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Q7M722 (TR114_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Taste receptor type 2 member 114

Short name=T2R114
Short name=mT2R46
Gene names
Name:Tas2r114
Synonyms:T2r46
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Putative taste receptor which may play a role in the perception of bitterness.

Subcellular location

Membrane; Multi-pass membrane protein.

Miscellaneous

Several bitter taste receptors are expressed in a single taste receptor cell.

Sequence similarities

Belongs to the G-protein coupled receptor T2R family.

Ontologies

Keywords
   Biological processSensory transduction
Taste
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processsensory perception of taste

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionG-protein coupled receptor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 309309Taste receptor type 2 member 114
PRO_0000248473

Regions

Topological domain1 – 77Extracellular Potential
Transmembrane8 – 2821Helical; Name=1; Potential
Topological domain29 – 4315Cytoplasmic Potential
Transmembrane44 – 6421Helical; Name=2; Potential
Topological domain65 – 8723Extracellular Potential
Transmembrane88 – 10821Helical; Name=3; Potential
Topological domain109 – 12719Cytoplasmic Potential
Transmembrane128 – 14821Helical; Name=4; Potential
Topological domain149 – 18234Extracellular Potential
Transmembrane183 – 20321Helical; Name=5; Potential
Topological domain204 – 23330Cytoplasmic Potential
Transmembrane234 – 25421Helical; Name=6; Potential
Topological domain255 – 2595Extracellular Potential
Transmembrane260 – 28021Helical; Name=7; Potential
Topological domain281 – 30929Cytoplasmic Potential

Amino acid modifications

Glycosylation1611N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q7M722 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: D6456A379D5EEE64

FASTA30935,732
        10         20         30         40         50         60 
MLSTMEGVLL SVSTSEAVLG IVGNTFIALV NCMDYNRNKK LSNIGFILTG LAISRICLVL 

        70         80         90        100        110        120 
ILITEAYIKI FYPQLLSPVN IIELISYLWI IICQLNVWFA TSLSIFYFLK IANFSHYIFV 

       130        140        150        160        170        180 
WLKRRIDLVF FFLIGCLLIS WLFSFPVVAK MVKDNKMLYI NTSWQIHMKK SELIINYVFT 

       190        200        210        220        230        240 
NGGVFLFFMI MLIVCFLLII SLWRHRRQME SNKLGFRDLN TEVHVRTIKV LLSFIILFIL 

       250        260        270        280        290        300 
HFMGITINVI CLLIPESNLL FMFGLTTAFI YPGCHSLILI LANSRLKQCS VMILQLLKCC 


ENGKELRDT 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC129318 Genomic DNA. No translation available.
BK001075 Genomic DNA. Translation: DAA01214.1.
CCDSCCDS20613.1.
RefSeqNP_996902.1. NM_207019.1.
UniGeneMm.377908.

3D structure databases

ProteinModelPortalQ7M722.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PRIDEQ7M722.

Protocols and materials databases

DNASU387346.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000080619; ENSMUSP00000079453; ENSMUSG00000063478.
GeneID387346.
KEGGmmu:387346.
UCSCuc009eja.1. mouse.

Organism-specific databases

CTD387346.
MGIMGI:2681218. Tas2r114.

Phylogenomic databases

eggNOGNOG46344.
GeneTreeENSGT00560000076963.
HOGENOMHOG000234595.
HOVERGENHBG060698.
InParanoidQ7M722.
KOK08474.
OMACHSLILI.
OrthoDBEOG744T9S.
PhylomeDBQ7M722.
TreeFamTF335891.

Gene expression databases

CleanExMM_TAS2R114.
GenevestigatorQ7M722.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR017452. GPCR_Rhodpsn_7TM.
IPR007960. TAS2_rcpt.
[Graphical view]
PfamPF05296. TAS2R. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio405854.
PROQ7M722.
SOURCESearch...

Entry information

Entry nameTR114_MOUSE
AccessionPrimary (citable) accession number: Q7M722
Entry history
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: December 15, 2003
Last modified: July 9, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries