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Q7M6U3

- TEX14_MOUSE

UniProt

Q7M6U3 - TEX14_MOUSE

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Protein

Inactive serine/threonine-protein kinase TEX14

Gene
Tex14
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro.4 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei267 – 2671ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi205 – 2139ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein binding Source: UniProtKB
  3. protein kinase activity Source: InterPro

GO - Biological processi

  1. attachment of spindle microtubules to kinetochore Source: UniProtKB
  2. intercellular bridge organization Source: UniProtKB
  3. male meiosis Source: UniProtKB
  4. mitotic sister chromatid separation Source: UniProtKB
  5. mitotic spindle assembly checkpoint Source: UniProtKB
  6. negative regulation of cytokinesis Source: MGI
  7. negative regulation of protein binding Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive serine/threonine-protein kinase TEX14
Alternative name(s):
Testis-expressed sequence 14
Testis-expressed sequence 14 protein
Gene namesi
Name:Tex14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1933227. Tex14.

Subcellular locationi

Cytoplasm. Midbody. Chromosomecentromerekinetochore
Note: Detected in the intercellular bridges that connect male germ cell daughter cells after cell division.6 Publications

GO - Cellular componenti

  1. cell Source: UniProtKB
  2. condensed chromosome kinetochore Source: UniProtKB-SubCell
  3. cytoplasm Source: UniProtKB-SubCell
  4. intercellular bridge Source: UniProtKB
  5. kinetochore Source: UniProtKB
  6. midbody Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Kinetochore

Pathology & Biotechi

Disruption phenotypei

Male mice are sterile, due to the absence of intercellular bridges. Intercellular bridges do not form during spermatogenesis, and male mice are sterile. In females, embryonic intercellular bridges are also absent, mice have fewer oocytes, but they are fertile.2 Publications

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi431 – 4311S → A: Reduced phosphorylation by PLK1 and abolishes depletion from kinetochores and subsequent degradation by the APC/C complex. 1 Publication
Mutagenesisi431 – 4311S → D or E: Mimicks phosphorylation state; inducing early depletion from kinetochores and subsequent degradation by the APC/C complex. 1 Publication
Mutagenesisi791 – 7911G → A: Does not affect interaction with CEP55. 1 Publication
Mutagenesisi792 – 7921P → A: Abolishes interaction with CEP55. 1 Publication
Mutagenesisi797 – 7971Y → A: Abolishes interaction with CEP55. 1 Publication
Mutagenesisi889 – 8979Missing: Prevents degradation during metaphase. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14501450Inactive serine/threonine-protein kinase TEX14PRO_0000246996Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei431 – 4311Phosphoserine; by PLK11 Publication

Post-translational modificationi

Phosphorylated on Thr residues by CDK1 during early phases of mitosis, promoting the interaction with PLK1 and recruitment to kinetochores. Phosphorylated on Ser-431 by PLK1 during late prometaphase promotes the rapid depletion from kinetochores and its subsequent degradation by the APC/C complex.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ7M6U3.
PRIDEiQ7M6U3.

PTM databases

PhosphoSiteiQ7M6U3.

Expressioni

Tissue specificityi

Detected in testis and spermatogonia. Not detectable in the other tissues tested.3 Publications

Developmental stagei

Detected at low levels in developing testis at 5 and 10 days after birth. Highly expressed in testis 15 and 20 days after birth. Highly expressed in pachytene, diplotene and meiotically dividing spermatocytes and in early round spermatids.1 Publication

Gene expression databases

ArrayExpressiQ7M6U3.
BgeeiQ7M6U3.
CleanExiMM_TEX14.
GenevestigatoriQ7M6U3.

Interactioni

Subunit structurei

Interacts with KIF23 and RBM44. Interacts with CEP55; inhibiting interaction between CEP55 and PDCD6IP/ALIX and TSG101.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Cep55Q8BT0711EBI-6674575,EBI-2552328

Protein-protein interaction databases

IntActiQ7M6U3. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ7M6U3.
SMRiQ7M6U3. Positions 23-133, 225-533.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati27 – 5428ANK 1Add
BLAST
Repeati55 – 8430ANK 2Add
BLAST
Repeati88 – 11730ANK 3Add
BLAST
Domaini199 – 512314Protein kinaseAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi791 – 7977GPPX3Y
Motifi889 – 8979D-box

Domaini

The protein kinase domain is predicted to be catalytically inactive.
The GPPX3Y motif mediates interaction with CEP55 (1 Publication).

Sequence similaritiesi

Contains 3 ANK repeats.

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00390000015123.
HOVERGENiHBG094035.
InParanoidiQ7M6U3.
KOiK17540.
OMAiFSFFSGP.
OrthoDBiEOG75F4C9.
PhylomeDBiQ7M6U3.
TreeFamiTF328704.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q7M6U3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSRGAPFPVP CPVLLGTFTD DSLEAQLHEY AKQGNCVKLK KILKKGVCVD     50
AVNTQGQSAL FVAALLGHVK LVDVLVDYGS DPNHRCFDGS TPVHAAAFSG 100
NQWILSKLLT AGGDLRLHDE KGRNPQAWAL TAGKDRSTQM VEFMQRCTSH 150
MKAIIQGFSY DLLKKIDSPQ RLIGSPPWFG SLIQGSPNSS PNRQLKPGII 200
SAQNIYSFGF GKFYLTSGMQ LTYPGSLPVI GEKEVVQADD EPTFSFFSGP 250
YMVMTNLVWN RSRVTVKELN LPTRPHCSRL RLADLLIAEQ EHSSNLRHPN 300
LLQLMAVCLS RDLEKIRLVY ERITVGTLFS VLHERRSQFP VLHMEVIVHL 350
LLQVADALIY LHSRGFIHRS LSSYAVHIVS AGEARLTNLE YLTESQDSGA 400
HRNVTRMPLP TQLYNWAAPE VVLQKAATVK SDIYSFSVII QEILTDSIPW 450
NGLDGSLVKE TIALGNYLEA DVRLPEPYYD IVKSGIHAKQ KNRTMNLQDI 500
RYILKNDLKE FIGAQKTQPT ESPRGQSYEP HPDVNICLGL TSEYQKDPPD 550
LDIKELKEMG SQPHSPTDHS FLTVKPTLAP QTLDSSLSAQ KPDNANVPSP 600
PAACLAEEVR SPTASQDSLC SFEINEIYSG CLTLGTDKEE ECLGTAASPE 650
GDRPNQGDEL PSLEEELDKM ERELHCFCEE DKSISEVDTD LLFEDDDWQS 700
DSLGSLNLPE PTREAKGKTS SWSKTDEYVS KCVLNLKISQ VMMQQSAEWL 750
RKLEQEVEEL EWAQKELDSQ CSSLRDASLK FANAKFQPAV GPPSLAYLPP 800
VMQLPGLKQP ENGGTWLTLA RSPGNEREFQ EGHFSKKPEK LSACGWKPFT 850
QVSEESRGDC SELNNQLPTL RGPGKQSTGE QLPSTQEARE SLEKNTNQNS 900
RSMASVSSEI YATKSRNNED NGEAHLKWRL AVKEMAEKAV SGQLLLPPWN 950
PQSSAPFESK VENESTPLPR PPIRGPESTE WQHILEYQRE NDEPKGNTKF 1000
GKMDNSDCDK NKHSRWTGLQ RFTGIRYPFF RNHEQPEQNE ASQASCDTSV 1050
GTEKFYSTSS PIGDDFERFQ DSFAQRQGYV EENFQIREIF EKNAEILTKP 1100
QFQAIQCAED KQDETLGETP KELKEKNTSL TDIQDLSSIT YDQDGYFKET 1150
SYKTPKLKHA PTSASTPLSP ESISSAASHY EDCLENTTFH VKRGSTFCWN 1200
GQEAMRTLSA KFTTVRERAK SLESLLASSK SLPAKLTDSK RLCMLSETGS 1250
SNVSAAFVTS THATKRKSLP RELAEATSQQ HLDELPPPAQ ELLDEIEQLK 1300
QQQVSSLASH ENTARDLSVT NKDKKHLEEQ ETNSSKDSSF LSSREIQDLE 1350
DTERAHSSLD EDLERFLQSP EENTALLDPT KGSTREKKNK DQDVVEQKRK 1400
KKESIKPERR ESDSSLGTLE EDELKPCFWK RLGWSEPSRI IVLDQSDLSD 1450
Length:1,450
Mass (Da):162,541
Last modified:July 25, 2006 - v2
Checksum:i0628605EBE0FF0A4
GO
Isoform 2 (identifier: Q7M6U3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-218: Missing.

Show »
Length:1,232
Mass (Da):138,851
Checksum:iA2CDBD69A483AF39
GO

Sequence cautioni

The sequence CAI35965.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 218218Missing in isoform 2. VSP_019870Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti324 – 3241T → A in AAK31963. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF285584 mRNA. Translation: AAK31963.1.
AL596086, AL669902 Genomic DNA. Translation: CAI35127.1.
AL669902 Genomic DNA. Translation: CAI35965.1. Different initiation.
AL669902, AL596086 Genomic DNA. Translation: CAI35966.1.
CU406969, CU406988 Genomic DNA. Translation: CAQ52018.1.
CU406988, CU406969 Genomic DNA. Translation: CAQ52278.1.
AY193717 mRNA. Translation: AAN86761.1.
AY193718 mRNA. Translation: AAN86762.1.
BK000966 mRNA. Translation: DAA01357.1.
BK000967 mRNA. Translation: DAA01358.1.
AK139808 mRNA. Translation: BAE24144.1.
CCDSiCCDS48877.1. [Q7M6U3-1]
RefSeqiNP_001186222.1. NM_001199293.1.
NP_113563.2. NM_031386.2. [Q7M6U3-1]
XP_006534611.1. XM_006534548.1. [Q7M6U3-2]
XP_006534612.1. XM_006534549.1. [Q7M6U3-2]
XP_006536545.1. XM_006536482.1. [Q7M6U3-2]
XP_006536546.1. XM_006536483.1. [Q7M6U3-2]
UniGeneiMm.440758.

Genome annotation databases

EnsembliENSMUST00000060835; ENSMUSP00000054444; ENSMUSG00000010342. [Q7M6U3-1]
GeneIDi83560.
KEGGimmu:83560.
UCSCiuc007ktr.2. mouse. [Q7M6U3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF285584 mRNA. Translation: AAK31963.1 .
AL596086 , AL669902 Genomic DNA. Translation: CAI35127.1 .
AL669902 Genomic DNA. Translation: CAI35965.1 . Different initiation.
AL669902 , AL596086 Genomic DNA. Translation: CAI35966.1 .
CU406969 , CU406988 Genomic DNA. Translation: CAQ52018.1 .
CU406988 , CU406969 Genomic DNA. Translation: CAQ52278.1 .
AY193717 mRNA. Translation: AAN86761.1 .
AY193718 mRNA. Translation: AAN86762.1 .
BK000966 mRNA. Translation: DAA01357.1 .
BK000967 mRNA. Translation: DAA01358.1 .
AK139808 mRNA. Translation: BAE24144.1 .
CCDSi CCDS48877.1. [Q7M6U3-1 ]
RefSeqi NP_001186222.1. NM_001199293.1.
NP_113563.2. NM_031386.2. [Q7M6U3-1 ]
XP_006534611.1. XM_006534548.1. [Q7M6U3-2 ]
XP_006534612.1. XM_006534549.1. [Q7M6U3-2 ]
XP_006536545.1. XM_006536482.1. [Q7M6U3-2 ]
XP_006536546.1. XM_006536483.1. [Q7M6U3-2 ]
UniGenei Mm.440758.

3D structure databases

ProteinModelPortali Q7M6U3.
SMRi Q7M6U3. Positions 23-133, 225-533.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q7M6U3. 2 interactions.

PTM databases

PhosphoSitei Q7M6U3.

Proteomic databases

PaxDbi Q7M6U3.
PRIDEi Q7M6U3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000060835 ; ENSMUSP00000054444 ; ENSMUSG00000010342 . [Q7M6U3-1 ]
GeneIDi 83560.
KEGGi mmu:83560.
UCSCi uc007ktr.2. mouse. [Q7M6U3-1 ]

Organism-specific databases

CTDi 56155.
MGIi MGI:1933227. Tex14.

Phylogenomic databases

eggNOGi COG0666.
GeneTreei ENSGT00390000015123.
HOVERGENi HBG094035.
InParanoidi Q7M6U3.
KOi K17540.
OMAi FSFFSGP.
OrthoDBi EOG75F4C9.
PhylomeDBi Q7M6U3.
TreeFami TF328704.

Miscellaneous databases

NextBioi 350646.
PROi Q7M6U3.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q7M6U3.
Bgeei Q7M6U3.
CleanExi MM_TEX14.
Genevestigatori Q7M6U3.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF12796. Ank_2. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
SMARTi SM00248. ANK. 3 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "An abundance of X-linked genes expressed in spermatogonia."
    Wang P.J., McCarrey J.R., Yang F., Page D.C.
    Nat. Genet. 27:422-426(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Sequence and expression of testis-expressed gene 14 (Tex14): a gene encoding a protein kinase preferentially expressed during spermatogenesis."
    Wu M.-H., Rajkovic A., Burns K.H., Yan W., Lin Y.-N., Matzuk M.M.
    Gene Expr. Patterns 3:231-236(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-227 (ISOFORM 1), IDENTIFICATION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 714-1396.
    Strain: C57BL/6J.
    Tissue: Egg.
  5. Cited for: FUNCTION, ABSENCE OF PROTEIN KINASE ACTIVITY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
  6. "Conversion of midbodies into germ cell intercellular bridges."
    Greenbaum M.P., Ma L., Matzuk M.M.
    Dev. Biol. 305:389-396(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH KIF23.
  7. "Mouse TEX14 is required for embryonic germ cell intercellular bridges but not female fertility."
    Greenbaum M.P., Iwamori N., Agno J.E., Matzuk M.M.
    Biol. Reprod. 80:449-457(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE, SUBCELLULAR LOCATION.
  8. Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CEP55, MUTAGENESIS OF GLY-791; PRO-792 AND TYR-797.
  9. "Identification and characterization of RBM44 as a novel intercellular bridge protein."
    Iwamori T., Lin Y.N., Ma L., Iwamori N., Matzuk M.M.
    PLoS ONE 6:E17066-E17066(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RBM44.
  10. "Mouse germ cell clusters form by aggregation as well as clonal divisions."
    Mork L., Tang H., Batchvarov I., Capel B.
    Mech. Dev. 128:591-596(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  11. "Tex14, a plk1-regulated protein, is required for kinetochore-microtubule attachment and regulation of the spindle assembly checkpoint."
    Mondal G., Ohashi A., Yang L., Rowley M., Couch F.J.
    Mol. Cell 45:680-695(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION AT SER-431, MUTAGENESIS OF SER-431 AND 889-ARG--ASN-897.

Entry informationi

Entry nameiTEX14_MOUSE
AccessioniPrimary (citable) accession number: Q7M6U3
Secondary accession number(s): B2KGL0
, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: July 9, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Used as a marker for intercellular bridges (1 Publication).

Caution

Ser-370 is present instead of the conserved Asp which is expected to be an active site residue.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi