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Q7M729

- SCN4B_MOUSE

UniProt

Q7M729 - SCN4B_MOUSE

Protein

Sodium channel subunit beta-4

Gene

Scn4b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the suceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom By similarity.By similarity

    GO - Molecular functioni

    1. sodium channel regulator activity Source: UniProtKB
    2. voltage-gated sodium channel activity Source: MGI
    3. voltage-gated sodium channel activity involved in cardiac muscle cell action potential Source: Ensembl

    GO - Biological processi

    1. AV node cell to bundle of His cell communication Source: Ensembl
    2. cardiac muscle cell action potential involved in contraction Source: Ensembl
    3. cardiac muscle contraction Source: Ensembl
    4. positive regulation of sodium ion transport Source: Ensembl
    5. regulation of heart rate by cardiac conduction Source: Ensembl
    6. regulation of sodium ion transmembrane transporter activity Source: UniProtKB
    7. regulation of ventricular cardiac muscle cell membrane repolarization Source: Ensembl
    8. sodium ion transmembrane transport Source: MGI

    Keywords - Molecular functioni

    Ion channel, Sodium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Sodium transport, Transport

    Keywords - Ligandi

    Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium channel subunit beta-4
    Gene namesi
    Name:Scn4b
    Synonyms:Gm1471
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:2687406. Scn4b.

    Subcellular locationi

    GO - Cellular componenti

    1. intercalated disc Source: BHF-UCL
    2. intrinsic component of plasma membrane Source: UniProtKB
    3. voltage-gated sodium channel complex Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030Sequence AnalysisAdd
    BLAST
    Chaini31 – 228198Sodium channel subunit beta-4PRO_0000014938Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi45 – 451N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi53 ↔ 131PROSITE-ProRule annotation
    Disulfide bondi58 – 58Interchain; with alpha subunitPROSITE-ProRule annotation
    Glycosylationi71 – 711N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi142 – 1421N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Contains an interchain disulfide bond with SCN2A.By similarity
    N-glycosylated.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ7M729.

    PTM databases

    PhosphoSiteiQ7M729.

    Expressioni

    Gene expression databases

    BgeeiQ7M729.
    CleanExiMM_SCN4B.
    GenevestigatoriQ7M729.

    Interactioni

    Subunit structurei

    Component of the voltage-sensitive sodium channel complex that consists of an ion-conducting pore-forming alpha subunit and one or more regulatory beta subunits. Heterooligomer with SCN2A; disulfide-linked By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ7M729.
    SMRiQ7M729. Positions 36-155.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini31 – 161131ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini183 – 22846CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei162 – 18221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini31 – 148118Ig-like C2-typeAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46712.
    GeneTreeiENSGT00640000091161.
    HOGENOMiHOG000048715.
    HOVERGENiHBG056581.
    InParanoidiQ7M729.
    KOiK04848.
    OMAiREKKKEC.
    OrthoDBiEOG7WT42T.
    PhylomeDBiQ7M729.
    TreeFamiTF331728.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view]
    PfamiPF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q7M729-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRAGNRGNT QARWLGTGLL GLFLLPMYLS LEVSVGKATT IYAINGSSIL    50
    LPCTFSSCYG FENLYFKWSY NNSETSRILI DGIVKNDKSD PKVRVKDDDR 100
    ITLEGSTKEK TNNISILLSD LEFSDTGRYT CFVRNPKEKD LNNSATIFLQ 150
    VVDKLEKVDN TVTLIILAVV GGVIGLLVCI LLLKKLITFI LKKTREKKKE 200
    CLVSSSGNDN TENGLPGSKA EEKPPTKV 228
    Length:228
    Mass (Da):25,192
    Last modified:December 15, 2003 - v1
    Checksum:iBD4839047672C911
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY669079 mRNA. Translation: AAU05394.1.
    AC122305 Genomic DNA. No translation available.
    AC122504 Genomic DNA. No translation available.
    BK001031 mRNA. Translation: DAA01205.1.
    CCDSiCCDS23130.1.
    RefSeqiNP_001013408.1. NM_001013390.2.
    UniGeneiMm.335112.

    Genome annotation databases

    EnsembliENSMUST00000060125; ENSMUSP00000062507; ENSMUSG00000046480.
    GeneIDi399548.
    KEGGimmu:399548.
    UCSCiuc009pfh.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY669079 mRNA. Translation: AAU05394.1 .
    AC122305 Genomic DNA. No translation available.
    AC122504 Genomic DNA. No translation available.
    BK001031 mRNA. Translation: DAA01205.1 .
    CCDSi CCDS23130.1.
    RefSeqi NP_001013408.1. NM_001013390.2.
    UniGenei Mm.335112.

    3D structure databases

    ProteinModelPortali Q7M729.
    SMRi Q7M729. Positions 36-155.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q7M729.

    Proteomic databases

    PRIDEi Q7M729.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000060125 ; ENSMUSP00000062507 ; ENSMUSG00000046480 .
    GeneIDi 399548.
    KEGGi mmu:399548.
    UCSCi uc009pfh.1. mouse.

    Organism-specific databases

    CTDi 6330.
    MGIi MGI:2687406. Scn4b.

    Phylogenomic databases

    eggNOGi NOG46712.
    GeneTreei ENSGT00640000091161.
    HOGENOMi HOG000048715.
    HOVERGENi HBG056581.
    InParanoidi Q7M729.
    KOi K04848.
    OMAi REKKKEC.
    OrthoDBi EOG7WT42T.
    PhylomeDBi Q7M729.
    TreeFami TF331728.

    Miscellaneous databases

    NextBioi 406014.
    PROi Q7M729.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q7M729.
    CleanExi MM_SCN4B.
    Genevestigatori Q7M729.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view ]
    Pfami PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning of the mouse sodium channel beta 4 subunit (scn4b)."
      Puhl H.L. III, Ikeda S.R.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Swiss Webster.
      Tissue: Spinal ganglion.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2."
      Yu F.H., Westenbroek R.E., Silos-Santiago I., McCormick K.A., Lawson D., Ge P., Ferriera H., Lilly J., DiStefano P.S., Catterall W.A., Scheuer T., Curtis R.
      J. Neurosci. 23:7577-7585(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiSCN4B_MOUSE
    AccessioniPrimary (citable) accession number: Q7M729
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 4, 2005
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3