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Q7M722

- TR114_MOUSE

UniProt

Q7M722 - TR114_MOUSE

Protein

Taste receptor type 2 member 114

Gene

Tas2r114

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    Putative taste receptor which may play a role in the perception of bitterness.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. sensory perception of taste Source: UniProtKB-KW

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Sensory transduction, Taste

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Taste receptor type 2 member 114
    Short name:
    T2R114
    Short name:
    mT2R46
    Gene namesi
    Name:Tas2r114Imported
    Synonyms:T2r461 Publication
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:2681218. Tas2r114.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 309309Taste receptor type 2 member 114PRO_0000248473Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ7M722.

    Expressioni

    Gene expression databases

    CleanExiMM_TAS2R114.
    GenevestigatoriQ7M722.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7M722.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 77ExtracellularSequence Analysis
    Topological domaini29 – 4315CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini65 – 8723ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini109 – 12719CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini149 – 18234ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini204 – 23330CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini255 – 2595ExtracellularSequence Analysis
    Topological domaini281 – 30929CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 2821Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei44 – 6421Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei88 – 10821Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei128 – 14821Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei183 – 20321Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei234 – 25421Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei260 – 28021Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor T2R family.Sequence Analysis

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46344.
    GeneTreeiENSGT00560000076963.
    HOGENOMiHOG000234595.
    HOVERGENiHBG060698.
    InParanoidiQ7M722.
    KOiK08474.
    OMAiCHSLILI.
    OrthoDBiEOG744T9S.
    PhylomeDBiQ7M722.
    TreeFamiTF335891.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR017452. GPCR_Rhodpsn_7TM.
    IPR007960. TAS2_rcpt.
    [Graphical view]
    PfamiPF05296. TAS2R. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7M722-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSTMEGVLL SVSTSEAVLG IVGNTFIALV NCMDYNRNKK LSNIGFILTG    50
    LAISRICLVL ILITEAYIKI FYPQLLSPVN IIELISYLWI IICQLNVWFA 100
    TSLSIFYFLK IANFSHYIFV WLKRRIDLVF FFLIGCLLIS WLFSFPVVAK 150
    MVKDNKMLYI NTSWQIHMKK SELIINYVFT NGGVFLFFMI MLIVCFLLII 200
    SLWRHRRQME SNKLGFRDLN TEVHVRTIKV LLSFIILFIL HFMGITINVI 250
    CLLIPESNLL FMFGLTTAFI YPGCHSLILI LANSRLKQCS VMILQLLKCC 300
    ENGKELRDT 309
    Length:309
    Mass (Da):35,732
    Last modified:December 15, 2003 - v1
    Checksum:iD6456A379D5EEE64
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC129318 Genomic DNA. No translation available.
    BK001075 Genomic DNA. Translation: DAA01214.1.
    CCDSiCCDS20613.1.
    RefSeqiNP_996902.1. NM_207019.1.
    UniGeneiMm.377908.

    Genome annotation databases

    EnsembliENSMUST00000080619; ENSMUSP00000079453; ENSMUSG00000063478.
    GeneIDi387346.
    KEGGimmu:387346.
    UCSCiuc009eja.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC129318 Genomic DNA. No translation available.
    BK001075 Genomic DNA. Translation: DAA01214.1 .
    CCDSi CCDS20613.1.
    RefSeqi NP_996902.1. NM_207019.1.
    UniGenei Mm.377908.

    3D structure databases

    ProteinModelPortali Q7M722.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PRIDEi Q7M722.

    Protocols and materials databases

    DNASUi 387346.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000080619 ; ENSMUSP00000079453 ; ENSMUSG00000063478 .
    GeneIDi 387346.
    KEGGi mmu:387346.
    UCSCi uc009eja.1. mouse.

    Organism-specific databases

    CTDi 387346.
    MGIi MGI:2681218. Tas2r114.

    Phylogenomic databases

    eggNOGi NOG46344.
    GeneTreei ENSGT00560000076963.
    HOGENOMi HOG000234595.
    HOVERGENi HBG060698.
    InParanoidi Q7M722.
    KOi K08474.
    OMAi CHSLILI.
    OrthoDBi EOG744T9S.
    PhylomeDBi Q7M722.
    TreeFami TF335891.

    Miscellaneous databases

    NextBioi 405854.
    PROi Q7M722.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_TAS2R114.
    Genevestigatori Q7M722.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR017452. GPCR_Rhodpsn_7TM.
    IPR007960. TAS2_rcpt.
    [Graphical view ]
    Pfami PF05296. TAS2R. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "Adaptive diversification of bitter taste receptor genes in mammalian evolution."
      Shi P., Zhang J., Yang H., Zhang Y.-P.
      Mol. Biol. Evol. 20:805-814(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiTR114_MOUSE
    AccessioniPrimary (citable) accession number: Q7M722
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 5, 2006
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Several bitter taste receptors are expressed in a single taste receptor cell.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3