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Protein

Sodium channel subunit beta-4

Gene

Scn4b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the suceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel subunit beta-4
Gene namesi
Name:Scn4b
Synonyms:Gm1471
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2687406. Scn4b.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 161ExtracellularSequence analysisAdd BLAST131
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
Topological domaini183 – 228CytoplasmicSequence analysisAdd BLAST46

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000001493831 – 228Sodium channel subunit beta-4Add BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi45N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi53 ↔ 131PROSITE-ProRule annotation
Disulfide bondi58Interchain; with alpha subunitPROSITE-ProRule annotation
Glycosylationi71N-linked (GlcNAc...)Sequence analysis1
Glycosylationi113N-linked (GlcNAc...)Sequence analysis1
Glycosylationi142N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Contains an interchain disulfide bond with SCN2A.By similarity
N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ7M729.
PRIDEiQ7M729.

PTM databases

iPTMnetiQ7M729.
PhosphoSitePlusiQ7M729.

Expressioni

Gene expression databases

BgeeiENSMUSG00000046480.
CleanExiMM_SCN4B.
ExpressionAtlasiQ7M729. baseline and differential.
GenevisibleiQ7M729. MM.

Interactioni

Subunit structurei

Component of the voltage-sensitive sodium channel complex that consists of an ion-conducting pore-forming alpha subunit and one or more regulatory beta subunits. Heterooligomer with SCN2A; disulfide-linked (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062507.

Structurei

Secondary structure

1228
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi32 – 35Combined sources4
Beta strandi37 – 44Combined sources8
Beta strandi49 – 51Combined sources3
Beta strandi54 – 57Combined sources4
Beta strandi62 – 71Combined sources10
Beta strandi76 – 84Combined sources9
Beta strandi92 – 97Combined sources6
Beta strandi101 – 103Combined sources3
Beta strandi116 – 118Combined sources3
Helixi123 – 125Combined sources3
Beta strandi127 – 134Combined sources8
Beta strandi144 – 152Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5AYQX-ray1.70A/B30-160[»]
ProteinModelPortaliQ7M729.
SMRiQ7M729.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 148Ig-like C2-typeAdd BLAST118

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXQZ. Eukaryota.
ENOG4111PJ2. LUCA.
GeneTreeiENSGT00640000091161.
HOGENOMiHOG000048715.
HOVERGENiHBG056581.
InParanoidiQ7M729.
KOiK04848.
OMAiREKKKEC.
OrthoDBiEOG091G0MQV.
PhylomeDBiQ7M729.
TreeFamiTF331728.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR000920. Myelin_P0-rel.
[Graphical view]
PANTHERiPTHR13869. PTHR13869. 1 hit.
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7M729-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRAGNRGNT QARWLGTGLL GLFLLPMYLS LEVSVGKATT IYAINGSSIL
60 70 80 90 100
LPCTFSSCYG FENLYFKWSY NNSETSRILI DGIVKNDKSD PKVRVKDDDR
110 120 130 140 150
ITLEGSTKEK TNNISILLSD LEFSDTGRYT CFVRNPKEKD LNNSATIFLQ
160 170 180 190 200
VVDKLEKVDN TVTLIILAVV GGVIGLLVCI LLLKKLITFI LKKTREKKKE
210 220
CLVSSSGNDN TENGLPGSKA EEKPPTKV
Length:228
Mass (Da):25,192
Last modified:December 15, 2003 - v1
Checksum:iBD4839047672C911
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY669079 mRNA. Translation: AAU05394.1.
AC122305 Genomic DNA. No translation available.
AC122504 Genomic DNA. No translation available.
BK001031 mRNA. Translation: DAA01205.1.
CCDSiCCDS23130.1.
RefSeqiNP_001013408.1. NM_001013390.2.
UniGeneiMm.335112.

Genome annotation databases

EnsembliENSMUST00000060125; ENSMUSP00000062507; ENSMUSG00000046480.
GeneIDi399548.
KEGGimmu:399548.
UCSCiuc009pfh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY669079 mRNA. Translation: AAU05394.1.
AC122305 Genomic DNA. No translation available.
AC122504 Genomic DNA. No translation available.
BK001031 mRNA. Translation: DAA01205.1.
CCDSiCCDS23130.1.
RefSeqiNP_001013408.1. NM_001013390.2.
UniGeneiMm.335112.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5AYQX-ray1.70A/B30-160[»]
ProteinModelPortaliQ7M729.
SMRiQ7M729.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062507.

PTM databases

iPTMnetiQ7M729.
PhosphoSitePlusiQ7M729.

Proteomic databases

PaxDbiQ7M729.
PRIDEiQ7M729.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060125; ENSMUSP00000062507; ENSMUSG00000046480.
GeneIDi399548.
KEGGimmu:399548.
UCSCiuc009pfh.1. mouse.

Organism-specific databases

CTDi6330.
MGIiMGI:2687406. Scn4b.

Phylogenomic databases

eggNOGiENOG410IXQZ. Eukaryota.
ENOG4111PJ2. LUCA.
GeneTreeiENSGT00640000091161.
HOGENOMiHOG000048715.
HOVERGENiHBG056581.
InParanoidiQ7M729.
KOiK04848.
OMAiREKKKEC.
OrthoDBiEOG091G0MQV.
PhylomeDBiQ7M729.
TreeFamiTF331728.

Miscellaneous databases

PROiQ7M729.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046480.
CleanExiMM_SCN4B.
ExpressionAtlasiQ7M729. baseline and differential.
GenevisibleiQ7M729. MM.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR000920. Myelin_P0-rel.
[Graphical view]
PANTHERiPTHR13869. PTHR13869. 1 hit.
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCN4B_MOUSE
AccessioniPrimary (citable) accession number: Q7M729
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: December 15, 2003
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.