Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sodium channel subunit beta-4

Gene

Scn4b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the suceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel subunit beta-4
Gene namesi
Name:Scn4b
Synonyms:Gm1471
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2687406. Scn4b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 161131ExtracellularSequence AnalysisAdd
BLAST
Transmembranei162 – 18221HelicalSequence AnalysisAdd
BLAST
Topological domaini183 – 22846CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence AnalysisAdd
BLAST
Chaini31 – 228198Sodium channel subunit beta-4PRO_0000014938Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi45 – 451N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi53 ↔ 131PROSITE-ProRule annotation
Disulfide bondi58 – 58Interchain; with alpha subunitPROSITE-ProRule annotation
Glycosylationi71 – 711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi142 – 1421N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Contains an interchain disulfide bond with SCN2A.By similarity
N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ7M729.

PTM databases

PhosphoSiteiQ7M729.

Expressioni

Gene expression databases

BgeeiQ7M729.
CleanExiMM_SCN4B.
ExpressionAtlasiQ7M729. baseline and differential.
GenevisibleiQ7M729. MM.

Interactioni

Subunit structurei

Component of the voltage-sensitive sodium channel complex that consists of an ion-conducting pore-forming alpha subunit and one or more regulatory beta subunits. Heterooligomer with SCN2A; disulfide-linked (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062507.

Structurei

3D structure databases

ProteinModelPortaliQ7M729.
SMRiQ7M729. Positions 36-155.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 148118Ig-like C2-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46712.
GeneTreeiENSGT00640000091161.
HOGENOMiHOG000048715.
HOVERGENiHBG056581.
InParanoidiQ7M729.
KOiK04848.
OMAiREKKKEC.
OrthoDBiEOG7WT42T.
PhylomeDBiQ7M729.
TreeFamiTF331728.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR000920. Myelin_P0-rel.
[Graphical view]
PANTHERiPTHR13869. PTHR13869. 1 hit.
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7M729-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRAGNRGNT QARWLGTGLL GLFLLPMYLS LEVSVGKATT IYAINGSSIL
60 70 80 90 100
LPCTFSSCYG FENLYFKWSY NNSETSRILI DGIVKNDKSD PKVRVKDDDR
110 120 130 140 150
ITLEGSTKEK TNNISILLSD LEFSDTGRYT CFVRNPKEKD LNNSATIFLQ
160 170 180 190 200
VVDKLEKVDN TVTLIILAVV GGVIGLLVCI LLLKKLITFI LKKTREKKKE
210 220
CLVSSSGNDN TENGLPGSKA EEKPPTKV
Length:228
Mass (Da):25,192
Last modified:December 15, 2003 - v1
Checksum:iBD4839047672C911
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY669079 mRNA. Translation: AAU05394.1.
AC122305 Genomic DNA. No translation available.
AC122504 Genomic DNA. No translation available.
BK001031 mRNA. Translation: DAA01205.1.
CCDSiCCDS23130.1.
RefSeqiNP_001013408.1. NM_001013390.2.
UniGeneiMm.335112.

Genome annotation databases

EnsembliENSMUST00000060125; ENSMUSP00000062507; ENSMUSG00000046480.
GeneIDi399548.
KEGGimmu:399548.
UCSCiuc009pfh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY669079 mRNA. Translation: AAU05394.1.
AC122305 Genomic DNA. No translation available.
AC122504 Genomic DNA. No translation available.
BK001031 mRNA. Translation: DAA01205.1.
CCDSiCCDS23130.1.
RefSeqiNP_001013408.1. NM_001013390.2.
UniGeneiMm.335112.

3D structure databases

ProteinModelPortaliQ7M729.
SMRiQ7M729. Positions 36-155.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062507.

PTM databases

PhosphoSiteiQ7M729.

Proteomic databases

PRIDEiQ7M729.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060125; ENSMUSP00000062507; ENSMUSG00000046480.
GeneIDi399548.
KEGGimmu:399548.
UCSCiuc009pfh.1. mouse.

Organism-specific databases

CTDi6330.
MGIiMGI:2687406. Scn4b.

Phylogenomic databases

eggNOGiNOG46712.
GeneTreeiENSGT00640000091161.
HOGENOMiHOG000048715.
HOVERGENiHBG056581.
InParanoidiQ7M729.
KOiK04848.
OMAiREKKKEC.
OrthoDBiEOG7WT42T.
PhylomeDBiQ7M729.
TreeFamiTF331728.

Miscellaneous databases

NextBioi406014.
PROiQ7M729.
SOURCEiSearch...

Gene expression databases

BgeeiQ7M729.
CleanExiMM_SCN4B.
ExpressionAtlasiQ7M729. baseline and differential.
GenevisibleiQ7M729. MM.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR000920. Myelin_P0-rel.
[Graphical view]
PANTHERiPTHR13869. PTHR13869. 1 hit.
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning of the mouse sodium channel beta 4 subunit (scn4b)."
    Puhl H.L. III, Ikeda S.R.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Swiss Webster.
    Tissue: Spinal ganglion.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2."
    Yu F.H., Westenbroek R.E., Silos-Santiago I., McCormick K.A., Lawson D., Ge P., Ferriera H., Lilly J., DiStefano P.S., Catterall W.A., Scheuer T., Curtis R.
    J. Neurosci. 23:7577-7585(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiSCN4B_MOUSE
AccessioniPrimary (citable) accession number: Q7M729
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: December 15, 2003
Last modified: July 22, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.