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Q7M720

- T2R13_MOUSE

UniProt

Q7M720 - T2R13_MOUSE

Protein

Taste receptor type 2 member 13

Gene

Tas2r13

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 By similarity.By similarity

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. sensory perception of taste Source: UniProtKB-KW

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Sensory transduction, Taste

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Taste receptor type 2 member 13
    Short name:
    T2R13
    Alternative name(s):
    Taste receptor type 2 member 121
    Short name:
    T2R121
    Short name:
    mT2R48
    Gene namesi
    Name:Tas2r13By similarity
    Synonyms:Tas2r121Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:2681259. Tas2r121.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 305305Taste receptor type 2 member 13PRO_0000082252Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi162 – 1621N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ7M720.

    Expressioni

    Gene expression databases

    CleanExiMM_TAS2R121.
    GenevestigatoriQ7M720.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000093044.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7M720.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 77ExtracellularSequence Analysis
    Topological domaini29 – 4315CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini65 – 8824ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini110 – 12819CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini150 – 18233ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini204 – 23229CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini254 – 2629ExtracellularSequence Analysis
    Topological domaini284 – 30522CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 2821Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei44 – 6421Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei89 – 10921Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei129 – 14921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei183 – 20321Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei233 – 25321Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei263 – 28321Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor T2R family.Sequence Analysis

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG42620.
    GeneTreeiENSGT00560000076963.
    HOGENOMiHOG000234595.
    HOVERGENiHBG060698.
    InParanoidiQ7M720.
    KOiK08474.
    OMAiLNLIQIN.
    OrthoDBiEOG741Z3C.
    PhylomeDBiQ7M720.
    TreeFamiTF335891.

    Family and domain databases

    InterProiIPR017452. GPCR_Rhodpsn_7TM.
    IPR007960. TAS2_rcpt.
    [Graphical view]
    PfamiPF05296. TAS2R. 1 hit.
    [Graphical view]
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7M720-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSNVYGILT MVMIAEFVFG NMSNGFIVLI NCIDWVRKGT LSSIGWILLF    50
    LAISRMVLIW EMLITWIKYM KYSFSFVTGT ELRGIMFTWV ISNHFSLWLA 100
    TILSIFYLLK IASFSKPVFL YLKWREKKVL LIVLLGNLIF LMLNILQINK 150
    HIEHWMYQYE RNITWSSRVS DFAGFSNLVL LEMIVFSVTP FTVALVSFIL 200
    LIFSLWKHLQ KMHLNSRGER DPSTKAHVNA LRIMVSFLLL YATYFISFFL 250
    SLIPMAHKTR LGLMFSITVG LFYPSSHSFI LILGHSNLRQ ASLWVMTYLK 300
    CGQKH 305
    Length:305
    Mass (Da):35,521
    Last modified:December 15, 2003 - v1
    Checksum:iB97DB33A6DD6FAA7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC124523 Genomic DNA. No translation available.
    BC104410 mRNA. Translation: AAI04411.1.
    BC104411 mRNA. Translation: AAI04412.1.
    BK001077 Genomic DNA. Translation: DAA01216.1.
    CCDSiCCDS20618.1.
    RefSeqiNP_996907.1. NM_207024.1.
    UniGeneiMm.377911.

    Genome annotation databases

    EnsembliENSMUST00000095395; ENSMUSP00000093044; ENSMUSG00000071150.
    GeneIDi387349.
    KEGGimmu:387349.
    UCSCiuc009ejj.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC124523 Genomic DNA. No translation available.
    BC104410 mRNA. Translation: AAI04411.1 .
    BC104411 mRNA. Translation: AAI04412.1 .
    BK001077 Genomic DNA. Translation: DAA01216.1 .
    CCDSi CCDS20618.1.
    RefSeqi NP_996907.1. NM_207024.1.
    UniGenei Mm.377911.

    3D structure databases

    ProteinModelPortali Q7M720.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000093044.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PRIDEi Q7M720.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000095395 ; ENSMUSP00000093044 ; ENSMUSG00000071150 .
    GeneIDi 387349.
    KEGGi mmu:387349.
    UCSCi uc009ejj.1. mouse.

    Organism-specific databases

    CTDi 387349.
    MGIi MGI:2681259. Tas2r121.

    Phylogenomic databases

    eggNOGi NOG42620.
    GeneTreei ENSGT00560000076963.
    HOGENOMi HOG000234595.
    HOVERGENi HBG060698.
    InParanoidi Q7M720.
    KOi K08474.
    OMAi LNLIQIN.
    OrthoDBi EOG741Z3C.
    PhylomeDBi Q7M720.
    TreeFami TF335891.

    Miscellaneous databases

    NextBioi 405866.
    PROi Q7M720.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_TAS2R121.
    Genevestigatori Q7M720.

    Family and domain databases

    InterProi IPR017452. GPCR_Rhodpsn_7TM.
    IPR007960. TAS2_rcpt.
    [Graphical view ]
    Pfami PF05296. TAS2R. 1 hit.
    [Graphical view ]
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Adaptive diversification of bitter taste receptor genes in mammalian evolution."
      Shi P., Zhang J., Yang H., Zhang Y.-P.
      Mol. Biol. Evol. 20:805-814(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiT2R13_MOUSE
    AccessioniPrimary (citable) accession number: Q7M720
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3