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Protein

Reticulon-4 receptor-like 2

Gene

Rtn4rl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in regulating axonal regeneration and plasticity in the adult nervous system.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulon-4 receptor-like 2
Alternative name(s):
Nogo receptor-like 3
Nogo-66 receptor homolog 1
Nogo-66 receptor-related protein 2
Short name:
NgR2
Gene namesi
Name:Rtn4rl2Imported
Synonyms:Ngrl3Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2669796. Rtn4rl2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000004605031 – 398Reticulon-4 receptor-like 2Add BLAST368
PropeptideiPRO_0000046051399 – 420Removed in mature formSequence analysisAdd BLAST22

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi50N-linked (GlcNAc...)Sequence analysis1
Lipidationi398GPI-anchor amidated glycineSequence analysis1

Post-translational modificationi

Undergoes zinc metalloproteinase-mediated ectodomain shedding in neuroblastoma cells; where BRE is released as a full-length ectodomain and an N-terminal fragment containing the leucine-rich repeat (LRR) region of the protein.By similarity

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ7M6Z0.
PRIDEiQ7M6Z0.

PTM databases

iPTMnetiQ7M6Z0.
PhosphoSitePlusiQ7M6Z0.

Expressioni

Developmental stagei

At E13.5, strongly expressed in PNS ganglia and developing heart, and weakly expressed in brain and spinal cord. By postnatal day 1, strongly expressed in dorsal root ganglia and in dorsal and gray matter areas of spinal cord. Expressed in various adult brain structures including the amygdala, cerebral cortex, cerebellum, hippocampus and olfactory bulb.1 Publication

Gene expression databases

BgeeiENSMUSG00000050896.
CleanExiMM_RTN4RL2.
ExpressionAtlasiQ7M6Z0. baseline and differential.
GenevisibleiQ7M6Z0. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057725.

Structurei

3D structure databases

ProteinModelPortaliQ7M6Z0.
SMRiQ7M6Z0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 60LRRNTAdd BLAST30
Repeati61 – 82LRR 1Add BLAST22
Repeati83 – 104LRR 2Add BLAST22
Repeati107 – 129LRR 3Add BLAST23
Repeati132 – 153LRR 4Add BLAST22
Repeati156 – 177LRR 5Add BLAST22
Repeati180 – 201LRR 6Add BLAST22
Repeati204 – 225LRR 7Add BLAST22
Repeati228 – 249LRR 8Add BLAST22
Domaini261 – 312LRRCTAdd BLAST52

Sequence similaritiesi

Belongs to the Nogo receptor family.Curated
Contains 8 LRR (leucine-rich) repeats.Sequence analysis
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000116109.
HOVERGENiHBG063707.
InParanoidiQ7M6Z0.
KOiK16661.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 8 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7M6Z0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPGLRRLLQ GPASACLLLT LLALPSVTPS CPMLCTCYSS PPTVSCQANN
60 70 80 90 100
FSSVPLSLPP STQRLFLQNN LIRSLRPGTF GPNLLTLWLF SNNLSTIHPG
110 120 130 140 150
TFRHLQALEE LDLGDNRHLR SLEPDTFQGL ERLQSLHLYR CQLSSLPGNI
160 170 180 190 200
FRGLVSLQYL YLQENSLLHL QDDLFADLAN LSHLFLHGNR LRLLTEHVFR
210 220 230 240 250
GLGSLDRLLL HGNRLQGVHR AAFHGLSRLT ILYLFNNSLA SLPGEALADL
260 270 280 290 300
PALEFLRLNA NPWACDCRAR PLWAWFQRAR VSSSDVTCAT PPERQGRDLR
310 320 330 340 350
ALRDSDFQAC PPPTPTRPGS RARGNSSSNH LYGVAEAGAP PADPSTLYRD
360 370 380 390 400
LPAEDSRGRQ GGDAPTEDDY WGGYGGEDQR GEQTCPGAAC QAPADSRGPA
410 420
LSAGLRTPLL CLLPLALHHL
Length:420
Mass (Da):46,075
Last modified:December 15, 2003 - v1
Checksum:i412500FEE8154B47
GO

Sequence cautioni

The sequence BAE25181 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY250220 mRNA. Translation: AAP82837.1.
BC132523 mRNA. Translation: AAI32524.1.
BC138154 mRNA. Translation: AAI38155.1.
AK142743 mRNA. Translation: BAE25181.1. Sequence problems.
BK001303 mRNA. Translation: DAA01386.1.
CCDSiCCDS16197.1.
RefSeqiNP_954693.1. NM_199223.1.
UniGeneiMm.389289.
Mm.86447.

Genome annotation databases

EnsembliENSMUST00000054514; ENSMUSP00000057725; ENSMUSG00000050896.
GeneIDi269295.
KEGGimmu:269295.
UCSCiuc008kjm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY250220 mRNA. Translation: AAP82837.1.
BC132523 mRNA. Translation: AAI32524.1.
BC138154 mRNA. Translation: AAI38155.1.
AK142743 mRNA. Translation: BAE25181.1. Sequence problems.
BK001303 mRNA. Translation: DAA01386.1.
CCDSiCCDS16197.1.
RefSeqiNP_954693.1. NM_199223.1.
UniGeneiMm.389289.
Mm.86447.

3D structure databases

ProteinModelPortaliQ7M6Z0.
SMRiQ7M6Z0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057725.

PTM databases

iPTMnetiQ7M6Z0.
PhosphoSitePlusiQ7M6Z0.

Proteomic databases

PaxDbiQ7M6Z0.
PRIDEiQ7M6Z0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054514; ENSMUSP00000057725; ENSMUSG00000050896.
GeneIDi269295.
KEGGimmu:269295.
UCSCiuc008kjm.1. mouse.

Organism-specific databases

CTDi349667.
MGIiMGI:2669796. Rtn4rl2.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000116109.
HOVERGENiHBG063707.
InParanoidiQ7M6Z0.
KOiK16661.

Miscellaneous databases

PROiQ7M6Z0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050896.
CleanExiMM_RTN4RL2.
ExpressionAtlasiQ7M6Z0. baseline and differential.
GenevisibleiQ7M6Z0. MM.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 8 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiR4RL2_MOUSE
AccessioniPrimary (citable) accession number: Q7M6Z0
Secondary accession number(s): A2RTJ0, Q3UQ62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: December 15, 2003
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.