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Protein

Hermansky-Pudlak syndrome 6 protein homolog

Gene

Hps6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Acts as cargo adapter for the dynein-dynactin motor complex to mediate the transport of lysosomes from the cell periphery to the perinuclear region. Facilitates retrograde lysosomal trafficking by linking the motor complex to lysosomes, and perinuclear positioning of lysosomes is crucial for the delivery of endocytic cargos to lysosomes, for lysosome maturation and functioning.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Hermansky-Pudlak syndrome 6 protein homolog
Alternative name(s):
Ruby-eye protein homolog
Ruby-eye-like protein
Short name:
Ru
Gene namesi
Name:Hps6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi631341. Hps6.

Subcellular locationi

  • Microsome membrane By similarity
  • Cytoplasmcytosol By similarity
  • Early endosome membrane By similarity
  • Lysosome membrane By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Endosome, Lysosome, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000840581 – 809Hermansky-Pudlak syndrome 6 protein homologAdd BLAST809

Proteomic databases

PaxDbiQ7M733.
PRIDEiQ7M733.

PTM databases

PhosphoSitePlusiQ7M733.

Expressioni

Gene expression databases

BgeeiENSRNOG00000018433.
GenevisibleiQ7M733. RN.

Interactioni

Subunit structurei

Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6. Interacts with HPS5 and HPS3. Interacts with biogenesis of lysosome-related organelles complex-1 (BLOC1) (By similarity). Interacts with AP-3 complex (PubMed:19010779). Interacts with DCTN1 and dynein intermediate chain (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024898.

Structurei

3D structure databases

SMRiQ7M733.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IKBU. Eukaryota.
ENOG41102BX. LUCA.
GeneTreeiENSGT00390000001546.
HOGENOMiHOG000237333.
HOVERGENiHBG049024.
InParanoidiQ7M733.
KOiK20192.
OMAiFELLCQC.
OrthoDBiEOG091G02CU.
PhylomeDBiQ7M733.
TreeFamiTF331635.

Family and domain databases

InterProiView protein in InterPro
IPR017218. BLOC-2_complex_Hps6_subunit.
PANTHERiPTHR14696:SF3. PTHR14696:SF3. 1 hit.
PfamiView protein in Pfam
PF15702. HPS6. 1 hit.
PIRSFiPIRSF037476. BLOC-2_complex_Hps6. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7M733-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRAGTLRLL SDLSNFTGAA RLRELLAGDP AILVRCSPDG RHLLLLRPPG
60 70 80 90 100
SPAPQLLVAV RGPGLPLERA WSEGDPSPLD VFFVPWLARP ALILVWESGL
110 120 130 140 150
TEVWGVGMEP GWKLLQSTEL CPDGGARVMA VAATRGRLVW CEERQPGVED
160 170 180 190 200
QPGQLSMAFN HCVCVKTLDT SGEAGTKLGC THILLHHCPS FGLIASRKEL
210 220 230 240 250
FLVPTSTTWP GVAHVLLIWS PSKGKVIVAA PSLGLSHSKS LNPKQGDTWD
260 270 280 290 300
FRTLLRGLPG FLSPREPLAV HTWAPSSQGL LLLDLKGKVS LVQCHGGTRT
310 320 330 340 350
VGLLQEAPVG LQGSAALGTF HGTLACVLGS TLELLDMSSG RLLERKVLST
360 370 380 390 400
DRVHLLEPPA PGVKNEEDLE TRGALRLLSA LGLFCVCWEA PQGLEVPSDK
410 420 430 440 450
DLVFEEACGY YQRRSLRGTQ LTPEELRHNS MFRAPQALAS ILQGHLPPSA
460 470 480 490 500
LLTTLRAELR DYRSIEQLKA QLVAGDDEET GWTELAEHEV ARLLRTHLTG
510 520 530 540 550
DQLAQFNTIF QALPTAAWSA TLQALQLQPD RSGRLRSQAP PDVWKKVLRA
560 570 580 590 600
PTAGKEHPNG ILPPFELLCQ CLGQLEPQWL PPFVELAQQQ GGPGWGAEGP
610 620 630 640 650
SLPLYRRALS VLGEEGKRPE ALELELLLGS GRPKAVLQAV RQLIKKEQWE
660 670 680 690 700
RALEAGLTLD SSSPLLRSEI FNLLLAEFAQ HRRLDTHLPL LCRLCPPEVA
710 720 730 740 750
PDELLLLLRT HLPDDAGATP FPEPGAEPGA EPPLTVGLVR ALLEQTGAQG
760 770 780 790 800
RSSGPVQSTF EDILWDSGTP PPTPPRGPMT TLQASDHPGQ EAWGPSGQGL

GAADVGVHS
Length:809
Mass (Da):87,463
Last modified:December 15, 2003 - v1
Checksum:iE3D6A10D877C1DBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093941 Genomic DNA. No translation available.
BK000658 Genomic DNA. Translation: DAA00971.1.
BC086975 mRNA. Translation: AAH86975.1.
RefSeqiNP_852097.1. NM_181432.2.
UniGeneiRn.69203.

Genome annotation databases

EnsembliENSRNOT00000024898; ENSRNOP00000024898; ENSRNOG00000018433.
GeneIDi309446.
KEGGirno:309446.
UCSCiRGD:631341. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093941 Genomic DNA. No translation available.
BK000658 Genomic DNA. Translation: DAA00971.1.
BC086975 mRNA. Translation: AAH86975.1.
RefSeqiNP_852097.1. NM_181432.2.
UniGeneiRn.69203.

3D structure databases

SMRiQ7M733.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024898.

PTM databases

PhosphoSitePlusiQ7M733.

Proteomic databases

PaxDbiQ7M733.
PRIDEiQ7M733.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000024898; ENSRNOP00000024898; ENSRNOG00000018433.
GeneIDi309446.
KEGGirno:309446.
UCSCiRGD:631341. rat.

Organism-specific databases

CTDi79803.
RGDi631341. Hps6.

Phylogenomic databases

eggNOGiENOG410IKBU. Eukaryota.
ENOG41102BX. LUCA.
GeneTreeiENSGT00390000001546.
HOGENOMiHOG000237333.
HOVERGENiHBG049024.
InParanoidiQ7M733.
KOiK20192.
OMAiFELLCQC.
OrthoDBiEOG091G02CU.
PhylomeDBiQ7M733.
TreeFamiTF331635.

Miscellaneous databases

PROiPR:Q7M733.

Gene expression databases

BgeeiENSRNOG00000018433.
GenevisibleiQ7M733. RN.

Family and domain databases

InterProiView protein in InterPro
IPR017218. BLOC-2_complex_Hps6_subunit.
PANTHERiPTHR14696:SF3. PTHR14696:SF3. 1 hit.
PfamiView protein in Pfam
PF15702. HPS6. 1 hit.
PIRSFiPIRSF037476. BLOC-2_complex_Hps6. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHPS6_RAT
AccessioniPrimary (citable) accession number: Q7M733
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: December 15, 2003
Last modified: June 7, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.