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Protein

Kinesin-like protein KIF27

Gene

Kif27

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays an essential role in motile ciliogenesis.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi84 – 91ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Cilium biogenesis/degradation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF27
Gene namesi
Name:Kif27
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi621071. Kif27.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003071451 – 1394Kinesin-like protein KIF27Add BLAST1394

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei643PhosphoserineBy similarity1
Modified residuei646PhosphoserineBy similarity1
Modified residuei672PhosphoserineCombined sources1
Modified residuei675PhosphoserineCombined sources1
Modified residuei704PhosphoserineCombined sources1
Modified residuei999PhosphoserineCombined sources1
Modified residuei1365PhosphoserineCombined sources1
Modified residuei1387PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ7M6Z5.
PRIDEiQ7M6Z5.

PTM databases

iPTMnetiQ7M6Z5.
PhosphoSitePlusiQ7M6Z5.

Expressioni

Gene expression databases

BgeeiENSRNOG00000019257.
ExpressionAtlasiQ7M6Z5. differential.

Interactioni

Subunit structurei

Interacts with STK36.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026054.

Structurei

3D structure databases

ProteinModelPortaliQ7M6Z5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 341Kinesin motorPROSITE-ProRule annotationAdd BLAST337

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili352 – 418Sequence analysisAdd BLAST67
Coiled coili493 – 554Sequence analysisAdd BLAST62
Coiled coili709 – 980Sequence analysisAdd BLAST272
Coiled coili1010 – 1078Sequence analysisAdd BLAST69
Coiled coili1118 – 1152Sequence analysisAdd BLAST35
Coiled coili1187 – 1226Sequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1282 – 1285Poly-Ser4
Compositional biasi1334 – 1337Poly-Pro4

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF27 subfamily.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0244. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00860000133670.
HOGENOMiHOG000068072.
HOVERGENiHBG054858.
InParanoidiQ7M6Z5.
KOiK10395.
OMAiRSWIQKP.
OrthoDBiEOG091G0156.
PhylomeDBiQ7M6Z5.
TreeFamiTF325946.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 4 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7M6Z5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEIPIKVAV RIRPLLCKEV LHNHQVCVRD IPKTQQIIIG RDRVFTFDFV
60 70 80 90 100
FGKNSTQDEV YSTCIKPLVL SLIEGYNATV FAYGQTGSGK TYTIGGGHVA
110 120 130 140 150
SVVDGQKGII PRAIQEIFQS ISGNPNIDFK IKVSYIEVYK EDLRDLLELE
160 170 180 190 200
TSMKDLHIRE DEKGNTVIVG AKECQVDSVE DVMGLLQVGN AARHTGTTQM
210 220 230 240 250
NEHSSRSHAI FTISVCQVGK SAEATEDGEW CSHRHIVSKF HFVDLAGSER
260 270 280 290 300
VTKTGNTGER FKESIQINSG LLALGNVISA LGDPRRKSSH VPYRDAKITR
310 320 330 340 350
LLKDSLGGSA KTVMITCVSP SSSDFDESLN SLKYANRARN IRNKPTLNFS
360 370 380 390 400
PQADRMDEME FEIKLLREAL QSHQASISQT SQTASENVPD QNRIHSLEEQ
410 420 430 440 450
IAQLQEECLG YQDCIEQAFA FLVDLKDAVR LNQKQQHKLQ QWFSRTQEVR
460 470 480 490 500
KAVLTPLPGN QSIGNLEEGP QHVTVLQLKR ELKKYQCALA ADQVVFTQKE
510 520 530 540 550
LELEELRRQM QLMAQESKGH AVSLKEAQKV NRLQNEKIIE QQLLVDQLSE
560 570 580 590 600
ELAKRSSSMP TSTKESCGDG PDARAPEKRP HTAPFDSHWG HYVYIPSRQD
610 620 630 640 650
FKKVCSSSPV YSLDQVFAGF RTRSQMLMGH LEDQDEVLHC QFSDNSDDED
660 670 680 690 700
SEGQEKPRVR SRSHSWVKKP GSVCSLVEMS DTQAECQRSY LGNGDLKMES
710 720 730 740 750
LQESQELNLQ KLRTSELILN KAKQKMRELT INIRMKEDLI KELIKTGDNA
760 770 780 790 800
KSVSRQYSLK VTKLEHEAEQ AKVELTETRK QLQELEGKDL SDVALKVKLQ
810 820 830 840 850
KEFRKKMDAA KLRVQVLQKK QQDSKKLASL SIQNEKRASE LEQNVDHLKY
860 870 880 890 900
QKVQLQRRLR EESEKKKQLD AEVKRDQQKL KELQLNAGQG EGLHPKAEDT
910 920 930 940 950
DAFNLNRRKG PFRSVDQLQK LDEQRKWLDE EVEKVLSQRQ ELEMLEEELK
960 970 980 990 1000
KREAIVSKKE ALLQEKSHLE NKKLRSSQAL STDSLKISAR LNLLDQELSE
1010 1020 1030 1040 1050
KSLLLENSPT EEKVKISEQV QALQREREQL QRQRNSVDEK LRHGRVLSPK
1060 1070 1080 1090 1100
EEHLLFQLEE GIEALEAAIE FKNESIQNRQ SSLKSSFQNL SQSESNVLEK
1110 1120 1130 1140 1150
LVCLNIAEIR AILFKYFNKV INLREAERKQ QLQNKEMKMK VLERDNMVHE
1160 1170 1180 1190 1200
LESALEYLRL QCDRRLTLQQ KEHEQKMQLL LHHFKDQDGE GIIETLNKYE
1210 1220 1230 1240 1250
DKIQQLEKDL YFYKKTSRDL KKRLKDPVQG AVQWQRTLTE HHDAGDGVLN
1260 1270 1280 1290 1300
PEEAAVLSEE LKWASRTENT KLNGREKEVD NSSSSLKTPP LTQQILEDGP
1310 1320 1330 1340 1350
DSLPVCGSLA PSSGQLQSSA DKTEAHAFTQ SQSPPPPQLQ PVRSIAQLQG
1360 1370 1380 1390
VKPVKVCRRE LRQISALELT LRRSSLGAGV RSVTADSLEE PEES
Length:1,394
Mass (Da):158,880
Last modified:December 15, 2003 - v1
Checksum:i78E6AA7FF01C7987
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03104681 Genomic DNA. No translation available.
AABR03107397 Genomic DNA. No translation available.
AABR03106101 Genomic DNA. No translation available.
AABR03107556 Genomic DNA. No translation available.
BK001053 mRNA. Translation: DAA01311.1.
RefSeqiNP_932167.1. NM_198050.1.
XP_006253618.1. XM_006253556.3.
XP_008769646.1. XM_008771424.2.
UniGeneiRn.214231.

Genome annotation databases

EnsembliENSRNOT00000026054; ENSRNOP00000026054; ENSRNOG00000019257.
ENSRNOT00000080683; ENSRNOP00000074434; ENSRNOG00000019257.
GeneIDi246209.
KEGGirno:246209.
UCSCiRGD:621071. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03104681 Genomic DNA. No translation available.
AABR03107397 Genomic DNA. No translation available.
AABR03106101 Genomic DNA. No translation available.
AABR03107556 Genomic DNA. No translation available.
BK001053 mRNA. Translation: DAA01311.1.
RefSeqiNP_932167.1. NM_198050.1.
XP_006253618.1. XM_006253556.3.
XP_008769646.1. XM_008771424.2.
UniGeneiRn.214231.

3D structure databases

ProteinModelPortaliQ7M6Z5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026054.

PTM databases

iPTMnetiQ7M6Z5.
PhosphoSitePlusiQ7M6Z5.

Proteomic databases

PaxDbiQ7M6Z5.
PRIDEiQ7M6Z5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026054; ENSRNOP00000026054; ENSRNOG00000019257.
ENSRNOT00000080683; ENSRNOP00000074434; ENSRNOG00000019257.
GeneIDi246209.
KEGGirno:246209.
UCSCiRGD:621071. rat.

Organism-specific databases

CTDi55582.
RGDi621071. Kif27.

Phylogenomic databases

eggNOGiKOG0244. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00860000133670.
HOGENOMiHOG000068072.
HOVERGENiHBG054858.
InParanoidiQ7M6Z5.
KOiK10395.
OMAiRSWIQKP.
OrthoDBiEOG091G0156.
PhylomeDBiQ7M6Z5.
TreeFamiTF325946.

Miscellaneous databases

PROiQ7M6Z5.

Gene expression databases

BgeeiENSRNOG00000019257.
ExpressionAtlasiQ7M6Z5. differential.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 4 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKIF27_RAT
AccessioniPrimary (citable) accession number: Q7M6Z5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: December 15, 2003
Last modified: November 30, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.