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Protein

Extracellular giant hemoglobin major globin subunit A1

Gene

ghbA1

Organism
Oligobrachia mashikoi (Beard worm)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The extracellular giant hemoglobin is able to bind and transport oxygen and hydrosulfide simultaneously and reversibly at two different sites.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei79HydrosulfideCurated1
Metal bindingi110Iron (heme proximal ligand)1

GO - Molecular functioni

Keywordsi

Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Extracellular giant hemoglobin major globin subunit A1
Short name:
Major globin chain b
Gene namesi
Name:ghbA1
OrganismiOligobrachia mashikoi (Beard worm)
Taxonomic identifieri55676 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaAnnelidaPolychaetaPalpataCanalipalpataSabellidaSiboglinidaeOligobrachia

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 162 PublicationsAdd BLAST16
ChainiPRO_000005251817 – 156Extracellular giant hemoglobin major globin subunit A1Add BLAST140

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi18 ↔ 1461 Publication
Disulfide bondi137Interchain (with C-142 in subunit B2)1 Publication

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

The 400 kDa hemoglobin consists of a spherical 24-mer arranged as a double layer of dome-shaped dodecamers. Each dodecamer is composed of the 3-fold trimer of the tetramer A1-A2-B1-B2 having one intra-tetramer (A1-B2) disulfide bond and one inter-tetramer (B1-B2) disulfide bond per tetramer.1 Publication

Structurei

Secondary structure

1156
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi20 – 34Combined sources15
Helixi40 – 53Combined sources14
Helixi56 – 62Combined sources7
Turni63 – 68Combined sources6
Helixi73 – 90Combined sources18
Turni91 – 94Combined sources4
Helixi96 – 109Combined sources14
Beta strandi111 – 113Combined sources3
Helixi117 – 130Combined sources14
Helixi131 – 134Combined sources4
Helixi140 – 153Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D2MX-ray2.85A17-156[»]
2D2NX-ray3.20A17-156[»]
2ZFOX-ray1.95A17-156[»]
2ZS0X-ray1.60A17-156[»]
2ZS1X-ray1.70A17-156[»]
ProteinModelPortaliQ7M419
SMRiQ7M419
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7M419

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR014610 Haemoglobin_extracell
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PIRSFiPIRSF036517 Ext_hemo, 1 hit
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7M419-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVLIIFACL VVMASAVCNR LEQILVKTQW AQSYGEAENR AAFSRDLFSE
60 70 80 90 100
LFNIQGSSRA LFSGVGVDDM NSAAFTAHCL RVTGALNRLI SQLDQQATIN
110 120 130 140 150
ADLAHLAGQH ASRNLDASNF AAMGQAVMSV VPTHLDCFNQ HAWGECYERI

ASGISG
Length:156
Mass (Da):16,866
Last modified:January 23, 2007 - v2
Checksum:iE8F6B30F5121343B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB185392 mRNA Translation: BAD86543.1
PIRiS72252

Similar proteinsi

Entry informationi

Entry nameiGLBA1_OLIMA
AccessioniPrimary (citable) accession number: Q7M419
Secondary accession number(s): Q5KSB9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 68 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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