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Q7M722

- TR114_MOUSE

UniProt

Q7M722 - TR114_MOUSE

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Protein

Taste receptor type 2 member 114

Gene
Tas2r114, T2r46
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Putative taste receptor which may play a role in the perception of bitterness.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW

GO - Biological processi

  1. sensory perception of taste Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 114
Short name:
T2R114
Short name:
mT2R46
Gene namesi
Name:Tas2r114
Synonyms:T2r46
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:2681218. Tas2r114.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77Extracellular Reviewed prediction
Transmembranei8 – 2821Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini29 – 4315Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei44 – 6421Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini65 – 8723Extracellular Reviewed predictionAdd
BLAST
Transmembranei88 – 10821Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini109 – 12719Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei128 – 14821Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini149 – 18234Extracellular Reviewed predictionAdd
BLAST
Transmembranei183 – 20321Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini204 – 23330Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei234 – 25421Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini255 – 2595Extracellular Reviewed prediction
Transmembranei260 – 28021Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini281 – 30929Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Taste receptor type 2 member 114PRO_0000248473Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi161 – 1611N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ7M722.

Expressioni

Gene expression databases

CleanExiMM_TAS2R114.
GenevestigatoriQ7M722.

Structurei

3D structure databases

ProteinModelPortaliQ7M722.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46344.
GeneTreeiENSGT00560000076963.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
InParanoidiQ7M722.
KOiK08474.
OMAiCHSLILI.
OrthoDBiEOG744T9S.
PhylomeDBiQ7M722.
TreeFamiTF335891.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR007960. TAS2_rcpt.
[Graphical view]
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7M722-1 [UniParc]FASTAAdd to Basket

« Hide

MLSTMEGVLL SVSTSEAVLG IVGNTFIALV NCMDYNRNKK LSNIGFILTG    50
LAISRICLVL ILITEAYIKI FYPQLLSPVN IIELISYLWI IICQLNVWFA 100
TSLSIFYFLK IANFSHYIFV WLKRRIDLVF FFLIGCLLIS WLFSFPVVAK 150
MVKDNKMLYI NTSWQIHMKK SELIINYVFT NGGVFLFFMI MLIVCFLLII 200
SLWRHRRQME SNKLGFRDLN TEVHVRTIKV LLSFIILFIL HFMGITINVI 250
CLLIPESNLL FMFGLTTAFI YPGCHSLILI LANSRLKQCS VMILQLLKCC 300
ENGKELRDT 309
Length:309
Mass (Da):35,732
Last modified:December 15, 2003 - v1
Checksum:iD6456A379D5EEE64
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC129318 Genomic DNA. No translation available.
BK001075 Genomic DNA. Translation: DAA01214.1.
CCDSiCCDS20613.1.
RefSeqiNP_996902.1. NM_207019.1.
UniGeneiMm.377908.

Genome annotation databases

EnsembliENSMUST00000080619; ENSMUSP00000079453; ENSMUSG00000063478.
GeneIDi387346.
KEGGimmu:387346.
UCSCiuc009eja.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC129318 Genomic DNA. No translation available.
BK001075 Genomic DNA. Translation: DAA01214.1 .
CCDSi CCDS20613.1.
RefSeqi NP_996902.1. NM_207019.1.
UniGenei Mm.377908.

3D structure databases

ProteinModelPortali Q7M722.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PRIDEi Q7M722.

Protocols and materials databases

DNASUi 387346.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000080619 ; ENSMUSP00000079453 ; ENSMUSG00000063478 .
GeneIDi 387346.
KEGGi mmu:387346.
UCSCi uc009eja.1. mouse.

Organism-specific databases

CTDi 387346.
MGIi MGI:2681218. Tas2r114.

Phylogenomic databases

eggNOGi NOG46344.
GeneTreei ENSGT00560000076963.
HOGENOMi HOG000234595.
HOVERGENi HBG060698.
InParanoidi Q7M722.
KOi K08474.
OMAi CHSLILI.
OrthoDBi EOG744T9S.
PhylomeDBi Q7M722.
TreeFami TF335891.

Miscellaneous databases

NextBioi 405854.
PROi Q7M722.
SOURCEi Search...

Gene expression databases

CleanExi MM_TAS2R114.
Genevestigatori Q7M722.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR017452. GPCR_Rhodpsn_7TM.
IPR007960. TAS2_rcpt.
[Graphical view ]
Pfami PF05296. TAS2R. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "Adaptive diversification of bitter taste receptor genes in mammalian evolution."
    Shi P., Zhang J., Yang H., Zhang Y.-P.
    Mol. Biol. Evol. 20:805-814(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiTR114_MOUSE
AccessioniPrimary (citable) accession number: Q7M722
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: December 15, 2003
Last modified: July 9, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Several bitter taste receptors are expressed in a single taste receptor cell.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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