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Protein

Sodium channel subunit beta-4

Gene

Scn4b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the suceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel subunit beta-4
Gene namesi
Name:Scn4b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi631404. Scn4b.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 161ExtracellularSequence analysisAdd BLAST131
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
Topological domaini183 – 228CytoplasmicSequence analysisAdd BLAST46

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000001493931 – 228Sodium channel subunit beta-4Add BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi45N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi53 ↔ 131PROSITE-ProRule annotation
Disulfide bondi58Interchain; with alpha subunitPROSITE-ProRule annotation
Glycosylationi71N-linked (GlcNAc...)Sequence analysis1
Glycosylationi113N-linked (GlcNAc...)Sequence analysis1
Glycosylationi142N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Contains an interchain disulfide bond with SCN2A.
N-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ7M730.
PRIDEiQ7M730.

PTM databases

iPTMnetiQ7M730.
PhosphoSitePlusiQ7M730.
UniCarbKBiQ7M730.

Expressioni

Tissue specificityi

Expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart.1 Publication

Gene expression databases

BgeeiENSRNOG00000026679.
GenevisibleiQ7M730. RN.

Interactioni

Subunit structurei

Component of the voltage-sensitive sodium channel complex that consists of an ion-conducting pore-forming alpha subunit and one or more regulatory beta subunits. Heterooligomer with SCN2A; disulfide-linked.1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000033284.

Structurei

3D structure databases

ProteinModelPortaliQ7M730.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 148Ig-like C2-typeAdd BLAST118

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXQZ. Eukaryota.
ENOG4111PJ2. LUCA.
GeneTreeiENSGT00640000091161.
HOGENOMiHOG000048715.
HOVERGENiHBG056581.
InParanoidiQ7M730.
KOiK04848.
OMAiREKKKEC.
OrthoDBiEOG091G0MQV.
PhylomeDBiQ7M730.
TreeFamiTF331728.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR000920. Myelin_P0-rel.
[Graphical view]
PANTHERiPTHR13869. PTHR13869. 1 hit.
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7M730-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRAGNRGNT QARWLGIGLL GLFLLPMYLS LEVSVGKATT IYAINGSAIL
60 70 80 90 100
LPCTFSSCYG FENLYFRWSY NNSETSRILI DGIVKNDKSD PKVRVKDDDR
110 120 130 140 150
ITLEGSTKEK MNNISILLSD LEFSDTGRYT CFVRNPKEKD LNNSATIFLQ
160 170 180 190 200
VVDKLEEVDN TVTLIILAVV GGVIGLLVCI LLLKKLITFI LKKTREKKKE
210 220
CLVSSSGNDN TENGLPGSKA EEKPPTKV
Length:228
Mass (Da):25,247
Last modified:December 15, 2003 - v1
Checksum:i8E5A752281D25DEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC129680 Genomic DNA. No translation available.
AC129457 Genomic DNA. No translation available.
AC136555 Genomic DNA. No translation available.
AF544988 mRNA. Translation: AAO62631.1.
BK001030 mRNA. Translation: DAA01204.1.
RefSeqiNP_001008880.1. NM_001008880.1.
UniGeneiRn.22230.

Genome annotation databases

EnsembliENSRNOT00000030152; ENSRNOP00000033284; ENSRNOG00000026679.
GeneIDi315611.
KEGGirno:315611.
UCSCiRGD:631404. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC129680 Genomic DNA. No translation available.
AC129457 Genomic DNA. No translation available.
AC136555 Genomic DNA. No translation available.
AF544988 mRNA. Translation: AAO62631.1.
BK001030 mRNA. Translation: DAA01204.1.
RefSeqiNP_001008880.1. NM_001008880.1.
UniGeneiRn.22230.

3D structure databases

ProteinModelPortaliQ7M730.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000033284.

PTM databases

iPTMnetiQ7M730.
PhosphoSitePlusiQ7M730.
UniCarbKBiQ7M730.

Proteomic databases

PaxDbiQ7M730.
PRIDEiQ7M730.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000030152; ENSRNOP00000033284; ENSRNOG00000026679.
GeneIDi315611.
KEGGirno:315611.
UCSCiRGD:631404. rat.

Organism-specific databases

CTDi6330.
RGDi631404. Scn4b.

Phylogenomic databases

eggNOGiENOG410IXQZ. Eukaryota.
ENOG4111PJ2. LUCA.
GeneTreeiENSGT00640000091161.
HOGENOMiHOG000048715.
HOVERGENiHBG056581.
InParanoidiQ7M730.
KOiK04848.
OMAiREKKKEC.
OrthoDBiEOG091G0MQV.
PhylomeDBiQ7M730.
TreeFamiTF331728.

Miscellaneous databases

PROiQ7M730.

Gene expression databases

BgeeiENSRNOG00000026679.
GenevisibleiQ7M730. RN.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR000920. Myelin_P0-rel.
[Graphical view]
PANTHERiPTHR13869. PTHR13869. 1 hit.
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCN4B_RAT
AccessioniPrimary (citable) accession number: Q7M730
Secondary accession number(s): Q80Z84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: December 15, 2003
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.