Q7M6U3 (TEX14_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inactive serine/threonine-protein kinase TEX14

Alternative name(s):
Testis-expressed sequence 14
Testis-expressed sequence 14 protein

Gene names

Name:

Tex14

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1450 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro. Ref.5 Ref.7 Ref.8 Ref.11
Subunit structure	Interacts with KIF23 and RBM44. Interacts with CEP55; inhibiting interaction between CEP55 and PDCD6IP/ALIX and TSG101. Ref.6 Ref.8 Ref.9
Subcellular location	Cytoplasm. Midbody. Chromosome › centromere › kinetochore. Note: Detected in the intercellular bridges that connect male germ cell daughter cells after cell division. Ref.5 Ref.6 Ref.7 Ref.8 Ref.10 Ref.11
Tissue specificity	Detected in testis and spermatogonia. Not detectable in the other tissues tested. Ref.1 Ref.3 Ref.5
Developmental stage	Detected at low levels in developing testis at 5 and 10 days after birth. Highly expressed in testis 15 and 20 days after birth. Highly expressed in pachytene, diplotene and meiotically dividing spermatocytes and in early round spermatids. Ref.3
Domain	The protein kinase domain is predicted to be catalytically inactive. The GPPX3Y motif mediates interaction with CEP55 (Ref.8).
Post-translational modification	Phosphorylated on Thr residues by CDK1 during early phases of mitosis, promoting the interaction with PLK1 and recruitment to kinetochores. Phosphorylated on Ser-431 by PLK1 during late prometaphase promotes the rapid depletion from kinetochores and its subsequent degradation by the APC/C complex. Ref.11
Disruption phenotype	Male mice are sterile, due to the absence of intercellular bridges. Intercellular bridges do not form during spermatogenesis, and male mice are sterile. In females, embryonic intercellular bridges are also absent, mice have fewer oocytes, but they are fertile. Ref.5 Ref.7
Miscellaneous	Used as a marker for intercellular bridges (Ref.10).
Sequence similarities	Belongs to the protein kinase superfamily. Contains 3 ANK repeats. Contains 1 protein kinase domain.
Caution	Ser-370 is present instead of the conserved Asp which is expected to be an active site residue.
Sequence caution	The sequence CAI35965.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis
Cellular component	Centromere Chromosome Cytoplasm Kinetochore
Coding sequence diversity	Alternative splicing
Domain	ANK repeat Repeat
Ligand	ATP-binding Nucleotide-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	attachment of spindle microtubules to kinetochore Inferred from mutant phenotype Ref.11. Source: UniProtKB cell division Inferred from electronic annotation. Source: UniProtKB-KW intercellular bridge organization Inferred from direct assay Ref.5. Source: UniProtKB male meiosis Inferred from mutant phenotype Ref.5. Source: UniProtKB mitotic sister chromatid separation Inferred from mutant phenotype Ref.11. Source: UniProtKB mitotic spindle assembly checkpoint Inferred from mutant phenotype Ref.11. Source: UniProtKB negative regulation of cytokinesis Inferred from direct assay Ref.8. Source: MGI negative regulation of protein binding Inferred from direct assay Ref.8. Source: MGI
Cellular_component	condensed chromosome kinetochore Inferred from electronic annotation. Source: UniProtKB-SubCell cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell intercellular bridge Inferred from direct assay Ref.5Ref.6. Source: UniProtKB kinetochore Inferred from direct assay Ref.11. Source: UniProtKB midbody Inferred from direct assay Ref.11. Source: UniProtKB
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q7M6U3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q7M6U3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-218: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1450	1450	Inactive serine/threonine-protein kinase TEX14		PRO_0000246996
Regions
	Repeat	27 – 54	28	ANK 1
	Repeat	55 – 84	30	ANK 2
	Repeat	88 – 117	30	ANK 3
	Domain	199 – 512	314	Protein kinase
	Nucleotide binding	205 – 213	9	ATP By similarity
	Motif	791 – 797	7	GPPX3Y
	Motif	889 – 897	9	D-box
Sites
	Binding site	267	1	ATP By similarity
Amino acid modifications
	Modified residue	431	1	Phosphoserine; by PLK1 Ref.11
Natural variations
	Alternative sequence	1 – 218	218	Missing in isoform 2.		VSP_019870
Experimental info
	Mutagenesis	431	1	S → A: Reduced phosphorylation by PLK1 and abolishes depletion from kinetochores and subsequent degradation by the APC/C complex. Ref.11
	Mutagenesis	431	1	S → D or E: Mimicks phosphorylation state; inducing early depletion from kinetochores and subsequent degradation by the APC/C complex. Ref.11
	Mutagenesis	791	1	G → A: Does not affect interaction with CEP55. Ref.8
	Mutagenesis	792	1	P → A: Abolishes interaction with CEP55. Ref.8
	Mutagenesis	797	1	Y → A: Abolishes interaction with CEP55. Ref.8
	Mutagenesis	889 – 897	9	Missing: Prevents degradation during metaphase. Ref.11
	Sequence conflict	324	1	T → A in AAK31963. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 25, 2006. Version 2. Checksum: 0628605EBE0FF0A4	FASTA	1,450	162,541
	10 20 30 40 50 60 MSRGAPFPVP CPVLLGTFTD DSLEAQLHEY AKQGNCVKLK KILKKGVCVD AVNTQGQSAL 70 80 90 100 110 120 FVAALLGHVK LVDVLVDYGS DPNHRCFDGS TPVHAAAFSG NQWILSKLLT AGGDLRLHDE 130 140 150 160 170 180 KGRNPQAWAL TAGKDRSTQM VEFMQRCTSH MKAIIQGFSY DLLKKIDSPQ RLIGSPPWFG 190 200 210 220 230 240 SLIQGSPNSS PNRQLKPGII SAQNIYSFGF GKFYLTSGMQ LTYPGSLPVI GEKEVVQADD 250 260 270 280 290 300 EPTFSFFSGP YMVMTNLVWN RSRVTVKELN LPTRPHCSRL RLADLLIAEQ EHSSNLRHPN 310 320 330 340 350 360 LLQLMAVCLS RDLEKIRLVY ERITVGTLFS VLHERRSQFP VLHMEVIVHL LLQVADALIY 370 380 390 400 410 420 LHSRGFIHRS LSSYAVHIVS AGEARLTNLE YLTESQDSGA HRNVTRMPLP TQLYNWAAPE 430 440 450 460 470 480 VVLQKAATVK SDIYSFSVII QEILTDSIPW NGLDGSLVKE TIALGNYLEA DVRLPEPYYD 490 500 510 520 530 540 IVKSGIHAKQ KNRTMNLQDI RYILKNDLKE FIGAQKTQPT ESPRGQSYEP HPDVNICLGL 550 560 570 580 590 600 TSEYQKDPPD LDIKELKEMG SQPHSPTDHS FLTVKPTLAP QTLDSSLSAQ KPDNANVPSP 610 620 630 640 650 660 PAACLAEEVR SPTASQDSLC SFEINEIYSG CLTLGTDKEE ECLGTAASPE GDRPNQGDEL 670 680 690 700 710 720 PSLEEELDKM ERELHCFCEE DKSISEVDTD LLFEDDDWQS DSLGSLNLPE PTREAKGKTS 730 740 750 760 770 780 SWSKTDEYVS KCVLNLKISQ VMMQQSAEWL RKLEQEVEEL EWAQKELDSQ CSSLRDASLK 790 800 810 820 830 840 FANAKFQPAV GPPSLAYLPP VMQLPGLKQP ENGGTWLTLA RSPGNEREFQ EGHFSKKPEK 850 860 870 880 890 900 LSACGWKPFT QVSEESRGDC SELNNQLPTL RGPGKQSTGE QLPSTQEARE SLEKNTNQNS 910 920 930 940 950 960 RSMASVSSEI YATKSRNNED NGEAHLKWRL AVKEMAEKAV SGQLLLPPWN PQSSAPFESK 970 980 990 1000 1010 1020 VENESTPLPR PPIRGPESTE WQHILEYQRE NDEPKGNTKF GKMDNSDCDK NKHSRWTGLQ 1030 1040 1050 1060 1070 1080 RFTGIRYPFF RNHEQPEQNE ASQASCDTSV GTEKFYSTSS PIGDDFERFQ DSFAQRQGYV 1090 1100 1110 1120 1130 1140 EENFQIREIF EKNAEILTKP QFQAIQCAED KQDETLGETP KELKEKNTSL TDIQDLSSIT 1150 1160 1170 1180 1190 1200 YDQDGYFKET SYKTPKLKHA PTSASTPLSP ESISSAASHY EDCLENTTFH VKRGSTFCWN 1210 1220 1230 1240 1250 1260 GQEAMRTLSA KFTTVRERAK SLESLLASSK SLPAKLTDSK RLCMLSETGS SNVSAAFVTS 1270 1280 1290 1300 1310 1320 THATKRKSLP RELAEATSQQ HLDELPPPAQ ELLDEIEQLK QQQVSSLASH ENTARDLSVT 1330 1340 1350 1360 1370 1380 NKDKKHLEEQ ETNSSKDSSF LSSREIQDLE DTERAHSSLD EDLERFLQSP EENTALLDPT 1390 1400 1410 1420 1430 1440 KGSTREKKNK DQDVVEQKRK KKESIKPERR ESDSSLGTLE EDELKPCFWK RLGWSEPSRI 1450 IVLDQSDLSD
	Isoform 2 [UniParc]. Checksum: A2CDBD69A483AF39	FASTA	1,232	138,851
	10 20 30 40 50 60 MQLTYPGSLP VIGEKEVVQA DDEPTFSFFS GPYMVMTNLV WNRSRVTVKE LNLPTRPHCS 70 80 90 100 110 120 RLRLADLLIA EQEHSSNLRH PNLLQLMAVC LSRDLEKIRL VYERITVGTL FSVLHERRSQ 130 140 150 160 170 180 FPVLHMEVIV HLLLQVADAL IYLHSRGFIH RSLSSYAVHI VSAGEARLTN LEYLTESQDS 190 200 210 220 230 240 GAHRNVTRMP LPTQLYNWAA PEVVLQKAAT VKSDIYSFSV IIQEILTDSI PWNGLDGSLV 250 260 270 280 290 300 KETIALGNYL EADVRLPEPY YDIVKSGIHA KQKNRTMNLQ DIRYILKNDL KEFIGAQKTQ 310 320 330 340 350 360 PTESPRGQSY EPHPDVNICL GLTSEYQKDP PDLDIKELKE MGSQPHSPTD HSFLTVKPTL 370 380 390 400 410 420 APQTLDSSLS AQKPDNANVP SPPAACLAEE VRSPTASQDS LCSFEINEIY SGCLTLGTDK 430 440 450 460 470 480 EEECLGTAAS PEGDRPNQGD ELPSLEEELD KMERELHCFC EEDKSISEVD TDLLFEDDDW 490 500 510 520 530 540 QSDSLGSLNL PEPTREAKGK TSSWSKTDEY VSKCVLNLKI SQVMMQQSAE WLRKLEQEVE 550 560 570 580 590 600 ELEWAQKELD SQCSSLRDAS LKFANAKFQP AVGPPSLAYL PPVMQLPGLK QPENGGTWLT 610 620 630 640 650 660 LARSPGNERE FQEGHFSKKP EKLSACGWKP FTQVSEESRG DCSELNNQLP TLRGPGKQST 670 680 690 700 710 720 GEQLPSTQEA RESLEKNTNQ NSRSMASVSS EIYATKSRNN EDNGEAHLKW RLAVKEMAEK 730 740 750 760 770 780 AVSGQLLLPP WNPQSSAPFE SKVENESTPL PRPPIRGPES TEWQHILEYQ RENDEPKGNT 790 800 810 820 830 840 KFGKMDNSDC DKNKHSRWTG LQRFTGIRYP FFRNHEQPEQ NEASQASCDT SVGTEKFYST 850 860 870 880 890 900 SSPIGDDFER FQDSFAQRQG YVEENFQIRE IFEKNAEILT KPQFQAIQCA EDKQDETLGE 910 920 930 940 950 960 TPKELKEKNT SLTDIQDLSS ITYDQDGYFK ETSYKTPKLK HAPTSASTPL SPESISSAAS 970 980 990 1000 1010 1020 HYEDCLENTT FHVKRGSTFC WNGQEAMRTL SAKFTTVRER AKSLESLLAS SKSLPAKLTD 1030 1040 1050 1060 1070 1080 SKRLCMLSET GSSNVSAAFV TSTHATKRKS LPRELAEATS QQHLDELPPP AQELLDEIEQ 1090 1100 1110 1120 1130 1140 LKQQQVSSLA SHENTARDLS VTNKDKKHLE EQETNSSKDS SFLSSREIQD LEDTERAHSS 1150 1160 1170 1180 1190 1200 LDEDLERFLQ SPEENTALLD PTKGSTREKK NKDQDVVEQK RKKKESIKPE RRESDSSLGT 1210 1220 1230 LEEDELKPCF WKRLGWSEPS RIIVLDQSDL SD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"An abundance of X-linked genes expressed in spermatogonia." Wang P.J., McCarrey J.R., Yang F., Page D.C. Nat. Genet. 27:422-426(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY. Tissue: Testis.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"Sequence and expression of testis-expressed gene 14 (Tex14): a gene encoding a protein kinase preferentially expressed during spermatogenesis." Wu M.-H., Rajkovic A., Burns K.H., Yan W., Lin Y.-N., Matzuk M.M. Gene Expr. Patterns 3:231-236(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-227 (ISOFORM 1), IDENTIFICATION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
[4]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 714-1396. Strain: C57BL/6J. Tissue: Egg.
[5]	"TEX14 is essential for intercellular bridges and fertility in male mice." Greenbaum M.P., Yan W., Wu M.H., Lin Y.N., Agno J.E., Sharma M., Braun R.E., Rajkovic A., Matzuk M.M. Proc. Natl. Acad. Sci. U.S.A. 103:4982-4987(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, ABSENCE OF PROTEIN KINASE ACTIVITY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
[6]	"Conversion of midbodies into germ cell intercellular bridges." Greenbaum M.P., Ma L., Matzuk M.M. Dev. Biol. 305:389-396(2007) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, INTERACTION WITH KIF23.
[7]	"Mouse TEX14 is required for embryonic germ cell intercellular bridges but not female fertility." Greenbaum M.P., Iwamori N., Agno J.E., Matzuk M.M. Biol. Reprod. 80:449-457(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, DISRUPTION PHENOTYPE, SUBCELLULAR LOCATION.
[8]	"TEX14 interacts with CEP55 to block cell abscission." Iwamori T., Iwamori N., Ma L., Edson M.A., Greenbaum M.P., Matzuk M.M. Mol. Cell. Biol. 30:2280-2292(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CEP55, MUTAGENESIS OF GLY-791; PRO-792 AND TYR-797.
[9]	"Identification and characterization of RBM44 as a novel intercellular bridge protein." Iwamori T., Lin Y.N., Ma L., Iwamori N., Matzuk M.M. PLoS ONE 6:E17066-E17066(2011) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH RBM44.
[10]	"Mouse germ cell clusters form by aggregation as well as clonal divisions." Mork L., Tang H., Batchvarov I., Capel B. Mech. Dev. 128:591-596(2012) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
[11]	"Tex14, a plk1-regulated protein, is required for kinetochore-microtubule attachment and regulation of the spindle assembly checkpoint." Mondal G., Ohashi A., Yang L., Rowley M., Couch F.J. Mol. Cell 45:680-695(2012) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION AT SER-431, MUTAGENESIS OF SER-431 AND 889-ARG--ASN-897.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF285584 mRNA. Translation: AAK31963.1. AL596086, AL669902 Genomic DNA. Translation: CAI35127.1. AL669902 Genomic DNA. Translation: CAI35965.1. Different initiation. AL669902, AL596086 Genomic DNA. Translation: CAI35966.1. CU406969, CU406988 Genomic DNA. Translation: CAQ52018.1. CU406988, CU406969 Genomic DNA. Translation: CAQ52278.1. AY193717 mRNA. Translation: AAN86761.1. AY193718 mRNA. Translation: AAN86762.1. BK000966 mRNA. Translation: DAA01357.1. BK000967 mRNA. Translation: DAA01358.1. AK139808 mRNA. Translation: BAE24144.1.
IPI	IPI00320923. IPI00776008.
RefSeq	NP_001186222.1. NM_001199293.1. NP_113563.2. NM_031386.2.
UniGene	Mm.440758.
3D structure databases
ProteinModelPortal	Q7M6U3.
SMR	Q7M6U3. Positions 23-133, 249-533.
ModBase	Search...
PTM databases
PhosphoSite	Q7M6U3.
Proteomic databases
PaxDb	Q7M6U3.
PRIDE	Q7M6U3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000060835; ENSMUSP00000054444; ENSMUSG00000010342.
GeneID	83560.
KEGG	mmu:83560.
UCSC	uc007ktr.2. mouse.
Organism-specific databases
CTD	56155.
MGI	MGI:1933227. Tex14.
Phylogenomic databases
eggNOG	COG0666.
GeneTree	ENSGT00390000015123.
HOVERGEN	HBG094035.
InParanoid	Q7M6U3.
OMA	FSFFSGP.
OrthoDB	EOG45QHCB.
Gene expression databases
ArrayExpress	Q7M6U3.
Bgee	Q7M6U3.
CleanEx	MM_TEX14.
Genevestigator	Q7M6U3.
GermOnline	ENSMUSG00000010342. Mus musculus.
Family and domain databases
Gene3D	1.25.40.20. 1 hit.
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. [Graphical view]
Pfam	PF12796. Ank_2. 1 hit. PF07714. Pkinase_Tyr. 1 hit. [Graphical view]
SMART	SM00248. ANK. 3 hits. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit. SSF56112. Kinase_like. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 2 hits. PS50011. PROTEIN_KINASE_DOM. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	350646.
SOURCE	Search...

Entry information

Entry name

TEX14_MOUSE

Accession

Primary (citable) accession number: Q7M6U3
Secondary accession number(s): B2KGL0 , Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
Last sequence update:	July 25, 2006
Last modified:	May 29, 2013
This is version 91 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program