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Q7M729

- SCN4B_MOUSE

UniProt

Q7M729 - SCN4B_MOUSE

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Protein

Sodium channel subunit beta-4

Gene

Scn4b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the suceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom (By similarity).By similarity

GO - Molecular functioni

  1. sodium channel regulator activity Source: UniProtKB
  2. voltage-gated sodium channel activity Source: MGI
  3. voltage-gated sodium channel activity involved in cardiac muscle cell action potential Source: Ensembl

GO - Biological processi

  1. AV node cell to bundle of His cell communication Source: Ensembl
  2. cardiac muscle cell action potential involved in contraction Source: Ensembl
  3. cardiac muscle contraction Source: Ensembl
  4. positive regulation of sodium ion transport Source: Ensembl
  5. regulation of heart rate by cardiac conduction Source: Ensembl
  6. regulation of sodium ion transmembrane transporter activity Source: UniProtKB
  7. regulation of ventricular cardiac muscle cell membrane repolarization Source: Ensembl
  8. sodium ion transmembrane transport Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel subunit beta-4
Gene namesi
Name:Scn4b
Synonyms:Gm1471
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:2687406. Scn4b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 161131ExtracellularSequence AnalysisAdd
BLAST
Transmembranei162 – 18221HelicalSequence AnalysisAdd
BLAST
Topological domaini183 – 22846CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. intercalated disc Source: BHF-UCL
  2. intrinsic component of plasma membrane Source: UniProtKB
  3. voltage-gated sodium channel complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence AnalysisAdd
BLAST
Chaini31 – 228198Sodium channel subunit beta-4PRO_0000014938Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi45 – 451N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi53 ↔ 131PROSITE-ProRule annotation
Disulfide bondi58 – 58Interchain; with alpha subunitPROSITE-ProRule annotation
Glycosylationi71 – 711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi142 – 1421N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Contains an interchain disulfide bond with SCN2A.By similarity
N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ7M729.

PTM databases

PhosphoSiteiQ7M729.

Expressioni

Gene expression databases

BgeeiQ7M729.
CleanExiMM_SCN4B.
ExpressionAtlasiQ7M729. baseline and differential.
GenevestigatoriQ7M729.

Interactioni

Subunit structurei

Component of the voltage-sensitive sodium channel complex that consists of an ion-conducting pore-forming alpha subunit and one or more regulatory beta subunits. Heterooligomer with SCN2A; disulfide-linked (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ7M729.
SMRiQ7M729. Positions 36-155.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 148118Ig-like C2-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46712.
GeneTreeiENSGT00640000091161.
HOGENOMiHOG000048715.
HOVERGENiHBG056581.
InParanoidiQ7M729.
KOiK04848.
OMAiREKKKEC.
OrthoDBiEOG7WT42T.
PhylomeDBiQ7M729.
TreeFamiTF331728.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7M729-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRAGNRGNT QARWLGTGLL GLFLLPMYLS LEVSVGKATT IYAINGSSIL
60 70 80 90 100
LPCTFSSCYG FENLYFKWSY NNSETSRILI DGIVKNDKSD PKVRVKDDDR
110 120 130 140 150
ITLEGSTKEK TNNISILLSD LEFSDTGRYT CFVRNPKEKD LNNSATIFLQ
160 170 180 190 200
VVDKLEKVDN TVTLIILAVV GGVIGLLVCI LLLKKLITFI LKKTREKKKE
210 220
CLVSSSGNDN TENGLPGSKA EEKPPTKV
Length:228
Mass (Da):25,192
Last modified:December 15, 2003 - v1
Checksum:iBD4839047672C911
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY669079 mRNA. Translation: AAU05394.1.
AC122305 Genomic DNA. No translation available.
AC122504 Genomic DNA. No translation available.
BK001031 mRNA. Translation: DAA01205.1.
CCDSiCCDS23130.1.
RefSeqiNP_001013408.1. NM_001013390.2.
UniGeneiMm.335112.

Genome annotation databases

EnsembliENSMUST00000060125; ENSMUSP00000062507; ENSMUSG00000046480.
GeneIDi399548.
KEGGimmu:399548.
UCSCiuc009pfh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY669079 mRNA. Translation: AAU05394.1 .
AC122305 Genomic DNA. No translation available.
AC122504 Genomic DNA. No translation available.
BK001031 mRNA. Translation: DAA01205.1 .
CCDSi CCDS23130.1.
RefSeqi NP_001013408.1. NM_001013390.2.
UniGenei Mm.335112.

3D structure databases

ProteinModelPortali Q7M729.
SMRi Q7M729. Positions 36-155.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q7M729.

Proteomic databases

PRIDEi Q7M729.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000060125 ; ENSMUSP00000062507 ; ENSMUSG00000046480 .
GeneIDi 399548.
KEGGi mmu:399548.
UCSCi uc009pfh.1. mouse.

Organism-specific databases

CTDi 6330.
MGIi MGI:2687406. Scn4b.

Phylogenomic databases

eggNOGi NOG46712.
GeneTreei ENSGT00640000091161.
HOGENOMi HOG000048715.
HOVERGENi HBG056581.
InParanoidi Q7M729.
KOi K04848.
OMAi REKKKEC.
OrthoDBi EOG7WT42T.
PhylomeDBi Q7M729.
TreeFami TF331728.

Miscellaneous databases

NextBioi 406014.
PROi Q7M729.
SOURCEi Search...

Gene expression databases

Bgeei Q7M729.
CleanExi MM_SCN4B.
ExpressionAtlasi Q7M729. baseline and differential.
Genevestigatori Q7M729.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view ]
Pfami PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning of the mouse sodium channel beta 4 subunit (scn4b)."
    Puhl H.L. III, Ikeda S.R.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Swiss Webster.
    Tissue: Spinal ganglion.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2."
    Yu F.H., Westenbroek R.E., Silos-Santiago I., McCormick K.A., Lawson D., Ge P., Ferriera H., Lilly J., DiStefano P.S., Catterall W.A., Scheuer T., Curtis R.
    J. Neurosci. 23:7577-7585(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiSCN4B_MOUSE
AccessioniPrimary (citable) accession number: Q7M729
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: December 15, 2003
Last modified: October 29, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3