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Protein

Transcription factor SOX-11

Gene

Sox11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional factor involved in the embryonic neurogenesis. May also have a role in tissue modeling during development.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi49 – 11769HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • cardiac ventricle formation Source: UniProtKB
  • closure of optic fissure Source: UniProtKB
  • cornea development in camera-type eye Source: UniProtKB
  • embryonic digestive tract morphogenesis Source: UniProtKB
  • embryonic skeletal system morphogenesis Source: UniProtKB
  • eyelid development in camera-type eye Source: UniProtKB
  • glial cell development Source: UniProtKB
  • glial cell proliferation Source: UniProtKB
  • hard palate development Source: UniProtKB
  • kidney development Source: Ensembl
  • lens morphogenesis in camera-type eye Source: UniProtKB
  • limb bud formation Source: UniProtKB
  • lung morphogenesis Source: UniProtKB
  • negative regulation of cell death Source: UniProtKB
  • negative regulation of gene expression Source: UniProtKB
  • negative regulation of glial cell proliferation Source: UniProtKB
  • negative regulation of lymphocyte proliferation Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • negative regulation of transcription regulatory region DNA binding Source: UniProtKB
  • neural crest cell development Source: UniProtKB
  • neural tube formation Source: UniProtKB
  • neuroepithelial cell differentiation Source: UniProtKB
  • noradrenergic neuron differentiation Source: UniProtKB
  • oligodendrocyte development Source: Ensembl
  • outflow tract morphogenesis Source: UniProtKB
  • positive regulation of BMP signaling pathway Source: UniProtKB
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of hippo signaling Source: UniProtKB
  • positive regulation of hormone secretion Source: UniProtKB
  • positive regulation of lens epithelial cell proliferation Source: UniProtKB
  • positive regulation of neurogenesis Source: UniProtKB
  • positive regulation of neuron differentiation Source: UniProtKB
  • positive regulation of ossification Source: UniProtKB
  • positive regulation of osteoblast differentiation Source: UniProtKB
  • positive regulation of stem cell proliferation Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
  • signal transduction involved in cell cycle checkpoint Source: Ensembl
  • skeletal muscle cell differentiation Source: MGI
  • skeletal system development Source: UniProtKB
  • soft palate development Source: UniProtKB
  • somite development Source: UniProtKB
  • spinal cord development Source: UniProtKB
  • sympathetic nervous system development Source: UniProtKB
  • translation Source: MGI
  • ventricular septum morphogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-11
Gene namesi
Name:Sox11
Synonyms:Sox-11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:98359. Sox11.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation1 Publication

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 395395Transcription factor SOX-11PRO_0000048751Add
BLAST

Proteomic databases

MaxQBiQ7M6Y2.
PaxDbiQ7M6Y2.
PRIDEiQ7M6Y2.

PTM databases

iPTMnetiQ7M6Y2.
PhosphoSiteiQ7M6Y2.

Expressioni

Tissue specificityi

Expression prominent in the periventricular cells of the central nervous system, also observed in a wide range of tissues involved in epithelial-mesenchymal interactions.

Developmental stagei

Expression detected from 8.5 dpc through to 13.5 dpc, with a considerable increase in expression apparent at 13.5 dpc.

Gene expression databases

BgeeiQ7M6Y2.
CleanExiMM_SOX11.
GenevisibleiQ7M6Y2. MM.

Interactioni

Protein-protein interaction databases

BioGridi203398. 1 interaction.
STRINGi10090.ENSMUSP00000078070.

Structurei

3D structure databases

ProteinModelPortaliQ7M6Y2.
SMRiQ7M6Y2. Positions 47-122.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi188 – 21427Asp/Glu-rich (highly acidic)Add
BLAST
Compositional biasi297 – 30812Poly-SerAdd
BLAST

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0527. Eukaryota.
ENOG410XT0K. LUCA.
GeneTreeiENSGT00760000118988.
HOGENOMiHOG000231874.
HOVERGENiHBG005040.
InParanoidiQ7M6Y2.
KOiK09268.
OMAiTVKCVFM.
OrthoDBiEOG7TMZVP.
PhylomeDBiQ7M6Y2.
TreeFamiTF351735.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR029551. SOX-11.
[Graphical view]
PANTHERiPTHR10270:SF113. PTHR10270:SF113. 1 hit.
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7M6Y2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQQAESSEA ESNLPRDALD TEEGEFMACS PVALDESDPD WCKTASGHIK
60 70 80 90 100
RPMNAFMVWS KIERRKIMEQ SPDMHNAEIS KRLGKRWKML KDSEKIPFIR
110 120 130 140 150
EAERLRLKHM ADYPDYKYRP RKKPKTDPAA KPSAGQSPDK SAAGAKAAKG
160 170 180 190 200
PGKKCAKLKA PAGKAGAGKA AQPGDCAAGK AAKCVFLDDD DEDDDEDDEL
210 220 230 240 250
QLRPKPDADD DDDEPAHSHL LPPPTQQQPP QLLRRYSVAK VPASPTLSSA
260 270 280 290 300
AESPEGASLY DEVRAGGRLY YSFKNITKQQ PPPAPPALSP ASSRCVSTSS
310 320 330 340 350
SSGSSSGSGA EDADDLMFDL SLNFSQGAHS ACEQPLGAGA AGNLSLSLVD
360 370 380 390
KDLDSFSEGS LGSHFEFPDY CTPELSEMIA GDWLEANFSD LVFTY
Length:395
Mass (Da):42,629
Last modified:December 15, 2003 - v1
Checksum:iAFA34270A054C6C5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti103 – 1031E → G in AAB82425 (PubMed:9337129).Curated
Sequence conflicti147 – 1471A → T in AAB82425 (PubMed:9337129).Curated
Sequence conflicti171 – 1711A → V in AAB82425 (PubMed:9337129).Curated
Sequence conflicti177 – 1771A → G (PubMed:9337129).Curated
Sequence conflicti177 – 1771A → G (PubMed:15456859).Curated
Sequence conflicti192 – 1965EDDDE → DEEDD in AAB82425 (PubMed:9337129).Curated
Sequence conflicti225 – 2251T → A in AAB82425 (PubMed:9337129).Curated
Sequence conflicti280 – 2812QP → EA in AAB82425 (PubMed:9337129).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009414 mRNA. Translation: AAB82425.1.
AB108675 mRNA. Translation: BAC75670.1.
BK001484 mRNA. Translation: DAA01568.1.
AK165693 mRNA. Translation: BAE38341.1.
AK146514 mRNA. Translation: BAE27226.1.
BC062095 mRNA. Translation: AAH62095.1.
Z18960 mRNA. Translation: CAA79485.1.
CCDSiCCDS25849.1.
RefSeqiNP_033260.4. NM_009234.6.
UniGeneiMm.41702.
Mm.466344.

Genome annotation databases

EnsembliENSMUST00000079063; ENSMUSP00000078070; ENSMUSG00000063632.
GeneIDi20666.
KEGGimmu:20666.
UCSCiuc007nfn.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009414 mRNA. Translation: AAB82425.1.
AB108675 mRNA. Translation: BAC75670.1.
BK001484 mRNA. Translation: DAA01568.1.
AK165693 mRNA. Translation: BAE38341.1.
AK146514 mRNA. Translation: BAE27226.1.
BC062095 mRNA. Translation: AAH62095.1.
Z18960 mRNA. Translation: CAA79485.1.
CCDSiCCDS25849.1.
RefSeqiNP_033260.4. NM_009234.6.
UniGeneiMm.41702.
Mm.466344.

3D structure databases

ProteinModelPortaliQ7M6Y2.
SMRiQ7M6Y2. Positions 47-122.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203398. 1 interaction.
STRINGi10090.ENSMUSP00000078070.

PTM databases

iPTMnetiQ7M6Y2.
PhosphoSiteiQ7M6Y2.

Proteomic databases

MaxQBiQ7M6Y2.
PaxDbiQ7M6Y2.
PRIDEiQ7M6Y2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000079063; ENSMUSP00000078070; ENSMUSG00000063632.
GeneIDi20666.
KEGGimmu:20666.
UCSCiuc007nfn.2. mouse.

Organism-specific databases

CTDi6664.
MGIiMGI:98359. Sox11.

Phylogenomic databases

eggNOGiKOG0527. Eukaryota.
ENOG410XT0K. LUCA.
GeneTreeiENSGT00760000118988.
HOGENOMiHOG000231874.
HOVERGENiHBG005040.
InParanoidiQ7M6Y2.
KOiK09268.
OMAiTVKCVFM.
OrthoDBiEOG7TMZVP.
PhylomeDBiQ7M6Y2.
TreeFamiTF351735.

Miscellaneous databases

ChiTaRSiSox11. mouse.
PROiQ7M6Y2.
SOURCEiSearch...

Gene expression databases

BgeeiQ7M6Y2.
CleanExiMM_SOX11.
GenevisibleiQ7M6Y2. MM.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR029551. SOX-11.
[Graphical view]
PANTHERiPTHR10270:SF113. PTHR10270:SF113. 1 hit.
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of the Sox11 gene in mouse embryos suggests roles in neuronal maturation and epithelio-mesenchymal induction."
    Hargrave M., Wright E., Kun J., Emery J., Cooper L., Koopman P.
    Dev. Dyn. 210:79-86(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryo.
  2. "Interplay of SOX and POU factors in regulation of the nestin gene in neural primordial cells."
    Tanaka S., Kamachi Y., Tanouchi A., Hamada H., Jing N., Kondoh H.
    Mol. Cell. Biol. 24:8834-8846(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
    Strain: 129/Ola.
  3. "Screening for mammalian neural genes via fluorescence-activated cell sorter purification of neural precursors from Sox1-gfp knock-in mice."
    Aubert J., Stavridis M.P., Tweedie S., O'Reilly M., Vierlinger K., Li M., Ghazal P., Pratt T., Mason J.O., Roy D., Smith A.
    Proc. Natl. Acad. Sci. U.S.A. 100:11836-11841(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Heart and Lung.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  6. "Seven new members of the Sox gene family expressed during mouse development."
    Wright E.M., Snopek B., Koopman P.
    Nucleic Acids Res. 21:744-744(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 57-112.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.

Entry informationi

Entry nameiSOX11_MOUSE
AccessioniPrimary (citable) accession number: Q7M6Y2
Secondary accession number(s): O35178
, O89036, Q04889, Q80XF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 15, 2003
Last modified: July 6, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.