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Protein

Tropomyosin

Gene
N/A
Organism
Turbo cornutus (Horned turban) (Battilus cornutus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Tropomyosin
Alternative name(s):
Major allergen Tur c 1
Allergen: Tur c 1
OrganismiTurbo cornutus (Horned turban) (Battilus cornutus)
Taxonomic identifieri63673 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaVetigastropodaTrochoideaTurbinidaeTurboBatillus

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei656. Tur c 1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 146›146TropomyosinPRO_0000205672Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili‹1 – 146›146By similarityAdd
BLAST

Domaini

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

Sequence similaritiesi

Belongs to the tropomyosin family.Curated

Keywords - Domaini

Coiled coil, Repeat

Family and domain databases

InterProiIPR000533. Tropomyosin.
[Graphical view]
PfamiPF00261. Tropomyosin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragments.

Q7M3Y8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AANLENDFDN VNEQLQDALS KITLLEEDLE RNEERLQTAT ERLEEASKYI
60 70 80 90 100
AEDAERKLAI TEVDLERAEA RLEAAEAKSL EISEQEASQR EDSYEETIRD
110 120 130 140
LTQRLKTVSK LQKEVDRLED ELLAEKEKYK AISDELDQTF AELAGY
Length:146
Mass (Da):16,839
Last modified:December 15, 2003 - v1
Checksum:iCAA859DA08A320F6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-adjacent residuesi20 – 212Curated
Non-adjacent residuesi47 – 482Curated
Non-adjacent residuesi55 – 562Curated
Non-adjacent residuesi77 – 782Curated
Non-adjacent residuesi106 – 1072Curated

Sequence databases

PIRiJE0229.

Cross-referencesi

Sequence databases

PIRiJE0229.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei656. Tur c 1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR000533. Tropomyosin.
[Graphical view]
PfamiPF00261. Tropomyosin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Purification and IgE-binding epitopes of a major allergen in the gastropod Turbo cornutus."
    Ishikawa M., Ishida M., Shimakura K., Nagashima Y., Shiomi K.
    Biosci. Biotechnol. Biochem. 62:1337-1343(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Tissue: Muscle.

Entry informationi

Entry nameiTPM_TURCO
AccessioniPrimary (citable) accession number: Q7M3Y8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: December 15, 2003
Last modified: October 1, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.