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Q7M720

- T2R13_MOUSE

UniProt

Q7M720 - T2R13_MOUSE

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Protein
Taste receptor type 2 member 13
Gene
Tas2r13, Tas2r121
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 By similarity.By similarity

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW

GO - Biological processi

  1. sensory perception of taste Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 13
Short name:
T2R13
Alternative name(s):
Taste receptor type 2 member 121
Short name:
T2R121
Short name:
mT2R48
Gene namesi
Name:Tas2r13
Synonyms:Tas2r121
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:2681259. Tas2r121.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77Extracellular Reviewed prediction
Transmembranei8 – 2821Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini29 – 4315Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei44 – 6421Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini65 – 8824Extracellular Reviewed prediction
Add
BLAST
Transmembranei89 – 10921Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini110 – 12819Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei129 – 14921Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini150 – 18233Extracellular Reviewed prediction
Add
BLAST
Transmembranei183 – 20321Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini204 – 23229Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei233 – 25321Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini254 – 2629Extracellular Reviewed prediction
Transmembranei263 – 28321Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini284 – 30522Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305Taste receptor type 2 member 13
PRO_0000082252Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi162 – 1621N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ7M720.

Expressioni

Gene expression databases

CleanExiMM_TAS2R121.
GenevestigatoriQ7M720.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093044.

Structurei

3D structure databases

ProteinModelPortaliQ7M720.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG42620.
GeneTreeiENSGT00560000076963.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
InParanoidiQ7M720.
KOiK08474.
OMAiLNLIQIN.
OrthoDBiEOG741Z3C.
PhylomeDBiQ7M720.
TreeFamiTF335891.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR007960. TAS2_rcpt.
[Graphical view]
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7M720-1 [UniParc]FASTAAdd to Basket

« Hide

MGSNVYGILT MVMIAEFVFG NMSNGFIVLI NCIDWVRKGT LSSIGWILLF    50
LAISRMVLIW EMLITWIKYM KYSFSFVTGT ELRGIMFTWV ISNHFSLWLA 100
TILSIFYLLK IASFSKPVFL YLKWREKKVL LIVLLGNLIF LMLNILQINK 150
HIEHWMYQYE RNITWSSRVS DFAGFSNLVL LEMIVFSVTP FTVALVSFIL 200
LIFSLWKHLQ KMHLNSRGER DPSTKAHVNA LRIMVSFLLL YATYFISFFL 250
SLIPMAHKTR LGLMFSITVG LFYPSSHSFI LILGHSNLRQ ASLWVMTYLK 300
CGQKH 305
Length:305
Mass (Da):35,521
Last modified:December 15, 2003 - v1
Checksum:iB97DB33A6DD6FAA7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC124523 Genomic DNA. No translation available.
BC104410 mRNA. Translation: AAI04411.1.
BC104411 mRNA. Translation: AAI04412.1.
BK001077 Genomic DNA. Translation: DAA01216.1.
CCDSiCCDS20618.1.
RefSeqiNP_996907.1. NM_207024.1.
UniGeneiMm.377911.

Genome annotation databases

EnsembliENSMUST00000095395; ENSMUSP00000093044; ENSMUSG00000071150.
GeneIDi387349.
KEGGimmu:387349.
UCSCiuc009ejj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC124523 Genomic DNA. No translation available.
BC104410 mRNA. Translation: AAI04411.1 .
BC104411 mRNA. Translation: AAI04412.1 .
BK001077 Genomic DNA. Translation: DAA01216.1 .
CCDSi CCDS20618.1.
RefSeqi NP_996907.1. NM_207024.1.
UniGenei Mm.377911.

3D structure databases

ProteinModelPortali Q7M720.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000093044.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PRIDEi Q7M720.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000095395 ; ENSMUSP00000093044 ; ENSMUSG00000071150 .
GeneIDi 387349.
KEGGi mmu:387349.
UCSCi uc009ejj.1. mouse.

Organism-specific databases

CTDi 387349.
MGIi MGI:2681259. Tas2r121.

Phylogenomic databases

eggNOGi NOG42620.
GeneTreei ENSGT00560000076963.
HOGENOMi HOG000234595.
HOVERGENi HBG060698.
InParanoidi Q7M720.
KOi K08474.
OMAi LNLIQIN.
OrthoDBi EOG741Z3C.
PhylomeDBi Q7M720.
TreeFami TF335891.

Miscellaneous databases

NextBioi 405866.
PROi Q7M720.
SOURCEi Search...

Gene expression databases

CleanExi MM_TAS2R121.
Genevestigatori Q7M720.

Family and domain databases

InterProi IPR017452. GPCR_Rhodpsn_7TM.
IPR007960. TAS2_rcpt.
[Graphical view ]
Pfami PF05296. TAS2R. 1 hit.
[Graphical view ]
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Adaptive diversification of bitter taste receptor genes in mammalian evolution."
    Shi P., Zhang J., Yang H., Zhang Y.-P.
    Mol. Biol. Evol. 20:805-814(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiT2R13_MOUSE
AccessioniPrimary (citable) accession number: Q7M720
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: December 15, 2003
Last modified: July 9, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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