Q7M6Y2 (SOX11_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transcription factor SOX-11

Gene names

Name:	Sox11
Synonyms:	Sox-11

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	395 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probably important in the developing nervous system. May also have a role in tissue modeling during development.
Subcellular location	Nucleus Ref.2.
Tissue specificity	Expression prominent in the periventricular cells of the central nervous system, also observed in a wide range of tissues involved in epithelial-mesenchymal interactions.
Developmental stage	Expression detected from 8.5 dpc through to 13.5 dpc, with a considerable increase in expression apparent at 13.5 dpc.
Sequence similarities	Contains 1 HMG box DNA-binding domain.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Molecular function	Developmental protein
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cardiac ventricle formation Inferred from mutant phenotype PubMed 20596238. Source: UniProtKB closure of optic fissure Inferred from mutant phenotype PubMed 18423449. Source: UniProtKB cornea development in camera-type eye Inferred from mutant phenotype PubMed 18423449. Source: UniProtKB embryonic digestive tract morphogenesis Inferred from mutant phenotype PubMed 15254231. Source: UniProtKB embryonic skeletal system morphogenesis Inferred from mutant phenotype PubMed 15254231. Source: UniProtKB eyelid development in camera-type eye Inferred from mutant phenotype PubMed 15254231. Source: UniProtKB glial cell development Inferred from mutant phenotype PubMed 20147379PubMed 20646169. Source: UniProtKB glial cell proliferation Inferred from mutant phenotype PubMed 20147379. Source: UniProtKB hard palate development Inferred from mutant phenotype PubMed 15254231. Source: UniProtKB kidney development Inferred from electronic annotation. Source: Compara lens morphogenesis in camera-type eye Inferred from mutant phenotype PubMed 18423449. Source: UniProtKB limb bud formation Inferred from mutant phenotype PubMed 20596238. Source: UniProtKB lung morphogenesis Inferred from mutant phenotype PubMed 15254231. Source: UniProtKB negative regulation of cell death Inferred from mutant phenotype PubMed 20596238PubMed 20646169. Source: UniProtKB negative regulation of glial cell proliferation Inferred from mutant phenotype PubMed 19808959. Source: UniProtKB negative regulation of lymphocyte proliferation Inferred from electronic annotation. Source: Compara negative regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 19808959. Source: UniProtKB negative regulation of transcription regulatory region DNA binding Inferred from sequence or structural similarity. Source: UniProtKB neural crest cell development Inferred from mutant phenotype PubMed 20596238. Source: UniProtKB neural tube formation Inferred from mutant phenotype PubMed 20596238. Source: UniProtKB neuroepithelial cell differentiation Inferred from mutant phenotype PubMed 20646169. Source: UniProtKB noradrenergic neuron differentiation Inferred from mutant phenotype PubMed 20147379. Source: UniProtKB oligodendrocyte development Inferred from electronic annotation. Source: Compara outflow tract morphogenesis Inferred from mutant phenotype PubMed 15254231. Source: UniProtKB positive regulation of BMP signaling pathway Inferred from mutant phenotype PubMed 18423449. Source: UniProtKB positive regulation of hippo signaling cascade Inferred from mutant phenotype PubMed 20596238. Source: UniProtKB positive regulation of hormone secretion Inferred from mutant phenotype PubMed 21527504. Source: UniProtKB positive regulation of lens epithelial cell proliferation Inferred from mutant phenotype PubMed 18423449. Source: UniProtKB positive regulation of neurogenesis Inferred from direct assay PubMed 19490090. Source: UniProtKB positive regulation of neuron differentiation Inferred from direct assay PubMed 19490090. Source: UniProtKB positive regulation of ossification Inferred from mutant phenotype PubMed 15254231. Source: UniProtKB positive regulation of osteoblast differentiation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of stem cell proliferation Inferred from sequence or structural similarity. Source: UniProtKB regulation of transforming growth factor beta receptor signaling pathway Inferred from electronic annotation. Source: Compara skeletal muscle cell differentiation Inferred from mutant phenotype PubMed 20847309. Source: MGI soft palate development Inferred from mutant phenotype PubMed 15254231. Source: UniProtKB somite development Inferred from mutant phenotype PubMed 20596238. Source: UniProtKB spinal cord development Inferred from mutant phenotype PubMed 20646169. Source: UniProtKB sympathetic nervous system development Inferred from mutant phenotype PubMed 20147379. Source: UniProtKB ventricular septum morphogenesis Inferred from mutant phenotype PubMed 15254231. Source: UniProtKB
Cellular_component	cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB nucleus Inferred from direct assay Ref.2PubMed 19490090PubMed 21527504. Source: UniProtKB
Molecular_function	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Inferred from direct assay PubMed 18505825. Source: UniProtKB RNA polymerase II core promoter sequence-specific DNA binding Inferred from electronic annotation. Source: Compara RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Inferred from sequence orthology PubMed 9632656. Source: MGI RNA polymerase II transcription coactivator activity Inferred from direct assay PubMed 18505825. Source: UniProtKB enhancer sequence-specific DNA binding Inferred from direct assay PubMed 19808959PubMed 21527504. Source: UniProtKB translation factor activity, nucleic acid binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 395	395	Transcription factor SOX-11		PRO_0000048751
Regions
	DNA binding	49 – 117	69	HMG box
	Compositional bias	188 – 214	27	Asp/Glu-rich (highly acidic)
	Compositional bias	297 – 308	12	Poly-Ser
Amino acid modifications
	Modified residue	244	1	Phosphoserine Ref.7
Experimental info
	Sequence conflict	103	1	E → G in AAB82425. Ref.1
	Sequence conflict	147	1	A → T in AAB82425. Ref.1
	Sequence conflict	171	1	A → V in AAB82425. Ref.1
	Sequence conflict	177	1	A → G Ref.1
	Sequence conflict	177	1	A → G Ref.2
	Sequence conflict	192 – 196	5	EDDDE → DEEDD in AAB82425. Ref.1
	Sequence conflict	225	1	T → A in AAB82425. Ref.1
	Sequence conflict	280 – 281	2	QP → EA in AAB82425. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q7M6Y2 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: AFA34270A054C6C5	FASTA	395	42,629
	10 20 30 40 50 60 MVQQAESSEA ESNLPRDALD TEEGEFMACS PVALDESDPD WCKTASGHIK RPMNAFMVWS 70 80 90 100 110 120 KIERRKIMEQ SPDMHNAEIS KRLGKRWKML KDSEKIPFIR EAERLRLKHM ADYPDYKYRP 130 140 150 160 170 180 RKKPKTDPAA KPSAGQSPDK SAAGAKAAKG PGKKCAKLKA PAGKAGAGKA AQPGDCAAGK 190 200 210 220 230 240 AAKCVFLDDD DEDDDEDDEL QLRPKPDADD DDDEPAHSHL LPPPTQQQPP QLLRRYSVAK 250 260 270 280 290 300 VPASPTLSSA AESPEGASLY DEVRAGGRLY YSFKNITKQQ PPPAPPALSP ASSRCVSTSS 310 320 330 340 350 360 SSGSSSGSGA EDADDLMFDL SLNFSQGAHS ACEQPLGAGA AGNLSLSLVD KDLDSFSEGS 370 380 390 LGSHFEFPDY CTPELSEMIA GDWLEANFSD LVFTY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression of the Sox11 gene in mouse embryos suggests roles in neuronal maturation and epithelio-mesenchymal induction." Hargrave M., Wright E., Kun J., Emery J., Cooper L., Koopman P. Dev. Dyn. 210:79-86(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Embryo.
[2]	"Interplay of SOX and POU factors in regulation of the nestin gene in neural primordial cells." Tanaka S., Kamachi Y., Tanouchi A., Hamada H., Jing N., Kondoh H. Mol. Cell. Biol. 24:8834-8846(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION. Strain: 129/Ola.
[3]	"Screening for mammalian neural genes via fluorescence-activated cell sorter purification of neural precursors from Sox1-gfp knock-in mice." Aubert J., Stavridis M.P., Tweedie S., O'Reilly M., Vierlinger K., Li M., Ghazal P., Pratt T., Mason J.O., Roy D., Smith A. Proc. Natl. Acad. Sci. U.S.A. 100:11836-11841(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[4]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Heart and Lung.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6.
[6]	"Seven new members of the Sox gene family expressed during mouse development." Wright E.M., Snopek B., Koopman P. Nucleic Acids Res. 21:744-744(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 57-112.
[7]	"Phosphoproteomic analysis of the developing mouse brain." Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P. Mol. Cell. Proteomics 3:1093-1101(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-244, MASS SPECTROMETRY. Tissue: Embryonic brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF009414 mRNA. Translation: AAB82425.1. AB108675 mRNA. Translation: BAC75670.1. BK001484 mRNA. Translation: DAA01568.1. AK165693 mRNA. Translation: BAE38341.1. AK146514 mRNA. Translation: BAE27226.1. BC062095 mRNA. Translation: AAH62095.1. Z18960 mRNA. Translation: CAA79485.1.
IPI	IPI00556698.
RefSeq	NP_033260.4. NM_009234.6.
UniGene	Mm.41702. Mm.466344.
3D structure databases
ProteinModelPortal	Q7M6Y2.
SMR	Q7M6Y2. Positions 47-122.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000078070.
PTM databases
PhosphoSite	Q7M6Y2.
Proteomic databases
PRIDE	Q7M6Y2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000079063; ENSMUSP00000078070; ENSMUSG00000063632.
GeneID	20666.
KEGG	mmu:20666.
UCSC	uc007nfn.2. mouse.
Organism-specific databases
CTD	6664.
MGI	MGI:98359. Sox11.
Phylogenomic databases
eggNOG	NOG130659.
GeneTree	ENSGT00690000101789.
HOGENOM	HOG000231874.
HOVERGEN	HBG005040.
InParanoid	Q7M6Y2.
KO	K09268.
OMA	TEEGEFM.
OrthoDB	EOG4QVCCX.
Gene expression databases
Bgee	Q7M6Y2.
CleanEx	MM_SOX11.
Genevestigator	Q7M6Y2.
GermOnline	ENSMUSG00000063632. Mus musculus.
Family and domain databases
Gene3D	1.10.30.10. 1 hit.
InterPro	IPR009071. HMG_box_dom. IPR017386. SOX-12/11/4a. [Graphical view]
Pfam	PF00505. HMG_box. 1 hit. [Graphical view]
PIRSF	PIRSF038098. SOX-12/11/4a. 1 hit.
SMART	SM00398. HMG. 1 hit. [Graphical view]
SUPFAM	SSF47095. HMG-box. 1 hit.
PROSITE	PS50118. HMG_BOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SOX11. mouse.
NextBio	299129.
SOURCE	Search...

Entry information

Entry name

SOX11_MOUSE

Accession

Primary (citable) accession number: Q7M6Y2
Secondary accession number(s): O35178 , O89036, Q04889, Q80XF0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	December 15, 2003
Last modified:	May 1, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program