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Q7M6Z0 (R4RL2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Reticulon-4 receptor-like 2
Alternative name(s):
Nogo receptor-like 3
Nogo-66 receptor homolog 1
Nogo-66 receptor-related protein 2
Short name=NgR2
Gene names
Name:Rtn4rl2
Synonyms:Ngrl3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length420 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in regulating axonal regeneration and plasticity in the adult nervous system By similarity. UniProtKB Q86UN3

Subcellular location

Cell membrane; Lipid-anchorGPI-anchor Potential.

Developmental stage

At E13.5, strongly expressed in PNS ganglia and developing heart, and weakly expressed in brain and spinal cord. By postnatal day 1, strongly expressed in dorsal root ganglia and in dorsal and gray matter areas of spinal cord. Expressed in various adult brain structures including the amygdala, cerebral cortex, cerebellum, hippocampus and olfactory bulb. Ref.1

Post-translational modification

Undergoes zinc metalloproteinase-mediated ectodomain shedding in neuroblastoma cells; where BRE is released as a full-length ectodomain and an N-terminal fragment containing the leucine-rich repeat (LRR) region of the protein By similarity.

Sequence similarities

Belongs to the Nogo receptor family.

Contains 8 LRR (leucine-rich) repeats.

Contains 1 LRRCT domain.

Contains 1 LRRNT domain.

Sequence caution

The sequence BAE25181.1 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3030 Potential
Chain31 – 398368Reticulon-4 receptor-like 2
PRO_0000046050
Propeptide399 – 42022Removed in mature form Potential
PRO_0000046051

Regions

Domain31 – 6030LRRNT
Repeat61 – 8222LRR 1
Repeat83 – 10422LRR 2
Repeat107 – 12923LRR 3
Repeat132 – 15322LRR 4
Repeat156 – 17722LRR 5
Repeat180 – 20122LRR 6
Repeat204 – 22522LRR 7
Repeat228 – 24922LRR 8
Domain261 – 31252LRRCT

Amino acid modifications

Lipidation3981GPI-anchor amidated glycine Potential
Glycosylation501N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q7M6Z0 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 412500FEE8154B47

FASTA42046,075
        10         20         30         40         50         60 
MLPGLRRLLQ GPASACLLLT LLALPSVTPS CPMLCTCYSS PPTVSCQANN FSSVPLSLPP 

        70         80         90        100        110        120 
STQRLFLQNN LIRSLRPGTF GPNLLTLWLF SNNLSTIHPG TFRHLQALEE LDLGDNRHLR 

       130        140        150        160        170        180 
SLEPDTFQGL ERLQSLHLYR CQLSSLPGNI FRGLVSLQYL YLQENSLLHL QDDLFADLAN 

       190        200        210        220        230        240 
LSHLFLHGNR LRLLTEHVFR GLGSLDRLLL HGNRLQGVHR AAFHGLSRLT ILYLFNNSLA 

       250        260        270        280        290        300 
SLPGEALADL PALEFLRLNA NPWACDCRAR PLWAWFQRAR VSSSDVTCAT PPERQGRDLR 

       310        320        330        340        350        360 
ALRDSDFQAC PPPTPTRPGS RARGNSSSNH LYGVAEAGAP PADPSTLYRD LPAEDSRGRQ 

       370        380        390        400        410        420 
GGDAPTEDDY WGGYGGEDQR GEQTCPGAAC QAPADSRGPA LSAGLRTPLL CLLPLALHHL 

« Hide

References

« Hide 'large scale' references
[1]"Two novel mammalian nogo receptor homologs differentially expressed in the central and peripheral nervous systems."
Lauren J., Airaksinen M.S., Saarma M., Timmusk T.
Mol. Cell. Neurosci. 24:581-594(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 379-420.
Strain: C57BL/6J.
Tissue: Heart.
[4]"Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins."
Barton W.A., Liu B.P., Tzvetkova D., Jeffrey P.D., Fournier A.E., Sah D., Cate R., Strittmatter S.M., Nikolov D.B.
EMBO J. 22:3291-3302(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY250220 mRNA. Translation: AAP82837.1.
BC132523 mRNA. Translation: AAI32524.1.
BC138154 mRNA. Translation: AAI38155.1.
AK142743 mRNA. Translation: BAE25181.1. Sequence problems.
BK001303 mRNA. Translation: DAA01386.1.
RefSeqNP_954693.1. NM_199223.1.
UniGeneMm.389289.
Mm.86447.

3D structure databases

ProteinModelPortalQ7M6Z0.
SMRQ7M6Z0. Positions 31-344.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ7M6Z0.

Proteomic databases

PaxDbQ7M6Z0.
PRIDEQ7M6Z0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000054514; ENSMUSP00000057725; ENSMUSG00000050896.
GeneID269295.
KEGGmmu:269295.
UCSCuc008kjm.1. mouse.

Organism-specific databases

CTD349667.
MGIMGI:2669796. Rtn4rl2.

Phylogenomic databases

eggNOGCOG4886.
GeneTreeENSGT00750000117338.
HOGENOMHOG000116109.
HOVERGENHBG063707.
InParanoidA2RTJ0.
KOK16661.

Gene expression databases

ArrayExpressQ7M6Z0.
BgeeQ7M6Z0.
CleanExMM_RTN4RL2.
GenevestigatorQ7M6Z0.

Family and domain databases

InterProIPR000483. Cys-rich_flank_reg_C.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
SMARTSM00369. LRR_TYP. 4 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio392775.
PROQ7M6Z0.
SOURCESearch...

Entry information

Entry nameR4RL2_MOUSE
AccessionPrimary (citable) accession number: Q7M6Z0
Secondary accession number(s): A2RTJ0, Q3UQ62
Entry history
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: December 15, 2003
Last modified: April 16, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot