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Protein
Submitted name:

Lectin CEL-I, N-acetyl-D-galactosamine-specific C-type

Gene
N/A
Organism
Cucumaria echinata (Sea cucumber)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi77 – 771Calcium 1Combined sources
Metal bindingi81 – 811Calcium 1Combined sources
Metal bindingi81 – 811Calcium 2Combined sources
Metal bindingi101 – 1011Calcium 3Combined sources
Metal bindingi103 – 1031Calcium 3Combined sources
Metal bindingi104 – 1041Calcium 1Combined sources
Metal bindingi109 – 1091Calcium 1; via carbonyl oxygenCombined sources
Metal bindingi109 – 1091Calcium 3Combined sources
Metal bindingi109 – 1091Calcium 4Combined sources
Binding sitei109 – 1091MannoseCombined sources
Binding sitei109 – 1091N-acetyl-D-galactosamineCombined sources
Metal bindingi110 – 1101Calcium 1Combined sources
Metal bindingi110 – 1101Calcium 2Combined sources
Binding sitei115 – 1151MannoseCombined sources
Binding sitei115 – 1151N-acetyl-D-galactosamineCombined sources
Metal bindingi123 – 1231Calcium 3Combined sources
Metal bindingi123 – 1231Calcium 4Combined sources
Metal bindingi124 – 1241Calcium 3Combined sources
Metal bindingi124 – 1241Calcium 4Combined sources

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

CalciumCombined sources, Metal-bindingCombined sources

Names & Taxonomyi

Protein namesi
Submitted name:
Lectin CEL-I, N-acetyl-D-galactosamine-specific C-typeImported
OrganismiCucumaria echinata (Sea cucumber)Imported
Taxonomic identifieri40245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaHolothuroideaDendrochirotaceaDendrochirotidaCucumariidaeCucumaria

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi3 ↔ 14Combined sources
Disulfide bondi31 ↔ 135Combined sources
Disulfide bondi36 – 36InterchainCombined sources

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WMYX-ray2.00A/B1-140[»]
1WMZX-ray1.70A/B/C/D1-140[»]
4WQQX-ray1.70A/B/C/D1-140[»]
ProteinModelPortaliQ7M462.
SMRiQ7M462. Positions 1-140.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7M462.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 136127C-type lectinInterPro annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni101 – 1033N-acetyl-D-galactosamine bindingCombined sources
Regioni123 – 1242Mannose bindingCombined sources
Regioni123 – 1242N-acetyl-D-galactosamine bindingCombined sources

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7M462-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
NQCPTDWEAE GDHCYRFFNT LTTWENAHHE CVSYSCSTLN VRSDLVSVHS
60 70 80 90 100
AAEQAYVFNY WRGIDSQAGQ LWIGLYDKYN EGDFIWTDGS KVGYTKWAGG
110 120 130 140
QPDNWNNAED YGQFRHTEGG AWNDNSAAAQ AKYMCKLTFE
Length:140
Mass (Da):16,032
Last modified:December 15, 2003 - v1
Checksum:i385F2088058EA01C
GO

Sequence databases

PIRiJC7786.

Cross-referencesi

Sequence databases

PIRiJC7786.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WMYX-ray2.00A/B1-140[»]
1WMZX-ray1.70A/B/C/D1-140[»]
4WQQX-ray1.70A/B/C/D1-140[»]
ProteinModelPortaliQ7M462.
SMRiQ7M462. Positions 1-140.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ7M462.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characteristic recognition of N-acetylgalactosamine by an invertebrate C-type Lectin, CEL-I, revealed by X-ray crystallographic analysis."
    Sugawara H., Kusunoki M., Kurisu G., Fujimoto T., Aoyagi H., Hatakeyama T.
    J. Biol. Chem. 279:45219-45225(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) IN COMPLEX WITH CALCIUM AND N-ACETYL-D-GALACTOSAMINE, DISULFIDE BONDS.
  2. "Mannose-recognition mutant of the galactose/N-acetylgalactosamine-specific C-type lectin CEL-I engineered by site-directed mutagenesis."
    Moriuchi H., Unno H., Goda S., Tateno H., Hirabayashi J., Hatakeyama T.
    Biochim. Biophys. Acta 1850:1457-1465(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) IN COMPLEX WITH CALCIUM AND MANNOSE, DISULFIDE BONDS.

Entry informationi

Entry nameiQ7M462_CUCEC
AccessioniPrimary (citable) accession number: Q7M462
Entry historyi
Integrated into UniProtKB/TrEMBL: December 15, 2003
Last sequence update: December 15, 2003
Last modified: February 17, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.