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Protein

Venom protease

Gene
N/A
Organism
Bombus pensylvanicus (American bumblebee) (Apis pensylvanica)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei49 – 491Charge relay systemBy similarity
Active sitei97 – 971Charge relay systemBy similarity
Active sitei193 – 1931Charge relay systemBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Names & Taxonomyi

Protein namesi
Recommended name:
Venom protease (EC:3.4.21.-)
Alternative name(s):
Allergen: Bom p 4
OrganismiBombus pensylvanicus (American bumblebee) (Apis pensylvanica)
Taxonomic identifieri28643 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataApoideaApidaeBombusFervidobombus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.By similarity

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei154. Bom p 4.
3158. Bom p 4.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 243243Venom proteasePRO_0000401926Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 50PROSITE-ProRule annotation
Disulfide bondi165 ↔ 178PROSITE-ProRule annotation
Disulfide bondi189 ↔ 217PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

ProteinModelPortaliQ7M4I3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 243243Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7M4I3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VVGGKPAKLG AWPWMVALGF HNYRQPKKSP EWKCGGSLRI SRHVLTAAHC
60 70 80 90 100
AIHRSLYVVR IADLNLKRDD DGAHPIQMGI ESKLIHPDYV YSEHHDDIAI
110 120 130 140 150
LKLEKDVSFS EYIRPICLPI EESLRNNNFI GYNPFVAGWG RLRYKGPLSD
160 170 180 190 200
ALMEVQVPVV RNKVCKRAYS DVSDTVICAG YPKGRKDSCQ GDSGGPLMIP
210 220 230 240
QESTYYEIGV VSYGHECALP KYPGVYTRVT SYLDSFILPA LKK
Length:243
Mass (Da):27,251
Last modified:December 15, 2003 - v1
Checksum:i4A4282AA17DC44EB
GO

Sequence databases

PIRiA56338.

Cross-referencesi

Sequence databases

PIRiA56338.

3D structure databases

ProteinModelPortaliQ7M4I3.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei154. Bom p 4.
3158. Bom p 4.0101.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSP4_BOMPE
AccessioniPrimary (citable) accession number: Q7M4I3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: December 15, 2003
Last modified: September 7, 2016
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.