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Protein

Taste receptor type 2 member 13

Gene

Tas2r13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).By similarity

GO - Molecular functioni

  1. bitter taste receptor activity Source: MGI

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception of bitter taste Source: MGI
  2. positive regulation of cytokinesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

ReactomeiREACT_331048. G alpha (i) signalling events.
REACT_336829. Class C/3 (Metabotropic glutamate/pheromone receptors).

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 13
Short name:
T2R13
Alternative name(s):
Taste receptor type 2 member 121
Short name:
T2R121
Short name:
mT2R48
Gene namesi
Name:Tas2r13By similarity
Synonyms:Tas2r121Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2681259. Tas2r121.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77ExtracellularSequence Analysis
Transmembranei8 – 2821Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini29 – 4315CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei44 – 6421Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini65 – 8824ExtracellularSequence AnalysisAdd
BLAST
Transmembranei89 – 10921Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini110 – 12819CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei129 – 14921Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini150 – 18233ExtracellularSequence AnalysisAdd
BLAST
Transmembranei183 – 20321Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini204 – 23229CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei233 – 25321Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini254 – 2629ExtracellularSequence Analysis
Transmembranei263 – 28321Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini284 – 30522CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305Taste receptor type 2 member 13PRO_0000082252Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi162 – 1621N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ7M720.

Expressioni

Gene expression databases

CleanExiMM_TAS2R121.
GenevestigatoriQ7M720.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093044.

Structurei

3D structure databases

ProteinModelPortaliQ7M720.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor T2R family.Sequence Analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG42620.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
InParanoidiQ7M720.
KOiK08474.
OMAiLNLIQIN.
OrthoDBiEOG741Z3C.
PhylomeDBiQ7M720.
TreeFamiTF335891.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR007960. T2R.
[Graphical view]
PANTHERiPTHR11394. PTHR11394. 1 hit.
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7M720-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSNVYGILT MVMIAEFVFG NMSNGFIVLI NCIDWVRKGT LSSIGWILLF
60 70 80 90 100
LAISRMVLIW EMLITWIKYM KYSFSFVTGT ELRGIMFTWV ISNHFSLWLA
110 120 130 140 150
TILSIFYLLK IASFSKPVFL YLKWREKKVL LIVLLGNLIF LMLNILQINK
160 170 180 190 200
HIEHWMYQYE RNITWSSRVS DFAGFSNLVL LEMIVFSVTP FTVALVSFIL
210 220 230 240 250
LIFSLWKHLQ KMHLNSRGER DPSTKAHVNA LRIMVSFLLL YATYFISFFL
260 270 280 290 300
SLIPMAHKTR LGLMFSITVG LFYPSSHSFI LILGHSNLRQ ASLWVMTYLK

CGQKH
Length:305
Mass (Da):35,521
Last modified:December 15, 2003 - v1
Checksum:iB97DB33A6DD6FAA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124523 Genomic DNA. No translation available.
BC104410 mRNA. Translation: AAI04411.1.
BC104411 mRNA. Translation: AAI04412.1.
BK001077 Genomic DNA. Translation: DAA01216.1.
CCDSiCCDS20618.1.
RefSeqiNP_996907.1. NM_207024.1.
UniGeneiMm.377911.

Genome annotation databases

EnsembliENSMUST00000095395; ENSMUSP00000093044; ENSMUSG00000071150.
GeneIDi387349.
KEGGimmu:387349.
UCSCiuc009ejj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124523 Genomic DNA. No translation available.
BC104410 mRNA. Translation: AAI04411.1.
BC104411 mRNA. Translation: AAI04412.1.
BK001077 Genomic DNA. Translation: DAA01216.1.
CCDSiCCDS20618.1.
RefSeqiNP_996907.1. NM_207024.1.
UniGeneiMm.377911.

3D structure databases

ProteinModelPortaliQ7M720.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093044.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PRIDEiQ7M720.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000095395; ENSMUSP00000093044; ENSMUSG00000071150.
GeneIDi387349.
KEGGimmu:387349.
UCSCiuc009ejj.1. mouse.

Organism-specific databases

CTDi387349.
MGIiMGI:2681259. Tas2r121.

Phylogenomic databases

eggNOGiNOG42620.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
InParanoidiQ7M720.
KOiK08474.
OMAiLNLIQIN.
OrthoDBiEOG741Z3C.
PhylomeDBiQ7M720.
TreeFamiTF335891.

Enzyme and pathway databases

ReactomeiREACT_331048. G alpha (i) signalling events.
REACT_336829. Class C/3 (Metabotropic glutamate/pheromone receptors).

Miscellaneous databases

NextBioi405866.
PROiQ7M720.
SOURCEiSearch...

Gene expression databases

CleanExiMM_TAS2R121.
GenevestigatoriQ7M720.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR007960. T2R.
[Graphical view]
PANTHERiPTHR11394. PTHR11394. 1 hit.
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Adaptive diversification of bitter taste receptor genes in mammalian evolution."
    Shi P., Zhang J., Yang H., Zhang Y.-P.
    Mol. Biol. Evol. 20:805-814(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiT2R13_MOUSE
AccessioniPrimary (citable) accession number: Q7M720
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: December 15, 2003
Last modified: April 1, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.