Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q7M720

- T2R13_MOUSE

UniProt

Q7M720 - T2R13_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Taste receptor type 2 member 13

Gene

Tas2r13

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).By similarity

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW

GO - Biological processi

  1. sensory perception of taste Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

ReactomeiREACT_250376. G alpha (i) signalling events.
REACT_262510. Class C/3 (Metabotropic glutamate/pheromone receptors).

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 13
Short name:
T2R13
Alternative name(s):
Taste receptor type 2 member 121
Short name:
T2R121
Short name:
mT2R48
Gene namesi
Name:Tas2r13By similarity
Synonyms:Tas2r121Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:2681259. Tas2r121.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77ExtracellularSequence Analysis
Transmembranei8 – 2821Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini29 – 4315CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei44 – 6421Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini65 – 8824ExtracellularSequence AnalysisAdd
BLAST
Transmembranei89 – 10921Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini110 – 12819CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei129 – 14921Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini150 – 18233ExtracellularSequence AnalysisAdd
BLAST
Transmembranei183 – 20321Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini204 – 23229CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei233 – 25321Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini254 – 2629ExtracellularSequence Analysis
Transmembranei263 – 28321Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini284 – 30522CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305Taste receptor type 2 member 13PRO_0000082252Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi162 – 1621N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ7M720.

Expressioni

Gene expression databases

CleanExiMM_TAS2R121.
GenevestigatoriQ7M720.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093044.

Structurei

3D structure databases

ProteinModelPortaliQ7M720.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor T2R family.Sequence Analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG42620.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
InParanoidiQ7M720.
KOiK08474.
OMAiLNLIQIN.
OrthoDBiEOG741Z3C.
PhylomeDBiQ7M720.
TreeFamiTF335891.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR007960. TAS2_rcpt.
[Graphical view]
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7M720-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGSNVYGILT MVMIAEFVFG NMSNGFIVLI NCIDWVRKGT LSSIGWILLF
60 70 80 90 100
LAISRMVLIW EMLITWIKYM KYSFSFVTGT ELRGIMFTWV ISNHFSLWLA
110 120 130 140 150
TILSIFYLLK IASFSKPVFL YLKWREKKVL LIVLLGNLIF LMLNILQINK
160 170 180 190 200
HIEHWMYQYE RNITWSSRVS DFAGFSNLVL LEMIVFSVTP FTVALVSFIL
210 220 230 240 250
LIFSLWKHLQ KMHLNSRGER DPSTKAHVNA LRIMVSFLLL YATYFISFFL
260 270 280 290 300
SLIPMAHKTR LGLMFSITVG LFYPSSHSFI LILGHSNLRQ ASLWVMTYLK

CGQKH
Length:305
Mass (Da):35,521
Last modified:December 15, 2003 - v1
Checksum:iB97DB33A6DD6FAA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124523 Genomic DNA. No translation available.
BC104410 mRNA. Translation: AAI04411.1.
BC104411 mRNA. Translation: AAI04412.1.
BK001077 Genomic DNA. Translation: DAA01216.1.
CCDSiCCDS20618.1.
RefSeqiNP_996907.1. NM_207024.1.
UniGeneiMm.377911.

Genome annotation databases

EnsembliENSMUST00000095395; ENSMUSP00000093044; ENSMUSG00000071150.
GeneIDi387349.
KEGGimmu:387349.
UCSCiuc009ejj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124523 Genomic DNA. No translation available.
BC104410 mRNA. Translation: AAI04411.1 .
BC104411 mRNA. Translation: AAI04412.1 .
BK001077 Genomic DNA. Translation: DAA01216.1 .
CCDSi CCDS20618.1.
RefSeqi NP_996907.1. NM_207024.1.
UniGenei Mm.377911.

3D structure databases

ProteinModelPortali Q7M720.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000093044.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PRIDEi Q7M720.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000095395 ; ENSMUSP00000093044 ; ENSMUSG00000071150 .
GeneIDi 387349.
KEGGi mmu:387349.
UCSCi uc009ejj.1. mouse.

Organism-specific databases

CTDi 387349.
MGIi MGI:2681259. Tas2r121.

Phylogenomic databases

eggNOGi NOG42620.
GeneTreei ENSGT00760000119096.
HOGENOMi HOG000234595.
HOVERGENi HBG060698.
InParanoidi Q7M720.
KOi K08474.
OMAi LNLIQIN.
OrthoDBi EOG741Z3C.
PhylomeDBi Q7M720.
TreeFami TF335891.

Enzyme and pathway databases

Reactomei REACT_250376. G alpha (i) signalling events.
REACT_262510. Class C/3 (Metabotropic glutamate/pheromone receptors).

Miscellaneous databases

NextBioi 405866.
PROi Q7M720.
SOURCEi Search...

Gene expression databases

CleanExi MM_TAS2R121.
Genevestigatori Q7M720.

Family and domain databases

InterProi IPR017452. GPCR_Rhodpsn_7TM.
IPR007960. TAS2_rcpt.
[Graphical view ]
Pfami PF05296. TAS2R. 1 hit.
[Graphical view ]
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Adaptive diversification of bitter taste receptor genes in mammalian evolution."
    Shi P., Zhang J., Yang H., Zhang Y.-P.
    Mol. Biol. Evol. 20:805-814(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiT2R13_MOUSE
AccessioniPrimary (citable) accession number: Q7M720
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: December 15, 2003
Last modified: November 26, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3