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Q7M6Z0

- R4RL2_MOUSE

UniProt

Q7M6Z0 - R4RL2_MOUSE

Protein

Reticulon-4 receptor-like 2

Gene

Rtn4rl2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    May play a role in regulating axonal regeneration and plasticity in the adult nervous system.By similarity

    GO - Molecular functioni

    1. receptor activity Source: UniProtKB

    GO - Biological processi

    1. axon regeneration Source: UniProtKB

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Reticulon-4 receptor-like 2
    Alternative name(s):
    Nogo receptor-like 3
    Nogo-66 receptor homolog 1
    Nogo-66 receptor-related protein 2
    Short name:
    NgR2
    Gene namesi
    Name:Rtn4rl2Imported
    Synonyms:Ngrl3Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:2669796. Rtn4rl2.

    Subcellular locationi

    GO - Cellular componenti

    1. anchored component of plasma membrane Source: UniProtKB
    2. external side of plasma membrane Source: Ensembl
    3. membrane raft Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030Sequence AnalysisAdd
    BLAST
    Chaini31 – 398368Reticulon-4 receptor-like 2PRO_0000046050Add
    BLAST
    Propeptidei399 – 42022Removed in mature formSequence AnalysisPRO_0000046051Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi50 – 501N-linked (GlcNAc...)Sequence Analysis
    Lipidationi398 – 3981GPI-anchor amidated glycineSequence Analysis

    Post-translational modificationi

    Undergoes zinc metalloproteinase-mediated ectodomain shedding in neuroblastoma cells; where BRE is released as a full-length ectodomain and an N-terminal fragment containing the leucine-rich repeat (LRR) region of the protein.By similarity

    Keywords - PTMi

    Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    PaxDbiQ7M6Z0.
    PRIDEiQ7M6Z0.

    PTM databases

    PhosphoSiteiQ7M6Z0.

    Expressioni

    Developmental stagei

    At E13.5, strongly expressed in PNS ganglia and developing heart, and weakly expressed in brain and spinal cord. By postnatal day 1, strongly expressed in dorsal root ganglia and in dorsal and gray matter areas of spinal cord. Expressed in various adult brain structures including the amygdala, cerebral cortex, cerebellum, hippocampus and olfactory bulb.1 Publication

    Gene expression databases

    ArrayExpressiQ7M6Z0.
    BgeeiQ7M6Z0.
    CleanExiMM_RTN4RL2.
    GenevestigatoriQ7M6Z0.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7M6Z0.
    SMRiQ7M6Z0. Positions 1-310.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini31 – 6030LRRNTAdd
    BLAST
    Repeati61 – 8222LRR 1Add
    BLAST
    Repeati83 – 10422LRR 2Add
    BLAST
    Repeati107 – 12923LRR 3Add
    BLAST
    Repeati132 – 15322LRR 4Add
    BLAST
    Repeati156 – 17722LRR 5Add
    BLAST
    Repeati180 – 20122LRR 6Add
    BLAST
    Repeati204 – 22522LRR 7Add
    BLAST
    Repeati228 – 24922LRR 8Add
    BLAST
    Domaini261 – 31252LRRCTAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Nogo receptor family.Curated
    Contains 8 LRR (leucine-rich) repeats.Sequence Analysis
    Contains 1 LRRCT domain.Curated
    Contains 1 LRRNT domain.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG4886.
    GeneTreeiENSGT00750000117338.
    HOGENOMiHOG000116109.
    HOVERGENiHBG063707.
    InParanoidiA2RTJ0.
    KOiK16661.

    Family and domain databases

    InterProiIPR000483. Cys-rich_flank_reg_C.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    [Graphical view]
    PfamiPF13855. LRR_8. 2 hits.
    [Graphical view]
    SMARTiSM00369. LRR_TYP. 4 hits.
    SM00082. LRRCT. 1 hit.
    SM00013. LRRNT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q7M6Z0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLPGLRRLLQ GPASACLLLT LLALPSVTPS CPMLCTCYSS PPTVSCQANN    50
    FSSVPLSLPP STQRLFLQNN LIRSLRPGTF GPNLLTLWLF SNNLSTIHPG 100
    TFRHLQALEE LDLGDNRHLR SLEPDTFQGL ERLQSLHLYR CQLSSLPGNI 150
    FRGLVSLQYL YLQENSLLHL QDDLFADLAN LSHLFLHGNR LRLLTEHVFR 200
    GLGSLDRLLL HGNRLQGVHR AAFHGLSRLT ILYLFNNSLA SLPGEALADL 250
    PALEFLRLNA NPWACDCRAR PLWAWFQRAR VSSSDVTCAT PPERQGRDLR 300
    ALRDSDFQAC PPPTPTRPGS RARGNSSSNH LYGVAEAGAP PADPSTLYRD 350
    LPAEDSRGRQ GGDAPTEDDY WGGYGGEDQR GEQTCPGAAC QAPADSRGPA 400
    LSAGLRTPLL CLLPLALHHL 420
    Length:420
    Mass (Da):46,075
    Last modified:December 15, 2003 - v1
    Checksum:i412500FEE8154B47
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY250220 mRNA. Translation: AAP82837.1.
    BC132523 mRNA. Translation: AAI32524.1.
    BC138154 mRNA. Translation: AAI38155.1.
    AK142743 mRNA. Translation: BAE25181.1. Sequence problems.
    BK001303 mRNA. Translation: DAA01386.1.
    CCDSiCCDS16197.1.
    RefSeqiNP_954693.1. NM_199223.1.
    UniGeneiMm.389289.
    Mm.86447.

    Genome annotation databases

    EnsembliENSMUST00000054514; ENSMUSP00000057725; ENSMUSG00000050896.
    GeneIDi269295.
    KEGGimmu:269295.
    UCSCiuc008kjm.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY250220 mRNA. Translation: AAP82837.1 .
    BC132523 mRNA. Translation: AAI32524.1 .
    BC138154 mRNA. Translation: AAI38155.1 .
    AK142743 mRNA. Translation: BAE25181.1 . Sequence problems.
    BK001303 mRNA. Translation: DAA01386.1 .
    CCDSi CCDS16197.1.
    RefSeqi NP_954693.1. NM_199223.1.
    UniGenei Mm.389289.
    Mm.86447.

    3D structure databases

    ProteinModelPortali Q7M6Z0.
    SMRi Q7M6Z0. Positions 1-310.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q7M6Z0.

    Proteomic databases

    PaxDbi Q7M6Z0.
    PRIDEi Q7M6Z0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000054514 ; ENSMUSP00000057725 ; ENSMUSG00000050896 .
    GeneIDi 269295.
    KEGGi mmu:269295.
    UCSCi uc008kjm.1. mouse.

    Organism-specific databases

    CTDi 349667.
    MGIi MGI:2669796. Rtn4rl2.

    Phylogenomic databases

    eggNOGi COG4886.
    GeneTreei ENSGT00750000117338.
    HOGENOMi HOG000116109.
    HOVERGENi HBG063707.
    InParanoidi A2RTJ0.
    KOi K16661.

    Miscellaneous databases

    NextBioi 392775.
    PROi Q7M6Z0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q7M6Z0.
    Bgeei Q7M6Z0.
    CleanExi MM_RTN4RL2.
    Genevestigatori Q7M6Z0.

    Family and domain databases

    InterProi IPR000483. Cys-rich_flank_reg_C.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    [Graphical view ]
    Pfami PF13855. LRR_8. 2 hits.
    [Graphical view ]
    SMARTi SM00369. LRR_TYP. 4 hits.
    SM00082. LRRCT. 1 hit.
    SM00013. LRRNT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Two novel mammalian nogo receptor homologs differentially expressed in the central and peripheral nervous systems."
      Lauren J., Airaksinen M.S., Saarma M., Timmusk T.
      Mol. Cell. Neurosci. 24:581-594(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
      Tissue: Brain1 Publication.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 379-420.
      Strain: C57BL/6JImported.
      Tissue: HeartImported.
    4. "Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins."
      Barton W.A., Liu B.P., Tzvetkova D., Jeffrey P.D., Fournier A.E., Sah D., Cate R., Strittmatter S.M., Nikolov D.B.
      EMBO J. 22:3291-3302(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiR4RL2_MOUSE
    AccessioniPrimary (citable) accession number: Q7M6Z0
    Secondary accession number(s): A2RTJ0, Q3UQ62
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 7, 2006
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3