Q7M3Y8 (TPM_TURCO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Tropomyosin Alternative name(s): Major allergen Tur c 1 Allergen=Tur c 1
Organism	Turbo cornutus (Horned turban) (Battilus cornutus)
Taxonomic identifier	63673 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Lophotrochozoa › Mollusca › Gastropoda › Vetigastropoda › Trochoidea › Turbinidae › Turbo › Batillus

Protein attributes

Sequence length	146 AA.
Sequence status	Fragments.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.
Subunit structure	Homodimer By similarity.
Domain	The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
Allergenic properties	Causes an allergic reaction in human.
Sequence similarities	Belongs to the tropomyosin family.

Ontologies

Keywords
Disease	Allergen
Domain	Coiled coil Repeat
Technical term	Direct protein sequencing
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 146	›146	Tropomyosin		PRO_0000205672
Regions
	Coiled coil	‹1 – 146	›146	By similarity
Experimental info
	Non-adjacent residues	20 – 21	2
	Non-adjacent residues	47 – 48	2
	Non-adjacent residues	55 – 56	2
	Non-adjacent residues	77 – 78	2
	Non-adjacent residues	106 – 107	2
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	Q7M3Y8 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: CAA859DA08A320F6	FASTA	146	16,839
	10 20 30 40 50 60 AANLENDFDN VNEQLQDALS KITLLEEDLE RNEERLQTAT ERLEEASKYI AEDAERKLAI 70 80 90 100 110 120 TEVDLERAEA RLEAAEAKSL EISEQEASQR EDSYEETIRD LTQRLKTVSK LQKEVDRLED 130 140 ELLAEKEKYK AISDELDQTF AELAGY

References

[1]	"Purification and IgE-binding epitopes of a major allergen in the gastropod Turbo cornutus." Ishikawa M., Ishida M., Shimakura K., Nagashima Y., Shiomi K. Biosci. Biotechnol. Biochem. 62:1337-1343(1998) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Muscle.

Cross-references

Sequence databases
PIR	JE0229.
3D structure databases
ModBase	Search...
Protein family/group databases
Allergome	656. Tur c 1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR000533. Tropomyosin. [Graphical view]
Pfam	PF00261. Tropomyosin. 1 hit. [Graphical view]
PROSITE	PS00326. TROPOMYOSIN. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TPM_TURCO

Accession

Primary (citable) accession number: Q7M3Y8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
Last sequence update:	December 15, 2003
Last modified:	April 3, 2013
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)