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Protein

SH2 domain-containing adapter protein F

Gene

SHF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Adapter protein which may play a role in the regulation of apoptosis in response to PDGF.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

SignaLinkiQ7M4L6.

Names & Taxonomyi

Protein namesi
Recommended name:
SH2 domain-containing adapter protein F
Gene namesi
Name:SHFImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:25116. SHF.

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi308153498.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 423423SH2 domain-containing adapter protein FPRO_0000322558Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei201 – 2011PhosphotyrosineBy similarity

Post-translational modificationi

May become phosphorylated upon binding to PDGFRA.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ7M4L6.
PeptideAtlasiQ7M4L6.
PRIDEiQ7M4L6.

PTM databases

iPTMnetiQ7M4L6.
PhosphoSiteiQ7M4L6.

Expressioni

Tissue specificityi

Expressed in skeletal muscle, brain, liver, prostate, testis, ovary, small intestine and colon.1 Publication

Gene expression databases

BgeeiENSG00000138606.
CleanExiHS_SHF.
ExpressionAtlasiQ7M4L6. baseline and differential.
GenevisibleiQ7M4L6. HS.

Organism-specific databases

HPAiHPA046113.
HPA057381.

Interactioni

Subunit structurei

Interacts with phosphorylated 'Tyr-720' of PDGFRA via its SH2 domain.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000290894.

Structurei

3D structure databases

ProteinModelPortaliQ7M4L6.
SMRiQ7M4L6. Positions 323-418.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini323 – 41896SH2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiENOG410IGWI. Eukaryota.
ENOG410XQJ2. LUCA.
GeneTreeiENSGT00390000015203.
HOGENOMiHOG000038038.
HOVERGENiHBG066172.
InParanoidiQ7M4L6.
OrthoDBiEOG091G0I06.
PhylomeDBiQ7M4L6.
TreeFamiTF325799.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q7M4L6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQQEGGPVRS APCRTGTLEG SRQGSPGHRK RASPKGSLSS AQPHSWMLTP
60 70 80 90 100
SPLNSHCAHR EPISSSPQPV ANGPKQKKKS NWRSTTRLRI IRLRDRLEPR
110 120 130 140 150
PLAILEDYAD PFDVQETGEG SAGASGAPEK VPENDGYMEP YEAQKMMAEI
160 170 180 190 200
RGSKETATQP LPLYDTPYEP EEDGATAEGE GAPWPRESRL PEDDERPPEE
210 220 230 240 250
YDQPWEWKKE RISKAFAVDI KVIKDLPWPP PVGQLDSSPS LPDGDRDISG
260 270 280 290 300
PASPLPEPSL EDSSAQFEGP EKSCLSPGRE EKGRLPPRLS AGNPKSAKPL
310 320 330 340 350
SMEPSSPLGE WTDPALPLEN QVWYHGAISR TDAENLLRLC KEASYLVRNS
360 370 380 390 400
ETSKNDFSLS LKSSQGFMHM KLSRTKEHKY VLGQNSPPFS SVPEIVHHYA
410 420
SRKLPIKGAE HMSLLYPVAI RTL
Length:423
Mass (Da):46,768
Last modified:October 5, 2010 - v2
Checksum:iB63C06255825CC6C
GO
Isoform 21 Publication (identifier: Q7M4L6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     218-264: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:376
Mass (Da):41,865
Checksum:i288181FDF18CAD0E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti177 – 1771A → P in AAH07586 (PubMed:15489334).Curated
Sequence conflicti377 – 3782EH → NN no nucleotide entry (PubMed:11095946).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei218 – 26447Missing in isoform 2. 1 PublicationVSP_052699Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC051619 Genomic DNA. No translation available.
BC007586 mRNA. Translation: AAH07586.1.
CCDSiCCDS10120.2. [Q7M4L6-1]
PIRiJC7552.
UniGeneiHs.310399.

Genome annotation databases

EnsembliENST00000290894; ENSP00000290894; ENSG00000138606. [Q7M4L6-1]
UCSCiuc001zuy.3. human. [Q7M4L6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC051619 Genomic DNA. No translation available.
BC007586 mRNA. Translation: AAH07586.1.
CCDSiCCDS10120.2. [Q7M4L6-1]
PIRiJC7552.
UniGeneiHs.310399.

3D structure databases

ProteinModelPortaliQ7M4L6.
SMRiQ7M4L6. Positions 323-418.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000290894.

PTM databases

iPTMnetiQ7M4L6.
PhosphoSiteiQ7M4L6.

Polymorphism and mutation databases

DMDMi308153498.

Proteomic databases

PaxDbiQ7M4L6.
PeptideAtlasiQ7M4L6.
PRIDEiQ7M4L6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000290894; ENSP00000290894; ENSG00000138606. [Q7M4L6-1]
UCSCiuc001zuy.3. human. [Q7M4L6-1]

Organism-specific databases

GeneCardsiSHF.
HGNCiHGNC:25116. SHF.
HPAiHPA046113.
HPA057381.
neXtProtiNX_Q7M4L6.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGWI. Eukaryota.
ENOG410XQJ2. LUCA.
GeneTreeiENSGT00390000015203.
HOGENOMiHOG000038038.
HOVERGENiHBG066172.
InParanoidiQ7M4L6.
OrthoDBiEOG091G0I06.
PhylomeDBiQ7M4L6.
TreeFamiTF325799.

Enzyme and pathway databases

SignaLinkiQ7M4L6.

Miscellaneous databases

PROiQ7M4L6.

Gene expression databases

BgeeiENSG00000138606.
CleanExiHS_SHF.
ExpressionAtlasiQ7M4L6. baseline and differential.
GenevisibleiQ7M4L6. HS.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSHF_HUMAN
AccessioniPrimary (citable) accession number: Q7M4L6
Secondary accession number(s): Q96IE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 5, 2010
Last modified: September 7, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The sequence described in PubMed:11095946 is over-extended by 57 aa at the N-terminus due to the presence of an uncorrected 5' mismatch compared to the reference genome sequence.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.