
Last modified:December 15, 2003 - v1
Checksum:i5DC21DFEAD6D34CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC131114 Genomic DNA. No translation available.
BN000129 mRNA. Translation: CAD67582.1.
CCDSiCCDS29494.1.
RefSeqiNP_001009546.1. NM_001009546.1.
UniGeneiMm.359041.

Genome annotation databases

EnsembliENSMUST00000044451; ENSMUSP00000044231; ENSMUSG00000054999.
GeneIDi381204.
KEGGimmu:381204.
UCSCiuc008ghk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC131114 Genomic DNA. No translation available.
BN000129 mRNA. Translation: CAD67582.1.
CCDSiCCDS29494.1.
RefSeqiNP_001009546.1. NM_001009546.1.
UniGeneiMm.359041.

3D structure databases

ProteinModelPortaliQ7M758.
SMRiQ7M758.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ7M758. 1 interactor.
STRINGi10090.ENSMUSP00000044231.

Protein family/group databases

MEROPSiM28.011.

PTM databases

iPTMnetiQ7M758.
PhosphoSitePlusiQ7M758.

Proteomic databases

MaxQBiQ7M758.
PaxDbiQ7M758.
PeptideAtlasiQ7M758.
PRIDEiQ7M758.

Protocols and materials databases

DNASUi381204.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044451; ENSMUSP00000044231; ENSMUSG00000054999.
GeneIDi381204.
KEGGimmu:381204.
UCSCiuc008ghk.1. mouse.

Organism-specific databases

CTDi10004.
MGIiMGI:2685810. Naaladl1.

Phylogenomic databases

eggNOGiKOG2195. Eukaryota.
COG2234. LUCA.
GeneTreeiENSGT00550000074421.
HOGENOMiHOG000211921.
HOVERGENiHBG051639.
InParanoidiQ7M758.
KOiK01301.
OMAiTSMDLAY.
OrthoDBiEOG091G02ZM.
PhylomeDBiQ7M758.
TreeFamiTF312981.

Miscellaneous databases

PROiQ7M758.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000054999.
GenevisibleiQ7M758. MM.

Family and domain databases

Gene3Di1.20.930.40. 1 hit.
InterProiIPR003137. PA_domain.
IPR007484. Peptidase_M28.
IPR007365. TFR-like_dimer_dom.
[Graphical view]
PfamiPF02225. PA. 1 hit.
PF04389. Peptidase_M28. 1 hit.
PF04253. TFR_dimer. 1 hit.
[Graphical view]
SUPFAMiSSF47672. SSF47672. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNALDL_MOUSE
AccessioniPrimary (citable) accession number: Q7M758
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: December 15, 2003
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.