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Protein

Conotoxin r11e

Gene
N/A
Organism
Conus radiatus (Rayed cone)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Causes hyperactivity, circular motion, convulsion, urination and death, when injected into 13- to 15-day-old mice. Causes gasping, backward swimming or swimming in a vertical direction and death, when intraperitoneally injected into goldfish.

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Conotoxin r11e
OrganismiConus radiatus (Rayed cone)
Taxonomic identifieri61198 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Organism-specific databases

ConoServeri1478. RXIE.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000448831 – 37Conotoxin r11eAdd BLAST37

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi2 ↔ 16By similarity
Disulfide bondi9 ↔ 21By similarity
Modified residuei134-carboxyglutamate1 Publication1
Modified residuei144-carboxyglutamate1 Publication1
Disulfide bondi15 ↔ 26By similarity
Disulfide bondi20 ↔ 33By similarity
Modified residuei346'-bromotryptophan1 Publication1

Keywords - PTMi

Bromination, Disulfide bond, Gamma-carboxyglutamic acid

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

SMRiQ7M4K5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is XI (C-C-CC-CC-C-C).

Sequence similaritiesi

Belongs to the conotoxin I1 superfamily.Curated

Family and domain databases

InterProiView protein in InterPro
IPR013141. Conotoxin-I_CS.
IPR012624. Toxin_19.
PfamiView protein in Pfam
PF08088. Toxin_19. 1 hit.
PROSITEiView protein in PROSITE
PS60019. I_CONOTOXIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7M4K5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
ECKTNKMSCS LHEECCRFRC CFHGKCQTSV FGCWVDP
Length:37
Mass (Da):4,304
Last modified:December 15, 2003 - v1
Checksum:i82A9AAF718D29F35
GO

Mass spectrometryi

Molecular mass is 4463.67 Da from positions 1 - 37. 1 Publication

Sequence databases

PIRiA59457.

Entry informationi

Entry nameiCI1BE_CONRA
AccessioniPrimary (citable) accession number: Q7M4K5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: December 15, 2003
Last modified: November 22, 2017
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families