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Q7M6Z4 (KIF27_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kinesin-like protein KIF27
Gene names
Name:Kif27
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1394 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays an essential role in motile ciliogenesis. Ref.5

Subunit structure

Interacts with STK36. Ref.5

Subcellular location

Cytoplasmcytoskeleton Probable. Cell projectioncilium. Note: Localizes to centrioles and basal bodies. Ref.5

Sequence similarities

Belongs to the kinesin-like protein family. KIF27 subfamily.

Contains 1 kinesin-motor domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q7M6Z4-1)

Also known as: KIF27A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q7M6Z4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-484: Missing.
     485-486: YQ → ML

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13941394Kinesin-like protein KIF27
PRO_0000307144

Regions

Domain1 – 269269Kinesin-motor
Nucleotide binding84 – 918ATP Potential
Coiled coil352 – 41867 Potential
Coiled coil498 – 55457 Potential
Coiled coil709 – 891183 Potential
Coiled coil921 – 1078158 Potential
Coiled coil1118 – 115235 Potential
Coiled coil1186 – 122641 Potential
Compositional bias1282 – 12854Poly-Ser

Amino acid modifications

Cross-link1084Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.4

Natural variations

Alternative sequence1 – 484484Missing in isoform 2.
VSP_028607
Alternative sequence485 – 4862YQ → ML in isoform 2.
VSP_028608

Experimental info

Sequence conflict13771G → E in BAC28083. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (KIF27A) [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: AC5F7CCD2CA61D6B

FASTA1,394158,956
        10         20         30         40         50         60 
MEEIPIKVAV RIRPLLCKEV LHNHQVCVRD IPNTQQIIIG RDRVFTFDFV FGKNSTQDEV 

        70         80         90        100        110        120 
YNTCIKPLVL SLIEGYNATV FAYGQTGSGK TYTIGGGHVA SVVEGQKGII PRAIQEIFQS 

       130        140        150        160        170        180 
ISENPSIDFK IKVSYIEVYK EDLRDLLELE TSMKDLHIRE DEKGNTVIVG AKECQVESVE 

       190        200        210        220        230        240 
DVMSLLQVGN AARHTGTTQM NEHSSRSHAI FTISVCQVEK NAEAAENGEW YSHRHIVSKF 

       250        260        270        280        290        300 
HFVDLAGSER VTKTGNTGER FKESIQINSG LLALGNVISA LGDPRRKSSH IPYRDAKITR 

       310        320        330        340        350        360 
LLKDSLGGSA KTVMITCVSP SSSDFDESLN SLKYANRARN IRNKPALNIS PQADRMDEME 

       370        380        390        400        410        420 
FEIKLLREAL QSHQASISQA SQASSENVPD QNRIHSLEEQ VAQLQEECLG YQDCIEQAFA 

       430        440        450        460        470        480 
FLVDLKDAVK LNQKQQHKLQ EWFSRTQEVR KAVLTPLPGN QGIGNLEEGP QHLTVLQLKR 

       490        500        510        520        530        540 
ELKKYQCALA ADQVVFTQKD LELEELRTQV QLMMQESKGH AVSLKEAQKV NRLQNEKIIE 

       550        560        570        580        590        600 
QQLLVDQLSA ELAKRSLSVP TSAKESCGDG PDARASEKRP HTAPFESHWG HYVYIPSRQD 

       610        620        630        640        650        660 
FKKVCSSTPV YSLDQVFAGF RTRSQMLMGH LEDQDEVLHC QFSDNSDDED SEGQEKPRVR 

       670        680        690        700        710        720 
SRSHSWAKKP GSVCSLVELS DTQAESQRSY LGNGDLKMES LQESQEINLQ KLRTSELILN 

       730        740        750        760        770        780 
KAKQKMRELT INIRMKEDLI KELIKTGNNA KSVSRQYSLK VTKLEHEAEQ AKVELTETRK 

       790        800        810        820        830        840 
QLQELESKDL SDVALKVKLQ KEFRKKMDAA KMRVQVLQKK QQDSKKLASL SIQNEKRASE 

       850        860        870        880        890        900 
LEHNVDHLKY QKVQLQRRLR EEGEKKKQLD AEIKRDQQKI KELQLKAGQG EGLNPKAEDQ 

       910        920        930        940        950        960 
DGFNLNRRKS PFRSGDQFQK LDEQRKWLDE EVEKVLSQRQ ELEMLEEDLK KREAIVSKKE 

       970        980        990       1000       1010       1020 
ALLQEKSLLE NKKLRSSQAL STDGLKISAR LNLLDQELSE KSLQLESSPT EEKMKISEQV 

      1030       1040       1050       1060       1070       1080 
QALQRERDQL QRQRNSVDER LKHGRVLSPK EEHLLFQLEE GIEALEAAIE FKNESIQSRQ 

      1090       1100       1110       1120       1130       1140 
NSLKASFQNL SQSEANVLEK LVCLNITEIR AILFKYFNKV INLRETERKQ QLQNKEMKMK 

      1150       1160       1170       1180       1190       1200 
VLERDNVVHE LESALEHLRL QCDRRLTLQQ KEHEQKMQLL LQHFKDQDGD SIIETLKNYE 

      1210       1220       1230       1240       1250       1260 
DKIQQLEKDL YFYKKTSRDL KKRLKDPAQG AAQWQRTLTE HHDAGDGVLN PEETTVLSEE 

      1270       1280       1290       1300       1310       1320 
LKWASRTENT KLNGSEREVD NSSSSLKTQP LTQQIPEDGP DSLPARSSIA PSSGQLQSIA 

      1330       1340       1350       1360       1370       1380 
DKTEARPFTH SQSPVPHQFQ PVRSIGPLQG VKPVKLCRRE LRQISAMELS LRRCSLGAGG 

      1390 
RSMTADSLED PEEN 

« Hide

Isoform 2 [UniParc].

Checksum: 375B4C11BBFAB80D
Show »

FASTA910104,716

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 726-1394 (ISOFORM 1).
Strain: C57BL/6J.
[3]"Gene discovery in the hamster: a comparative genomics approach for gene annotation by sequencing of hamster testis cDNAs."
Oduru S., Campbell J.L., Karri S., Hendry W.J., Khan S.A., Williams S.C.
BMC Genomics 4:22-22(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION (ISOFORM 1).
[4]"A proteomics approach to identify the ubiquitinated proteins in mouse heart."
Jeon H.B., Choi E.S., Yoon J.H., Hwang J.H., Chang J.W., Lee E.K., Choi H.W., Park Z.-Y., Yoo Y.J.
Biochem. Biophys. Res. Commun. 357:731-736(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-1084.
Tissue: Heart.
[5]"Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis."
Wilson C.W., Nguyen C.T., Chen M.H., Yang J.H., Gacayan R., Huang J., Chen J.N., Chuang P.T.
Nature 459:98-102(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH STK36.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC116646 mRNA. Translation: AAI16647.1.
AK032912 mRNA. Translation: BAC28083.1.
BK001056 mRNA. Translation: DAA01314.1.
RefSeqNP_780423.2. NM_175214.3.
XP_006517489.1. XM_006517426.1.
XP_006517490.1. XM_006517427.1.
XP_006517491.1. XM_006517428.1.
XP_006517492.1. XM_006517429.1.
XP_006517493.1. XM_006517430.1.
XP_006517494.1. XM_006517431.1.
XP_006517495.1. XM_006517432.1.
XP_006517496.1. XM_006517433.1.
XP_006517497.1. XM_006517434.1.
XP_006517498.1. XM_006517435.1.
XP_006517499.1. XM_006517436.1.
UniGeneMm.446094.

3D structure databases

ProteinModelPortalQ7M6Z4.
SMRQ7M6Z4. Positions 2-374.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-59753N.
STRING10090.ENSMUSP00000043304.

PTM databases

PhosphoSiteQ7M6Z4.

Proteomic databases

PaxDbQ7M6Z4.
PRIDEQ7M6Z4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000043605; ENSMUSP00000043304; ENSMUSG00000060176. [Q7M6Z4-1]
GeneID75050.
KEGGmmu:75050.
UCSCuc007qtq.1. mouse. [Q7M6Z4-1]
uc011zao.1. mouse. [Q7M6Z4-2]

Organism-specific databases

CTD55582.
MGIMGI:1922300. Kif27.

Phylogenomic databases

eggNOGCOG5059.
GeneTreeENSGT00750000117462.
HOGENOMHOG000068072.
HOVERGENHBG054858.
InParanoidQ7M6Z4.
KOK10395.
OMANTSMERE.
OrthoDBEOG7K3TK3.
PhylomeDBQ7M6Z4.
TreeFamTF325946.

Gene expression databases

BgeeQ7M6Z4.
CleanExMM_KIF27.
GenevestigatorQ7M6Z4.

Family and domain databases

Gene3D3.40.850.10. 1 hit.
InterProIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR24115. PTHR24115. 1 hit.
PfamPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSPR00380. KINESINHEAVY.
SMARTSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00411. KINESIN_MOTOR_DOMAIN1. 1 hit.
PS50067. KINESIN_MOTOR_DOMAIN2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio342092.
PROQ7M6Z4.
SOURCESearch...

Entry information

Entry nameKIF27_MOUSE
AccessionPrimary (citable) accession number: Q7M6Z4
Secondary accession number(s): Q14AX5, Q8BMB9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: December 15, 2003
Last modified: April 16, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot