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Q7M6Z0

- R4RL2_MOUSE

UniProt

Q7M6Z0 - R4RL2_MOUSE

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Protein

Reticulon-4 receptor-like 2

Gene
Rtn4rl2, Ngrl3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May play a role in regulating axonal regeneration and plasticity in the adult nervous system By similarity.By similarity

GO - Molecular functioni

  1. receptor activity Source: UniProtKB

GO - Biological processi

  1. axon regeneration Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulon-4 receptor-like 2
Alternative name(s):
Nogo receptor-like 3
Nogo-66 receptor homolog 1
Nogo-66 receptor-related protein 2
Short name:
NgR2
Gene namesi
Name:Rtn4rl2
Synonyms:Ngrl3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:2669796. Rtn4rl2.

Subcellular locationi

Cell membrane; Lipid-anchorGPI-anchor Reviewed prediction

GO - Cellular componenti

  1. anchored component of plasma membrane Source: UniProtKB
  2. external side of plasma membrane Source: Ensembl
  3. membrane raft Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030 Reviewed predictionAdd
BLAST
Chaini31 – 398368Reticulon-4 receptor-like 2PRO_0000046050Add
BLAST
Propeptidei399 – 42022Removed in mature form Reviewed predictionPRO_0000046051Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi50 – 501N-linked (GlcNAc...) Reviewed prediction
Lipidationi398 – 3981GPI-anchor amidated glycine Reviewed prediction

Post-translational modificationi

Undergoes zinc metalloproteinase-mediated ectodomain shedding in neuroblastoma cells; where BRE is released as a full-length ectodomain and an N-terminal fragment containing the leucine-rich repeat (LRR) region of the protein By similarity.

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ7M6Z0.
PRIDEiQ7M6Z0.

PTM databases

PhosphoSiteiQ7M6Z0.

Expressioni

Developmental stagei

At E13.5, strongly expressed in PNS ganglia and developing heart, and weakly expressed in brain and spinal cord. By postnatal day 1, strongly expressed in dorsal root ganglia and in dorsal and gray matter areas of spinal cord. Expressed in various adult brain structures including the amygdala, cerebral cortex, cerebellum, hippocampus and olfactory bulb.1 Publication

Gene expression databases

ArrayExpressiQ7M6Z0.
BgeeiQ7M6Z0.
CleanExiMM_RTN4RL2.
GenevestigatoriQ7M6Z0.

Structurei

3D structure databases

ProteinModelPortaliQ7M6Z0.
SMRiQ7M6Z0. Positions 1-310.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 6030LRRNTAdd
BLAST
Repeati61 – 8222LRR 1Add
BLAST
Repeati83 – 10422LRR 2Add
BLAST
Repeati107 – 12923LRR 3Add
BLAST
Repeati132 – 15322LRR 4Add
BLAST
Repeati156 – 17722LRR 5Add
BLAST
Repeati180 – 20122LRR 6Add
BLAST
Repeati204 – 22522LRR 7Add
BLAST
Repeati228 – 24922LRR 8Add
BLAST
Domaini261 – 31252LRRCTAdd
BLAST

Sequence similaritiesi

Belongs to the Nogo receptor family.
Contains 1 LRRCT domain.
Contains 1 LRRNT domain.

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00750000117338.
HOGENOMiHOG000116109.
HOVERGENiHBG063707.
InParanoidiA2RTJ0.
KOiK16661.

Family and domain databases

InterProiIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7M6Z0-1 [UniParc]FASTAAdd to Basket

« Hide

MLPGLRRLLQ GPASACLLLT LLALPSVTPS CPMLCTCYSS PPTVSCQANN    50
FSSVPLSLPP STQRLFLQNN LIRSLRPGTF GPNLLTLWLF SNNLSTIHPG 100
TFRHLQALEE LDLGDNRHLR SLEPDTFQGL ERLQSLHLYR CQLSSLPGNI 150
FRGLVSLQYL YLQENSLLHL QDDLFADLAN LSHLFLHGNR LRLLTEHVFR 200
GLGSLDRLLL HGNRLQGVHR AAFHGLSRLT ILYLFNNSLA SLPGEALADL 250
PALEFLRLNA NPWACDCRAR PLWAWFQRAR VSSSDVTCAT PPERQGRDLR 300
ALRDSDFQAC PPPTPTRPGS RARGNSSSNH LYGVAEAGAP PADPSTLYRD 350
LPAEDSRGRQ GGDAPTEDDY WGGYGGEDQR GEQTCPGAAC QAPADSRGPA 400
LSAGLRTPLL CLLPLALHHL 420
Length:420
Mass (Da):46,075
Last modified:December 15, 2003 - v1
Checksum:i412500FEE8154B47
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY250220 mRNA. Translation: AAP82837.1.
BC132523 mRNA. Translation: AAI32524.1.
BC138154 mRNA. Translation: AAI38155.1.
AK142743 mRNA. Translation: BAE25181.1. Sequence problems.
BK001303 mRNA. Translation: DAA01386.1.
CCDSiCCDS16197.1.
RefSeqiNP_954693.1. NM_199223.1.
UniGeneiMm.389289.
Mm.86447.

Genome annotation databases

EnsembliENSMUST00000054514; ENSMUSP00000057725; ENSMUSG00000050896.
GeneIDi269295.
KEGGimmu:269295.
UCSCiuc008kjm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY250220 mRNA. Translation: AAP82837.1 .
BC132523 mRNA. Translation: AAI32524.1 .
BC138154 mRNA. Translation: AAI38155.1 .
AK142743 mRNA. Translation: BAE25181.1 . Sequence problems.
BK001303 mRNA. Translation: DAA01386.1 .
CCDSi CCDS16197.1.
RefSeqi NP_954693.1. NM_199223.1.
UniGenei Mm.389289.
Mm.86447.

3D structure databases

ProteinModelPortali Q7M6Z0.
SMRi Q7M6Z0. Positions 1-310.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q7M6Z0.

Proteomic databases

PaxDbi Q7M6Z0.
PRIDEi Q7M6Z0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000054514 ; ENSMUSP00000057725 ; ENSMUSG00000050896 .
GeneIDi 269295.
KEGGi mmu:269295.
UCSCi uc008kjm.1. mouse.

Organism-specific databases

CTDi 349667.
MGIi MGI:2669796. Rtn4rl2.

Phylogenomic databases

eggNOGi COG4886.
GeneTreei ENSGT00750000117338.
HOGENOMi HOG000116109.
HOVERGENi HBG063707.
InParanoidi A2RTJ0.
KOi K16661.

Miscellaneous databases

NextBioi 392775.
PROi Q7M6Z0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q7M6Z0.
Bgeei Q7M6Z0.
CleanExi MM_RTN4RL2.
Genevestigatori Q7M6Z0.

Family and domain databases

InterProi IPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view ]
Pfami PF13855. LRR_8. 2 hits.
[Graphical view ]
SMARTi SM00369. LRR_TYP. 4 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Two novel mammalian nogo receptor homologs differentially expressed in the central and peripheral nervous systems."
    Lauren J., Airaksinen M.S., Saarma M., Timmusk T.
    Mol. Cell. Neurosci. 24:581-594(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 379-420.
    Strain: C57BL/6J.
    Tissue: Heart.
  4. "Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins."
    Barton W.A., Liu B.P., Tzvetkova D., Jeffrey P.D., Fournier A.E., Sah D., Cate R., Strittmatter S.M., Nikolov D.B.
    EMBO J. 22:3291-3302(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiR4RL2_MOUSE
AccessioniPrimary (citable) accession number: Q7M6Z0
Secondary accession number(s): A2RTJ0, Q3UQ62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: December 15, 2003
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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