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Q7M720 (T2R13_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Taste receptor type 2 member 13

Short name=T2R13
Alternative name(s):
Taste receptor type 2 member 121
Short name=T2R121
Short name=mT2R48
Gene names
Name:Tas2r13
Synonyms:Tas2r121
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length305 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 By similarity. UniProtKB Q9NYV9

Subcellular location

Cell membrane; Multi-pass membrane protein.

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

Sequence similarities

Belongs to the G-protein coupled receptor T2R family.

Ontologies

Keywords
   Biological processSensory transduction
Taste
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processsensory perception of taste

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionG-protein coupled receptor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 305305Taste receptor type 2 member 13
PRO_0000082252

Regions

Topological domain1 – 77Extracellular Potential
Transmembrane8 – 2821Helical; Name=1; Potential
Topological domain29 – 4315Cytoplasmic Potential
Transmembrane44 – 6421Helical; Name=2; Potential
Topological domain65 – 8824Extracellular Potential
Transmembrane89 – 10921Helical; Name=3; Potential
Topological domain110 – 12819Cytoplasmic Potential
Transmembrane129 – 14921Helical; Name=4; Potential
Topological domain150 – 18233Extracellular Potential
Transmembrane183 – 20321Helical; Name=5; Potential
Topological domain204 – 23229Cytoplasmic Potential
Transmembrane233 – 25321Helical; Name=6; Potential
Topological domain254 – 2629Extracellular Potential
Transmembrane263 – 28321Helical; Name=7; Potential
Topological domain284 – 30522Cytoplasmic Potential

Amino acid modifications

Glycosylation1621N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q7M720 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: B97DB33A6DD6FAA7

FASTA30535,521
        10         20         30         40         50         60 
MGSNVYGILT MVMIAEFVFG NMSNGFIVLI NCIDWVRKGT LSSIGWILLF LAISRMVLIW 

        70         80         90        100        110        120 
EMLITWIKYM KYSFSFVTGT ELRGIMFTWV ISNHFSLWLA TILSIFYLLK IASFSKPVFL 

       130        140        150        160        170        180 
YLKWREKKVL LIVLLGNLIF LMLNILQINK HIEHWMYQYE RNITWSSRVS DFAGFSNLVL 

       190        200        210        220        230        240 
LEMIVFSVTP FTVALVSFIL LIFSLWKHLQ KMHLNSRGER DPSTKAHVNA LRIMVSFLLL 

       250        260        270        280        290        300 
YATYFISFFL SLIPMAHKTR LGLMFSITVG LFYPSSHSFI LILGHSNLRQ ASLWVMTYLK 


CGQKH 

« Hide

References

« Hide 'large scale' references
[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"Adaptive diversification of bitter taste receptor genes in mammalian evolution."
Shi P., Zhang J., Yang H., Zhang Y.-P.
Mol. Biol. Evol. 20:805-814(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC124523 Genomic DNA. No translation available.
BC104410 mRNA. Translation: AAI04411.1.
BC104411 mRNA. Translation: AAI04412.1.
BK001077 Genomic DNA. Translation: DAA01216.1.
RefSeqNP_996907.1. NM_207024.1.
UniGeneMm.377911.

3D structure databases

ProteinModelPortalQ7M720.
SMRQ7M720. Positions 207-245.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000093044.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PRIDEQ7M720.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000095395; ENSMUSP00000093044; ENSMUSG00000071150.
GeneID387349.
KEGGmmu:387349.
UCSCuc009ejj.1. mouse.

Organism-specific databases

CTD387349.
MGIMGI:2681259. Tas2r121.

Phylogenomic databases

eggNOGNOG42620.
GeneTreeENSGT00560000076963.
HOGENOMHOG000234595.
HOVERGENHBG060698.
InParanoidQ7M720.
KOK08474.
OMALNLIQIN.
OrthoDBEOG741Z3C.
PhylomeDBQ7M720.
TreeFamTF335891.

Gene expression databases

CleanExMM_TAS2R121.
GenevestigatorQ7M720.

Family and domain databases

InterProIPR017452. GPCR_Rhodpsn_7TM.
IPR007960. TAS2_rcpt.
[Graphical view]
PfamPF05296. TAS2R. 1 hit.
[Graphical view]
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio405866.
PROQ7M720.
SOURCESearch...

Entry information

Entry nameT2R13_MOUSE
AccessionPrimary (citable) accession number: Q7M720
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: December 15, 2003
Last modified: April 16, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries