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Q7M6Z4

- KIF27_MOUSE

UniProt

Q7M6Z4 - KIF27_MOUSE

Protein

Kinesin-like protein KIF27

Gene

Kif27

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    Plays an essential role in motile ciliogenesis.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi84 – 918ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. microtubule motor activity Source: InterPro
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. cilium assembly Source: UniProtKB
    2. epithelial cilium movement Source: MGI
    3. ventricular system development Source: MGI

    Keywords - Molecular functioni

    Motor protein

    Keywords - Biological processi

    Cilium biogenesis/degradation

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kinesin-like protein KIF27
    Gene namesi
    Name:Kif27
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:1922300. Kif27.

    Subcellular locationi

    Cytoplasmcytoskeleton 1 Publication. Cell projectioncilium 1 Publication
    Note: Localizes to centrioles and basal bodies.

    GO - Cellular componenti

    1. cilium Source: UniProtKB
    2. cytoplasm Source: UniProtKB-KW
    3. kinesin complex Source: InterPro
    4. microtubule Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell projection, Cilium, Cytoplasm, Cytoskeleton, Microtubule

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13941394Kinesin-like protein KIF27PRO_0000307144Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki1084 – 1084Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    Proteomic databases

    PaxDbiQ7M6Z4.
    PRIDEiQ7M6Z4.

    PTM databases

    PhosphoSiteiQ7M6Z4.

    Expressioni

    Gene expression databases

    BgeeiQ7M6Z4.
    CleanExiMM_KIF27.
    GenevestigatoriQ7M6Z4.

    Interactioni

    Subunit structurei

    Interacts with STK36.1 Publication

    Protein-protein interaction databases

    DIPiDIP-59753N.
    STRINGi10090.ENSMUSP00000043304.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7M6Z4.
    SMRiQ7M6Z4. Positions 2-339.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini5 – 341337Kinesin motorPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili352 – 41867Sequence AnalysisAdd
    BLAST
    Coiled coili498 – 55457Sequence AnalysisAdd
    BLAST
    Coiled coili709 – 891183Sequence AnalysisAdd
    BLAST
    Coiled coili921 – 1078158Sequence AnalysisAdd
    BLAST
    Coiled coili1118 – 115235Sequence AnalysisAdd
    BLAST
    Coiled coili1186 – 122641Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1282 – 12854Poly-Ser

    Sequence similaritiesi

    Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF27 subfamily.PROSITE-ProRule annotation
    Contains 1 kinesin motor domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5059.
    GeneTreeiENSGT00750000117462.
    HOGENOMiHOG000068072.
    HOVERGENiHBG054858.
    InParanoidiQ7M6Z4.
    KOiK10395.
    OMAiRETIVSK.
    OrthoDBiEOG7K3TK3.
    PhylomeDBiQ7M6Z4.
    TreeFamiTF325946.

    Family and domain databases

    Gene3Di3.40.850.10. 1 hit.
    InterProiIPR027640. Kinesin-like_fam.
    IPR019821. Kinesin_motor_CS.
    IPR001752. Kinesin_motor_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR24115. PTHR24115. 1 hit.
    PfamiPF00225. Kinesin. 1 hit.
    [Graphical view]
    PRINTSiPR00380. KINESINHEAVY.
    SMARTiSM00129. KISc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
    PS50067. KINESIN_MOTOR_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q7M6Z4-1) [UniParc]FASTAAdd to Basket

    Also known as: KIF27A

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEEIPIKVAV RIRPLLCKEV LHNHQVCVRD IPNTQQIIIG RDRVFTFDFV     50
    FGKNSTQDEV YNTCIKPLVL SLIEGYNATV FAYGQTGSGK TYTIGGGHVA 100
    SVVEGQKGII PRAIQEIFQS ISENPSIDFK IKVSYIEVYK EDLRDLLELE 150
    TSMKDLHIRE DEKGNTVIVG AKECQVESVE DVMSLLQVGN AARHTGTTQM 200
    NEHSSRSHAI FTISVCQVEK NAEAAENGEW YSHRHIVSKF HFVDLAGSER 250
    VTKTGNTGER FKESIQINSG LLALGNVISA LGDPRRKSSH IPYRDAKITR 300
    LLKDSLGGSA KTVMITCVSP SSSDFDESLN SLKYANRARN IRNKPALNIS 350
    PQADRMDEME FEIKLLREAL QSHQASISQA SQASSENVPD QNRIHSLEEQ 400
    VAQLQEECLG YQDCIEQAFA FLVDLKDAVK LNQKQQHKLQ EWFSRTQEVR 450
    KAVLTPLPGN QGIGNLEEGP QHLTVLQLKR ELKKYQCALA ADQVVFTQKD 500
    LELEELRTQV QLMMQESKGH AVSLKEAQKV NRLQNEKIIE QQLLVDQLSA 550
    ELAKRSLSVP TSAKESCGDG PDARASEKRP HTAPFESHWG HYVYIPSRQD 600
    FKKVCSSTPV YSLDQVFAGF RTRSQMLMGH LEDQDEVLHC QFSDNSDDED 650
    SEGQEKPRVR SRSHSWAKKP GSVCSLVELS DTQAESQRSY LGNGDLKMES 700
    LQESQEINLQ KLRTSELILN KAKQKMRELT INIRMKEDLI KELIKTGNNA 750
    KSVSRQYSLK VTKLEHEAEQ AKVELTETRK QLQELESKDL SDVALKVKLQ 800
    KEFRKKMDAA KMRVQVLQKK QQDSKKLASL SIQNEKRASE LEHNVDHLKY 850
    QKVQLQRRLR EEGEKKKQLD AEIKRDQQKI KELQLKAGQG EGLNPKAEDQ 900
    DGFNLNRRKS PFRSGDQFQK LDEQRKWLDE EVEKVLSQRQ ELEMLEEDLK 950
    KREAIVSKKE ALLQEKSLLE NKKLRSSQAL STDGLKISAR LNLLDQELSE 1000
    KSLQLESSPT EEKMKISEQV QALQRERDQL QRQRNSVDER LKHGRVLSPK 1050
    EEHLLFQLEE GIEALEAAIE FKNESIQSRQ NSLKASFQNL SQSEANVLEK 1100
    LVCLNITEIR AILFKYFNKV INLRETERKQ QLQNKEMKMK VLERDNVVHE 1150
    LESALEHLRL QCDRRLTLQQ KEHEQKMQLL LQHFKDQDGD SIIETLKNYE 1200
    DKIQQLEKDL YFYKKTSRDL KKRLKDPAQG AAQWQRTLTE HHDAGDGVLN 1250
    PEETTVLSEE LKWASRTENT KLNGSEREVD NSSSSLKTQP LTQQIPEDGP 1300
    DSLPARSSIA PSSGQLQSIA DKTEARPFTH SQSPVPHQFQ PVRSIGPLQG 1350
    VKPVKLCRRE LRQISAMELS LRRCSLGAGG RSMTADSLED PEEN 1394
    Length:1,394
    Mass (Da):158,956
    Last modified:December 15, 2003 - v1
    Checksum:iAC5F7CCD2CA61D6B
    GO
    Isoform 2 (identifier: Q7M6Z4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-484: Missing.
         485-486: YQ → ML

    Show »
    Length:910
    Mass (Da):104,716
    Checksum:i375B4C11BBFAB80D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1377 – 13771G → E in BAC28083. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 484484Missing in isoform 2. 1 PublicationVSP_028607Add
    BLAST
    Alternative sequencei485 – 4862YQ → ML in isoform 2. 1 PublicationVSP_028608

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC116646 mRNA. Translation: AAI16647.1.
    AK032912 mRNA. Translation: BAC28083.1.
    BK001056 mRNA. Translation: DAA01314.1.
    CCDSiCCDS26570.1. [Q7M6Z4-1]
    RefSeqiNP_780423.2. NM_175214.3. [Q7M6Z4-1]
    XP_006517489.1. XM_006517426.1. [Q7M6Z4-1]
    XP_006517490.1. XM_006517427.1. [Q7M6Z4-1]
    XP_006517491.1. XM_006517428.1. [Q7M6Z4-1]
    XP_006517492.1. XM_006517429.1. [Q7M6Z4-1]
    XP_006517493.1. XM_006517430.1. [Q7M6Z4-1]
    XP_006517494.1. XM_006517431.1. [Q7M6Z4-1]
    XP_006517495.1. XM_006517432.1. [Q7M6Z4-1]
    XP_006517496.1. XM_006517433.1. [Q7M6Z4-1]
    XP_006517497.1. XM_006517434.1. [Q7M6Z4-1]
    XP_006517498.1. XM_006517435.1. [Q7M6Z4-1]
    XP_006517499.1. XM_006517436.1. [Q7M6Z4-1]
    UniGeneiMm.446094.

    Genome annotation databases

    EnsembliENSMUST00000043605; ENSMUSP00000043304; ENSMUSG00000060176. [Q7M6Z4-1]
    GeneIDi75050.
    KEGGimmu:75050.
    UCSCiuc007qtq.1. mouse. [Q7M6Z4-1]
    uc011zao.1. mouse. [Q7M6Z4-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC116646 mRNA. Translation: AAI16647.1 .
    AK032912 mRNA. Translation: BAC28083.1 .
    BK001056 mRNA. Translation: DAA01314.1 .
    CCDSi CCDS26570.1. [Q7M6Z4-1 ]
    RefSeqi NP_780423.2. NM_175214.3. [Q7M6Z4-1 ]
    XP_006517489.1. XM_006517426.1. [Q7M6Z4-1 ]
    XP_006517490.1. XM_006517427.1. [Q7M6Z4-1 ]
    XP_006517491.1. XM_006517428.1. [Q7M6Z4-1 ]
    XP_006517492.1. XM_006517429.1. [Q7M6Z4-1 ]
    XP_006517493.1. XM_006517430.1. [Q7M6Z4-1 ]
    XP_006517494.1. XM_006517431.1. [Q7M6Z4-1 ]
    XP_006517495.1. XM_006517432.1. [Q7M6Z4-1 ]
    XP_006517496.1. XM_006517433.1. [Q7M6Z4-1 ]
    XP_006517497.1. XM_006517434.1. [Q7M6Z4-1 ]
    XP_006517498.1. XM_006517435.1. [Q7M6Z4-1 ]
    XP_006517499.1. XM_006517436.1. [Q7M6Z4-1 ]
    UniGenei Mm.446094.

    3D structure databases

    ProteinModelPortali Q7M6Z4.
    SMRi Q7M6Z4. Positions 2-339.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-59753N.
    STRINGi 10090.ENSMUSP00000043304.

    PTM databases

    PhosphoSitei Q7M6Z4.

    Proteomic databases

    PaxDbi Q7M6Z4.
    PRIDEi Q7M6Z4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000043605 ; ENSMUSP00000043304 ; ENSMUSG00000060176 . [Q7M6Z4-1 ]
    GeneIDi 75050.
    KEGGi mmu:75050.
    UCSCi uc007qtq.1. mouse. [Q7M6Z4-1 ]
    uc011zao.1. mouse. [Q7M6Z4-2 ]

    Organism-specific databases

    CTDi 55582.
    MGIi MGI:1922300. Kif27.

    Phylogenomic databases

    eggNOGi COG5059.
    GeneTreei ENSGT00750000117462.
    HOGENOMi HOG000068072.
    HOVERGENi HBG054858.
    InParanoidi Q7M6Z4.
    KOi K10395.
    OMAi RETIVSK.
    OrthoDBi EOG7K3TK3.
    PhylomeDBi Q7M6Z4.
    TreeFami TF325946.

    Miscellaneous databases

    NextBioi 342092.
    PROi Q7M6Z4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q7M6Z4.
    CleanExi MM_KIF27.
    Genevestigatori Q7M6Z4.

    Family and domain databases

    Gene3Di 3.40.850.10. 1 hit.
    InterProi IPR027640. Kinesin-like_fam.
    IPR019821. Kinesin_motor_CS.
    IPR001752. Kinesin_motor_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR24115. PTHR24115. 1 hit.
    Pfami PF00225. Kinesin. 1 hit.
    [Graphical view ]
    PRINTSi PR00380. KINESINHEAVY.
    SMARTi SM00129. KISc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00411. KINESIN_MOTOR_1. 1 hit.
    PS50067. KINESIN_MOTOR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 726-1394 (ISOFORM 1).
      Strain: C57BL/6J.
    3. "Gene discovery in the hamster: a comparative genomics approach for gene annotation by sequencing of hamster testis cDNAs."
      Oduru S., Campbell J.L., Karri S., Hendry W.J., Khan S.A., Williams S.C.
      BMC Genomics 4:22-22(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION (ISOFORM 1).
    4. "A proteomics approach to identify the ubiquitinated proteins in mouse heart."
      Jeon H.B., Choi E.S., Yoon J.H., Hwang J.H., Chang J.W., Lee E.K., Choi H.W., Park Z.-Y., Yoo Y.J.
      Biochem. Biophys. Res. Commun. 357:731-736(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-1084.
      Tissue: Heart.
    5. "Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis."
      Wilson C.W., Nguyen C.T., Chen M.H., Yang J.H., Gacayan R., Huang J., Chen J.N., Chuang P.T.
      Nature 459:98-102(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH STK36.

    Entry informationi

    Entry nameiKIF27_MOUSE
    AccessioniPrimary (citable) accession number: Q7M6Z4
    Secondary accession number(s): Q14AX5, Q8BMB9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3