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Protein

Taste receptor type 2 member 114

Gene

Tas2r114

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Putative taste receptor which may play a role in the perception of bitterness.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

ReactomeiREACT_331048. G alpha (i) signalling events.
REACT_336829. Class C/3 (Metabotropic glutamate/pheromone receptors).

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 114
Short name:
T2R114
Short name:
mT2R46
Gene namesi
Name:Tas2r114Imported
Synonyms:T2r461 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2681218. Tas2r114.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77ExtracellularSequence Analysis
Transmembranei8 – 2821Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini29 – 4315CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei44 – 6421Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini65 – 8723ExtracellularSequence AnalysisAdd
BLAST
Transmembranei88 – 10821Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini109 – 12719CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei128 – 14821Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini149 – 18234ExtracellularSequence AnalysisAdd
BLAST
Transmembranei183 – 20321Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini204 – 23330CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei234 – 25421Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini255 – 2595ExtracellularSequence Analysis
Transmembranei260 – 28021Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini281 – 30929CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Taste receptor type 2 member 114PRO_0000248473Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ7M722.

Expressioni

Gene expression databases

CleanExiMM_TAS2R114.
GenevestigatoriQ7M722.

Structurei

3D structure databases

ProteinModelPortaliQ7M722.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor T2R family.Sequence Analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46344.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
InParanoidiQ7M722.
KOiK08474.
OMAiCHSLILI.
OrthoDBiEOG744T9S.
PhylomeDBiQ7M722.
TreeFamiTF335891.

Family and domain databases

InterProiIPR007960. T2R.
[Graphical view]
PANTHERiPTHR11394. PTHR11394. 1 hit.
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7M722-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSTMEGVLL SVSTSEAVLG IVGNTFIALV NCMDYNRNKK LSNIGFILTG
60 70 80 90 100
LAISRICLVL ILITEAYIKI FYPQLLSPVN IIELISYLWI IICQLNVWFA
110 120 130 140 150
TSLSIFYFLK IANFSHYIFV WLKRRIDLVF FFLIGCLLIS WLFSFPVVAK
160 170 180 190 200
MVKDNKMLYI NTSWQIHMKK SELIINYVFT NGGVFLFFMI MLIVCFLLII
210 220 230 240 250
SLWRHRRQME SNKLGFRDLN TEVHVRTIKV LLSFIILFIL HFMGITINVI
260 270 280 290 300
CLLIPESNLL FMFGLTTAFI YPGCHSLILI LANSRLKQCS VMILQLLKCC

ENGKELRDT
Length:309
Mass (Da):35,732
Last modified:December 15, 2003 - v1
Checksum:iD6456A379D5EEE64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC129318 Genomic DNA. No translation available.
BK001075 Genomic DNA. Translation: DAA01214.1.
CCDSiCCDS20613.1.
RefSeqiNP_996902.1. NM_207019.1.
UniGeneiMm.377908.

Genome annotation databases

EnsembliENSMUST00000080619; ENSMUSP00000079453; ENSMUSG00000063478.
GeneIDi387346.
KEGGimmu:387346.
UCSCiuc009eja.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC129318 Genomic DNA. No translation available.
BK001075 Genomic DNA. Translation: DAA01214.1.
CCDSiCCDS20613.1.
RefSeqiNP_996902.1. NM_207019.1.
UniGeneiMm.377908.

3D structure databases

ProteinModelPortaliQ7M722.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PRIDEiQ7M722.

Protocols and materials databases

DNASUi387346.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000080619; ENSMUSP00000079453; ENSMUSG00000063478.
GeneIDi387346.
KEGGimmu:387346.
UCSCiuc009eja.1. mouse.

Organism-specific databases

CTDi387346.
MGIiMGI:2681218. Tas2r114.

Phylogenomic databases

eggNOGiNOG46344.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
InParanoidiQ7M722.
KOiK08474.
OMAiCHSLILI.
OrthoDBiEOG744T9S.
PhylomeDBiQ7M722.
TreeFamiTF335891.

Enzyme and pathway databases

ReactomeiREACT_331048. G alpha (i) signalling events.
REACT_336829. Class C/3 (Metabotropic glutamate/pheromone receptors).

Miscellaneous databases

NextBioi405854.
PROiQ7M722.
SOURCEiSearch...

Gene expression databases

CleanExiMM_TAS2R114.
GenevestigatoriQ7M722.

Family and domain databases

InterProiIPR007960. T2R.
[Graphical view]
PANTHERiPTHR11394. PTHR11394. 1 hit.
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "Adaptive diversification of bitter taste receptor genes in mammalian evolution."
    Shi P., Zhang J., Yang H., Zhang Y.-P.
    Mol. Biol. Evol. 20:805-814(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiTR114_MOUSE
AccessioniPrimary (citable) accession number: Q7M722
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: December 15, 2003
Last modified: April 29, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Several bitter taste receptors are expressed in a single taste receptor cell.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.